Short report: Inhibition by tumor necrosis factor-alpha-activated macrophages of the transition of Paracoccidioides brasiliensis conidia to yeast cells through a mechanism independent of nitric oxide

ABSTRACT : It is known that peritoneal murine macrophages activated with interferon- exert a fungicidal effect againstParacoccidioides brasiliensisconidia by a nitric oxide (NO)−mediated mechanism. This NO-mediated effect can also beinduced by other cytokines such as tumor necrosis factor- (TNF- )....

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Autores:
González Marín, Ángel Augusto
Restrepo Moreno, Ángela
Cano Gómez, Erika
Cano Restrepo, Luz Elena
Aristizábal Bernal, Beatriz Helena
Tipo de recurso:
Article of investigation
Fecha de publicación:
2004
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/20573
Acceso en línea:
http://hdl.handle.net/10495/20573
Palabra clave:
Óxido Nítrico
Nitric Oxide
Necrosis
Paracoccidioides
Activación de Macrófagos
Macrophage Activation
Paracoccidioidomicosis
Paracoccidioidomycosis
Rights
openAccess
License
https://creativecommons.org/licenses/by/4.0/
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oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/20573
network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv Short report: Inhibition by tumor necrosis factor-alpha-activated macrophages of the transition of Paracoccidioides brasiliensis conidia to yeast cells through a mechanism independent of nitric oxide
title Short report: Inhibition by tumor necrosis factor-alpha-activated macrophages of the transition of Paracoccidioides brasiliensis conidia to yeast cells through a mechanism independent of nitric oxide
spellingShingle Short report: Inhibition by tumor necrosis factor-alpha-activated macrophages of the transition of Paracoccidioides brasiliensis conidia to yeast cells through a mechanism independent of nitric oxide
Óxido Nítrico
Nitric Oxide
Necrosis
Paracoccidioides
Activación de Macrófagos
Macrophage Activation
Paracoccidioidomicosis
Paracoccidioidomycosis
title_short Short report: Inhibition by tumor necrosis factor-alpha-activated macrophages of the transition of Paracoccidioides brasiliensis conidia to yeast cells through a mechanism independent of nitric oxide
title_full Short report: Inhibition by tumor necrosis factor-alpha-activated macrophages of the transition of Paracoccidioides brasiliensis conidia to yeast cells through a mechanism independent of nitric oxide
title_fullStr Short report: Inhibition by tumor necrosis factor-alpha-activated macrophages of the transition of Paracoccidioides brasiliensis conidia to yeast cells through a mechanism independent of nitric oxide
title_full_unstemmed Short report: Inhibition by tumor necrosis factor-alpha-activated macrophages of the transition of Paracoccidioides brasiliensis conidia to yeast cells through a mechanism independent of nitric oxide
title_sort Short report: Inhibition by tumor necrosis factor-alpha-activated macrophages of the transition of Paracoccidioides brasiliensis conidia to yeast cells through a mechanism independent of nitric oxide
dc.creator.fl_str_mv González Marín, Ángel Augusto
Restrepo Moreno, Ángela
Cano Gómez, Erika
Cano Restrepo, Luz Elena
Aristizábal Bernal, Beatriz Helena
dc.contributor.author.none.fl_str_mv González Marín, Ángel Augusto
Restrepo Moreno, Ángela
Cano Gómez, Erika
Cano Restrepo, Luz Elena
Aristizábal Bernal, Beatriz Helena
dc.contributor.researchgroup.spa.fl_str_mv Micología Médica y Experimental
Microbiología Molecular
dc.subject.decs.none.fl_str_mv Óxido Nítrico
Nitric Oxide
Necrosis
Paracoccidioides
Activación de Macrófagos
Macrophage Activation
Paracoccidioidomicosis
Paracoccidioidomycosis
topic Óxido Nítrico
Nitric Oxide
Necrosis
Paracoccidioides
Activación de Macrófagos
Macrophage Activation
Paracoccidioidomicosis
Paracoccidioidomycosis
description ABSTRACT : It is known that peritoneal murine macrophages activated with interferon- exert a fungicidal effect againstParacoccidioides brasiliensisconidia by a nitric oxide (NO)−mediated mechanism. This NO-mediated effect can also beinduced by other cytokines such as tumor necrosis factor- (TNF- ). The aim of this study was to determine ifTNF- −activated peritoneal murine macrophages infected withP. brasiliensiswere able to show fungistatic/fungicidaleffects mediated by NO. The results indicated that although macrophage activation with TNF- did not result in NOproduction, these cells played an important role in inhibiting the conidia from becoming yeast cells.In vivo, theNO-independent inhibitory effect would prove of importance for the establishment ofP. brasiliensisin host tissues.
publishDate 2004
dc.date.issued.none.fl_str_mv 2004
dc.date.accessioned.none.fl_str_mv 2021-07-01T21:53:44Z
dc.date.available.none.fl_str_mv 2021-07-01T21:53:44Z
dc.type.spa.fl_str_mv Artículo de investigación
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
