Podotimod in pediatric recurrent respiratory tract infections: a cost-utility analysis

ABSTRACT: Introduction: Despite the growing evidence on efficacy, few economic evaluations have evaluated the cost-utility of Pidotimod (PDT) supplementation to decrease the probability of recurrent respiratory tract infections in children. This study aimed to determine the cost-utility of PDT to reduce the incidence rate of recurrent respiratory tract infections in children. Methods: A decision tree model was used to estimate the cost and quality-adjusted life-years (QALYs) of PDT in a patient aged 1-6 with a history of recurrent respiratory tract infections. Multiple sensitivity analyses were conducted to evaluate the robustness of the model. Cost-effectiveness was evaluated at a willingness-to-pay (WTP) value of US$5180. Results: The base-case analysis showed that compared with placebo, PDT was associated with lower costs and higher QALYs. The expected annual cost per patient with PDT was US$797 (CI 95% US$794- US$801) and with placebo was US$1175 (CI 95% US$1169- US$1181). The QALYs per person estimated with PDT was 0.95 (CI 95% 0.94-0.95) and with placebo was 0.94 (CI 95% 0.94-0.94). The NMB with PDT was US$ 4121 (CI 95% 4114-4127) and with placebo was US$ 3710 (CI 95% 3700-3720). This position of absolute dominance (PDT has lower costs and higher QALYs than placebo) of PDT it is unnecessary to estimate the incremental cost-effectiveness ratio. Conclusion: In conclusion our study shows that PDT is a cost-effective strategy to reduce the incidence rate of recurrent respiratory tract infections in children. Our study provides evidence that should be used by decision-makers to improve clinical practice guidelines.

• Autores: Buendía Rodríguez, Jefferson Antonio; Lindarte Rincón, Erika Fernanda; Guerrero Patiño, Diana
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2022
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/45375
• Acceso en línea: https://hdl.handle.net/10495/45375
• Palabra clave: Niño; Child; Colombia; Análisis Costo-Beneficio; Cost-Benefit Analysis; Infecciones del Tracto Respiratorio; Respiratory Tract Infections; Economía y Organizaciones para la Atención de la Salud; Health Care Economics and Organizations; Corticoesteroides; Adrenal Cortex Hormones; https://id.nlm.nih.gov/mesh/D002648; https://id.nlm.nih.gov/mesh/D003105; https://id.nlm.nih.gov/mesh/D003362; http://id.nlm.nih.gov/mesh/D012141; https://id.nlm.nih.gov/mesh/D004472; https://id.nlm.nih.gov/mesh/D000305
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/