Rol de la Microglía en el desarrollo del Glioblastoma

Glioblastoma multiforme is one of the most aggressive brain cancers, with an average survival of less than 15 months. Its high proliferation, invasion and suppression capacity immune make it resistant to chemotherapy, radiotherapy and surgery. what drives development of new therapies. A key factor i...

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Autores:
Gómez Rivas Gabriel Nicolas
Tipo de recurso:
Fecha de publicación:
2024
Institución:
Universidad Antonio Nariño
Repositorio:
Repositorio UAN
Idioma:
spa
OAI Identifier:
oai:repositorio.uan.edu.co:123456789/11843
Acceso en línea:
https://repositorio.uan.edu.co/handle/123456789/11843
Palabra clave:
Microglia,
Glioblastoma
Angiogenesis
Evasión Immune
Microglia,
Glioblastoma
Angiogenesis
Immune Evasion
Rights
License
Acceso cerrado
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oai_identifier_str oai:repositorio.uan.edu.co:123456789/11843
network_acronym_str UAntonioN2
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repository_id_str
dc.title.none.fl_str_mv Rol de la Microglía en el desarrollo del Glioblastoma
title Rol de la Microglía en el desarrollo del Glioblastoma
spellingShingle Rol de la Microglía en el desarrollo del Glioblastoma
Microglia,
Glioblastoma
Angiogenesis
Evasión Immune
Microglia,
Glioblastoma
Angiogenesis
Immune Evasion
title_short Rol de la Microglía en el desarrollo del Glioblastoma
title_full Rol de la Microglía en el desarrollo del Glioblastoma
title_fullStr Rol de la Microglía en el desarrollo del Glioblastoma
title_full_unstemmed Rol de la Microglía en el desarrollo del Glioblastoma
title_sort Rol de la Microglía en el desarrollo del Glioblastoma
dc.creator.fl_str_mv Gómez Rivas Gabriel Nicolas
dc.contributor.advisor.none.fl_str_mv Losada Barragán, Mónica
dc.contributor.author.none.fl_str_mv Gómez Rivas Gabriel Nicolas
dc.subject.none.fl_str_mv Microglia,
Glioblastoma
Angiogenesis
Evasión Immune
topic Microglia,
Glioblastoma
Angiogenesis
Evasión Immune
Microglia,
Glioblastoma
Angiogenesis
Immune Evasion
dc.subject.keyword.none.fl_str_mv Microglia,
Glioblastoma
Angiogenesis
Immune Evasion
description Glioblastoma multiforme is one of the most aggressive brain cancers, with an average survival of less than 15 months. Its high proliferation, invasion and suppression capacity immune make it resistant to chemotherapy, radiotherapy and surgery. what drives development of new therapies. A key factor in its lethality is its tumor microenvironment, which is consisting mainly of the tumor and microglia. Microglia are exclusive macrophages of the central nervous system which serves as the main defender against an infection or signs of damage, through phagocytosis and pro-inflammatory or anti-inflammatory mechanisms depending on the severity and status of the infection or injury.
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2024-11-13T16:42:31Z
dc.date.available.none.fl_str_mv 2024-11-13T16:42:31Z
dc.date.created.none.fl_str_mv 2024-06-26
dc.date.issued.none.fl_str_mv 2024-11-13
dc.type.none.fl_str_mv Tesis/Trabajo de grado - Monografía - Pregrado
dc.type.document.none.fl_str_mv Estudio descriptivo
dc.type.version.none.fl_str_mv Versión original del autor, Borrador, Manuscrito
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/PIC
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_b1a7d7d4d402bcce
dc.identifier.uri.none.fl_str_mv https://repositorio.uan.edu.co/handle/123456789/11843
url https://repositorio.uan.edu.co/handle/123456789/11843
dc.language.iso.fl_str_mv spa
language spa
dc.rights.accessrights.none.fl_str_mv Acceso cerrado
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_16ec
rights_invalid_str_mv Acceso cerrado
http://purl.org/coar/access_right/c_16ec
dc.format.medium.none.fl_str_mv pdf
dc.publisher.none.fl_str_mv Universidad Antonio Nariño
dc.publisher.program.none.fl_str_mv Biotecnología
dc.publisher.faculty.none.fl_str_mv Facultad de Ciencias
dc.publisher.campus.none.fl_str_mv Bogotá - Circunvalar
publisher.none.fl_str_mv Universidad Antonio Nariño
dc.source.none.fl_str_mv instname:Universidad Antonio Nariño
instname_str Universidad Antonio Nariño
institution Universidad Antonio Nariño
dc.source.bibliographicCitation.none.fl_str_mv Ahir, B. K., Engelhard, H. H., & Lakka, S. S. (2020). Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma. In Molecular Neurobiology (Vol. 57, Issue 5, pp. 2461–2478). Springer. https://doi.org/10.1007/s12035-020-01892-8
Albakova, Z., Mangasarova, Y., Albakov, A., & Gorenkova, L. (2022). HSP70 and HSP90 in Cancer: Cytosolic, Endoplasmic Reticulum and Mitochondrial Chaperones of Tumorigenesis. In Frontiers in Oncology (Vol. 12). Frontiers Media S.A. https://doi.org/10.3389/fonc.2022.829520
Allen, N. J., & Lyons, D. A. (n.d.). Glia as architects of central nervous system formation and function. http://science.sciencemag.org/
Andersen, R. S., Anand, A., Harwood, D. S. L., & Kristensen, B. W. (2021). Tumorassociated microglia and macrophages in the glioblastoma microenvironment and their implications for therapy. In Cancers (Vol. 13, Issue 17). MDPI AG. https://doi.org/10.3390/cancers13174255
