Efecto citotóxico de Deoxinivalenol sobre la proliferación de la línea celular HepG2

Autores:: Garzón-González, Harold Duván
Jaimes-Mendez, Nancy
Rojas-Contreras, Liliana
Salmen-Halabi, Siham
Gil-Durán, Manuel Alejandro

Tipo de recurso:: Article of journal

Fecha de publicación:: 2021

Institución:: Universidad de Córdoba

Repositorio:: Repositorio Institucional Unicórdoba

Idioma:: spa

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dc.title.spa.fl_str_mv	Efecto citotóxico de Deoxinivalenol sobre la proliferación de la línea celular HepG2
dc.title.translated.eng.fl_str_mv	Cytotoxic effect of Deoxynivalenol on the proliferation of the HepG2 cell line
title	Efecto citotóxico de Deoxinivalenol sobre la proliferación de la línea celular HepG2
spellingShingle	Efecto citotóxico de Deoxinivalenol sobre la proliferación de la línea celular HepG2 Fusarium spp proliferation toxicity Fusarium spp proliferación toxicidad
title_short	Efecto citotóxico de Deoxinivalenol sobre la proliferación de la línea celular HepG2
title_full	Efecto citotóxico de Deoxinivalenol sobre la proliferación de la línea celular HepG2
title_fullStr	Efecto citotóxico de Deoxinivalenol sobre la proliferación de la línea celular HepG2
title_full_unstemmed	Efecto citotóxico de Deoxinivalenol sobre la proliferación de la línea celular HepG2
title_sort	Efecto citotóxico de Deoxinivalenol sobre la proliferación de la línea celular HepG2
dc.creator.fl_str_mv	Garzón-González, Harold Duván Jaimes-Mendez, Nancy Rojas-Contreras, Liliana Salmen-Halabi, Siham Gil-Durán, Manuel Alejandro
dc.contributor.author.spa.fl_str_mv	Garzón-González, Harold Duván Jaimes-Mendez, Nancy Rojas-Contreras, Liliana Salmen-Halabi, Siham Gil-Durán, Manuel Alejandro
dc.subject.eng.fl_str_mv	Fusarium spp proliferation toxicity
topic	Fusarium spp proliferation toxicity Fusarium spp proliferación toxicidad
dc.subject.spa.fl_str_mv	Fusarium spp proliferación toxicidad
publishDate	2021
dc.date.accessioned.none.fl_str_mv	2021-05-02 00:00:00 2022-07-01T21:01:39Z
dc.date.available.none.fl_str_mv	2021-05-02 00:00:00 2022-07-01T21:01:39Z
dc.date.issued.none.fl_str_mv	2021-05-02
dc.type.spa.fl_str_mv	Artículo de revista
dc.type.eng.fl_str_mv	Journal article
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dc.relation.references.spa.fl_str_mv	Mayer E, Novak B, Springler A, Schwartz-Zimmermann H, Nagl V, Reisinger N, et al. Effects of deoxynivalenol (DON) and its microbial biotransformation product deepoxy-deoxynivalenol (DOM-1) on a trout, pig, mouse, and human cell line. Mycotoxin Res. 2017; 33(4):297–308. https://link.springer.com/article/10.1007/s12550-017-0289-7 Pestka J. Toxicological mechanisms and potential health effects of deoxynivalenol and nivalenol. World Mycotoxin J. 2010; 3(4):323–347. https://doi.org/10.3920/WMJ2010.1247 Pinton P, Tsybulskyy D, Lucioli J, Laffitte J, Callu P, Lyazhri F, et al. Toxicity of deoxynivalenol and its acetylated derivatives on the intestine: Differential effects on morphology, barrier function, tight junctions proteins and MAPKinases. Toxicol Sci. 2012; 130(1):180–190. https://www.ncbi.nlm.nih.gov/pubmed/22859312 Ren Z, Wang Y, Deng H, Deng Y, Deng J, Zuo Z, et al. Deoxynivalenol induces apoptosis in chicken splenic lymphocytes via the reactive oxygen species-mediated mitochondrial pathway. Environ Toxicol Pharmacol. 2015; 39(1):339–346. https://www.ncbi.nlm.nih.gov/pubmed/25553575 Arunachalam C, Doohan F. Trichothecene toxicity in eukaryotes: Cellular and molecular mechanisms in plants and animals. Toxicol Lett. 2013; 217(2):149– 158. https://www.ncbi.nlm.nih.gov/pubmed/23274714 Wu F, Groopman F, Pestka J. Public Health Impacts of Foodborne Mycotoxins. Annu Rev Food Sci Technol. 2014; 5:351–372. https://www.ncbi.nlm.nih.gov/pubmed/24422587 Liao Y, Peng Z, Chen L, Nüssler A, Liu L, Yang W. Deoxynivalenol, gut microbiota and immunotoxicity: A potential approach? Food Chem Toxicol. 