Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone
ABSTRACT: Background: Population and study’s methodology heterogenicity became clinical evolution of chronic spontaneous urticaria (CSU) highly variable. Objective: In a prospective cohort, we evaluated the different pathways of clinical evolution of CSU and identified possible risk factors. Methods...
- Autores:
-
Sánchez Caraballo, Jorge Mario
Cardona Villa, Ricardo
Álvarez Ricardo, Leidy Lucía
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2022
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/33179
- Acceso en línea:
- https://hdl.handle.net/10495/33179
- Palabra clave:
- Urticaria Crónica
Chronic Urticaria
Recurrencia
Recurrence
Prurito
Pruritus
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
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| dc.title.spa.fl_str_mv |
Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone |
| title |
Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone |
| spellingShingle |
Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone Urticaria Crónica Chronic Urticaria Recurrencia Recurrence Prurito Pruritus |
| title_short |
Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone |
| title_full |
Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone |
| title_fullStr |
Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone |
| title_full_unstemmed |
Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone |
| title_sort |
Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone |
| dc.creator.fl_str_mv |
Sánchez Caraballo, Jorge Mario Cardona Villa, Ricardo Álvarez Ricardo, Leidy Lucía |
| dc.contributor.author.none.fl_str_mv |
Sánchez Caraballo, Jorge Mario Cardona Villa, Ricardo Álvarez Ricardo, Leidy Lucía |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo de Alergología Clínica y Experimental (GACE) |
| dc.subject.decs.none.fl_str_mv |
Urticaria Crónica Chronic Urticaria Recurrencia Recurrence Prurito Pruritus |
| topic |
Urticaria Crónica Chronic Urticaria Recurrencia Recurrence Prurito Pruritus |
| description |
ABSTRACT: Background: Population and study’s methodology heterogenicity became clinical evolution of chronic spontaneous urticaria (CSU) highly variable. Objective: In a prospective cohort, we evaluated the different pathways of clinical evolution of CSU and identified possible risk factors. Methods: A total of 685 CSU patients (>12 years) were prospectively followed over 5 years. Diagnosis and follow-up of urticaria were based on medical evaluation and photographic records. Remission was defined as at least 6 months without symptoms (hives, angioedema, or pruritus) and medication. The follow-up included at least 2 visits per year, with photographic registration and clinical evaluation. Predefined clinical and paraclinical variables were included in the regression analyses. Results: We identified four clinical evolution pathways; The cumulative prevalence of remission at 5 years was 59.1%, recurrence was 17.1%, persistence was 11.6%, and chronic pruritus without hives or angioedema was 12.2%. The probability of persistence increased with hypothyroidism diagnosis (HR 0.425, 95% CI 0.290–0.621) and each point in the UAS7 (HR 0.931 95% CI 0.918– 0.945). Conclusion: Chronic urticaria has different evolutions. Disease activity and hypothyroidism predict persistence and remission. Recurrence and chronic pruritus phenotypes require further study to evaluate their causality and prognosis. |
| publishDate |
2022 |
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2022 |
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2023-01-19T17:37:13Z |
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2023-01-19T17:37:13Z |
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Artículo de investigación |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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Sánchez J, Álvarez L, Cardona R. Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone. World Allergy Organ J. 2022 Oct 8;15(10):100705. doi: 10.1016/j.waojou.2022.100705. |
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https://hdl.handle.net/10495/33179 |
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10.1016/j.waojou.2022.100705 |
| dc.identifier.eissn.none.fl_str_mv |
1939-4551 |
| identifier_str_mv |
Sánchez J, Álvarez L, Cardona R. Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone. World Allergy Organ J. 2022 Oct 8;15(10):100705. doi: 10.1016/j.waojou.2022.100705. 10.1016/j.waojou.2022.100705 1939-4551 |
