Disseminated Cryptococcosis After Liver Transplant

ABSTRACT: Cryptococcosis is an opportunistic infection caused by the Basidiomycota Cryptococcus neoformans (Cryptococcus gattii), which affects immunosuppressed patients and less frequently immunocompetent patients. Solid-organ transplant recipients are a particularly high-risk group, depending on the net state of immunosuppression. In these patients, the infection usually appears after the first year after transplant, although it may occur earlier in liver transplant recipients. In most cases, the infection is secondary to the reactivation of a latent infection, although it may be due to an unidentified pretransplant infection by primary infection. Less frequently, it may be transmitted by the graft. The lung and central nervous system are most frequently involved. Extrapulmonary involvement is seen in 75% of the cases, and disseminated disease occurs in 61%, with mortality ranging from 17% to 50% when the central nervous system is involved. Here, we report a case of disseminated cryptococcosis (lymphadenitis, meningitis, pulmonary nodules, and possibly sacroiliitis) in a patient after liver transplant, with good clinical and microbiological outcomes and without relapse.

• Autores: Díaz Ramírez, Gabriel Sebastián; Martínez Casas, Omar Yesid; Marín Zuluaga, Juan Ignacio; Muñoz Maya, Octavio Germán; Santos Sánchez, Óscar; Ramírez Sánchez, Isabel Cristina; Restrepo Gutiérrez, Juan Carlos
• Tipo de recurso: Article of journal
• Fecha de publicación: 2020
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/44339
• Acceso en línea: https://hdl.handle.net/10495/44339
• Palabra clave: Antifúngicos; Antifungal Agents; Criptococosis; Cryptococcosis; Trasplante de Hígado; Liver Transplantation; Linfadenitis; Lymphadenitis; Sacroileítis; Sacroiliitis; Huésped Inmunocomprometido; Immunocompromised Host; Inmunosupresores; Immunosuppressive Agents; Enfermedades Pulmonares; Lung Diseases; Meningitis; Infecciones Oportunistas; Opportunistic Infections; Resultado del Tratamiento; Treatment Outcome; https://id.nlm.nih.gov/mesh/D016896; https://id.nlm.nih.gov/mesh/D000935; https://id.nlm.nih.gov/mesh/D003453; https://id.nlm.nih.gov/mesh/D016867; https://id.nlm.nih.gov/mesh/D007166; https://id.nlm.nih.gov/mesh/D016031; https://id.nlm.nih.gov/mesh/D008171; https://id.nlm.nih.gov/mesh/D008199; https://id.nlm.nih.gov/mesh/D008581; https://id.nlm.nih.gov/mesh/D009894; https://id.nlm.nih.gov/mesh/D058566
• Rights: openAccess
• License: https://creativecommons.org/licenses/by-nc-nd/4.0/