Evaluación del potencial antifúngico del extracto etanólico de Oxandra venezuelana contra aislamientos clínicos de candida spp
Las infecciones causadas por Candida spp., son una de las principales preocupaciones en la práctica médica, especialmente debido a la resistencia a los tratamientos convencionales y la capacidad de estas levaduras para formar biopelículas, lo que dificulta su erradicación. Es por esto que, los produ...
- Autores:
-
Castro Arrieta, Yessica Paola
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2025
- Institución:
- Universidad de Córdoba
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- Repositorio Institucional Unicórdoba
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- spa
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- https://repositorio.unicordoba.edu.co/handle/ucordoba/9346
https://repositorio.unicordoba.edu.co/
- Palabra clave:
- Candida spp
Oxandra venezuelana
Productos naturales
Antifúngico
Candida spp
Oxandra venezuelana
Natural products
Antifungal
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- openAccess
- License
- Copyright Universidad de Córdoba, 2025
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Evaluación del potencial antifúngico del extracto etanólico de Oxandra venezuelana contra aislamientos clínicos de candida spp |
| title |
Evaluación del potencial antifúngico del extracto etanólico de Oxandra venezuelana contra aislamientos clínicos de candida spp |
| spellingShingle |
Evaluación del potencial antifúngico del extracto etanólico de Oxandra venezuelana contra aislamientos clínicos de candida spp Candida spp Oxandra venezuelana Productos naturales Antifúngico Candida spp Oxandra venezuelana Natural products Antifungal |
| title_short |
Evaluación del potencial antifúngico del extracto etanólico de Oxandra venezuelana contra aislamientos clínicos de candida spp |
| title_full |
Evaluación del potencial antifúngico del extracto etanólico de Oxandra venezuelana contra aislamientos clínicos de candida spp |
| title_fullStr |
Evaluación del potencial antifúngico del extracto etanólico de Oxandra venezuelana contra aislamientos clínicos de candida spp |
| title_full_unstemmed |
Evaluación del potencial antifúngico del extracto etanólico de Oxandra venezuelana contra aislamientos clínicos de candida spp |
| title_sort |
Evaluación del potencial antifúngico del extracto etanólico de Oxandra venezuelana contra aislamientos clínicos de candida spp |
| dc.creator.fl_str_mv |
Castro Arrieta, Yessica Paola |
| dc.contributor.advisor.none.fl_str_mv |
Contreras Martínez, Orfa Inés Angulo Ortiz, Alberto |
| dc.contributor.author.none.fl_str_mv |
Castro Arrieta, Yessica Paola |
| dc.contributor.jury.none.fl_str_mv |
Villegas Gonzalez, Jazmith Paola Lorduy Rodriguez, Alvaro Jose |
| dc.subject.proposal.spa.fl_str_mv |
Candida spp Oxandra venezuelana Productos naturales Antifúngico |
| topic |
Candida spp Oxandra venezuelana Productos naturales Antifúngico Candida spp Oxandra venezuelana Natural products Antifungal |
| dc.subject.keywords.eng.fl_str_mv |
Candida spp Oxandra venezuelana Natural products Antifungal |
| description |
Las infecciones causadas por Candida spp., son una de las principales preocupaciones en la práctica médica, especialmente debido a la resistencia a los tratamientos convencionales y la capacidad de estas levaduras para formar biopelículas, lo que dificulta su erradicación. Es por esto que, los productos de origen vegetal emergen como una opción prometedora, ya que incluyen una variedad de compuestos bioactivos con propiedades antimicrobianas reconocidas. Esta investigación tuvo como objetivo evaluar el potencial antifúngico del extracto etanólico de Oxandra venezuelana contra aislamientos clínicos de Candida spp. La sensibilidad de las levaduras se determinó a través del método de microdilución en caldo y su efecto contra las biopelículas fúngicas se evaluó empleando la técnica de cristal violeta; Todos los aislamientos fueron sensibles al extracto evaluado, con valores de CMI90 entre 3920 y 9911 μg/mL. El extracto etanólico de hoja de O. venezuelana inhibió la formación de biopelículas fúngicas de todos los aislamientos clínicos evaluados, mostrando para C. krusei 07, C. parapsilosis 02, C. parapsilosis 03 y C. glabrata 85 más del 50 % de inhibición, superando los valores reportados con Anfotericina B (AFB). Así mismo, el efecto inhibitorio contra las biopelículas maduras se observó en la mayoría de los aislamientos, siendo este efecto mayor que el observado con AFB. Los resultados de esta investigación contribuyen a la búsqueda de compuestos bioactivos contra levaduras patógenas del género Candida y sirven como base a estudios futuros en miras de dilucidar compuestos de estos extractos y sus mecanismos de acción antimicrobianos. |
