Possible association between subclinical hypothyroidism and age at menopause in Colombian women

Objective: To evaluate the association between subclinical hypothyroidism with early menopause, premature menopause, and last menstrual bleeding before the natural age of menopause. Methods: This was a cross-sectional study conducted in 643 postmenopausal women aged 40–69years. Groups were formed according to last menstrual episode: ≥45 [Natural age at menopause], 40–44 and [Early menopause], <40 [Premature menopause], and <45 [last menstrual episode before the natural age of menopause]. The Zulewski scale was applied to identify manifestations related to hypothyroidism and subclinical hypothyroidism, diagnosed with a serum TSH > 4.5 µIU/mL plus T4-free between 0.7 and 1.9ng/dL. Results: It was found that 24.4% had the last menstrual episode before the natural age of menopause, 18.6% had early menopause, and 5.7% had premature menopause. Subclinical hypothyroidism was diagnosed in 4.5% of patients. Among women with subclinical hypothyroidism, there was a higher frequency of early menopause, premature menopause, and last menstrual episode before the natural age of menopause, than in women without subclinical hypothyroidism (p<0.05). Paresthesia (50%) and dry skin (40.7%) were the most reported hypothyroidism-related manifestations. Early menopause, premature menopause, and last menstrual episode before the natural age of menopause were associated with subclinical hypothyroidism, OR: 3.37 [95% CI: 1.40–8.10], OR: 4.31 [95% CI: 1.24–14.97], and OR: 3.57 [95% CI: 1.57–8.10], respectively. Conclusions: The last menstrual episode before the natural age of menopause, early menopause, and premature menopause were significantly associated with a higher chance of subclinical hypothyroidism

• Autores: Monterrosa-Castro, Álvaro; Monterrosa-Blanco, Angelica; Sánchez-Zarza, Sandra
• Tipo de recurso: Article of journal
• Fecha de publicación: 2024
• Institución: Universidad de Cartagena
• Repositorio: Repositorio Universidad de Cartagena
• Idioma: eng
• OAI Identifier: oai:repositorio.unicartagena.edu.co:11227/19444
• Acceso en línea: https://hdl.handle.net/11227/19444
• Palabra clave: 3. Ciencias Médicas y de la Salud; Edad de la menopausia; Menopausia temprana; Menopausia; Menopausia prematura; Climatérico; Hipotiroidismo; Hormona estimulante de la tiroides; Age at menopause; Early menopause; Menopause; Premature menopause; Climacteric; Hhypothyroidism; Thyroid-stimulating hormone; ODS 3: Salud y bienestar. Garantizar una vida sana y promover el bienestar de todos a todas las edades
• Rights: openAccess
• License: https://creativecommons.org/licenses/by-nc/4.0/