Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection
ABSTRACT: For the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, clinical manifestations are broad and highly heterogeneous for both sexes. We aimed to determine how biological sex and age impact immune gene expression, particularly influencing the humoral neutralizing antib...
- Autores:
-
Montaño Mendoza, Vicky Margarita
Méndez Cortina, Yorjagis Andrés
Rodríguez Perea, Ana Lucía
Fernández Geysson, Javier
Rugeles López, María Teresa
Velilla Hernández, Paula Andrea
Cardona Maya, Walter Darío
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2023
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/35334
- Acceso en línea:
- https://hdl.handle.net/10495/35334
- Palabra clave:
- SARS-CoV-2
Síndrome Respiratorio Agudo Grave
Severe Acute Respiratory Syndrome
Genes
Alergia e Inmunología
Allergy and Immunology
Anticuerpos Neutralizantes
Antibodies, Neutralizing
Citocinas
Cytokines
Distribución por Edad y Sexo
Age and Sex Distribution
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
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Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection |
| title |
Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection |
| spellingShingle |
Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection SARS-CoV-2 Síndrome Respiratorio Agudo Grave Severe Acute Respiratory Syndrome Genes Alergia e Inmunología Allergy and Immunology Anticuerpos Neutralizantes Antibodies, Neutralizing Citocinas Cytokines Distribución por Edad y Sexo Age and Sex Distribution |
| title_short |
Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection |
| title_full |
Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection |
| title_fullStr |
Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection |
| title_full_unstemmed |
Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection |
| title_sort |
Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection |
| dc.creator.fl_str_mv |
Montaño Mendoza, Vicky Margarita Méndez Cortina, Yorjagis Andrés Rodríguez Perea, Ana Lucía Fernández Geysson, Javier Rugeles López, María Teresa Velilla Hernández, Paula Andrea Cardona Maya, Walter Darío |
| dc.contributor.author.none.fl_str_mv |
Montaño Mendoza, Vicky Margarita Méndez Cortina, Yorjagis Andrés Rodríguez Perea, Ana Lucía Fernández Geysson, Javier Rugeles López, María Teresa Velilla Hernández, Paula Andrea Cardona Maya, Walter Darío |
| dc.contributor.researchgroup.spa.fl_str_mv |
Biología y Control de Enfermedades Infecciosas Grupo Reproducción Inmunovirología Unipluriversidad |
| dc.subject.decs.none.fl_str_mv |
SARS-CoV-2 Síndrome Respiratorio Agudo Grave Severe Acute Respiratory Syndrome Genes Alergia e Inmunología Allergy and Immunology Anticuerpos Neutralizantes Antibodies, Neutralizing Citocinas Cytokines Distribución por Edad y Sexo Age and Sex Distribution |
| topic |
SARS-CoV-2 Síndrome Respiratorio Agudo Grave Severe Acute Respiratory Syndrome Genes Alergia e Inmunología Allergy and Immunology Anticuerpos Neutralizantes Antibodies, Neutralizing Citocinas Cytokines Distribución por Edad y Sexo Age and Sex Distribution |
| description |
ABSTRACT: For the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, clinical manifestations are broad and highly heterogeneous for both sexes. We aimed to determine how biological sex and age impact immune gene expression, particularly influencing the humoral neutralizing antibody (NAb) response and the cytokine production in coronavirus disease 2019 (COVID-19) subjects. The immune gene expression, according to biological sex and age, was assessed using the genome wide expression profile of blood proteins from healthy individuals using the Genotype Tissue Expression (GTEx) database. Moreover, anti-SARS-CoV-2 neutralizing antibody titers and cytokine levels were determined in blood samples from 141 COVID-19 individuals from Medellín, Colombia. Among subjects with COVID-19, males had statistically significantly higher median NAb titers and serum concentrations of interleukin-6 and CC chemokine ligand 3 than females. Overall, our findings point out a more robust innate immune response in women that could help recognize and restrain the virus faster than in men. |
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2023 |
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2023-06-07T15:52:43Z |
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2023-06-07T15:52:43Z |
| dc.date.issued.none.fl_str_mv |
2023 |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
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Montaño Mendoza VM, Mendez Cortina YA, Rodríguez-Perea AL, Fernandez GJ, Rugeles MT, Velilla Hernandez PA, Cardona Maya WD. Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection. Heliyon. 2023 Jan;9(1):e13045. doi: 10.1016/j.heliyon.2023.e13045. Epub 2023 Jan 18. PMID: 36685472; PMCID: PMC9847338. |
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2405-8440 |
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https://hdl.handle.net/10495/35334 |