2018; 112:342–354. https://www.ncbi.nlm.nih.gov/pubmed/29331731 Pistritto G, Trisciuoglio D, Ceci C, Garufi A, D’Orazi G. Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies. Aging. 2016; 8(4):603–619. https://dx.doi.org/10.18632%2Faging.100934 Gordeziani M, Adamia G, Khatisashvili G, Gigolashvili G. Programmed cell self-liquidation (apoptosis). Annals of Agrarian Science. 2017;15(1):148–154. https://www.sciencedirect.com/science/article/pii/S151218871630029X Redza M, Averill D. Activation of apoptosis signalling pathways by reactive oxygen species. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2016; 1863(12):2977–2992. https://doi.org/10.1016/j.bbamcr.2016.09.012 Pestka J. Toxicological mechanisms and potential health effects of deoxynivalenol and nivalenol. World Mycotoxin J. 2010; 3(4):323–347. https://doi.org/10.3920/WMJ2010.1247 Oshikata A, Takezawa, T. Development of an oxygenation culture method for activating the liver-specific functions of HepG2 cells utilizing a collagen vitrigel membrane chamber. Cytotechnology. 2015; 68(5):1801–1811. https://doi.org/10.1007/s10616-015-9934-1 Pinton P, Oswald I. Effect of Deoxynivalenol and Other Type B Trichothecenes on the Intestine: A Review. Toxins. 2014; 6(5):1615-1643. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052256/ Juan A, Berrada H, Font G, Ruiz M. Evaluation of acute toxicity and genotoxicity of DON, 3-ADON and 15-ADON in HepG2 cells. Toxicology Letters. 2017; 280S: S254-S266. Kupcsik L. Estimation of Cell Number Based on Metabolic Activity: The MTT Reduction Assay. Mammalian Cell Viability. Methods Mol Biol. 2011; 740:13–19. https://doi.org/10.1007/978-1-61779-108-6_3 Jaimes N, Salmen S, Colmenares M, Burgos A, Tamayo L, Mendoza V, et al. Efecto citotóxico de los compuestos de inclusión de paladio (II) en la beta-ciclodextrina. Biomédica. 2016; 36(4):603-611. https://doi.org/10.7705/biomedica.v36i4.2880 Dinu D, Bodea G, Ceapa C, Munteanu M, Roming F, Serban A, et al. Adapted response of the antioxidant defense system to oxidative stress induced by deoxynivalenol in Hek-293 cells. Toxicon. 2011; 57(7-8):1023–1032. https://doi.org/10.1016/j.toxicon.2011.04.006 Alassane I, Kolf M, Gauthier T, Abrami R, Abiola F, Oswald I. New insights into mycotoxin mixtures: the toxicity of low doses of Type B trichothecenes on intestinal epithelial cells is synergistic. Toxicol Appl Pharmacol. 2013; 272(1):191–198. https://doi.org/10.1016/j.taap.2013.05.023 Fernández C, Elmo L, Waldner T, Ruiz M. Cytotoxic effects induced by patulin, deoxynivalenol and toxin T2 individually and in combination in hepatic cells (HepG2). Food Chem Toxicol. 2018; 120:12–23. https://doi.org/10.1016/j.fct.2018.06.019 Lei Y, Guanghui Z, Xi W, Yingting W, Xialu L, Fangfang Y, et al. Cellular responses to T-2 toxin and/or deoxynivalenol that induce cartilage damage are not specific to chondrocytes. Sci Rep. 2017; 7(2231):1-14. https://www.nature.com/articles/s41598-017-02568-5 Mikami O, Yamaguchi H, Murata H, Nakajima Y, Miyazaki S. Induction of apoptotic lesions in liver and lymphoid tissues and modulation of cytokine mRNA expression by acute exposure to deoxynivalenol in piglets. J Vet Sci. 2010; 11(2):107-113. https://dx.doi.org/10.4142%2Fjvs.2010.11.2.107 Ma Y, Zhang A, Shi Z, He C, Ding J, Wang X, et al. A mitochondria-mediated apoptotic pathway induced by deoxynivalenol in human colon cancer cells. Toxicol in Vitro. 2012; 26(3):414–420. https://doi.org/10.1016/j.tiv.2012.01.010
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dc.relation.citationedition.spa.fl_str_mv	Núm. 3 , Año 2021 : Revista MVZ Córdoba Volumen 26(3) Septiembre-Diciembre 2021
