Perfil de los factores fibrinolíticos en malaria por Plasmodium falciparum y Plasmodium vivax

La malaria es una enfermedad infecciosa de gran impacto en salud pública, especialmente en regiones tropicales y subtropicales donde circulan especies del género Plasmodium, principalmente P. falciparum y P. vivax. Esta infección, además de afectar múltiples órganos y sistemas, produce alteraciones...

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Autores:
Hernández Galarza, Nataly
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2025
Institución:
Universidad de Córdoba
Repositorio:
Repositorio Institucional Unicórdoba
Idioma:
spa
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oai:repositorio.unicordoba.edu.co:ucordoba/9485
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https://repositorio.unicordoba.edu.co/handle/ucordoba/9485
https://repositorio.unicordoba.edu.co/
Palabra clave:
Malaria
Plasmodium falciparum
Plasmodium vivax
Hemostasia
Fibrinólisis
Malaria
Plasmodium falciparum
Plasmodium vivax
Hemostasis
Fibrinolysis
Rights
openAccess
License
Copyright Universidad de Córdoba, 2025
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network_acronym_str UCORDOBA2
network_name_str Repositorio Institucional Unicórdoba
repository_id_str
dc.title.spa.fl_str_mv Perfil de los factores fibrinolíticos en malaria por Plasmodium falciparum y Plasmodium vivax
title Perfil de los factores fibrinolíticos en malaria por Plasmodium falciparum y Plasmodium vivax
spellingShingle Perfil de los factores fibrinolíticos en malaria por Plasmodium falciparum y Plasmodium vivax
Malaria
Plasmodium falciparum
Plasmodium vivax
Hemostasia
Fibrinólisis
Malaria
Plasmodium falciparum
Plasmodium vivax
Hemostasis
Fibrinolysis
title_short Perfil de los factores fibrinolíticos en malaria por Plasmodium falciparum y Plasmodium vivax
title_full Perfil de los factores fibrinolíticos en malaria por Plasmodium falciparum y Plasmodium vivax
title_fullStr Perfil de los factores fibrinolíticos en malaria por Plasmodium falciparum y Plasmodium vivax
title_full_unstemmed Perfil de los factores fibrinolíticos en malaria por Plasmodium falciparum y Plasmodium vivax
title_sort Perfil de los factores fibrinolíticos en malaria por Plasmodium falciparum y Plasmodium vivax
dc.creator.fl_str_mv Hernández Galarza, Nataly
dc.contributor.advisor.none.fl_str_mv Cantero Guevara, Miriam Elena
García del Castillo, Yuranis Andrea
dc.contributor.author.none.fl_str_mv Hernández Galarza, Nataly
dc.contributor.jury.none.fl_str_mv Castro Cavadia, Carlos Javier
Yasnot Acosta, María Fernanda
dc.subject.proposal.spa.fl_str_mv Malaria
Plasmodium falciparum
Plasmodium vivax
Hemostasia
Fibrinólisis
topic Malaria
Plasmodium falciparum
Plasmodium vivax
Hemostasia
Fibrinólisis
Malaria
Plasmodium falciparum
Plasmodium vivax
Hemostasis
Fibrinolysis
dc.subject.keywords.eng.fl_str_mv Malaria
Plasmodium falciparum
Plasmodium vivax
Hemostasis
Fibrinolysis
description La malaria es una enfermedad infecciosa de gran impacto en salud pública, especialmente en regiones tropicales y subtropicales donde circulan especies del género Plasmodium, principalmente P. falciparum y P. vivax. Esta infección, además de afectar múltiples órganos y sistemas, produce alteraciones significativas en el sistema hemostático, incluyendo activación del endotelio, consumo de factores de coagulación, trombocitopenia y disfunción fibrinolítica. En esta monografía se realizó una revisión bibliográfica sobre la epidemiología, fisiopatología y diagnóstico de la malaria, así como de los mecanismos de la hemostasia y su relación con marcadores como el dímero D, el activador tisular del plasminógeno (t-PA) y su inhibidor PAI-1, entre otros. Se identificaron estudios que respaldan el uso de estos marcadores como posibles predictores de gravedad o complicación. Esta revisión pretende servir como base para futuras investigaciones clínicas y para la comprensión integral de la malaria desde un enfoque hematológico.
