Short report: Inhibition by tumor necrosis factor-alpha-activated macrophages of the transition of Paracoccidioides brasiliensis conidia to yeast cells through a mechanism independent of nitric oxide

ABSTRACT : It is known that peritoneal murine macrophages activated with interferon- exert a fungicidal effect againstParacoccidioides brasiliensisconidia by a nitric oxide (NO)−mediated mechanism. This NO-mediated effect can also beinduced by other cytokines such as tumor necrosis factor- (TNF- ). The aim of this study was to determine ifTNF- −activated peritoneal murine macrophages infected withP. brasiliensiswere able to show fungistatic/fungicidaleffects mediated by NO. The results indicated that although macrophage activation with TNF- did not result in NOproduction, these cells played an important role in inhibiting the conidia from becoming yeast cells.In vivo, theNO-independent inhibitory effect would prove of importance for the establishment ofP. brasiliensisin host tissues.

• Autores: González Marín, Ángel Augusto; Restrepo Moreno, Ángela; Cano Gómez, Erika; Cano Restrepo, Luz Elena; Aristizábal Bernal, Beatriz Helena
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2004
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/20573
• Acceso en línea: http://hdl.handle.net/10495/20573
• Palabra clave: Óxido Nítrico; Nitric Oxide; Necrosis; Paracoccidioides; Activación de Macrófagos; Macrophage Activation; Paracoccidioidomicosis; Paracoccidioidomycosis
• Rights: openAccess
• License: https://creativecommons.org/licenses/by/4.0/