C-reactive protein, interleukin-6 and pre-eclampsia: large-scale evidence from the GenPE case-control study

Multiple small studies have suggested that women with pre-eclampsia present elevated levels of Creactive protein (CRP) and interleukin-6 (IL-6). However, little is known regarding the source of this CRP and IL-6 increase. Therefore, the aim of this study was to evaluate the relationship between CRP and IL-6 levels with pre-eclampsia considering different confounding factors. Using data from a large Colombian case-control study (3,590 cases of pre-eclampsia and 4,564 normotensive controls), CRP and IL-6 levels were measured in 914 cases and 1297 controls. The association between maternal serum levels of CRP and IL-6 with pre-eclampsia risk was evaluated using adjusted logistic regression models. Pre-eclampsia was defined as presence of blood pressure 140/90mmHg and proteinuria 300mg/24h (or 1þdipstick). There was no evidence of association between high levels of CRP and IL-6 with pre-eclampsia after adjusting for the following factors: maternal and gestational age, ethnicity, place and year of recruitment, multiple-pregnancy, socio-economic position, smoking, and presence of infections during pregnancy. The adjusted OR for 1SD increase in log-CRP and log-IL-6 was 0.96 (95%CI 0.85, 1.08) and 1.09 (95%CI 0.97, 1.22), respectively. Although previous reports have suggested an association between high CRP and IL-6 levels with pre-eclampsia, sample size may lack the sufficient power to draw robust conclusions, and this association is likely to be explained by unaccounted biases. Our results, the largest case-control study reported up to date, demonstrate that there is not a causal association between elevated levels of CRP and IL-6 and the presence of pre-eclampsia.

• Autores: Serrano, Norma C.; Guio, Elizabeth; Becerra-Bayona, Silvia M.; Quintero-Lesmes, Doris C.; Bautista-Niño, Paula K.; Colmenares-Mejia, Claudia; Paez, Marıa C.; Luna, Marıa L; Dıaz, Luis A.; Ortiz, Ricardo; Beltran, Monica; Monterrosa-Castro, Álvaro; Miranda, Yezid; Mesa, Clara M.; Saldarriaga, Wilmar; Casas, Juan P.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2020
• Institución: Universidad de Cartagena
• Repositorio: Repositorio Universidad de Cartagena
• Idioma: eng
• OAI Identifier: oai:repositorio.unicartagena.edu.co:11227/20067
• Acceso en línea: https://hdl.handle.net/11227/20067
• Palabra clave: 3. Ciencias Médicas y de la Salud; ODS 3: Salud y bienestar. Garantizar una vida sana y promover el bienestar de todos a todas las edades
• Rights: openAccess
• License: https://creativecommons.org/licenses/by-nc/4.0/