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2025 |
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2025-07-15T18:12:05Z |
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2025-07-14 |
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Trabajo de grado - Pregrado |
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info:eu-repo/semantics/bachelorThesis |
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http://purl.org/coar/resource_type/c_7a1f |
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Universidad de Córdoba |
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Repositorio Universidad de Córdoba |
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spa |
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Perlroth, J., Choi, B., & Spellberg, B. (2007). Nosocomial fungal infections: epidemiology, diagnosis, and treatment. Medical Mycology, 45(4), 321–346. https://doi.org/10.1080/13693780701218689 Atiencia-Carrera, M. B., Cabezas-Mera, F. S., Tejera, E., & Machado, A. (2022). Prevalence of biofilms in Candida spp. bloodstream infections: A meta-analysis. PLOS ONE, 17(2), e0263522. https://doi.org/10.1371/journal.pone.0263522 Barantsevich, N., & Barantsevich, E. (2022). Diagnosis and Treatment of Invasive Candidiasis. Antibiotics, 11(6), 718. https://doi.org/10.3390/antibiotics11060718 Bedout, C., & Gómez, B. L. (2010). Candida y candidiasis invasora: un reto continuo para su diagnóstico temprano. Infectio, 14, s159–s171. http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0123-93922010000600008 Alvarez, C., Cortes, A., & Denning, W. (2018). Burden of Fungal Infections in Colombia. Journal of Fungi, 4(2). https://doi.org/10.3390/JOF4020041 Pristov, K. E., & Ghannoum, M. A. (2019). Resistance of Candida to azoles and echinocandins worldwide. Clinical Microbiology and Infection, 25(7), 792–798. https://doi.org/10.1016/j.cmi.2019.03.028 Lee, Y., Puumala, E., Robbins, N., & Cowen, L. E. (2021). Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond. Chemical Reviews, 121(6), 3390–3411. https://doi.org/10.1021/acs.chemrev.0c00199 Bilal, H., Shafiq, M., Hou, B., Islam, R., Khan, M. N., Khan, R. U., & Zeng, Y. (2022). Distribution and antifungal susceptibility pattern of Candida species from mainland China: A systematic analysis. Virulence, 13(1), 1573–1589. https://doi.org/10.1080/21505594.2022.2123325 Cortés, J. A., Ruiz, J. F., Melgarejo-Moreno, L. N., & Lemos, E. V. (2020). Candidemia in Colombia. Biomedica, 40(1), 195-207. https://doi.org/10.7705/biomedica.4400 Gaziano, R., et al. (2019). Antimicrobial properties of the medicinal plant Cardiospermum halicacabum L: new evidence and future perspectives. European Review for Medical and Pharmacological Sciences, 23(16), 7135–7143. https://doi.org/10.26355/eurrev_201908_18759 Famuyide, I. M., et al. (2019). Antibacterial and antibiofilm activity of acetone leaf extracts of nine under-investigated South African Eugenia and Syzygium (Myrtaceae) species and their selectivity indices. BMC Complementary and Alternative Medicine, 19(1). https://doi.org/10.1186/s12906-019-2547-z Cruz-Chacón, I. D., et al. (2019). Antifungal activity in vitro of Sapranthus microcarpus (Annonaceae) against phytopathogens. Acta Botánica Mexicana, 126. https://doi.org/10.21829/abm127.2019.1420 Sharma, G., et al. (2023). Plants from Annonaceae family as antimalarials: An ethnopharmacology and phytochemistry review to identify potential lead molecules. South African Journal of Botany, 155(1). https://doi.org/10.1016/j.sajb.2023.02.015 Harahap, D., et al. (2022). Antibacterial activities of seven ethnomedicinal plants from family Annonaceae. Journal of Advanced Pharmaceutical Technology & Research, 13(3), 148–153. https://doi.org/10.4103/japtr.japtr_111_22 Kojima, N., & Tanaka, T. (2009). Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues. Molecules, 14(9), 3621–3661. https://doi.org/10.3390/molecules14093621 Contreras Martínez, O. I., et al. (2022). Antibacterial Screening of Isoespintanol, an Aromatic Monoterpene Isolated from Oxandra xylopioides Diels. Molecules, 27(22), 8004. https://doi.org/10.3390/molecules27228004 Contreras, O., et al. (2023). Isoespintanol Antifungal Activity Involves Mitochondrial Dysfunction, Inhibition of Biofilm Formation, and Damage to Cell Wall Integrity in Candida tropicalis. International Journal of Molecular Sciences, 24(12). https://doi.org/10.3390/IJMS241210187 Rojano, B., et al. (2007). Constituents of Oxandra cf. xylopioides with anti-inflammatory activity. Journal of Natural Products, 70(5), 835–838. https://doi.org/10.1021/np060333v Campos, L. M., et al. (2023). Antifungal Annona muricata L. (soursop) extract targets the cell envelope of multi-drug resistant Candida albicans. Journal of Ethnopharmacology, 301, 115856. https://doi.org/10.1016/j.jep.2022.115856 Kayo, M. T., et al. (2021). Antifungal potential of extracts, fractions and compounds from Uvaria comperei (Annonaceae) and Oxyanthus unilocularis (Rubiaceae). Natural Product Research, 35(24), 5732-5736. https://doi.org/10.1080/14786419.2020.1828409 Issakou Bakarnga-Via, et al. (2022). Antifungal, antiradical, anti-inflammatory and antineoplastic activities of essential oils of some medicinal plants of the Annonaceae family of Chad and Cameroon. Journal of Phytomolecules and Pharmacology, 1(2), 75–87. https://doi.org/10.56717/jpp.2022.v01i02.01 Contreras Martínez, O. I., et al. (2022). Antifungal potential of isoespintanol extracted from Oxandra xylopioides Diels (Annonaceae) against intrahospital isolations of Candida spp. Heliyon, 8(10), e11110. https://doi.org/10.1016/j.heliyon.2022.e11110 Ciurea, C. N., et al. (2020). Candida and Candidiasis—Opportunism Versus Pathogenicity: A Review of the Virulence Traits. Microorganisms, 8(6), 857. https://doi.org/10.3390/microorganisms8060857 Ponde, N. O., et al. (2021). Candida albicans biofilms and polymicrobial interactions. Critical Reviews in Microbiology, 47(1), 91–111. https://doi.org/10.1080/1040841x.2020.1843400 Silva, S., et al. (2012). Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, Pathogenicity and Antifungal Resistance. FEMS Microbiology Reviews, 36(2), 288–305. https://doi.org/10.1111/j.1574-6976.2011.00278.x García, C. S., et al. (2020). Candida auris: descripción de un brote. Enfermedades Infecciosas Y Microbiología Clínica, 38, 39–44. https://doi.org/10.1016/j.eimc.2020.02.007 Newman, D. J., & Cragg, G. M. (2007). Natural Products as Sources of New Drugs over the Last 25 Years. Journal of Natural Products, 70(3), 461–477. https://doi.org/10.1021/np068054v Junikka, L., et al. (2016). Revision of Oxandra (Annonaceae). Blumea - Biodiversity, Evolution and Biogeography of Plants, 61(3), 215–266. https://doi.org/10.3767/000651916x694283 Uuh-Narvaez, J. J., et al. (2023). Antioxidant Potential and Known Secondary Metabolites of Rare or Underutilized Plants of Yucatan Region. Future Pharmacology, 3(4), 664–685. https://doi.org/10.3390/futurepharmacol3040042 Shehata, M. G., et al. (2021). Nutritional, phytochemical, and in vitro anticancer potential of sugar apple (Annona squamosa) fruits. Scientific Reports, 11(1), 6224. https://doi.org/10.1038/s41598-021-85772-8 Taborda, M. (2025). Evaluación del potencial antifúngico de los extractos etanólicos de corteza y madera obtenidos de Duguetia vallicola (Annonaceae) contra aislamientos clínicos de Candida spp. Repositorio Institucional Unicordoba; Universidad de Córdoba. https://repositorio.unicordoba.edu.co/entities/publication/2f42d56d-ba60-4e16-b0c1-866f01fef52d Tascini, C., et al. (2018). The role of biofilm forming on mortality in patients with candidemia: a study derived from real world data. Infectious Diseases (London), 50(3), 214-219. https://doi.org/10.1080/23744235.2017.1384956 |