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dc.identifier.citation.spa.fl_str_mv Gonzalez A, Aristizábal BH, Gómez EC, Restrepo A, Cano LE. Short report: Inhibition by tumor necrosis factor-alpha-activated macrophages of the transition of Paracoccidioides brasiliensis conidia to yeast cells through a mechanism independent of nitric oxide. Am J Trop Med Hyg. 2004 Dec;71(6):828-30.
dc.identifier.issn.none.fl_str_mv 0002-9637
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10495/20573
dc.identifier.eissn.none.fl_str_mv 1476-1645
identifier_str_mv Gonzalez A, Aristizábal BH, Gómez EC, Restrepo A, Cano LE. Short report: Inhibition by tumor necrosis factor-alpha-activated macrophages of the transition of Paracoccidioides brasiliensis conidia to yeast cells through a mechanism independent of nitric oxide. Am J Trop Med Hyg. 2004 Dec;71(6):828-30.
0002-9637
1476-1645
url http://hdl.handle.net/10495/20573
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Am. j. trop. med. hyg.
dc.relation.citationendpage.spa.fl_str_mv 830
dc.relation.citationissue.spa.fl_str_mv 6
dc.relation.citationstartpage.spa.fl_str_mv 828
dc.relation.citationvolume.spa.fl_str_mv 71
dc.relation.ispartofjournal.spa.fl_str_mv American Journal of Tropical Medicine and Hygiene
dc.rights.uri.spa.fl_str_mv https://creativecommons.org/licenses/by/4.0/
dc.rights.uri.*.fl_str_mv https://creativecommons.org/licenses/by/2.5/co/
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dc.publisher.spa.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.publisher.place.spa.fl_str_mv Baltimore, Estados Unidos
institution Universidad de Antioquia
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spelling González Marín, Ángel AugustoRestrepo Moreno, ÁngelaCano Gómez, ErikaCano Restrepo, Luz ElenaAristizábal Bernal, Beatriz HelenaMicología Médica y ExperimentalMicrobiología Molecular2021-07-01T21:53:44Z2021-07-01T21:53:44Z2004Gonzalez A, Aristizábal BH, Gómez EC, Restrepo A, Cano LE. Short report: Inhibition by tumor necrosis factor-alpha-activated macrophages of the transition of Paracoccidioides brasiliensis conidia to yeast cells through a mechanism independent of nitric oxide. Am J Trop Med Hyg. 2004 Dec;71(6):828-30.0002-9637http://hdl.handle.net/10495/205731476-1645ABSTRACT : It is known that peritoneal murine macrophages activated with interferon- exert a fungicidal effect againstParacoccidioides brasiliensisconidia by a nitric oxide (NO)−mediated mechanism. This NO-mediated effect can also beinduced by other cytokines such as tumor necrosis factor- (TNF- ). The aim of this study was to determine ifTNF- −activated peritoneal murine macrophages infected withP. brasiliensiswere able to show fungistatic/fungicidaleffects mediated by NO. The results indicated that although macrophage activation with TNF- did not result in NOproduction, these cells played an important role in inhibiting the conidia from becoming yeast cells.In vivo, theNO-independent inhibitory effect would prove of importance for the establishment ofP. brasiliensisin host tissues.COL0013709COL00137463application/pdfengAmerican Society of Tropical Medicine and HygieneBaltimore, Estados Unidoshttps://creativecommons.org/licenses/by/4.0/https://creativecommons.org/licenses/by/2.5/co/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Short report: Inhibition by tumor necrosis factor-alpha-activated macrophages of the transition of Paracoccidioides brasiliensis conidia to yeast cells through a mechanism independent of nitric oxideArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionÓxido NítricoNitric OxideNecrosisParacoccidioidesActivación de MacrófagosMacrophage ActivationParacoccidioidomicosisParacoccidioidomycosisAm. j. trop. med. hyg.830682871American Journal of Tropical Medicine and HygienePublicationLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstreams/224998d5-b94f-4f1d-a9a9-86b3823ff6f3/download8a4605be74aa9ea9d79846c1fba20a33MD52falseAnonymousREADORIGINALGonzalezAngel_2004_Tumor MacrophagesParacoccidioides.pdfGonzalezAngel_2004_Tumor MacrophagesParacoccidioides.pdfArtículo de investigaciónapplication/pdf80550https://bibliotecadigital.udea.edu.co/bitstreams/d158f12b-52be-4086-9044-29ef52e82da4/downloadab12e59d2b16795b9b0d470e3045a4a7MD51trueAnonymousREADTEXTGonzalezAngel_2004_Tumor MacrophagesParacoccidioides.pdf.txtGonzalezAngel_2004_Tumor MacrophagesParacoccidioides.pdf.txtExtracted texttext/plain17845https://bibliotecadigital.udea.edu.co/bitstreams/6b3bf9ef-df65-4dab-8239-bef9d03fd757/download932b25c55ea991e5994a4d4b48c4d5aeMD53falseAnonymousREADTHUMBNAILGonzalezAngel_2004_Tumor MacrophagesParacoccidioides.pdf.jpgGonzalezAngel_2004_Tumor MacrophagesParacoccidioides.pdf.jpgGenerated Thumbnailimage/jpeg17700https://bibliotecadigital.udea.edu.co/bitstreams/3a40d28d-269d-4433-b26b-57a027e11821/download18ac9c65eb1a5e716634435345e2bac5MD54falseAnonymousREAD10495/20573oai:bibliotecadigital.udea.edu.co:10495/205732025-03-27 01:18:43.533https://creativecommons.org/licenses/by/4.0/open.accesshttps://bibliotecadigital.udea.edu.coRepositorio Institucional de la Universidad de Antioquiaaplicacionbibliotecadigitalbiblioteca@udea.edu.coTk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=

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