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10.1016/j.heliyon.2023.e13045. |
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2405-8440 |
| identifier_str_mv |
Montaño Mendoza VM, Mendez Cortina YA, Rodríguez-Perea AL, Fernandez GJ, Rugeles MT, Velilla Hernandez PA, Cardona Maya WD. Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection. Heliyon. 2023 Jan;9(1):e13045. doi: 10.1016/j.heliyon.2023.e13045. Epub 2023 Jan 18. PMID: 36685472; PMCID: PMC9847338. 2405-8440 10.1016/j.heliyon.2023.e13045. |
| url |
https://hdl.handle.net/10495/35334 |
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eng |
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eng |
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Heliyon |
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11 |
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9 |
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Heliyon |
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application/pdf |
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Elsevier |
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Londres, Inglaterra |
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Universidad de Antioquia |
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Montaño Mendoza, Vicky MargaritaMéndez Cortina, Yorjagis AndrésRodríguez Perea, Ana LucíaFernández Geysson, JavierRugeles López, María TeresaVelilla Hernández, Paula AndreaCardona Maya, Walter DaríoBiología y Control de Enfermedades InfecciosasGrupo ReproducciónInmunovirologíaUnipluriversidad2023-06-07T15:52:43Z2023-06-07T15:52:43Z2023Montaño Mendoza VM, Mendez Cortina YA, Rodríguez-Perea AL, Fernandez GJ, Rugeles MT, Velilla Hernandez PA, Cardona Maya WD. Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection. Heliyon. 2023 Jan;9(1):e13045. doi: 10.1016/j.heliyon.2023.e13045. Epub 2023 Jan 18. PMID: 36685472; PMCID: PMC9847338.2405-8440https://hdl.handle.net/10495/3533410.1016/j.heliyon.2023.e13045.2405-8440ABSTRACT: For the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, clinical manifestations are broad and highly heterogeneous for both sexes. We aimed to determine how biological sex and age impact immune gene expression, particularly influencing the humoral neutralizing antibody (NAb) response and the cytokine production in coronavirus disease 2019 (COVID-19) subjects. The immune gene expression, according to biological sex and age, was assessed using the genome wide expression profile of blood proteins from healthy individuals using the Genotype Tissue Expression (GTEx) database. Moreover, anti-SARS-CoV-2 neutralizing antibody titers and cytokine levels were determined in blood samples from 141 COVID-19 individuals from Medellín, Colombia. Among subjects with COVID-19, males had statistically significantly higher median NAb titers and serum concentrations of interleukin-6 and CC chemokine ligand 3 than females. Overall, our findings point out a more robust innate immune response in women that could help recognize and restrain the virus faster than in men.COL0007631COL0012444COL000786511application/pdfengElsevierLondres, Inglaterrahttps://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/2.5/co/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infectionArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionSARS-CoV-2Síndrome Respiratorio Agudo GraveSevere Acute Respiratory SyndromeGenesAlergia e InmunologíaAllergy and ImmunologyAnticuerpos NeutralizantesAntibodies, NeutralizingCitocinasCytokinesDistribución por Edad y SexoAge and Sex DistributionHeliyon11119HeliyonPublicationCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823https://bibliotecadigital.udea.edu.co/bitstreams/52d0c77c-021f-4235-b1cd-d9364251308f/downloadb88b088d9957e670ce3b3fbe2eedbc13MD52falseAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstreams/5218e965-4ad4-4960-872f-be228c84d5f5/download8a4605be74aa9ea9d79846c1fba20a33MD53falseAnonymousREADORIGINALRugelesMaria_2023_ GeneSARS-CoV-2.pdfRugelesMaria_2023_ GeneSARS-CoV-2.pdfArtículo de investigaciónapplication/pdf4953636https://bibliotecadigital.udea.edu.co/bitstreams/6ddefb8f-632b-431c-b9c6-6bb83b6f7e07/downloadbcd5b10756e58436b109ad1a4a97f86aMD51trueAnonymousREADTEXTRugelesMaria_2023_ GeneSARS-CoV-2.pdf.txtRugelesMaria_2023_ GeneSARS-CoV-2.pdf.txtExtracted texttext/plain51747https://bibliotecadigital.udea.edu.co/bitstreams/cf874e1c-b8fb-4d3f-97a5-649da0ad233b/download4721c4469669071dcd068407785e9cc8MD54falseAnonymousREADTHUMBNAILRugelesMaria_2023_ GeneSARS-CoV-2.pdf.jpgRugelesMaria_2023_ GeneSARS-CoV-2.pdf.jpgGenerated Thumbnailimage/jpeg13462https://bibliotecadigital.udea.edu.co/bitstreams/92b3f43d-67c1-4b91-b7a7-056efaf63f5b/downloaddabed722732f430f02840be93590102fMD55falseAnonymousREAD10495/35334oai:bibliotecadigital.udea.edu.co:10495/353342025-03-26 22:27:34.854https://creativecommons.org/licenses/by-nc-nd/4.0/open.accesshttps://bibliotecadigital.udea.edu.coRepositorio Institucional de la Universidad de Antioquiaaplicacionbibliotecadigitalbiblioteca@udea.edu.coTk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo= |