publishDate 2025
dc.date.accessioned.none.fl_str_mv 2025-07-25T16:48:52Z
dc.date.available.none.fl_str_mv 2025-07-25T16:48:52Z
dc.date.issued.none.fl_str_mv 2025-07-25
dc.type.none.fl_str_mv Trabajo de grado - Pregrado
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/bachelorThesis
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.version.none.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.none.fl_str_mv Text
format http://purl.org/coar/resource_type/c_7a1f
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dc.identifier.uri.none.fl_str_mv https://repositorio.unicordoba.edu.co/handle/ucordoba/9485
dc.identifier.instname.none.fl_str_mv Universidad de Córdoba
dc.identifier.reponame.none.fl_str_mv Repositorio Universidad de Córdoba
dc.identifier.repourl.none.fl_str_mv https://repositorio.unicordoba.edu.co/
url https://repositorio.unicordoba.edu.co/handle/ucordoba/9485
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identifier_str_mv Universidad de Córdoba
Repositorio Universidad de Córdoba
dc.language.iso.none.fl_str_mv spa
language spa
dc.relation.references.none.fl_str_mv Cowman, A. F., Healer, J., Marapana, D., & Marsh, K. (2016). Malaria: Biology and disease. Cell, 167(3), 610–624. https://doi.org/10.1016/j.cell.2016.07.055
Rosenthal, P. J. (2022). Malaria in 2022: Challenges and progress. The American Journal of Tropical Medicine and Hygiene, 106(1), 1–4. https://doi.org/10.4269/ajtmh.21-1084
Li, Q., Liu, T., Lv, K., Liao, F., Wang, J., Tu, Y., & Chen, Q. (2025). Malaria: Past, present, and future. Signal Transduction and Targeted Therapy, 10(188). https://doi.org/10.1038/s41392-025-02246-3
World Health Organization. (2024). World malaria report 2024: Addressing inequity in the global malaria response. Ginebra: OMS.
Pan American Health Organization (PAHO). (2025). PAHO urges expanded access to malaria diagnosis and treatment to accelerate elimination. Recuperado de https://www.paho.org/en/news/25-4-2025-paho-urges-expanded-access-malaria- diagnosis-and-treatment
Atlas Visual de la Malaria. (2025). Malaria en Colombia: 123 740 casos en 2024. Recuperado de https://atlasvisualdelamalaria.org/malaria-en-colombia-123-740-casos-en- 2024/
Atlas Visual de la Malaria. (2024). Malaria en Colombia: 110 343 casos y 16 muertes (SE44). Recuperado de https://atlasvisualdelamalaria.org/malaria-en-colombia-81- %E2%AC%86-se44-110343-casos-y-16-muertes/
Instituto Nacional de Salud (INS). (2025). Boletín Epidemiológico Semana 15 - 2025. Recuperado de https://www.ins.gov.co
Milner, D. A. Jr. (2018). Malaria pathogenesis. Cold Spring Harbor Perspectives in Medicine, 8(1), a025569. https://doi.org/10.1101/cshperspect.a025569
Tizifa, T. A., Kabaghe, A. N., McCann, R. S., van den Berg, H., Van Vugt, M., & Phiri, K. S. (2018). Prevention efforts for malaria. Current Tropical Medicine Reports, 5(1), 41– 50. https://doi.org/10.1007/s40475-018-0133-y
Zimmerman, P. A., & Howes, R. E. (2015). Malaria diagnosis for malaria elimination. Current Opinion in Infectious Diseases, 28(5), 446–454. https://doi.org/10.1097/QCO.0000000000000191
Portugal, S., Epiphanio, S., Akinc, A., Hadwiger, P., Jahn-Hofmann, K., et al. (2014). Malaria Biology and Disease. Cell Host & Microbe.
