Nanoparticles targeting monocytes and macrophages as diagnostic and therapeutic tools for autoimmune diseases
ABSTRACT: Autoimmune diseases are chronic conditions that result from an inadequate immune response to self-antigens and affect many people worldwide. Their signs, symptoms, and clinical severity change throughout the course of the disease, therefore the diagnosis and treatment of autoimmune disease...
- Autores:
-
Rojas López, Mauricio
Álvarez Díaz, Karen Dayanna
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2023
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/43141
- Acceso en línea:
- https://hdl.handle.net/10495/43141
- Palabra clave:
- Enfermedades Autoinmunes
Autoimmune Diseases
Monocitos
Monocytes
Macrófagos
Macrophages
Nanopartículas
Nanoparticles
https://id.nlm.nih.gov/mesh/D001327
https://id.nlm.nih.gov/mesh/D009000
https://id.nlm.nih.gov/mesh/D008264
https://id.nlm.nih.gov/mesh/D053758
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by/2.5/co/
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| dc.title.spa.fl_str_mv |
Nanoparticles targeting monocytes and macrophages as diagnostic and therapeutic tools for autoimmune diseases |
| title |
Nanoparticles targeting monocytes and macrophages as diagnostic and therapeutic tools for autoimmune diseases |
| spellingShingle |
Nanoparticles targeting monocytes and macrophages as diagnostic and therapeutic tools for autoimmune diseases Enfermedades Autoinmunes Autoimmune Diseases Monocitos Monocytes Macrófagos Macrophages Nanopartículas Nanoparticles https://id.nlm.nih.gov/mesh/D001327 https://id.nlm.nih.gov/mesh/D009000 https://id.nlm.nih.gov/mesh/D008264 https://id.nlm.nih.gov/mesh/D053758 |
| title_short |
Nanoparticles targeting monocytes and macrophages as diagnostic and therapeutic tools for autoimmune diseases |
| title_full |
Nanoparticles targeting monocytes and macrophages as diagnostic and therapeutic tools for autoimmune diseases |
| title_fullStr |
Nanoparticles targeting monocytes and macrophages as diagnostic and therapeutic tools for autoimmune diseases |
| title_full_unstemmed |
Nanoparticles targeting monocytes and macrophages as diagnostic and therapeutic tools for autoimmune diseases |
| title_sort |
Nanoparticles targeting monocytes and macrophages as diagnostic and therapeutic tools for autoimmune diseases |
| dc.creator.fl_str_mv |
Rojas López, Mauricio Álvarez Díaz, Karen Dayanna |
| dc.contributor.author.none.fl_str_mv |
Rojas López, Mauricio Álvarez Díaz, Karen Dayanna |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo de Inmunología Celular e Inmunogenética |
| dc.subject.decs.none.fl_str_mv |
Enfermedades Autoinmunes Autoimmune Diseases Monocitos Monocytes Macrófagos Macrophages Nanopartículas Nanoparticles |
| topic |
Enfermedades Autoinmunes Autoimmune Diseases Monocitos Monocytes Macrófagos Macrophages Nanopartículas Nanoparticles https://id.nlm.nih.gov/mesh/D001327 https://id.nlm.nih.gov/mesh/D009000 https://id.nlm.nih.gov/mesh/D008264 https://id.nlm.nih.gov/mesh/D053758 |
| dc.subject.meshuri.none.fl_str_mv |
https://id.nlm.nih.gov/mesh/D001327 https://id.nlm.nih.gov/mesh/D009000 https://id.nlm.nih.gov/mesh/D008264 https://id.nlm.nih.gov/mesh/D053758 |
| description |
ABSTRACT: Autoimmune diseases are chronic conditions that result from an inadequate immune response to self-antigens and affect many people worldwide. Their signs, symptoms, and clinical severity change throughout the course of the disease, therefore the diagnosis and treatment of autoimmune diseases are major challenges. Current diagnostic tools are often invasive and tend to identify the issue at advanced stages. Moreover, the available treatments for autoimmune diseases do not typically lead to complete remission and are associated with numerous side effects upon long-term usage. A promising strategy is the use of nanoparticles that can be used as contrast agents in diagnostic imaging techniques to detect specific cells present at the inflammatory infiltrates in tissues that are not easily accessible by biopsy. In addition, NPs can be designed to deliver drugs to a cell population or tissue. Considering the significant role played by monocytes in the development of chronic inflammatory conditions and their emergence as a target for extracorporeal monitoring and precise interventions, this review focuses on recent advancements in nanoparticle-based strategies for diagnosing and treating autoimmune diseases, with a particular emphasis on targeting monocyte populations. |
| publishDate |
2023 |
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2023 |
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2024-11-04T19:13:50Z |
| dc.date.available.none.fl_str_mv |
2024-11-04T19:13:50Z |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
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Álvarez K, Rojas M. Nanoparticles targeting monocytes and macrophages as diagnostic and therapeutic tools for autoimmune diseases. Heliyon. 2023 Sep 7;9(9):e19861. doi: 10.1016/j.heliyon.2023.e19861 |
