Dynamical brain connectivity markers in presymptomatic Alzheimer’s disease

Alzheimer's disease is the most prevalent cause of dementia generally with an onset after the 65 years. However, there are some genetic mutations that induce the onset of the neurocognitive symptoms before that age. The study of mutation carriers provides a unique opportunity to identify early preclinical changes related to Alzheimer's disease. The Event Related Potentials are a powerful tool used for the study of the neural substrates of cognitive function and deterioration. The connectivity analysis emerges as an alternative to the average approach typical in Event Related Potentials. In the current work two groups, mutation carriers and non-carriers, perform a memory task during Electroencephalography recording. Brain graphs are built at different time points using the directed Direct Transfer Function. Our results show how the dynamical study of the connectivity might help to detect neuronal changes in preclinical stage of Alzheimer's disease.

• Autores: Suárez Revelo, Jazmín Ximena; Ochoa Gómez, John Fredy; Duque Grajales, Jon Edinson; Tobón Quintero, Carlos Andrés
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2016
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/48203
• Acceso en línea: https://hdl.handle.net/10495/48203
• Palabra clave: Enfermedad de Alzheimer; Alzheimer Disease; Electroencefalografía; Electroencephalography; Redes Neuronales Gráficas; Graph Neural Networks; https://id.nlm.nih.gov/mesh/D000544; https://id.nlm.nih.gov/mesh/D004569; https://id.nlm.nih.gov/mesh/D000098422; ODS 3: Salud y bienestar. Garantizar una vida sana y promover el bienestar de todos a todas las edades
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-sa/4.0/