Nosocomial Plasmodium falciparum infections confirmed by molecular typing in Medellin, Colombia

ABSTRACT: Three cases of nosocomial malaria are reported from patients of the Internal Medicine Ward of a tertiary University teaching hospital in Medellin, Colombia. Epidemiological research, based on entomological captures, medical records review and interviews of nursery staff about patient care practices potentially involving contact with blood, were carried out. Molecular characterization of Plasmodium falciparum was based on the amplification of MSP1, MSP2 and GLURP genes. This method enabled confirmation of the same P. falciparum genotype in all three patients as well as in a fourth one (index case). The presence of nosocomial malaria was confirmed and it was concluded that the most likely source of transmission was through multi-dose preparations of heparin applied to heparin locks.

• Autores: Restrepo Pineda, Eliana; Blair Trujillo, Silvia; Maestre Buitrago, Amanda Elena; González, Lina; Ochoa, Jesús; Franco Hincapié, Liliana; Arroyave, Marta
• Tipo de recurso: Article of journal
• Fecha de publicación: 2005
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/34770
• Acceso en línea: https://hdl.handle.net/10495/34770
• Palabra clave: Antígenos de Protozoos - genética; Antigens, Protozoan - genetics; Colombia - epidemiología; Colombia - epidemiology; Infección Hospitalaria; Cross Infection; Combinación de Medicamentos; Drug Combinations; Contaminación de Equipos; Equipment Contamination; Resultado Fatal; Fatal Outcome; Malaria Falciparum; Malaria, Falciparum; Plasmodium falciparum; Proteína 1 de Superficie de Merozoito - genética; Merozoite Surface Protein 1 - genetics; Reacción en Cadena de la Polimerasa - métodos; Polymerase Chain Reaction - methods; Proteínas Protozoarias - génetica; Protozoan Proteins - genetics; Pirimetamina - uso terapéutico; Pyrimethamine - therapeutic use; Quinina - uso terapéutico; Quinine - therapeutic use; Sulfadoxina - uso terapéutico; Sulfadoxine - therapeutic use
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/