NK cells from Men Who Have Sex with Men at high risk for HIV-1 infection exhibit higher effector capacity

ABSTRACT: Despite being under constant exposure to HIV-1, some individuals do not show serological or clinical evidence of infection and are known as HESN (HIV-Exposed Seronegative). Multiple studies in different HESN cohorts have linked the NK cells as a correlate of resistance; however, little is known about the role of these cells in Men Who Have Sex with Men (MSM) with high risk sexual behaviors. We evaluated a general overview of activation and effector features of NK cells of MSM co-cultured with LT CD4+ HIV+ in which MSM at high risk of HIV-1 infection (HR-MSM) exhibit higher capacity to eliminate infected cells, reduced percentages of CD69+ cells when compared to MSM at low risk of infection (LR-MSM). In addition, we found that, despite the lower levels of CD69+ NK cells on HR-MSM group, within this population, higher percentages of CD69+ IFN-γ+ and CD69+ NKG2D+ NK cells were found together with higher levels of RANTES and Granzyme B production with higher antiviral capacity, resulting in a lower concentration of p24 protein and p24+ CD4+ T cells. Altogether, this information suggests that NK cells of MSM could impact the capacity to face the viral infection.

• Autores: Rincón Tabares, Daniel Santiago; Flórez Álvarez, Lizdany; Taborda Vanegas, Natalia Andrea; Hernández López, Juan Carlos; Rugeles López, María Teresa; Zapata Builes, Wildeman
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2023
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/41376
• Acceso en línea: https://hdl.handle.net/10495/41376
• Palabra clave: Enfermedad; Diseases; Enfermedades Transmisibles; Communicable Diseases; VIH-1; HIV-1; Infecciones por VIH; HIV Infections; Homosexualidad Masculina; Homosexuality, Male; Células Asesinas Naturales; Killer Cells, Natural; Conducta Sexual; Sexual Behavior; Minorías Sexuales y de Género; Sexual and Gender Minorities; https://id.nlm.nih.gov/mesh/D004194; https://id.nlm.nih.gov/mesh/D003141; https://id.nlm.nih.gov/mesh/D015497; https://id.nlm.nih.gov/mesh/D015658; https://id.nlm.nih.gov/mesh/D018451; https://id.nlm.nih.gov/mesh/D007694; https://id.nlm.nih.gov/mesh/D012725; https://id.nlm.nih.gov/mesh/D000072339
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/