Kojom Foko, L., & Singh, V. (2023). Malaria in pregnancy in India: A public health concern. Frontiers in Public Health. https://doi.org/10.3389/fpubh.2023.1150466
Hendriksen, I. C. E., et al. (2013). Pathophysiology of severe malaria: insights from clinical studies. Malaria Journal, 12(1), 67. https://doi.org/10.1186/1475-2875-12-67
Cunnington, A. J., Riley, E. M., & Walther, M. (2013). Microvascular dysfunction in severe Plasmodium falciparum malaria. Journal of Infectious Diseases, 207(3), 369–370. https://doi.org/10.1093/infdis/jis728
Hanson, J., Lee, S. J., Hossain, M. A., Anstey, N. M., Charunwatthana, P., Maude, R. J., ... & White, N. J. (2015). Endothelial activation in adults with severe falciparum malaria characterized by increased levels of circulating soluble ICAM-1 and von Willebrand factor. Clinical Infectious Diseases, 60(6), 845–852. https://doi.org/10.1093/cid/ciu954
Hunt, N. H., Ball, H. J., & Hansen, A. M. (2014). Cerebral malaria: γ-Interferon redux. Frontiers in Cellular and Infection Microbiology, 4, 113. https://doi.org/10.3389/fcimb.2014.00113
Cibulskis, R. E., Aregawi, M., Williams, R., Otten, M., Dye, C., & Snow, R. W. (2016). Malaria: Global progress 2000–2015. Infectious Diseases of Poverty, 5(1), 61. https://doi.org/10.1186/s40249-016-0151-8
Thanh, P. V., Hong, N. V., Van, N. N., Malaria Control Programme of Vietnam, et al. (2015). Epidemiology of forest malaria in Central Vietnam: the hidden parasite reservoir. Malaria Journal, 14, 86. https://doi.org/10.1186/s12936-015-0581-7
Mbengue, A., Bhattacharjee, S., Pandharkar, T., Liu, H., Estiu, G., Stahelin, R. V., ... & Haldar, K. (2015). A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. Nature, 520(7549), 683–687. https://doi.org/10.1038/nature14412
Vallejo, A. F., Chaparro, P. E., Benavides, Y., Álvarez, Á. M., Quintero, J. P., & Herrera, S. (2015). High prevalence of sub-microscopic infections in Colombia. Malaria Journal, 14, 201. https://doi.org/10.1186/s12936-015-0702-3
Hopkins, H., Gonzalez, I. J., Polley, S. D., et al. (2013). Performance of a new LAMP kit in a remote clinic in Uganda. Journal of Infectious Diseases, 208(4), 645–652. https://doi.org/10.1093/infdis/jit184
Cheng, Z., Wang, D., Tian, X., et al. (2015). Capture and ligation probe-PCR (CLIP-PCR) for molecular screening. Clinical Chemistry, 61(6), 821–828. https://doi.org/10.1373/clinchem.2014.234070
Taylor, B. J., Howell, A., Martin, K. A., et al. (2014). A lab-on-chip for malaria diagnosis and surveillance. Malaria Journal, 13, 179. https://doi.org/10.1186/1475-2875-13-179
Arya, A., Kojom Foko, L. P., Chaudhry, S., Sharma, A., & Singh, V. (2021). Artemisinin- based combination therapy and drug resistance molecular markers: A systematic review. International Journal for Parasitology: Drugs and Drug Resistance, 15, 43–56. https://doi.org/10.1016/j.ijpddr.2020.11.006
Anvikar, A. R., Sahu, P., Pradhan, M. M., Sharma, S., Ahmed, N., Yadav, C. P., et al. (2022). Active pharmacovigilance for primaquine radical cure of Plasmodium vivax malaria in Odisha, India. The American Journal of Tropical Medicine and Hygiene, 106(3), 831–840. https://doi.org/10.4269/ajtmh.21-0816
McCarthy, J. S., et al. (2021). Safety and antimalarial activity of M5717: A first-in-human study. The Lancet Infectious Diseases, 21(12), 1713–1724. https://doi.org/10.1016/S1473- 3099(21)00187-7
