DNA repair after oxidative stress: current challenges
ABSTRACT: Reactive oxygen and nitrogen species damage cellular macromolecules including DNA. Cells have a robust base excision repair pathway to deal with this damage in both nuclear and mitochondrial genomes. However, mitochondria lack nucleotide excision repair. Evidence suggests that chronic oxid...
- Autores:
-
Santa González, Gloria Angélica
Camargo Guerrero, Mauricio
Van Houten, Bennett
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2017
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/40126
- Acceso en línea:
- https://hdl.handle.net/10495/40126
- Palabra clave:
- Reparación del ADN
DNA Repair
Estrés Oxidativo
Oxidative Stress
Genotoxicidad
Genotoxicity
https://id.nlm.nih.gov/mesh/D004260
https://id.nlm.nih.gov/mesh/D018384
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/
| Summary: | ABSTRACT: Reactive oxygen and nitrogen species damage cellular macromolecules including DNA. Cells have a robust base excision repair pathway to deal with this damage in both nuclear and mitochondrial genomes. However, mitochondria lack nucleotide excision repair. Evidence suggests that chronic oxidative stress can induce protective pathways lowering genotoxicity. Understanding oxidant injury to DNA and its repair is critical for our understanding the pathophysiology of a wide range of human disorders. |
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