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spelling	Garzón-González, Harold Duván7d25a761-26a0-480c-a6a2-2dcd316b3d35-1Jaimes-Mendez, Nancy0c9e74fc-5f68-4865-95a3-e33b23a8963b-1Rojas-Contreras, Liliana5f57482a-e419-4698-a549-6480795a2c75-1Salmen-Halabi, Siham51356075-0005-4b8b-a56e-9a562f1bd0ff-1Gil-Durán, Manuel Alejandro040d2424-c8ae-4d5b-bb45-501cfd024b30-12021-05-02 00:00:002022-07-01T21:01:39Z2021-05-02 00:00:002022-07-01T21:01:39Z2021-05-020122-0268https://repositorio.unicordoba.edu.co/handle/ucordoba/609110.21897/rmvz.2080https://doi.org/10.21897/rmvz.20801909-0544application/pdfapplication/pdfapplication/zipapplication/zipapplication/xmlapplication/xmlaudio/mpegaudio/mpegspaUniversidad de CórdobaHarold Duván Garzón-González, Nancy Jaimes-Mendez, Liliana Rojas-Contreras, Siham Salmen-Halabi, Manuel Alejandro Gil-Durán - 2021https://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2https://revistamvz.unicordoba.edu.co/article/view/e2080Fusarium sppproliferationtoxicityFusarium sppproliferacióntoxicidadEfecto citotóxico de Deoxinivalenol sobre la proliferación de la línea celular HepG2Cytotoxic effect of Deoxynivalenol on the proliferation of the HepG2 cell lineArtículo de revistaJournal articleinfo:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/publishedVersionTexthttp://purl.org/redcol/resource_type/ARTREFhttp://purl.org/coar/version/c_970fb48d4fbd8a85Mayer E, Novak B, Springler A, Schwartz-Zimmermann H, Nagl V, Reisinger N, et al. Effects of deoxynivalenol (DON) and its microbial biotransformation product deepoxy-deoxynivalenol (DOM-1) on a trout, pig, mouse, and human cell line. Mycotoxin Res. 2017; 33(4):297–308. https://link.springer.com/article/10.1007/s12550-017-0289-7Pestka J. Toxicological mechanisms and potential health effects of deoxynivalenol and nivalenol. World Mycotoxin J. 2010; 3(4):323–347. https://doi.org/10.3920/WMJ2010.1247Pinton P, Tsybulskyy D, Lucioli J, Laffitte J, Callu P, Lyazhri F, et al. Toxicity of deoxynivalenol and its acetylated derivatives on the intestine: Differential effects on morphology, barrier function, tight junctions proteins and MAPKinases. Toxicol Sci. 2012; 130(1):180–190. https://www.ncbi.nlm.nih.gov/pubmed/22859312Ren Z, Wang Y, Deng H, Deng Y, Deng J, Zuo Z, et al. Deoxynivalenol induces apoptosis in chicken splenic lymphocytes via the reactive oxygen species-mediated mitochondrial pathway. Environ Toxicol Pharmacol. 2015; 39(1):339–346. https://www.ncbi.nlm.nih.gov/pubmed/25553575Arunachalam C, Doohan F. Trichothecene toxicity in eukaryotes: Cellular and molecular mechanisms in plants and animals. Toxicol Lett. 2013; 217(2):149– 158. https://www.ncbi.nlm.nih.gov/pubmed/23274714Wu F, Groopman F, Pestka J. Public Health Impacts of Foodborne Mycotoxins. Annu Rev Food Sci Technol. 2014; 5:351–372. https://www.ncbi.nlm.nih.gov/pubmed/24422587Liao Y, Peng Z, Chen L, Nüssler A, Liu L, Yang W. Deoxynivalenol, gut microbiota and immunotoxicity: A potential approach? Food Chem Toxicol. 2018; 112:342–354. https://www.ncbi.nlm.nih.gov/pubmed/29331731Pistritto G, Trisciuoglio D, Ceci C, Garufi A, D’Orazi G. Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies. Aging. 2016; 8(4):603–619. https://dx.doi.org/10.18632%2Faging.100934Gordeziani M, Adamia G, Khatisashvili G, Gigolashvili G. Programmed cell self-liquidation (apoptosis). Annals of Agrarian Science. 2017;15(1):148–154. https://www.sciencedirect.com/science/article/pii/S151218871630029XRedza M, Averill D. Activation of apoptosis signalling pathways by reactive oxygen species. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2016; 1863(12):2977–2992. https://doi.org/10.1016/j.bbamcr.2016.09.012Pestka J. Toxicological mechanisms and potential health effects of deoxynivalenol and nivalenol. World Mycotoxin J. 2010; 3(4):323–347. https://doi.org/10.3920/WMJ2010.1247Oshikata A, Takezawa, T. Development of an oxygenation culture method for activating the liver-specific functions of HepG2 cells utilizing a collagen vitrigel membrane chamber. Cytotechnology. 