Study of SARS-CoV-2 spike protein interaction with macrophages in presence of vitamin D
ABSTRACT: The macrophages are one of the most important cell populations playing a role in the development of the inflammatory response in SARS-CoV-2 infection. Indeed, the altered function of macrophages in cases of severe COVID-19 leads to a hyperactivated inflammatory response possibly due to dam...
- Autores:
-
di Filippo Villa, Diana Carolina
Montoya Guzmán, Melissa
López Osorio, María Camila
Urcuqui Inchima, Silvio
Jaimes, Javier A.
Navas Navas, María Cristina
- Tipo de recurso:
- http://purl.org/coar/resource_type/c_6670
- Fecha de publicación:
- 2022
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/37177
- Acceso en línea:
- https://hdl.handle.net/10495/37177
- Palabra clave:
- SARS-CoV-2
Macrófagos
Macrophages
Deficiencia de Vitamina D
Vitamin D Deficiency
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-sa/2.5/co/
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Study of SARS-CoV-2 spike protein interaction with macrophages in presence of vitamin D |
| title |
Study of SARS-CoV-2 spike protein interaction with macrophages in presence of vitamin D |
| spellingShingle |
Study of SARS-CoV-2 spike protein interaction with macrophages in presence of vitamin D SARS-CoV-2 Macrófagos Macrophages Deficiencia de Vitamina D Vitamin D Deficiency |
| title_short |
Study of SARS-CoV-2 spike protein interaction with macrophages in presence of vitamin D |
| title_full |
Study of SARS-CoV-2 spike protein interaction with macrophages in presence of vitamin D |
| title_fullStr |
Study of SARS-CoV-2 spike protein interaction with macrophages in presence of vitamin D |
| title_full_unstemmed |
Study of SARS-CoV-2 spike protein interaction with macrophages in presence of vitamin D |
| title_sort |
Study of SARS-CoV-2 spike protein interaction with macrophages in presence of vitamin D |
| dc.creator.fl_str_mv |
di Filippo Villa, Diana Carolina Montoya Guzmán, Melissa López Osorio, María Camila Urcuqui Inchima, Silvio Jaimes, Javier A. Navas Navas, María Cristina |
| dc.contributor.author.none.fl_str_mv |
di Filippo Villa, Diana Carolina Montoya Guzmán, Melissa López Osorio, María Camila Urcuqui Inchima, Silvio Jaimes, Javier A. Navas Navas, María Cristina |
| dc.contributor.conferencename.spa.fl_str_mv |
Annual meeting of American Society for Virology (41 : Del 16 al 20 de julio de 2022, University of Wisconsin, Madison, Estados Unidos) |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo de Gastrohepatología |
| dc.subject.decs.none.fl_str_mv |
SARS-CoV-2 Macrófagos Macrophages Deficiencia de Vitamina D Vitamin D Deficiency |
| topic |
SARS-CoV-2 Macrófagos Macrophages Deficiencia de Vitamina D Vitamin D Deficiency |
| description |
ABSTRACT: The macrophages are one of the most important cell populations playing a role in the development of the inflammatory response in SARS-CoV-2 infection. Indeed, the altered function of macrophages in cases of severe COVID-19 leads to a hyperactivated inflammatory response possibly due to damage of the respiratory tract epithelium and/or the interaction with viral particles through the recognition of the Toll-like receptors (TLR), even in the absence of active viral replication. Moreover, the activation and function modification of macrophages could be exacerbated in conditions of vitamin D deficiency, as described dengue virus infection. |
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2022 |
| dc.date.issued.none.fl_str_mv |
2022 |
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2023-11-06T20:43:16Z |
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2023-11-06T20:43:16Z |
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https://hdl.handle.net/10495/37177 |
