Antioxidant and antiproliferative activity of enzymatic hydrolysates from red tilapia (Oreochromis spp.) viscera

ABSTRACT: The antioxidant and antiproliferative activity of red tilapia (Oreochromis spp.) viscera hydrolysates (RTVH) was evaluated. For that, the hydrolysates was applied to three cancer cell lines (HepG2, Huh7 and SW480) and the control (CCD-18Co). Finally, the line on which the hydrolysate had the greatest effect (SW480) and the control (CCD-18Co) were subjected to the ApoTox-Glo Triplex Assay to determine apoptosis, toxicity, and cell viability. The result showed that hydrolysate had a dose-dependent cytotoxic effect selective on the three cancer cell lines, compared to the control cells. There is a relationship between the antioxidant capacity of RTVHs and their antiproliferative capacity on cancer cells evaluated, which achieved cell viability by action of RTVH of 34.68 and 41.58 and 25.41 %, to HepG2, Huh7 and SW480, respectively. The action of RTVH on cancer cell line SW480 is not due to the induction of apoptosis but to the rupture of the cell membrane.

• Autores: Zapata Montoya, José Edgar; Gómez Sampedro, Leidy Johanna
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2024
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/42930
• Acceso en línea: https://hdl.handle.net/10495/42930
• Palabra clave: Necrosis; Apoptosis; Antineoplásicos; Antineoplastic Agents; Células Hep G2; Hep G2 Cells; Citotoxicidad; Cytotoxicity; Oreochromis; http://aims.fao.org/aos/agrovoc/c_34251; http://aims.fao.org/aos/agrovoc/c_26596; https://id.nlm.nih.gov/mesh/D009336; https://id.nlm.nih.gov/mesh/D017209; https://id.nlm.nih.gov/mesh/D000970; https://id.nlm.nih.gov/mesh/D056945
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc/2.5/co/