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https://hdl.handle.net/10495/33179 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
World. Allergy. Organ. J. |
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9 |
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10 |
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15 |
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World Allergy Organization Journal |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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Elsevier |
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Atlanta, Estados Unidos |
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Universidad de Antioquia |
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Sánchez Caraballo, Jorge MarioCardona Villa, RicardoÁlvarez Ricardo, Leidy LucíaGrupo de Alergología Clínica y Experimental (GACE)2023-01-19T17:37:13Z2023-01-19T17:37:13Z2022Sánchez J, Álvarez L, Cardona R. Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone. World Allergy Organ J. 2022 Oct 8;15(10):100705. doi: 10.1016/j.waojou.2022.100705.https://hdl.handle.net/10495/3317910.1016/j.waojou.2022.1007051939-4551ABSTRACT: Background: Population and study’s methodology heterogenicity became clinical evolution of chronic spontaneous urticaria (CSU) highly variable. Objective: In a prospective cohort, we evaluated the different pathways of clinical evolution of CSU and identified possible risk factors. Methods: A total of 685 CSU patients (>12 years) were prospectively followed over 5 years. Diagnosis and follow-up of urticaria were based on medical evaluation and photographic records. Remission was defined as at least 6 months without symptoms (hives, angioedema, or pruritus) and medication. The follow-up included at least 2 visits per year, with photographic registration and clinical evaluation. Predefined clinical and paraclinical variables were included in the regression analyses. Results: We identified four clinical evolution pathways; The cumulative prevalence of remission at 5 years was 59.1%, recurrence was 17.1%, persistence was 11.6%, and chronic pruritus without hives or angioedema was 12.2%. The probability of persistence increased with hypothyroidism diagnosis (HR 0.425, 95% CI 0.290–0.621) and each point in the UAS7 (HR 0.931 95% CI 0.918– 0.945). Conclusion: Chronic urticaria has different evolutions. Disease activity and hypothyroidism predict persistence and remission. Recurrence and chronic pruritus phenotypes require further study to evaluate their causality and prognosis.COL00595679application/pdfengElsevierAtlanta, Estados Unidoshttps://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/2.5/co/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus aloneArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionUrticaria CrónicaChronic UrticariaRecurrenciaRecurrencePruritoPruritusWorld. Allergy. Organ. J.910115World Allergy Organization JournalPublicationCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823https://bibliotecadigital.udea.edu.co/bitstreams/4fdeec9e-9266-4652-8f5c-f75a9f6857c1/downloadb88b088d9957e670ce3b3fbe2eedbc13MD53falseAnonymousREADORIGINALSanchezJorge_2022_ChronicUrticariae.pdfSanchezJorge_2022_ChronicUrticariae.pdfArtículo de investigaciónapplication/pdf1090059https://bibliotecadigital.udea.edu.co/bitstreams/7c2d8898-955e-43a9-a0b8-5fdb9979234e/downloadec7e28e35aad8e01ea211586b72f5888MD52trueAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstreams/3bac50ae-8499-4c5c-ac1f-02f6010975ac/download8a4605be74aa9ea9d79846c1fba20a33MD54falseAnonymousREADTEXTSanchezJorge_2022_ChronicUrticariae.pdf.txtSanchezJorge_2022_ChronicUrticariae.pdf.txtExtracted texttext/plain40778https://bibliotecadigital.udea.edu.co/bitstreams/81b4dd15-42f8-4476-83a9-eb06dccf8fbe/download752b42560d9f963aeefda9b3a4e1ab86MD55falseAnonymousREADTHUMBNAILSanchezJorge_2022_ChronicUrticariae.pdf.jpgSanchezJorge_2022_ChronicUrticariae.pdf.jpgGenerated Thumbnailimage/jpeg16172https://bibliotecadigital.udea.edu.co/bitstreams/540d2a33-6e89-404f-ae30-16cebe305ad6/download80320999f41c1a92b108f10d4d481361MD56falseAnonymousREAD10495/33179oai:bibliotecadigital.udea.edu.co:10495/331792025-03-26 22:07:27.5https://creativecommons.org/licenses/by-nc-nd/4.0/open.accesshttps://bibliotecadigital.udea.edu.coRepositorio Institucional de la Universidad de Antioquiaaplicacionbibliotecadigitalbiblioteca@udea.edu.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 |