Obtaining a fused PLA‑calcium phosphate‑tobramycin‑based filament for 3D printing with potential antimicrobial application

ABSTRACT: Many eforts in the tissue engineering feld have been devoted to producing biomedical devices with several physico-chemical properties that could promote an increase in the quality of therapeutic treatments. Thus, 3D printing is an efcient method which facilitates manufacturing high quality products to be used as medical devices. However, high-performance materials are required for obtaining products that are able to be 3D printed to attend the biomedical concerns. In this work, fused PLA-calcium phosphate-tobramycin-based flaments with antimicrobial properties were produced. X-ray powder difraction, Fourier transform infrared spectroscopy and thermal analysis were performed to characterize the pure compounds as well as the composite flaments, revealing that the drug is preserved into the flaments by the implemented methodology, even after the hot extrusion procedure. The flaments and the printed pieces presented great antimicrobial efect and a controlledrelease profle was also observed by the drug-release assays for the flaments produced, thereby indicating this material as a promising candidate to be used for implantable medical devices in the future.

• Autores: Robledo Restrepo, Sara María; Ospina Aristizábal, Victoria Eugenia; Lopera Sepúlveda, Alex Arbey; Higuita Castro, Jorge Luis; Ramírez Gil, Francisco Javier; Ferraz, Humberto G.; Orlando, Marcos T. A.; Paucar Álvarez, Carlos Guillermo; Bezzon, Vinicius D. N.; García García, Claudia Patricia
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2023
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/44285
• Acceso en línea: https://hdl.handle.net/10495/44285
• Palabra clave: Impresión Tridimensional; Printing, Three-Dimensional; Fosfatos de Calcio; Calcium Phosphates; Tobramicina; Tobramycin; Antiinfecciosos; Anti-Infective Agents; Ingeniería de Tejidos; Tissue Engineering; Difracción de Polvo; Powder Diffraction; Espectroscopía Infrarroja por Transformada de Fourier; Spectroscopy, Fourier Transform Infrared; https://id.nlm.nih.gov/mesh/D066330; https://id.nlm.nih.gov/mesh/D002130; https://id.nlm.nih.gov/mesh/D014031; https://id.nlm.nih.gov/mesh/D000890; https://id.nlm.nih.gov/mesh/D023822; https://id.nlm.nih.gov/mesh/D033362; https://id.nlm.nih.gov/mesh/D017550
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-nd/2.5/co/