2015; 68(5):1801–1811. https://doi.org/10.1007/s10616-015-9934-1Pinton P, Oswald I. Effect of Deoxynivalenol and Other Type B Trichothecenes on the Intestine: A Review. Toxins. 2014; 6(5):1615-1643. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052256/Juan A, Berrada H, Font G, Ruiz M. Evaluation of acute toxicity and genotoxicity of DON, 3-ADON and 15-ADON in HepG2 cells. Toxicology Letters. 2017; 280S: S254-S266.Kupcsik L. Estimation of Cell Number Based on Metabolic Activity: The MTT Reduction Assay. Mammalian Cell Viability. Methods Mol Biol. 2011; 740:13–19. https://doi.org/10.1007/978-1-61779-108-6_3Jaimes N, Salmen S, Colmenares M, Burgos A, Tamayo L, Mendoza V, et al. Efecto citotóxico de los compuestos de inclusión de paladio (II) en la beta-ciclodextrina. Biomédica. 2016; 36(4):603-611. https://doi.org/10.7705/biomedica.v36i4.2880Dinu D, Bodea G, Ceapa C, Munteanu M, Roming F, Serban A, et al. Adapted response of the antioxidant defense system to oxidative stress induced by deoxynivalenol in Hek-293 cells. Toxicon. 2011; 57(7-8):1023–1032. https://doi.org/10.1016/j.toxicon.2011.04.006Alassane I, Kolf M, Gauthier T, Abrami R, Abiola F, Oswald I. New insights into mycotoxin mixtures: the toxicity of low doses of Type B trichothecenes on intestinal epithelial cells is synergistic. Toxicol Appl Pharmacol. 2013; 272(1):191–198. https://doi.org/10.1016/j.taap.2013.05.023Fernández C, Elmo L, Waldner T, Ruiz M. Cytotoxic effects induced by patulin, deoxynivalenol and toxin T2 individually and in combination in hepatic cells (HepG2). Food Chem Toxicol. 2018; 120:12–23. https://doi.org/10.1016/j.fct.2018.06.019Lei Y, Guanghui Z, Xi W, Yingting W, Xialu L, Fangfang Y, et al. Cellular responses to T-2 toxin and/or deoxynivalenol that induce cartilage damage are not specific to chondrocytes. Sci Rep. 2017; 7(2231):1-14. https://www.nature.com/articles/s41598-017-02568-5Mikami O, Yamaguchi H, Murata H, Nakajima Y, Miyazaki S. Induction of apoptotic lesions in liver and lymphoid tissues and modulation of cytokine mRNA expression by acute exposure to deoxynivalenol in piglets. J Vet Sci. 2010; 11(2):107-113. https://dx.doi.org/10.4142%2Fjvs.2010.11.2.107Ma Y, Zhang A, Shi Z, He C, Ding J, Wang X, et al. A mitochondria-mediated apoptotic pathway induced by deoxynivalenol in human colon cancer cells. Toxicol in Vitro. 2012; 26(3):414–420. https://doi.org/10.1016/j.tiv.2012.01.010https://revistamvz.unicordoba.edu.co/article/download/e2080/3406https://revistamvz.unicordoba.edu.co/article/download/e2080/3407https://revistamvz.unicordoba.edu.co/article/download/e2080/3539https://revistamvz.unicordoba.edu.co/article/download/e2080/3541https://revistamvz.unicordoba.edu.co/article/download/e2080/3540https://revistamvz.unicordoba.edu.co/article/download/e2080/3542https://revistamvz.unicordoba.edu.co/article/download/e2080/3408https://revistamvz.unicordoba.edu.co/article/download/e2080/3409Núm. 3 , Año 2021 : Revista MVZ Córdoba Volumen 26(3) Septiembre-Diciembre 2021e20803e208026Revista MVZ CórdobaPublicationOREORE.xmltext/xml3350https://repositorio.unicordoba.edu.co/bitstreams/8faff4d9-9434-4517-b292-ebe35fcc7051/downloadf66a664e13573d9233fea00083f9622bMD51ucordoba/6091oai:repositorio.unicordoba.edu.co:ucordoba/60912023-10-06 00:46:34.288https://creativecommons.org/licenses/by-nc-sa/4.0/Harold Duván Garzón-González, Nancy Jaimes-Mendez, Liliana Rojas-Contreras, Siham Salmen-Halabi, Manuel Alejandro Gil-Durán - 2021metadata.onlyhttps://repositorio.unicordoba.edu.coRepositorio Universidad de Córdobabdigital@metabiblioteca.com

Efecto citotóxico de Deoxinivalenol sobre la proliferación de la línea celular HepG2

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