Marongiu, F., Grandone, E., Scano, A., et al. (2021). Infectious agents including COVID- 19 and the involvement of blood coagulation and fibrinolysis: A narrative review. European Review for Medical and Pharmacological Sciences, 25(9), 3886–3897. https://doi.org/10.26355/eurrev_202105_25882
Follenzi, A., Boscolo, E., Bertero, T., et al. (2023). Hemostasis and endothelial functionality: the double face of coagulation factors. Blood Reviews, 57, 100999. https://doi.org/10.1016/j.blre.2022.100999
Mostafa, A. G., Bilal, N. E., Abass, A. E., et al. (2015). Coagulation and Fibrinolysis Indicators and Placental Malaria Infection in Central Sudan. Malaria Research and Treatment, 2015, Article ID 369237. https://doi.org/10.1155/2015/369237
Pala, Z. R., Ernest, M., Sweeney, B., et al. (2022). Beyond cuts and scrapes: Plasmin in malaria and other vector-borne diseases. Trends in Parasitology, 38(2), 147–159. https://doi.org/10.1016/j.pt.2021.09.008
Alves e Silva, T. L., Radtke, A., Balaban, A., et al. (2021). The fibrinolytic system enables the onset of Plasmodium infection in the mosquito vector and the mammalian host. Science Advances, 7, eabe3362. https://doi.org/10.1126/sciadv.abe3362
Kuijpers, M. J. E., Heemskerk, J. W. M., & Nagy, M. (2022). Molecular mechanisms of hemostasis, thrombosis and thrombo-inflammation. Cardiovascular Research, 118(5), 1130–1153. https://doi.org/10.1093/cvr/cvab365
Mandel, J., Subramaniam, S., & Schattner, M. (2022). Beyond hemostasis: platelet innate immune interactions and thromboinflammation. International Journal of Molecular Sciences, 23(14), 7911. https://doi.org/10.3390/ijms23147911
Hvas, C. L., & Larsen, J. B. (2023). The fibrinolytic system and its measurement: History, current uses and future directions for diagnosis and treatment. International Journal of Molecular Sciences, 24(18), 14179. https://doi.org/10.3390/ijms241814179
Obeagu, E. I., Obeagu, G. U., Chukwueze, C. M., et al. (2022). Evaluation of protein C, protein S and fibrinogen of pregnant women with malaria in Owerri Metropolis. Madonna University Journal of Medicine and Health Sciences, 2(2), 1–9. http://madonnauniversity.edu.ng/journals
Ghosh, S., Singh, N. M., & Mukherjee, A. (2023). Beyond cuts and scrapes: Plasmin in malaria and other vector-borne diseases. Current Topics in Medicinal Chemistry, 23(1), 3–17
Santos-Ciminera, P., Branch, O. H., & Udhayakumar, V. (2021). Elevations in D-dimer levels in patients with Plasmodium infections: A systematic review and meta-analysis. PLOS ONE, 16(5), e0251344.
Branch, O. H., Udhayakumar, V., & Santos-Ciminera, P. (2021). Elevations in D-dimer levels in patients with Plasmodium infections: A systematic review and meta-analysis. PLOS ONE, 16(5), e0251344. https://doi.org/10.1371/journal.pone.0251344
Barcus, M. J., Basri, H., Picarima, H., Manyakori, C., Sekartuti, Elyazar, I., & Baird, J. K. (2007). Demonstration of hypnozoite activation in Plasmodium vivax malaria. The American Journal of Tropical Medicine and Hygiene, 77(4), 727–732. https://doi.org/10.4269/ajtmh.2007.77.727
Rahimi, B. A., Thakkinstian, A., White, N. J., & Dondorp, A. M. (2014). Severe vivax malaria: A systematic review and meta-analysis of clinical studies since 1900. PLOS Neglected Tropical Diseases, 8(12), e3076. https://doi.org/10.1371/journal.pntd.0003076
Long, H., Tang, L., Xu, S., et al. (2021). Infectious agents including COVID-19 and the involvement of blood coagulation and fibrinolysis. Journal of Infection and Public Health, 14(9), 1171–1180.
