Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease
ABSTRACT: Non-alcoholic fatty liver disease is characterized by disturbed lipid metabolism and increased oxidative stress. These conditions lead to the activation of different cellular response mechanisms, including senescence. Cellular senescence constitutes an important response to injury in the l...
- Autores:
-
Pedroza Diaz, Nini Johanna
Arroyave Ospina, Johanna Carolina
Serna Salas, Sandra
Moshage, Han
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2022
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/39794
- Acceso en línea:
- https://hdl.handle.net/10495/39794
- Palabra clave:
- Estrés Oxidativo
Oxidative Stress
Metabolismo de los Lípidos
Lipid Metabolism
Envejecimiento
Aging
Enfermedad del Hígado Graso no Alcohólico
Non-alcoholic Fatty Liver Disease
Enfermedades Mitocondriales
Mitochondrial Diseases
https://id.nlm.nih.gov/mesh/D018384
https://id.nlm.nih.gov/mesh/D050356
https://id.nlm.nih.gov/mesh/D000375
https://id.nlm.nih.gov/mesh/D065626
https://id.nlm.nih.gov/mesh/D028361
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by/2.5/co/
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Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease |
| title |
Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease |
| spellingShingle |
Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease Estrés Oxidativo Oxidative Stress Metabolismo de los Lípidos Lipid Metabolism Envejecimiento Aging Enfermedad del Hígado Graso no Alcohólico Non-alcoholic Fatty Liver Disease Enfermedades Mitocondriales Mitochondrial Diseases https://id.nlm.nih.gov/mesh/D018384 https://id.nlm.nih.gov/mesh/D050356 https://id.nlm.nih.gov/mesh/D000375 https://id.nlm.nih.gov/mesh/D065626 https://id.nlm.nih.gov/mesh/D028361 |
| title_short |
Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease |
| title_full |
Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease |
| title_fullStr |
Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease |
| title_full_unstemmed |
Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease |
| title_sort |
Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease |
| dc.creator.fl_str_mv |
Pedroza Diaz, Nini Johanna Arroyave Ospina, Johanna Carolina Serna Salas, Sandra Moshage, Han |
| dc.contributor.author.none.fl_str_mv |
Pedroza Diaz, Nini Johanna Arroyave Ospina, Johanna Carolina Serna Salas, Sandra Moshage, Han |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo de Gastrohepatología |
| dc.subject.decs.none.fl_str_mv |
Estrés Oxidativo Oxidative Stress Metabolismo de los Lípidos Lipid Metabolism Envejecimiento Aging Enfermedad del Hígado Graso no Alcohólico Non-alcoholic Fatty Liver Disease Enfermedades Mitocondriales Mitochondrial Diseases |
| topic |
Estrés Oxidativo Oxidative Stress Metabolismo de los Lípidos Lipid Metabolism Envejecimiento Aging Enfermedad del Hígado Graso no Alcohólico Non-alcoholic Fatty Liver Disease Enfermedades Mitocondriales Mitochondrial Diseases https://id.nlm.nih.gov/mesh/D018384 https://id.nlm.nih.gov/mesh/D050356 https://id.nlm.nih.gov/mesh/D000375 https://id.nlm.nih.gov/mesh/D065626 https://id.nlm.nih.gov/mesh/D028361 |
| dc.subject.meshuri.none.fl_str_mv |
https://id.nlm.nih.gov/mesh/D018384 https://id.nlm.nih.gov/mesh/D050356 https://id.nlm.nih.gov/mesh/D000375 https://id.nlm.nih.gov/mesh/D065626 https://id.nlm.nih.gov/mesh/D028361 |
| description |
ABSTRACT: Non-alcoholic fatty liver disease is characterized by disturbed lipid metabolism and increased oxidative stress. These conditions lead to the activation of different cellular response mechanisms, including senescence. Cellular senescence constitutes an important response to injury in the liver. Recent findings show that chronic oxidative stress can induce senescence, and this might be a driving mechanism for NAFLD progression, aggravating the disturbance of lipid metabolism, organelle dysfunction, pro-inflammatory response and hepatocellular damage. In this context, the modulation of cellular senescence can be beneficial to ameliorate oxidative stress-related damage during NAFLD progression. This review focuses on the role of oxidative stress and senescence in the mechanisms leading to NAFLD and discusses the possibilities to modulate senescence as a therapeutic strategy in the treatment of NAFLD. Keywords: ER stress; ROS; lipid metabolism; mitochondrial dysfunction; non-alcoholic liver disease; oxidative stress; stress-induced senescence. |
