Epidemiology of drug-induced liver injury in a University Hospital from Colombia: Updated RUCAM being used for prospective causality assessment

ABSTRACT: Introduction and aim: Epidemiological information regarding drug-induced liver injury in some Latin American countries remains limited. Therefore, disease prevention and health promotion strategies are imperative to reduce drug-induced liver injuries and its fatal outcomes. This study aimed to collect epidemiological data regarding drug-induced liver injury and identify associated factors in patients admitted to a university hospital in Colombia. Methods and patients: A prospective study was conducted for 1 year to assess the incidence of druginduced liver injury in patients aged >18 years who showed elevated values in liver tests. Data were collected after obtaining informed consentfrom the patients. The updated Roussel Uclaf Causality Assessment Method was applied to assess the causality of drug-induced liver injury. Results: The study included 286 patients with elevated values in liver tests, 18 of whom presented with drug-induced liver injury. The mean age of patients was 54.7 ± 19.1 years. The associated pharmacological groups were anti-infectives and anticonvulsants (isoniazid, rifampicin, nitrofurantoin, phenytoin, and valproic acid), with a total of 15 drugs. The affected patients presented with cytopenia, jaundice, nausea, vomiting, or hepatomegaly. The most common type of liver injury was hepatocellular, and most patients recovered satisfactorily. The number of patients who had highly probable and probable causality grading was 1 and 9, respectively. Conclusion: The incidence of drug-induced liver injury in a university hospital in Colombia was 6%. Comorbidities and concomitant drugs are risk factors for drug-induced liver injury.

• Autores: Amariles Muñoz, Pedro; Cano Paniagua, Alejandra; Restrepo Garay, Margarita María; Angulo, Nancy
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2019
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/40144
• Acceso en línea: https://hdl.handle.net/10495/40144
• Palabra clave: Anciano; Aged; Anciano de 80 o más Años; Aged, 80 and over; Alanina Transaminasa - metabolismo; Alanine Transaminase - metabolism; Fosfatasa Alcalina - metabolismo; Alkaline Phosphatase - metabolism; Biomarcadores - metabolismo; Biomarkers - metabolism; Enfermedad Hepática Inducida por Sustancias y Drogas - diagnóstico; Chemical and Drug Induced Liver Injury - diagnosis; Enfermedad Hepática Inducida por Sustancias y Drogas - epidemiología; Chemical and Drug Induced Liver Injury - epidemiology; Colombia - epidemiología; Colombia - epidemiology; Estudios de Seguimiento; Follow-Up Studies; Hospitalización - estadística & datos numéricos; Hospitalization - statistics & numerical data; Hospitales Universitarios - estadística & datos numéricos; Hospitals, University - statistics & numerical data; Incidencia; Incidence; Hígado; Liver; Pruebas de Función Hepática; Liver Function Tests; Persona de Mediana Edad; Middle Aged; Pronóstico; Prognosis; Estudios Prospectivos; Prospective Studies; Medición de Riesgo - métodos; Risk Assessment - methods; Factores de Riesgo; Risk Factors; Adulto Joven; Young Adult; https://id.nlm.nih.gov/mesh/D000368; https://id.nlm.nih.gov/mesh/D000369; https://id.nlm.nih.gov/mesh/D000410; https://id.nlm.nih.gov/mesh/D000469; https://id.nlm.nih.gov/mesh/D015415; https://id.nlm.nih.gov/mesh/D056486; https://id.nlm.nih.gov/mesh/D003105; https://id.nlm.nih.gov/mesh/D005500; https://id.nlm.nih.gov/mesh/D006760; https://id.nlm.nih.gov/mesh/D006785; https://id.nlm.nih.gov/mesh/D015994; https://id.nlm.nih.gov/mesh/D008099; https://id.nlm.nih.gov/mesh/D008111; https://id.nlm.nih.gov/mesh/D008875; https://id.nlm.nih.gov/mesh/D011379; https://id.nlm.nih.gov/mesh/D011446; https://id.nlm.nih.gov/mesh/D018570; https://id.nlm.nih.gov/mesh/D012307; https://id.nlm.nih.gov/mesh/D055815
• Rights: openAccess
• License: https://creativecommons.org/licenses/by-nc-nd/4.0/