The spontaneous control of HIV replication is characterized by decreased pathological changes in the gut-associated lymphoid tissue

ABSTRAC: Background: HIV infection induces alterations in the gut-associated lymphoid tissue (GALT) that constitutes the most important site for viral replication due to the extensive presence of effector memory T-cells. In the case of HIV-controllers, several studies have reported fewer periph eral...

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Autores:
Taborda Vanegas, Natalia Andrea
Correa Londoño, Luis Alfonso
Feria Garzón, Manuel Gerónimo
Rugeles López, María Teresa
Tipo de recurso:
Article of investigation
Fecha de publicación:
2018
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/36784
Acceso en línea:
https://hdl.handle.net/10495/36784
Palabra clave:
Tejido Linfoide
Lymphoid Tissue
VIH
HIV
Linfocitos T CD4-Positivos
CD4-Positive T-Lymphocytes
VIH no-Progresivos
HIV Non-Progressors
Tracto Gastrointestinal
Gastrointestinal Tract
Células M
M Cells
Sobrevivientes de VIH a Largo Plazo
HIV Long-Term Survivors
Rights
openAccess
License
http://creativecommons.org/licenses/by/2.5/co/
Description
Summary:ABSTRAC: Background: HIV infection induces alterations in the gut-associated lymphoid tissue (GALT) that constitutes the most important site for viral replication due to the extensive presence of effector memory T-cells. In the case of HIV-controllers, several studies have reported fewer periph eral alterations and conserved immune responses that correlate with viral control; however, the histopathological characterization of GALT in those patients is still missing. In this study, we evalu ated pathological alterations in GALT, trying to associate them with clinical parameters of HIV in fected patients with or without evidence of viral control.