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https://hdl.handle.net/10495/37177 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.conferencedate.spa.fl_str_mv |
2022-07-16/2022-07-20 |
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University of Wisconsin, Madison, Estados Unidos |
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41th annual meeting of American Society for Virology |
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http://creativecommons.org/licenses/by-nc-sa/2.5/co/ |
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di Filippo Villa, Diana CarolinaMontoya Guzmán, MelissaLópez Osorio, María CamilaUrcuqui Inchima, SilvioJaimes, Javier A.Navas Navas, María CristinaAnnual meeting of American Society for Virology (41 : Del 16 al 20 de julio de 2022, University of Wisconsin, Madison, Estados Unidos)Grupo de Gastrohepatología2023-11-06T20:43:16Z2023-11-06T20:43:16Z2022https://hdl.handle.net/10495/37177ABSTRACT: The macrophages are one of the most important cell populations playing a role in the development of the inflammatory response in SARS-CoV-2 infection. Indeed, the altered function of macrophages in cases of severe COVID-19 leads to a hyperactivated inflammatory response possibly due to damage of the respiratory tract epithelium and/or the interaction with viral particles through the recognition of the Toll-like receptors (TLR), even in the absence of active viral replication. Moreover, the activation and function modification of macrophages could be exacerbated in conditions of vitamin D deficiency, as described dengue virus infection.COL0024159application/pdfenghttp://creativecommons.org/licenses/by-nc-sa/2.5/co/https://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Study of SARS-CoV-2 spike protein interaction with macrophages in presence of vitamin DPóster de conferenciahttp://purl.org/coar/resource_type/c_6670http://purl.org/coar/resource_type/c_c94fhttps://purl.org/redcol/resource_type/EChttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionMadison, Estados UnidosSARS-CoV-2MacrófagosMacrophagesDeficiencia de Vitamina DVitamin D Deficiency2022-07-16/2022-07-20University of Wisconsin, Madison, Estados Unidos41th annual meeting of American Society for VirologyPublicationCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81051https://bibliotecadigital.udea.edu.co/bitstreams/27461be8-6dc0-45b5-9ed4-f02810315969/downloade2060682c9c70d4d30c83c51448f4eedMD52falseAnonymousREADORIGINALDiFilippoDiana_2022_Study_SARS-CoV-2.pdfDiFilippoDiana_2022_Study_SARS-CoV-2.pdfPóster de conferenciaapplication/pdf1734713https://bibliotecadigital.udea.edu.co/bitstreams/17c77006-42fd-48d7-8574-ab9403a9b890/downloadc361a183efc1eb1ba9818a853b6c99b3MD51trueAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstreams/e699feef-e745-420e-88cc-14b66fddb375/download8a4605be74aa9ea9d79846c1fba20a33MD53falseAnonymousREADTEXTDiFilippoDiana_2022_Study_SARS-CoV-2.pdf.txtDiFilippoDiana_2022_Study_SARS-CoV-2.pdf.txtExtracted texttext/plain7673https://bibliotecadigital.udea.edu.co/bitstreams/2ec39618-b717-4bde-a14c-b73eb05f828b/downloadc930b9b1fd64e0c6e797d517656077b1MD54falseAnonymousREADTHUMBNAILDiFilippoDiana_2022_Study_SARS-CoV-2.pdf.jpgDiFilippoDiana_2022_Study_SARS-CoV-2.pdf.jpgGenerated Thumbnailimage/jpeg19578https://bibliotecadigital.udea.edu.co/bitstreams/ff50bc6f-6e67-449a-965d-34f24374f17f/download53d9f16e0a2da5809a1b6144615872aaMD55falseAnonymousREAD10495/37177oai:bibliotecadigital.udea.edu.co:10495/371772025-03-26 22:06:14.354http://creativecommons.org/licenses/by-nc-sa/2.5/co/open.accesshttps://bibliotecadigital.udea.edu.coRepositorio Institucional de la Universidad de Antioquiaaplicacionbibliotecadigitalbiblioteca@udea.edu.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 |