| publishDate |
2022 |
| dc.date.issued.none.fl_str_mv |
2022 |
| dc.date.accessioned.none.fl_str_mv |
2024-06-08T20:14:05Z |
| dc.date.available.none.fl_str_mv |
2024-06-08T20:14:05Z |
| dc.type.spa.fl_str_mv |
Artículo de revisión |
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Pedroza-Díaz J, Arroyave-Ospina JC, Serna Salas S, Moshage H. Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease. Antioxidants (Basel). 2022 May 16;11(5):975. doi: 10.3390/antiox11050975. |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/10495/39794 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/antiox11050975 |
| dc.identifier.eissn.none.fl_str_mv |
2076-3921 |
| identifier_str_mv |
Pedroza-Díaz J, Arroyave-Ospina JC, Serna Salas S, Moshage H. Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease. Antioxidants (Basel). 2022 May 16;11(5):975. doi: 10.3390/antiox11050975. 10.3390/antiox11050975 2076-3921 |
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https://hdl.handle.net/10495/39794 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Antioxidants |
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30 |
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5 |
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1 |
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11 |
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Antioxidants |
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http://creativecommons.org/licenses/by/2.5/co/ |
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https://creativecommons.org/licenses/by/4.0/ |
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30 páginas |
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Pedroza Diaz, Nini JohannaArroyave Ospina, Johanna CarolinaSerna Salas, SandraMoshage, HanGrupo de Gastrohepatología2024-06-08T20:14:05Z2024-06-08T20:14:05Z2022Pedroza-Díaz J, Arroyave-Ospina JC, Serna Salas S, Moshage H. Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease. Antioxidants (Basel). 2022 May 16;11(5):975. doi: 10.3390/antiox11050975.https://hdl.handle.net/10495/3979410.3390/antiox110509752076-3921ABSTRACT: Non-alcoholic fatty liver disease is characterized by disturbed lipid metabolism and increased oxidative stress. These conditions lead to the activation of different cellular response mechanisms, including senescence. Cellular senescence constitutes an important response to injury in the liver. Recent findings show that chronic oxidative stress can induce senescence, and this might be a driving mechanism for NAFLD progression, aggravating the disturbance of lipid metabolism, organelle dysfunction, pro-inflammatory response and hepatocellular damage. In this context, the modulation of cellular senescence can be beneficial to ameliorate oxidative stress-related damage during NAFLD progression. This review focuses on the role of oxidative stress and senescence in the mechanisms leading to NAFLD and discusses the possibilities to modulate senescence as a therapeutic strategy in the treatment of NAFLD. Keywords: ER stress; ROS; lipid metabolism; mitochondrial dysfunction; non-alcoholic liver disease; oxidative stress; stress-induced senescence.Colombia. Ministerio de Ciencia, Tecnología e Innovación - MincienciasCOL002415930 páginasapplication/pdfengMDPIBasilea, Suizahttp://creativecommons.org/licenses/by/2.5/co/https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver DiseaseArtículo de revisiónhttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTREVhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionEstrés OxidativoOxidative StressMetabolismo de los LípidosLipid MetabolismEnvejecimientoAgingEnfermedad del Hígado Graso no AlcohólicoNon-alcoholic Fatty Liver DiseaseEnfermedades MitocondrialesMitochondrial Diseaseshttps://id.nlm.nih.gov/mesh/D018384https://id.nlm.nih.gov/mesh/D050356https://id.nlm.nih.gov/mesh/D000375https://id.nlm.nih.gov/mesh/D065626https://id.nlm.nih.gov/mesh/D028361Antioxidants305111Antioxidants783-2017RoR:03fd5ne08PublicationLICENSElicense.txtlicense.txttext/plain; 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