DNA repair after oxidative stress: current challenges

ABSTRACT: Reactive oxygen and nitrogen species damage cellular macromolecules including DNA. Cells have a robust base excision repair pathway to deal with this damage in both nuclear and mitochondrial genomes. However, mitochondria lack nucleotide excision repair. Evidence suggests that chronic oxid...

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Autores:
Santa González, Gloria Angélica
Camargo Guerrero, Mauricio
Van Houten, Bennett
Tipo de recurso:
Article of investigation
Fecha de publicación:
2017
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/40126
Acceso en línea:
https://hdl.handle.net/10495/40126
Palabra clave:
Reparación del ADN
DNA Repair
Estrés Oxidativo
Oxidative Stress
Genotoxicidad
Genotoxicity
https://id.nlm.nih.gov/mesh/D004260
https://id.nlm.nih.gov/mesh/D018384
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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dc.title.spa.fl_str_mv DNA repair after oxidative stress: current challenges
title DNA repair after oxidative stress: current challenges
spellingShingle DNA repair after oxidative stress: current challenges
Reparación del ADN
DNA Repair
Estrés Oxidativo
Oxidative Stress
Genotoxicidad
Genotoxicity
https://id.nlm.nih.gov/mesh/D004260
https://id.nlm.nih.gov/mesh/D018384
title_short DNA repair after oxidative stress: current challenges
title_full DNA repair after oxidative stress: current challenges
title_fullStr DNA repair after oxidative stress: current challenges
title_full_unstemmed DNA repair after oxidative stress: current challenges
title_sort DNA repair after oxidative stress: current challenges
dc.creator.fl_str_mv Santa González, Gloria Angélica
Camargo Guerrero, Mauricio
Van Houten, Bennett
dc.contributor.author.none.fl_str_mv Santa González, Gloria Angélica
Camargo Guerrero, Mauricio
Van Houten, Bennett
dc.contributor.researchgroup.spa.fl_str_mv Genética, Regeneración y Cáncer
dc.subject.decs.none.fl_str_mv Reparación del ADN
DNA Repair
Estrés Oxidativo
Oxidative Stress
Genotoxicidad
Genotoxicity
topic Reparación del ADN
DNA Repair
Estrés Oxidativo
Oxidative Stress
Genotoxicidad
Genotoxicity
https://id.nlm.nih.gov/mesh/D004260
https://id.nlm.nih.gov/mesh/D018384
dc.subject.meshuri.none.fl_str_mv https://id.nlm.nih.gov/mesh/D004260
https://id.nlm.nih.gov/mesh/D018384
description ABSTRACT: Reactive oxygen and nitrogen species damage cellular macromolecules including DNA. Cells have a robust base excision repair pathway to deal with this damage in both nuclear and mitochondrial genomes. However, mitochondria lack nucleotide excision repair. Evidence suggests that chronic oxidative stress can induce protective pathways lowering genotoxicity. Understanding oxidant injury to DNA and its repair is critical for our understanding the pathophysiology of a wide range of human disorders.
publishDate 2017
dc.date.issued.none.fl_str_mv 2017
dc.date.accessioned.none.fl_str_mv 2024-06-18T20:08:25Z
dc.date.available.none.fl_str_mv 2024-06-18T20:08:25Z
dc.type.spa.fl_str_mv Artículo de investigación
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dc.identifier.citation.spa.fl_str_mv Van Houten B, Santa-Gonzalez GA, Camargo M. DNA repair after oxidative stress: current challenges. Curr Opin Toxicol. 2018 Feb;7:9-16. doi: 10.1016/j.cotox.2017.10.009.
dc.identifier.issn.none.fl_str_mv 2468-2934
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10495/40126
dc.identifier.doi.none.fl_str_mv 10.1016/j.cotox.2017.10.009
dc.identifier.eissn.none.fl_str_mv 2468-2020
identifier_str_mv Van Houten B, Santa-Gonzalez GA, Camargo M. DNA repair after oxidative stress: current challenges. Curr Opin Toxicol. 2018 Feb;7:9-16. doi: 10.1016/j.cotox.2017.10.009.
2468-2934
10.1016/j.cotox.2017.10.009
2468-2020
url https://hdl.handle.net/10495/40126
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Curr. Opin. Toxicol.
dc.relation.citationendpage.spa.fl_str_mv 16
dc.relation.citationstartpage.spa.fl_str_mv 1
dc.relation.citationvolume.spa.fl_str_mv 7
dc.relation.ispartofjournal.spa.fl_str_mv Current Opinion in Toxicology
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dc.format.extent.spa.fl_str_mv 16 páginas
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dc.publisher.spa.fl_str_mv Elsevier
dc.publisher.place.spa.fl_str_mv Ámsterdam, Países Bajos
institution Universidad de Antioquia
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spelling Santa González, Gloria AngélicaCamargo Guerrero, MauricioVan Houten, BennettGenética, Regeneración y Cáncer2024-06-18T20:08:25Z2024-06-18T20:08:25Z2017Van Houten B, Santa-Gonzalez GA, Camargo M. DNA repair after oxidative stress: current challenges. Curr Opin Toxicol. 2018 Feb;7:9-16. doi: 10.1016/j.cotox.2017.10.009.2468-2934https://hdl.handle.net/10495/4012610.1016/j.cotox.2017.10.0092468-2020ABSTRACT: Reactive oxygen and nitrogen species damage cellular macromolecules including DNA. Cells have a robust base excision repair pathway to deal with this damage in both nuclear and mitochondrial genomes. However, mitochondria lack nucleotide excision repair. Evidence suggests that chronic oxidative stress can induce protective pathways lowering genotoxicity. Understanding oxidant injury to DNA and its repair is critical for our understanding the pathophysiology of a wide range of human disorders.National Institutes of HealthCOL000676916 páginasapplication/pdfengElsevierÁmsterdam, Países Bajoshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2DNA repair after oxidative stress: current challengesArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionReparación del ADNDNA RepairEstrés OxidativoOxidative StressGenotoxicidadGenotoxicityhttps://id.nlm.nih.gov/mesh/D004260https://id.nlm.nih.gov/mesh/D018384Curr. Opin. 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