Pentraxin-3 is a candidate biomarker on the spectrum of severity from pre-eclampsia to HELLP syndrome: GenPE study

Pentraxin-3 has been reported as a promising biomarker of pre-eclampsia and its severity; however, available studies have small sample sizes, and analyses are not always adjusted for confounders. The aim of this study is to establish the strength of the association between maternal Pentraxin-3 level and pre-eclampsia or HELLP syndrome. It was a case-control study. Women with pre-eclampsia or HELLP syndrome were defined as cases, and women with healthy pregnancies at term (>37 weeks) were classified as controls. Plasma concentrations of Pentraxin-3 were determined at the time of delivery by quantitative enzyme immunoassay. Associations between Pentraxin-3 and pre-eclampsia and HELLP syndrome were assessed by multinomial logistic regression. Subsidiary analysis for the time of disease onset was also carried out. Odds ratios and 95% confidence intervals are reported. A total of 1024 pregnant women were included (461 controls, 368 preeclampsia, 195 HELLP). A positive log-linear relationship was found between the top pentraxin-3 quintile and HELLP syndrome. After adjustment for confounders (maternal age, ethnicity, socioeconomic position, date and place of recruitment, family history of pre-eclampsia, smoking, body mass index at beginning of pregnancy, gestational age and multiple pregnancy), the strength of the association was higher for HELLP syndrome [OR 1.13 (95% CI 1.08; 1.18)] than for preeclampsia [OR 1.03 (95% CI 1.03; 1.10)]. No difference according to time of onset or pentraxin-3 level was found. In summary, pentraxin-3 level was associated with pre-eclampsia, but it was more strongly associated with HELLP syndrome. Longitudinal studies with a lower probability of residual confounding are necessary to improve our knowledge about the role of pentraxin-3 in pre-eclampsia.

• Autores: Colmenares-Mejía, Claudia C.; Quintero-Lesmes, Doris C.; Bautista-Niño, Paula K.; Guio Mahecha, Elizabeth; Beltrán Avendaño, Mónica; Díaz Martínez, Luis Alfonso; Ortiz Serrano, Ricardo; Páez Leal, María Carolina; Monterrosa-Castro, Álvaro; Mesa Restrepo, Clara Maria; Monsalve, Germán; Sanín-Blair, Enrique; Saldarriaga, Wilmar; Luna, María Lucrecia; Casas, Juan P.; Serrano Díaz, Norma
• Tipo de recurso: Article of journal
• Fecha de publicación: 2020
• Institución: Universidad de Cartagena
• Repositorio: Repositorio Universidad de Cartagena
• Idioma: eng
• OAI Identifier: oai:repositorio.unicartagena.edu.co:11227/20084
• Acceso en línea: https://hdl.handle.net/11227/20084
• Palabra clave: 3. Ciencias Médicas y de la Salud; Pregnancy complications; Eclampsia; Childbirth - Complications; Hypertension; Pregnancy; ODS 3: Salud y bienestar. Garantizar una vida sana y promover el bienestar de todos a todas las edades
• Rights: openAccess
• License: https://creativecommons.org/licenses/by-nc/4.0/