Genomic description of human clinical Aspergillus fumigatus isolates, California, 2020
ABSTRACT: Aspergillus fumigatus, an environmental mold, causes life-threatening infections. Studies on the phylogenetic structure of human clinical A. fumigatus isolates are limited. Here, we performed whole genome sequencing of 24 A. fumigatus isolates collected from 18 patients in U.S. healthcare...
- Autores:
-
Misas Rivas, Elizabeth
Deng, John
Gold, Jeremy
Gade, Lalitha
Nunnally, Natalie
Georgacopoulos, Ourania
Bentz, Meghan
Berkow, Elizabeth
Litvintseva, Anastasia
Chiller, Tom
Klausner, Jeffrey
Chow, Nancy
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2023
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/45050
- Acceso en línea:
- https://hdl.handle.net/10495/45050
- Palabra clave:
- Antifúngicos
Antifungal Agents
Aspergilosis
Aspergillosis
Aspergillus fumigatus
Genómica
Genomics
Filogenia
Phylogeny
https://id.nlm.nih.gov/mesh/D000935
https://id.nlm.nih.gov/mesh/D001228
https://id.nlm.nih.gov/mesh/D001232
https://id.nlm.nih.gov/mesh/D023281
https://id.nlm.nih.gov/mesh/D010802
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc/2.5/co/
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Genomic description of human clinical Aspergillus fumigatus isolates, California, 2020 |
| title |
Genomic description of human clinical Aspergillus fumigatus isolates, California, 2020 |
| spellingShingle |
Genomic description of human clinical Aspergillus fumigatus isolates, California, 2020 Antifúngicos Antifungal Agents Aspergilosis Aspergillosis Aspergillus fumigatus Genómica Genomics Filogenia Phylogeny https://id.nlm.nih.gov/mesh/D000935 https://id.nlm.nih.gov/mesh/D001228 https://id.nlm.nih.gov/mesh/D001232 https://id.nlm.nih.gov/mesh/D023281 https://id.nlm.nih.gov/mesh/D010802 |
| title_short |
Genomic description of human clinical Aspergillus fumigatus isolates, California, 2020 |
| title_full |
Genomic description of human clinical Aspergillus fumigatus isolates, California, 2020 |
| title_fullStr |
Genomic description of human clinical Aspergillus fumigatus isolates, California, 2020 |
| title_full_unstemmed |
Genomic description of human clinical Aspergillus fumigatus isolates, California, 2020 |
| title_sort |
Genomic description of human clinical Aspergillus fumigatus isolates, California, 2020 |
| dc.creator.fl_str_mv |
Misas Rivas, Elizabeth Deng, John Gold, Jeremy Gade, Lalitha Nunnally, Natalie Georgacopoulos, Ourania Bentz, Meghan Berkow, Elizabeth Litvintseva, Anastasia Chiller, Tom Klausner, Jeffrey Chow, Nancy |
| dc.contributor.author.none.fl_str_mv |
Misas Rivas, Elizabeth Deng, John Gold, Jeremy Gade, Lalitha Nunnally, Natalie Georgacopoulos, Ourania Bentz, Meghan Berkow, Elizabeth Litvintseva, Anastasia Chiller, Tom Klausner, Jeffrey Chow, Nancy |
| dc.contributor.researchgroup.spa.fl_str_mv |
Biología Celular y Molecular CIB U. de A. U. del Rosario |
| dc.subject.decs.none.fl_str_mv |
Antifúngicos Antifungal Agents Aspergilosis Aspergillosis Aspergillus fumigatus Genómica Genomics Filogenia Phylogeny |
| topic |
Antifúngicos Antifungal Agents Aspergilosis Aspergillosis Aspergillus fumigatus Genómica Genomics Filogenia Phylogeny https://id.nlm.nih.gov/mesh/D000935 https://id.nlm.nih.gov/mesh/D001228 https://id.nlm.nih.gov/mesh/D001232 https://id.nlm.nih.gov/mesh/D023281 https://id.nlm.nih.gov/mesh/D010802 |
| dc.subject.meshuri.none.fl_str_mv |
https://id.nlm.nih.gov/mesh/D000935 https://id.nlm.nih.gov/mesh/D001228 https://id.nlm.nih.gov/mesh/D001232 https://id.nlm.nih.gov/mesh/D023281 https://id.nlm.nih.gov/mesh/D010802 |
| description |
ABSTRACT: Aspergillus fumigatus, an environmental mold, causes life-threatening infections. Studies on the phylogenetic structure of human clinical A. fumigatus isolates are limited. Here, we performed whole genome sequencing of 24 A. fumigatus isolates collected from 18 patients in U.S. healthcare facilities in California. Single-nucleotide polymorphism (SNP) differences between patient isolates ranged from 187 to 70 829 SNPs. For five patients with multiple isolates, we calculated the within-host diversities. Three patients had a within-host diversity that ranged from 4 to 10 SNPs and two patients ranged from 2 to 16 977 SNPs. Findings revealed highly diverse A. fumigatus strains among patients and two patterns of diversity for isolates that come from the same patient, low and extremely high diversity. |
| publishDate |
2023 |
