CAP—advancing the evaluation of preclinical Alzheimer disease treatments

ABSTRACT: If we are to find treatments to postpone, reduce the risk of, or completely prevent the clinical onset of Alzheimer disease (AD), we need faster methods to evaluate promising preclinical AD treatments, new ways to work together in support of common goals, and a determination to expedite the initiation and performance of preclinical AD trials. In this article, we note some of the current challenges, opportunities and emerging strategies in preclinical AD treatment. We describe the Collaboration for Alzheimer's Prevention (CAP)-a convening, harmonizing and consensus-building initiative to help stakeholders advance AD prevention research with rigour, care and maximal impact-and we demonstrate the impact of CAP on the goals and design of new preclinical AD trials.

• Autores: Lopera Restrepo, Francisco Javier; Langbaum, Jessica B.; Tariot, Pierre N.; Reiman, Eric M.; Bateman, Randall J.; Morris, John C.; Sperling, Reisa A.; Aisen, Paul S.; Roses, Allen D.; Welsh Bohmer, Kathleen A.; Carrillo, Maria C.; Weninger, Stacie
• Tipo de recurso: Review article
• Fecha de publicación: 2016
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/39580
• Acceso en línea: https://hdl.handle.net/10495/39580
• Palabra clave: Anciano de 80 o más Años; Aged, 80 and over; Enfermedad de Alzheimer; Alzheimer Disease; Farmacoterapia; Drug Therapy; Diagnóstico; Diagnosis; Genética; Genetics; Disfunción Cognitiva; Cognitive Dysfunction; Conducta Cooperativa; Cooperative Behavior; Progresión de la Enfermedad; Disease Progression; Evaluación Preclínica de Medicamentos; Drug Evaluation, Preclinical; Diagnóstico Precoz; Early Diagnosis; Adhesión a Directriz; Guideline Adherence; Comunicación Interdisciplinaria; Interdisciplinary Communication; Pruebas Neuropsicológicas; Neuropsychological Tests; Nootrópicos; Nootropic Agents; Síntomas Prodrómicos; Prodromal Symptoms; Ensayos Clínicos Controlados Aleatorios como Asunto; Randomized Controlled Trials as Topic; Resultado del Tratamiento; Treatment Outcome; https://id.nlm.nih.gov/mesh/D000369; https://id.nlm.nih.gov/mesh/D000544; https://id.nlm.nih.gov/mesh/D004358; https://id.nlm.nih.gov/mesh/D003933; https://id.nlm.nih.gov/mesh/D005823; https://id.nlm.nih.gov/mesh/D060825; https://id.nlm.nih.gov/mesh/D003299; https://id.nlm.nih.gov/mesh/D018450; https://id.nlm.nih.gov/mesh/D004353; https://id.nlm.nih.gov/mesh/D042241; https://id.nlm.nih.gov/mesh/D019983; https://id.nlm.nih.gov/mesh/D033183; https://id.nlm.nih.gov/mesh/D009483; https://id.nlm.nih.gov/mesh/D018697; https://id.nlm.nih.gov/mesh/D062706; https://id.nlm.nih.gov/mesh/D016032; https://id.nlm.nih.gov/mesh/D016896
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-nd/2.5/co/