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https://hdl.handle.net/10495/43141 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.heliyon.2023.e19861 |
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2405-8440 |
| identifier_str_mv |
Álvarez K, Rojas M. Nanoparticles targeting monocytes and macrophages as diagnostic and therapeutic tools for autoimmune diseases. Heliyon. 2023 Sep 7;9(9):e19861. doi: 10.1016/j.heliyon.2023.e19861 10.1016/j.heliyon.2023.e19861 2405-8440 |
| url |
https://hdl.handle.net/10495/43141 |
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eng |
| language |
eng |
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Heliyon |
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14 |
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14 páginas |
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Elsevier |
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Londres, Inglaterra |
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Rojas López, MauricioÁlvarez Díaz, Karen DayannaGrupo de Inmunología Celular e Inmunogenética2024-11-04T19:13:50Z2024-11-04T19:13:50Z2023Álvarez K, Rojas M. Nanoparticles targeting monocytes and macrophages as diagnostic and therapeutic tools for autoimmune diseases. Heliyon. 2023 Sep 7;9(9):e19861. doi: 10.1016/j.heliyon.2023.e19861https://hdl.handle.net/10495/4314110.1016/j.heliyon.2023.e198612405-8440ABSTRACT: Autoimmune diseases are chronic conditions that result from an inadequate immune response to self-antigens and affect many people worldwide. Their signs, symptoms, and clinical severity change throughout the course of the disease, therefore the diagnosis and treatment of autoimmune diseases are major challenges. Current diagnostic tools are often invasive and tend to identify the issue at advanced stages. Moreover, the available treatments for autoimmune diseases do not typically lead to complete remission and are associated with numerous side effects upon long-term usage. A promising strategy is the use of nanoparticles that can be used as contrast agents in diagnostic imaging techniques to detect specific cells present at the inflammatory infiltrates in tissues that are not easily accessible by biopsy. In addition, NPs can be designed to deliver drugs to a cell population or tissue. Considering the significant role played by monocytes in the development of chronic inflammatory conditions and their emergence as a target for extracorporeal monitoring and precise interventions, this review focuses on recent advancements in nanoparticle-based strategies for diagnosing and treating autoimmune diseases, with a particular emphasis on targeting monocyte populations.Colombia. Ministerio de Ciencia, Tecnología e Innovación - MinCienciasCOL000863914 páginasapplication/pdfengElsevierLondres, Inglaterrahttp://creativecommons.org/licenses/by/2.5/co/https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Nanoparticles targeting monocytes and macrophages as diagnostic and therapeutic tools for autoimmune diseasesArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionEnfermedades AutoinmunesAutoimmune DiseasesMonocitosMonocytesMacrófagosMacrophagesNanopartículasNanoparticleshttps://id.nlm.nih.gov/mesh/D001327https://id.nlm.nih.gov/mesh/D009000https://id.nlm.nih.gov/mesh/D008264https://id.nlm.nih.gov/mesh/D053758Heliyon14919HeliyonMinCiencias 111584467267RoR:03fd5ne08PublicationORIGINALAlvarezKaren_2023_Nanoparticles_Targeting_Monocytes.pdfAlvarezKaren_2023_Nanoparticles_Targeting_Monocytes.pdfArtículo de investigaciónapplication/pdf3685939https://bibliotecadigital.udea.edu.co/bitstreams/ea0dede4-bded-43de-b8e9-5e8e4992cf3e/download7021870a4dc64ff73064bc62738e3a09MD51trueAnonymousREADCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823https://bibliotecadigital.udea.edu.co/bitstreams/26e024f3-861b-41ca-9216-9613f24096b8/downloadb88b088d9957e670ce3b3fbe2eedbc13MD52falseAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstreams/9cef0cb7-ba6d-4ecb-9d38-e7085beff5cc/download8a4605be74aa9ea9d79846c1fba20a33MD53falseAnonymousREADTEXTAlvarezKaren_2023_Nanoparticles_Targeting_Monocytes.pdf.txtAlvarezKaren_2023_Nanoparticles_Targeting_Monocytes.pdf.txtExtracted texttext/plain87275https://bibliotecadigital.udea.edu.co/bitstreams/d9bdfa0c-67a5-43a1-b3e8-78101658db50/download965ee5304bfb96eb0ef1067143465af5MD54falseAnonymousREADTHUMBNAILAlvarezKaren_2023_Nanoparticles_Targeting_Monocytes.pdf.jpgAlvarezKaren_2023_Nanoparticles_Targeting_Monocytes.pdf.jpgGenerated Thumbnailimage/jpeg13419https://bibliotecadigital.udea.edu.co/bitstreams/ea31498f-35b5-49d8-bf32-e4b70b7a2810/download0930218c04e695bd2c0bcaa76b387fb3MD55falseAnonymousREAD10495/43141oai:bibliotecadigital.udea.edu.co:10495/431412025-03-26 19:24:57.29http://creativecommons.org/licenses/by/2.5/co/open.accesshttps://bibliotecadigital.udea.edu.coRepositorio Institucional de la Universidad de Antioquiaaplicacionbibliotecadigitalbiblioteca@udea.edu.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 |