Autoantibodies Neutralizing Type I IFNs in the Bronchoalveolar Lavage of at Least 10% of Patients During Life‑Threatening COVID‑19 Pneumonia

ABSTRACT: Autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) are found in the blood of at least 15% of unvaccinated patients with life-threatening COVID-19 pneumonia. We report here the presence of auto-Abs neutralizing type I IFNs in the bronchoalveolar lavage (BAL) of 54 of the 415 unvaccinated patients (13%) with life-threatening COVID-19 pneumonia tested. The 54 individuals with neutralizing auto-Abs in the BAL included 45 (11%) with auto-Abs against IFN-α2, 37 (9%) with auto-Abs against IFN-ω, 54 (13%) with auto-Abs against IFN-α2 and/or ω, and five (1%) with auto-Abs against IFN-β, including three (0.7%) with auto-Abs neutralizing IFN-α2, IFN-ω, and IFN-β, and two (0.5%) with auto-Abs neutralizing IFN-α2 and IFN-β. Auto-Abs against IFN-α2 also neutralize the other 12 subtypes of IFN-α. Paired plasma samples were available for 95 patients. All seven patients with paired samples who had detectable auto-Abs in BAL also had detectable auto-Abs in plasma, and one patient had auto-Abs detectable only in blood. Auto-Abs neutralizing type I IFNs are, therefore, present in the alveolar space of at least 10% of patients with life-threatening COVID-19 pneumonia. These findings suggest that these auto-Abs impair type I IFN immunity in the lower respiratory tract, thereby contributing to hypoxemic COVID-19 pneumonia.

• Autores: Arias Sierra, Andrés Augusto; Adle Biassette, Homa; Bastard, Paul; Blaize, Marion; Borie, Raphael; Bizien, Lucy; Casanova, Jean Laurent; Cobat, Aurélie; Crestani, Bruno; Conil, Clément; Desmons, Aurore; Duitman, Jan Willem; Edouard Luyt, Charles; Fekkar, Arnaud; Gervais, Adrian; Hammadi, Boualem; Jeljeli, Maxime; Jouanguy, Emmanuelle; Le Voyer, Tom; Migaud, Mélanie; Megarbane, Bruno; Marchal, Astrid; Puel, Anne; Qian, Zhang; Philippot, Quentin; Romano, Alessia; Rosain, Jérémie; Sene, Damien; Zhang, Qian; Mayaux, Julien; Lieuwe D. J., Bos
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2023
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/43127
• Acceso en línea: https://hdl.handle.net/10495/43127
• Palabra clave: Autoanticuerpos; Autoantibodies; Lavado Broncoalveolar; Bronchoalveolar Lavage; COVID-19; Interferón Tipo I; Interferon Type I; Interferón-alfa; Interferon-alpha; https://id.nlm.nih.gov/mesh/D001323; https://id.nlm.nih.gov/mesh/D018893; https://id.nlm.nih.gov/mesh/D000086382; https://id.nlm.nih.gov/mesh/D007370; https://id.nlm.nih.gov/mesh/D016898
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/