The Mendelian Legacy to Mental and Behavioral Disorders
ABSTRACT: Bipolar disorder is a highly heritable illness, associated with alterations of brain structure. As such, identification of genes influencing inter-individual differences in brain morphology may help elucidate the underlying pathophysiology of bipolar disorder (BP). To identify quantitative...
- Autores:
-
Arcos Burgos, Oscar Mauricio
Cuartas, Mauricio
- Tipo de recurso:
- Editorial
- Fecha de publicación:
- 2020
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/42125
- Acceso en línea:
- https://hdl.handle.net/10495/42125
- Palabra clave:
- Trastorno Bipolar
Bipolar Disorder
Trastorno de la Conducta
Conduct Disorder
https://id.nlm.nih.gov/mesh/D001714
https://id.nlm.nih.gov/mesh/D019955
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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| dc.title.spa.fl_str_mv |
The Mendelian Legacy to Mental and Behavioral Disorders |
| title |
The Mendelian Legacy to Mental and Behavioral Disorders |
| spellingShingle |
The Mendelian Legacy to Mental and Behavioral Disorders Trastorno Bipolar Bipolar Disorder Trastorno de la Conducta Conduct Disorder https://id.nlm.nih.gov/mesh/D001714 https://id.nlm.nih.gov/mesh/D019955 |
| title_short |
The Mendelian Legacy to Mental and Behavioral Disorders |
| title_full |
The Mendelian Legacy to Mental and Behavioral Disorders |
| title_fullStr |
The Mendelian Legacy to Mental and Behavioral Disorders |
| title_full_unstemmed |
The Mendelian Legacy to Mental and Behavioral Disorders |
| title_sort |
The Mendelian Legacy to Mental and Behavioral Disorders |
| dc.creator.fl_str_mv |
Arcos Burgos, Oscar Mauricio Cuartas, Mauricio |
| dc.contributor.author.none.fl_str_mv |
Arcos Burgos, Oscar Mauricio Cuartas, Mauricio |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo de Investigación en Psiquiatría GIPSI |
| dc.subject.decs.none.fl_str_mv |
Trastorno Bipolar Bipolar Disorder Trastorno de la Conducta Conduct Disorder |
| topic |
Trastorno Bipolar Bipolar Disorder Trastorno de la Conducta Conduct Disorder https://id.nlm.nih.gov/mesh/D001714 https://id.nlm.nih.gov/mesh/D019955 |
| dc.subject.meshuri.none.fl_str_mv |
https://id.nlm.nih.gov/mesh/D001714 https://id.nlm.nih.gov/mesh/D019955 |
| description |
ABSTRACT: Bipolar disorder is a highly heritable illness, associated with alterations of brain structure. As such, identification of genes influencing inter-individual differences in brain morphology may help elucidate the underlying pathophysiology of bipolar disorder (BP). To identify quantitative trait loci (QTL) that contribute to phenotypic variance of brain structure, structural neuroimages were acquired from family members (n = 527) of extended pedigrees heavily loaded for bipolar disorder ascertained from genetically isolated populations in Latin America. Genome-wide linkage and association analysis were conducted on the subset of heritable brain traits that showed significant evidence of association with bipolar disorder (n = 24) to map QTL influencing regional measures of brain volume and cortical thickness. Two chromosomal regions showed significant evidence of linkage; a QTL on chromosome 1p influencing corpus callosum volume and a region on chromosome 7p linked to cortical volume. Association analysis within the two QTLs identified three SNPs correlated with the brain measures. |
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2020 |
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2020 |
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2024-09-15T02:23:50Z |
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2024-09-15T02:23:50Z |
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Editorial |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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Arcos-Burgos M, Cuartas M. The Mendelian Legacy to Mental and Behavioral Disorders. Int J Psychol Res (Medellin). 2020 Jan-Jul;13(1):6-8. doi: 10.21500/20112084.4529. PMID: 32952958; PMCID: PMC7498122. |
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2011-2085 |
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https://hdl.handle.net/10495/42125 |
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10.21500/20112084.4529 |
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2011-7923 |
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Arcos-Burgos M, Cuartas M. The Mendelian Legacy to Mental and Behavioral Disorders. Int J Psychol Res (Medellin). 2020 Jan-Jul;13(1):6-8. doi: 10.21500/20112084.4529. PMID: 32952958; PMCID: PMC7498122. 2011-2085 10.21500/20112084.4529 2011-7923 |
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https://hdl.handle.net/10495/42125 |
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eng |
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eng |
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Int. J. Psychol. Res. |
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8 |
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1 |
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6 |
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13 |
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International Journal of Psychological Research |
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http://creativecommons.org/licenses/by-nc-nd/2.5/co/ |
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Universidad de San Buenaventura, Facultad de Psicología |
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Medellín, Colombia |
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Arcos Burgos, Oscar MauricioCuartas, MauricioGrupo de Investigación en Psiquiatría GIPSI2024-09-15T02:23:50Z2024-09-15T02:23:50Z2020Arcos-Burgos M, Cuartas M. The Mendelian Legacy to Mental and Behavioral Disorders. Int J Psychol Res (Medellin). 2020 Jan-Jul;13(1):6-8. doi: 10.21500/20112084.4529. PMID: 32952958; PMCID: PMC7498122.2011-2085https://hdl.handle.net/10495/4212510.21500/20112084.45292011-7923ABSTRACT: Bipolar disorder is a highly heritable illness, associated with alterations of brain structure. As such, identification of genes influencing inter-individual differences in brain morphology may help elucidate the underlying pathophysiology of bipolar disorder (BP). To identify quantitative trait loci (QTL) that contribute to phenotypic variance of brain structure, structural neuroimages were acquired from family members (n = 527) of extended pedigrees heavily loaded for bipolar disorder ascertained from genetically isolated populations in Latin America. Genome-wide linkage and association analysis were conducted on the subset of heritable brain traits that showed significant evidence of association with bipolar disorder (n = 24) to map QTL influencing regional measures of brain volume and cortical thickness. Two chromosomal regions showed significant evidence of linkage; a QTL on chromosome 1p influencing corpus callosum volume and a region on chromosome 7p linked to cortical volume. Association analysis within the two QTLs identified three SNPs correlated with the brain measures.COL00291473 páginasapplication/pdfengUniversidad de San Buenaventura, Facultad de PsicologíaMedellín, Colombiahttp://creativecommons.org/licenses/by-nc-nd/2.5/co/https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2The Mendelian Legacy to Mental and Behavioral DisordersEditorialhttp://purl.org/coar/resource_type/c_b239http://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTEDIThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionTrastorno BipolarBipolar DisorderTrastorno de la ConductaConduct Disorderhttps://id.nlm.nih.gov/mesh/D001714https://id.nlm.nih.gov/mesh/D019955Int. J. Psychol. 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