Morioka, T., et al. (2022). The Fibrinolytic System and Its Measurement: History, Current Uses and Future Directions. Frontiers in Medicine, 9, 1052168. https://doi.org/10.3389/fmed.2022.1052168
Kell, D. B., & Pretorius, E. (2017). Proteins behaving badly. PLOS ONE, 12(3), e0173677. https://doi.org/10.1371/journal.pone.0173677
Monteiro, R. Q., et al. (2020). The fibrinolytic system in inflammation and infection. Thrombosis Research, 191, S117–S122.
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spelling Cantero Guevara, Miriam ElenaGarcía del Castillo, Yuranis AndreaHernández Galarza, NatalyCastro Cavadia, Carlos JavierYasnot Acosta, María Fernanda2025-07-25T16:48:52Z2025-07-25T16:48:52Z2025-07-25https://repositorio.unicordoba.edu.co/handle/ucordoba/9485Universidad de CórdobaRepositorio Universidad de Córdobahttps://repositorio.unicordoba.edu.co/La malaria es una enfermedad infecciosa de gran impacto en salud pública, especialmente en regiones tropicales y subtropicales donde circulan especies del género Plasmodium, principalmente P. falciparum y P. vivax. Esta infección, además de afectar múltiples órganos y sistemas, produce alteraciones significativas en el sistema hemostático, incluyendo activación del endotelio, consumo de factores de coagulación, trombocitopenia y disfunción fibrinolítica. En esta monografía se realizó una revisión bibliográfica sobre la epidemiología, fisiopatología y diagnóstico de la malaria, así como de los mecanismos de la hemostasia y su relación con marcadores como el dímero D, el activador tisular del plasminógeno (t-PA) y su inhibidor PAI-1, entre otros. Se identificaron estudios que respaldan el uso de estos marcadores como posibles predictores de gravedad o complicación. Esta revisión pretende servir como base para futuras investigaciones clínicas y para la comprensión integral de la malaria desde un enfoque hematológico.Malaria is an infectious disease with significant public health impact, particularly in tropical and subtropical regions where species of the Plasmodium genus, mainly P. falciparum and P. vivax, are endemic. This infection, in addition to affecting multiple organs and systems, causes notable alterations in the hemostatic system, including endothelial activation, consumption of coagulation factors, thrombocytopenia, and fibrinolytic dysfunction. This monograph presents a literature review on the epidemiology, pathophysiology, and diagnosis of malaria, as well as the mechanisms of hemostasis and their relationship with markers such as D-dimer, tissue plasminogen activator (t-PA), and its inhibitor PAI-1, among others. Several studies support the use of these markers as potential predictors of disease severity or complications. This review aims to serve as a foundation for future clinical research and for a comprehensive understanding of malaria from a hematological perspective.PRESENTACIÓNRESUMENABSTRACTINTRODUCCIÓNMETODOLOGÍACAPÍTULO 1: MALARIACAPÍTULO 2: HEMOSTASIACAPÍTULO 3: FACTORES FIBRINOLÍTICOSCAPÍTULO 4: ALTERACIONES FIBRINOLÍTICAS EN MALARIA: ANÁLISIS COMPARATIVOREFERENCIAS BIBLIOGRÁFICASPregradoBacteriólogo(a)MonografíasspaUniversidad de CórdobaFacultad de Ciencias de la SaludMontería, Córdoba, ColombiaBacteriologíaCopyright Universidad de Córdoba, 2025https://creativecommons.org/licenses/by-nc-nd/4.0/Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Perfil