| dc.date.issued.none.fl_str_mv |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2025-02-19T21:34:15Z |
| dc.date.available.none.fl_str_mv |
2025-02-19T21:34:15Z |
| dc.type.spa.fl_str_mv |
Reporte de caso |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ARTCASO |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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Misas E, Deng JZ, Gold JAW, Gade L, Nunnally NS, Georgacopoulos O, Bentz M, Berkow EL, Litvintseva AP, Chiller TM, Klausner JD, Chow NA. Genomic description of human clinical Aspergillus fumigatus isolates, California, 2020. Med Mycol. 2023 Feb 3;61(2):myad012. doi: 10.1093/mmy/myad012. |
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1369-3787 |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/10495/45050 |
| dc.identifier.doi.none.fl_str_mv |
10.1093/mmy/myad012 |
| dc.identifier.eissn.none.fl_str_mv |
1460-2710 |
| identifier_str_mv |
Misas E, Deng JZ, Gold JAW, Gade L, Nunnally NS, Georgacopoulos O, Bentz M, Berkow EL, Litvintseva AP, Chiller TM, Klausner JD, Chow NA. Genomic description of human clinical Aspergillus fumigatus isolates, California, 2020. Med Mycol. 2023 Feb 3;61(2):myad012. doi: 10.1093/mmy/myad012. 1369-3787 10.1093/mmy/myad012 1460-2710 |
| url |
https://hdl.handle.net/10495/45050 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Med. Mycol. |
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3 |
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2 |
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1 |
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61 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Medical Mycology |
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http://creativecommons.org/licenses/by-nc/2.5/co/ |
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https://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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3 páginas |
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application/pdf |
| dc.publisher.spa.fl_str_mv |
Oxford University Press |
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Oxford, Inglaterra |
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Universidad de Antioquia |
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Misas Rivas, ElizabethDeng, JohnGold, JeremyGade, LalithaNunnally, NatalieGeorgacopoulos, OuraniaBentz, MeghanBerkow, ElizabethLitvintseva, AnastasiaChiller, TomKlausner, JeffreyChow, NancyBiología Celular y Molecular CIB U. de A. U. del Rosario2025-02-19T21:34:15Z2025-02-19T21:34:15Z2023Misas E, Deng JZ, Gold JAW, Gade L, Nunnally NS, Georgacopoulos O, Bentz M, Berkow EL, Litvintseva AP, Chiller TM, Klausner JD, Chow NA. Genomic description of human clinical Aspergillus fumigatus isolates, California, 2020. Med Mycol. 2023 Feb 3;61(2):myad012. doi: 10.1093/mmy/myad012.1369-3787https://hdl.handle.net/10495/4505010.1093/mmy/myad0121460-2710ABSTRACT: Aspergillus fumigatus, an environmental mold, causes life-threatening infections. Studies on the phylogenetic structure of human clinical A. fumigatus isolates are limited. Here, we performed whole genome sequencing of 24 A. fumigatus isolates collected from 18 patients in U.S. healthcare facilities in California. Single-nucleotide polymorphism (SNP) differences between patient isolates ranged from 187 to 70 829 SNPs. For five patients with multiple isolates, we calculated the within-host diversities. Three patients had a within-host diversity that ranged from 4 to 10 SNPs and two patients ranged from 2 to 16 977 SNPs. Findings revealed highly diverse A. fumigatus strains among patients and two patterns of diversity for isolates that come from the same patient, low and extremely high diversity.Oak Ridge Institute for Science and EducationCOL00009623 páginasapplication/pdfengOxford University PressOxford, Inglaterrahttp://creativecommons.org/licenses/by-nc/2.5/co/https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Genomic description of human clinical Aspergillus fumigatus isolates, California, 2020Reporte de casohttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTCASOhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAntifúngicosAntifungal AgentsAspergilosisAspergillosisAspergillus fumigatusGenómicaGenomicsFilogeniaPhylogenyhttps://id.nlm.nih.gov/mesh/D000935https://id.nlm.nih.gov/mesh/D001228https://id.nlm.nih.gov/mesh/D001232https://id.nlm.nih.gov/mesh/D023281https://id.nlm.nih.gov/mesh/D010802Med. 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