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Contreras Martínez, Orfa InésAngulo Ortiz, AlbertoCastro Arrieta, Yessica PaolaVillegas Gonzalez, Jazmith PaolaLorduy Rodriguez, Alvaro Jose2025-07-15T18:12:05Z2025-07-15T18:12:05Z2025-07-14https://repositorio.unicordoba.edu.co/handle/ucordoba/9346Universidad de CórdobaRepositorio Universidad de Córdobahttps://repositorio.unicordoba.edu.co/Las infecciones causadas por Candida spp., son una de las principales preocupaciones en la práctica médica, especialmente debido a la resistencia a los tratamientos convencionales y la capacidad de estas levaduras para formar biopelículas, lo que dificulta su erradicación. Es por esto que, los productos de origen vegetal emergen como una opción prometedora, ya que incluyen una variedad de compuestos bioactivos con propiedades antimicrobianas reconocidas. Esta investigación tuvo como objetivo evaluar el potencial antifúngico del extracto etanólico de Oxandra venezuelana contra aislamientos clínicos de Candida spp. La sensibilidad de las levaduras se determinó a través del método de microdilución en caldo y su efecto contra las biopelículas fúngicas se evaluó empleando la técnica de cristal violeta; Todos los aislamientos fueron sensibles al extracto evaluado, con valores de CMI90 entre 3920 y 9911 μg/mL. El extracto etanólico de hoja de O. venezuelana inhibió la formación de biopelículas fúngicas de todos los aislamientos clínicos evaluados, mostrando para C. krusei 07, C. parapsilosis 02, C. parapsilosis 03 y C. glabrata 85 más del 50 % de inhibición, superando los valores reportados con Anfotericina B (AFB). Así mismo, el efecto inhibitorio contra las biopelículas maduras se observó en la mayoría de los aislamientos, siendo este efecto mayor que el observado con AFB. Los resultados de esta investigación contribuyen a la búsqueda de compuestos bioactivos contra levaduras patógenas del género Candida y sirven como base a estudios futuros en miras de dilucidar compuestos de estos extractos y sus mecanismos de acción antimicrobianos.Infections caused by Candida spp. are a major concern in medical practice, especially due to their resistance to conventional treatments and their ability to form biofilms, making their eradication difficult. Therefore, plant-based products are emerging as a promising option, as they include a variety of bioactive compounds with recognized antimicrobial properties. This research aimed to evaluate the antifungal potential of the ethanolic extract of Oxandra venezuelana against clinical isolates of Candida spp. The sensitivity of the yeasts was determined using the broth microdilution method, and their effect against fungal biofilms was evaluated using the crystal violet technique. All isolates were sensitive to the extract tested, with MIC90 values between 3920 and 9911 μg/mL. The ethanolic extract of O. venezuelana leaves inhibited fungal biofilm formation in all clinical isolates tested, showing over 50% inhibition for C. krusei 07, C. parapsilosis 02, C. parapsilosis 03, and C. glabrata 85, exceeding the values reported with Amphotericin B (AFB). Furthermore, the inhibitory effect against mature biofilms was observed in most isolates, a effect that was greater than that observed with AFB. The results of this research contribute to the search for bioactive compounds against pathogenic yeasts of the genus Candida and serve as a basis for future studies aimed at elucidating the compounds of these extracts and their antimicrobial mechanisms of action.PregradoBiólogo(a)Trabajos de Investigación y/o Extensiónapplication/pdfspaUniversidad de CórdobaFacultad de Ciencias BásicasMontería, Córdoba, ColombiaBiologíaCopyright Universidad de Córdoba, 2025https://creativecommons.org/licenses/by-nc-nd/4.0/Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Evaluación del potencial antifúngico del extracto etanólico de Oxandra venezuelana contra aislamientos clínicos de candida sppTrabajo de grado - Pregradoinfo:eu-repo/semantics/bachelorThesishttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/acceptedVersionTextPerlroth, J., Choi, B., & Spellberg, B. (2007). Nosocomial fungal infections: epidemiology, diagnosis, and treatment. Medical Mycology, 45(4), 321–346. https://doi.org/10.1080/13693780701218689Atiencia-Carrera, M. B., Cabezas-Mera, F. S., Tejera, E., & Machado, A. (2022). Prevalence of biofilms in Candida spp. bloodstream infections: A meta-analysis. PLOS ONE, 