Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid

ABSTRACT: Microcrystalline cellulose II (MCCII) is a different allomorph of MCC that can be used as a filler and a disintegrant for direct compression. MCCII was studied as new pelletization aid with the aim to prepare pellets with a faster drug release than MCCI-based pellets. MCCII-based pellets s...

Full description

Autores:
Rojas Camargo, John Jairo
Kumar, Vijay
Tipo de recurso:
Article of investigation
Fecha de publicación:
2012
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/35417
Acceso en línea:
https://hdl.handle.net/10495/35417
Palabra clave:
Cápsulas
Capsules
Celulosa - Química
Cellulose - Chemistry
Química Farmacéutica
Chemistry, Pharmaceutical
Difenhidramina - Química
Diphenhydramine - Chemistry
Composición de Medicamentos
Drug Compounding
Excipientes - Química
Excipients - Chemistry
Griseofulvina - Química
Griseofulvin - Chemistry
Cinética
Kinetics
Microesferas
Microspheres
Tamaño de la Partícula
Particle Size
Porosidad
Porosity
Prostaglandinas F Sintéticas
Prostaglandins F, Synthetic
Solubilidad
Solubility
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid
title Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid
spellingShingle Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid
Cápsulas
Capsules
Celulosa - Química
Cellulose - Chemistry
Química Farmacéutica
Chemistry, Pharmaceutical
Difenhidramina - Química
Diphenhydramine - Chemistry
Composición de Medicamentos
Drug Compounding
Excipientes - Química
Excipients - Chemistry
Griseofulvina - Química
Griseofulvin - Chemistry
Cinética
Kinetics
Microesferas
Microspheres
Tamaño de la Partícula
Particle Size
Porosidad
Porosity
Prostaglandinas F Sintéticas
Prostaglandins F, Synthetic
Solubilidad
Solubility
title_short Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid
title_full Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid
title_fullStr Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid
title_full_unstemmed Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid
title_sort Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid
dc.creator.fl_str_mv Rojas Camargo, John Jairo
Kumar, Vijay
dc.contributor.author.none.fl_str_mv Rojas Camargo, John Jairo
Kumar, Vijay
dc.contributor.researchgroup.spa.fl_str_mv Diseño y Formulación de Medicamentos Cosméticos y Afines
dc.subject.decs.none.fl_str_mv Cápsulas
Capsules
Celulosa - Química
Cellulose - Chemistry
Química Farmacéutica
Chemistry, Pharmaceutical
Difenhidramina - Química
Diphenhydramine - Chemistry
Composición de Medicamentos
Drug Compounding
Excipientes - Química
Excipients - Chemistry
Griseofulvina - Química
Griseofulvin - Chemistry
Cinética
Kinetics
Microesferas
Microspheres
Tamaño de la Partícula
Particle Size
Porosidad
Porosity
Prostaglandinas F Sintéticas
Prostaglandins F, Synthetic
Solubilidad
Solubility
topic Cápsulas
Capsules
Celulosa - Química
Cellulose - Chemistry
Química Farmacéutica
Chemistry, Pharmaceutical
Difenhidramina - Química
Diphenhydramine - Chemistry
Composición de Medicamentos
Drug Compounding
Excipientes - Química
Excipients - Chemistry
Griseofulvina - Química
Griseofulvin - Chemistry
Cinética
Kinetics
Microesferas
Microspheres
Tamaño de la Partícula
Particle Size
Porosidad
Porosity
Prostaglandinas F Sintéticas
Prostaglandins F, Synthetic
Solubilidad
Solubility
description ABSTRACT: Microcrystalline cellulose II (MCCII) is a different allomorph of MCC that can be used as a filler and a disintegrant for direct compression. MCCII was studied as new pelletization aid with the aim to prepare pellets with a faster drug release than MCCI-based pellets. MCCII-based pellets showed an immediate diphenydramineHCl release profile comparable to that of Benadryl and a faster griseofulvin release than MCCI-based pellets. MCCII offers potential to use as an alternative pelletization aid.
publishDate 2012
dc.date.issued.none.fl_str_mv 2012
dc.date.accessioned.none.fl_str_mv 2023-06-09T13:21:54Z
dc.date.available.none.fl_str_mv 2023-06-09T13:21:54Z
dc.type.spa.fl_str_mv Artículo de investigación
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dc.identifier.citation.spa.fl_str_mv Rojas J, Kumar V. Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid. Pharmazie. 2012 Jul;67(7):595-7.
dc.identifier.issn.none.fl_str_mv 0031-7144
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10495/35417
dc.identifier.doi.none.fl_str_mv 10.1691/ph.2012.1130
identifier_str_mv Rojas J, Kumar V. Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid. Pharmazie. 2012 Jul;67(7):595-7.
0031-7144
10.1691/ph.2012.1130
url https://hdl.handle.net/10495/35417
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Pharmazie
dc.relation.citationendpage.spa.fl_str_mv 597
dc.relation.citationissue.spa.fl_str_mv 7
dc.relation.citationstartpage.spa.fl_str_mv 595
dc.relation.citationvolume.spa.fl_str_mv 67
dc.relation.ispartofjournal.spa.fl_str_mv Die Pharmazie
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rights.uri.spa.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
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dc.publisher.spa.fl_str_mv Govi-Verlag Pharmazautischer Verlag
dc.publisher.place.spa.fl_str_mv Berlín, Alemania
institution Universidad de Antioquia
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spelling Rojas Camargo, John JairoKumar, VijayDiseño y Formulación de Medicamentos Cosméticos y Afines2023-06-09T13:21:54Z2023-06-09T13:21:54Z2012Rojas J, Kumar V. Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid. Pharmazie. 2012 Jul;67(7):595-7.0031-7144https://hdl.handle.net/10495/3541710.1691/ph.2012.1130ABSTRACT: Microcrystalline cellulose II (MCCII) is a different allomorph of MCC that can be used as a filler and a disintegrant for direct compression. MCCII was studied as new pelletization aid with the aim to prepare pellets with a faster drug release than MCCI-based pellets. MCCII-based pellets showed an immediate diphenydramineHCl release profile comparable to that of Benadryl and a faster griseofulvin release than MCCI-based pellets. MCCII offers potential to use as an alternative pelletization aid.Universidad de Antioquia. Vicerrectoría de investigación. 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