A 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 confers protections against HIV-1 infection

ABSTRAC: We investigated whether a 6-amino acid insertion/deletion polymorphism in the mucin domain of TIM-1 (T-cell immunoglobulin and mucin domain 1), modulates susceptibility to HIV-1 infection. The polymorphism was genotyped in three case/control cohorts of HIV-1 exposed seronegative individuals (HESN) and HIV-1 infected subjects from Italy, Peru, and Colombia; data from a Thai population were retrieved from the literature. Across all cohorts, homozygosity for the short TIM-1 allele was more common in HESNs than in HIV-1 infected subjects. A meta analysis of the four association analyses yielded a p value of 0.005. In vitro infection assays of CD4þ T lymphocytes indicated that homo zygosity for the short allele is associated with lower rate of HIV-1 replication. These results suggest that the deletion allele protects from HIV-1 infection with a recessive effect.

• Autores: Aguilar Jimenez, Wbeimar; Sironi, Manuela; Saulle, Irma; Pontremoli, Chiara; Garziano, Micaela; Cagliani, Rachael; Trabattoni, Daria; Lo Caputo, Sergio; Vichi, Francesca; Mazzotta, Francesco; Forni, Diego; Riva, Stefania; Cedeño, Samandhy; Sánchez, Jorge; Brander, Christian; Zapata Builes, Wildeman; Rugeles López, María Teresa; Clerici, Mario; Biasin, Mara
• Tipo de recurso: Article of journal
• Fecha de publicación: 2017
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/36567
• Acceso en línea: https://hdl.handle.net/10495/36567
• Palabra clave: Infecciones por VIH; HIV Infections; Polimorfismo Genético; Polymorphism, Genetic; Mucina-1; Mucin-1; Aminoácidos; Amino Acids; Estudios de Casos y Controles; Case-Control Studies; Replicación Viral; Virus Replication
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-nd/2.5/co/