17(2), e0263522. https://doi.org/10.1371/journal.pone.0263522Barantsevich, N., & Barantsevich, E. (2022). Diagnosis and Treatment of Invasive Candidiasis. Antibiotics, 11(6), 718. https://doi.org/10.3390/antibiotics11060718Bedout, C., & Gómez, B. L. (2010). Candida y candidiasis invasora: un reto continuo para su diagnóstico temprano. Infectio, 14, s159–s171. http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0123-93922010000600008Alvarez, C., Cortes, A., & Denning, W. (2018). Burden of Fungal Infections in Colombia. Journal of Fungi, 4(2). https://doi.org/10.3390/JOF4020041Pristov, K. E., & Ghannoum, M. A. (2019). Resistance of Candida to azoles and echinocandins worldwide. Clinical Microbiology and Infection, 25(7), 792–798. https://doi.org/10.1016/j.cmi.2019.03.028Lee, Y., Puumala, E., Robbins, N., & Cowen, L. E. (2021). Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond. Chemical Reviews, 121(6), 3390–3411. https://doi.org/10.1021/acs.chemrev.0c00199Bilal, H., Shafiq, M., Hou, B., Islam, R., Khan, M. N., Khan, R. U., & Zeng, Y. (2022). Distribution and antifungal susceptibility pattern of Candida species from mainland China: A systematic analysis. Virulence, 13(1), 1573–1589. https://doi.org/10.1080/21505594.2022.2123325Cortés, J. A., Ruiz, J. F., Melgarejo-Moreno, L. N., & Lemos, E. V. (2020). Candidemia in Colombia. Biomedica, 40(1), 195-207. https://doi.org/10.7705/biomedica.4400Gaziano, R., et al. (2019). Antimicrobial properties of the medicinal plant Cardiospermum halicacabum L: new evidence and future perspectives. European Review for Medical and Pharmacological Sciences, 23(16), 7135–7143. https://doi.org/10.26355/eurrev_201908_18759Famuyide, I. M., et al. (2019). Antibacterial and antibiofilm activity of acetone leaf extracts of nine under-investigated South African Eugenia and Syzygium (Myrtaceae) species and their selectivity indices. BMC Complementary and Alternative Medicine, 19(1). https://doi.org/10.1186/s12906-019-2547-zCruz-Chacón, I. D., et al. (2019). Antifungal activity in vitro of Sapranthus microcarpus (Annonaceae) against phytopathogens. Acta Botánica Mexicana, 126. https://doi.org/10.21829/abm127.2019.1420Sharma, G., et al. (2023). Plants from Annonaceae family as antimalarials: An ethnopharmacology and phytochemistry review to identify potential lead molecules. South African Journal of Botany, 155(1). https://doi.org/10.1016/j.sajb.2023.02.015Harahap, D., et al. (2022). Antibacterial activities of seven ethnomedicinal plants from family Annonaceae. 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Evaluación del potencial antifúngico de los extractos etanólicos de corteza y madera obtenidos de Duguetia vallicola (Annonaceae) contra aislamientos clínicos de Candida spp. Repositorio Institucional Unicordoba; Universidad de Córdoba. https://repositorio.unicordoba.edu.co/entities/publication/2f42d56d-ba60-4e16-b0c1-866f01fef52dTascini, C., et al. (2018). The role of biofilm forming on mortality in patients with candidemia: a study derived from real world data. Infectious Diseases (London), 50(3), 214-219. https://doi.org/10.1080/23744235.2017.1384956Candida sppOxandra venezuelanaProductos naturalesAntifúngicoCandida sppOxandra venezuelanaNatural productsAntifungalPublicationLICENSElicense.txtlicense.txttext/plain; charset=utf-815543https://dspace8-unicordoba.metabuscador.org/bitstreams/6b3df566-fde3-4e9d-9c7b-0fe1bf2e89fd/download73a5432e0b76442b22b026844140d683MD53falseAnonymousREADORIGINALCastroArrietaYessicaPaola.pdfCastroArrietaYessicaPaola.pdfapplication/pdf527027https://dspace8-unicordoba.metabuscador.org/bitstreams/a6dc3904-a639-4456-80e4-61e23cf545e2/downloadec061b3c6b38d1f9dd6c683ab958c44dMD54trueAnonymousREADFormato de autorización.pdfFormato de autorización.pdfapplication/pdf391238https://dspace8-unicordoba.metabuscador.org/bitstreams/f58623e3-8760-49ae-8280-a5a31af20cee/download5902998f1c0d9584166ab0f9d58f3bdcMD55falseTEXTCastroArrietaYessicaPaola.pdf.txtCastroArrietaYessicaPaola.pdf.txtExtracted 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03:00:29.348https://creativecommons.org/licenses/by-nc-nd/4.0/Copyright Universidad de Córdoba, 2025open.accesshttps://dspace8-unicordoba.metabuscador.orgRepositorio institucional Universidad de 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