de los factores fibrinolíticos en malaria por Plasmodium falciparum y Plasmodium vivaxTrabajo de grado - Pregradoinfo:eu-repo/semantics/bachelorThesishttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/acceptedVersionTextCowman, A. F., Healer, J., Marapana, D., & Marsh, K. (2016). Malaria: Biology and disease. Cell, 167(3), 610–624. https://doi.org/10.1016/j.cell.2016.07.055Rosenthal, P. J. (2022). Malaria in 2022: Challenges and progress. The American Journal of Tropical Medicine and Hygiene, 106(1), 1–4. https://doi.org/10.4269/ajtmh.21-1084Li, Q., Liu, T., Lv, K., Liao, F., Wang, J., Tu, Y., & Chen, Q. (2025). Malaria: Past, present, and future. Signal Transduction and Targeted Therapy, 10(188). https://doi.org/10.1038/s41392-025-02246-3World Health Organization. (2024). World malaria report 2024: Addressing inequity in the global malaria response. Ginebra: OMS.Pan American Health Organization (PAHO). (2025). PAHO urges expanded access to malaria diagnosis and treatment to accelerate elimination. Recuperado de https://www.paho.org/en/news/25-4-2025-paho-urges-expanded-access-malaria- diagnosis-and-treatmentAtlas Visual de la Malaria. (2025). Malaria en Colombia: 123 740 casos en 2024. Recuperado de https://atlasvisualdelamalaria.org/malaria-en-colombia-123-740-casos-en- 2024/Atlas Visual de la Malaria. (2024). Malaria en Colombia: 110 343 casos y 16 muertes (SE44). Recuperado de https://atlasvisualdelamalaria.org/malaria-en-colombia-81- %E2%AC%86-se44-110343-casos-y-16-muertes/Instituto Nacional de Salud (INS). (2025). Boletín Epidemiológico Semana 15 - 2025. Recuperado de https://www.ins.gov.coMilner, D. A. Jr. (2018). Malaria pathogenesis. Cold Spring Harbor Perspectives in Medicine, 8(1), a025569. https://doi.org/10.1101/cshperspect.a025569Tizifa, T. A., Kabaghe, A. N., McCann, R. S., van den Berg, H., Van Vugt, M., & Phiri, K. S. (2018). Prevention efforts for malaria. Current Tropical Medicine Reports, 5(1), 41– 50. https://doi.org/10.1007/s40475-018-0133-yZimmerman, P. A., & Howes, R. E. (2015). Malaria diagnosis for malaria elimination. Current Opinion in Infectious Diseases, 28(5), 446–454. https://doi.org/10.1097/QCO.0000000000000191Portugal, S., Epiphanio, S., Akinc, A., Hadwiger, P., Jahn-Hofmann, K., et al. (2014). Malaria Biology and Disease. Cell Host & Microbe.Kojom Foko, L., & Singh, V. (2023). Malaria in pregnancy in India: A public health concern. Frontiers in Public Health. https://doi.org/10.3389/fpubh.2023.1150466Hendriksen, I. C. E., et al. (2013). Pathophysiology of severe malaria: insights from clinical studies. Malaria Journal, 12(1), 67. https://doi.org/10.1186/1475-2875-12-67Cunnington, A. J., Riley, E. M., & Walther, M. (2013). Microvascular dysfunction in severe Plasmodium falciparum malaria. Journal of Infectious Diseases, 207(3), 369–370. https://doi.org/10.1093/infdis/jis728Hanson, J., Lee, S. J., Hossain, M. A., Anstey, N. M., Charunwatthana, P., Maude, R. J., ... & White, N. J. (2015). 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03:00:30.26https://creativecommons.org/licenses/by-nc-nd/4.0/Copyright Universidad de Córdoba, 2025open.accesshttps://dspace8-unicordoba.metabuscador.orgRepositorio institucional Universidad de 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