Blitz, S. E., Kappel, A. D., Gessler, F. A., Klinger, N. V., Arnaout, O., Lu, Y., Peruzzi, P. P., Smith, T. R., Chiocca, E. A., Friedman, G. K., & Bernstock, J. D. (2022). TumorAssociated Macrophages/Microglia in Glioblastoma Oncolytic Virotherapy: A DoubleEdged Sword. In International Journal of Molecular Sciences (Vol. 23, Issue 3). MDPI. https://doi.org/10.3390/ijms23031808
Buonfiglioli, A., & Hambardzumyan, D. (2021). Macrophages and microglia: the cerberus of glioblastoma. In Acta Neuropathologica Communications (Vol. 9, Issue 1). BioMed Central Ltd. https://doi.org/10.1186/s40478-021-01156-z
Cloughesy, T. F., Mochizuki, A. Y., Orpilla, J. R., Hugo, W., Lee, A. H., Davidson, T. B., Wang, A. C., Ellingson, B. M., Rytlewski, J. A., Sanders, C. M., Kawaguchi, E. S., Du, L., Li, G., Yong, W. H., Gaffey, S. C., Cohen, A. L., Mellinghoff, I. K., Lee, E. Q., Reardon, D. A., … Prins, R. M. (2019). Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma. Nature Medicine, 25(3), 477–486. https://doi.org/10.1038/s41591-018-0337-7
Codrici, E., Popescu, I. D., Tanase, C., & Enciu, A. M. (2022). Friends with Benefits: Chemokines, Glioblastoma-Associated Microglia/Macrophages and Tumor Microenvironment. In International Journal of Molecular Sciences (Vol. 23, Issue 5). MDPI. https://doi.org/10.3390/ijms23052509
De Leo, A., Ugolini, A., & Veglia, F. (2021). Myeloid cells in glioblastoma microenvironment. In Cells (Vol. 10, Issue 1, pp. 1–20). MDPI. https://doi.org/10.3390/cells10010018
Dinarello, C. A. (2011). Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood, 117(14), 3720–3732. https://doi.org/10.1182/blood-2010-07-273417
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spelling Losada Barragán, MónicaGómez Rivas Gabriel Nicolas2024-11-13T16:42:31Z2024-11-13T16:42:31Z2024-06-262024-11-13https://repositorio.uan.edu.co/handle/123456789/11843Glioblastoma multiforme is one of the most aggressive brain cancers, with an average survival of less than 15 months. Its high proliferation, invasion and suppression capacity immune make it resistant to chemotherapy, radiotherapy and surgery. what drives development of new therapies. A key factor in its lethality is its tumor microenvironment, which is consisting mainly of the tumor and microglia. Microglia are exclusive macrophages of the central nervous system which serves as the main defender against an infection or signs of damage, through phagocytosis and pro-inflammatory or anti-inflammatory mechanisms depending on the severity and status of the infection or injury.El glioblastoma multiforme es uno de los cánceres cerebrales más agresivos, con una media de supervivencia inferior a los 15 meses. Su alta proliferación, invasión y capacidad de supresión inmune lo hacen resistente a la quimioterapia, radioterapia y cirugía. lo que impulsa el desarrollo de nuevas terapias. Un factor clave en su letalidad es su microambiente tumoral, el cual, está constituido principalmente por el tumor y la microglía. La microglía es un macrófago exclusivo del sistema nervioso central el cual funge como principal defensor ante una infección o señales de daño, por medio fagocitosis y mecanismos proinflamatorios o antiinflamatorios dependiendo de la gravedad y estado de la infección o la lesión.finalBiotecnólogo(a)PregradoPresencialMonografíapdfUniversidad Antonio NariñoBiotecnologíaFacultad de CienciasBogotá - Circunvalarinstname:Universidad Antonio NariñoAhir, B. K., Engelhard, H. H., & Lakka, S. S. (2020). Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma. In Molecular Neurobiology (Vol. 57, Issue 5, pp. 2461–2478). Springer. https://doi.org/10.1007/s12035-020-01892-8Albakova, Z., Mangasarova, Y., Albakov, A., & Gorenkova, L. (2022). HSP70 and HSP90 in Cancer: Cytosolic, Endoplasmic Reticulum and Mitochondrial Chaperones of Tumorigenesis. In Frontiers in Oncology (Vol. 12). Frontiers Media S.A. https://doi.org/10.3389/fonc.2022.829520Allen, N. J., & Lyons, D. A. (n.d.). Glia as architects of central nervous system formation and function. http://science.sciencemag.org/Andersen, R. S., Anand, A., Harwood, D. S. L., & Kristensen, B. W. (2021). Tumorassociated microglia and macrophages in the glioblastoma microenvironment and their implications for therapy. In Cancers (Vol. 13, Issue 17). MDPI AG. https://doi.org/10.3390/cancers13174255Blitz, S. E., Kappel, A. D., Gessler, F. A., Klinger, N. V., Arnaout, O., Lu, Y., Peruzzi, P. P., Smith, T. R., Chiocca, E. A., Friedman, G. K., & Bernstock, J. D. (2022). TumorAssociated Macrophages/Microglia in Glioblastoma Oncolytic Virotherapy: A DoubleEdged Sword. In International Journal of Molecular Sciences (Vol. 23, Issue 3). MDPI. https://doi.org/10.3390/ijms23031808Buonfiglioli, A., & Hambardzumyan, D. (2021). Macrophages and microglia: the cerberus of glioblastoma. In Acta Neuropathologica Communications (Vol. 9, Issue 1). BioMed Central Ltd. https://doi.org/10.1186/s40478-021-01156-zCloughesy, T. F., Mochizuki, A. Y., Orpilla, J. R., Hugo, W., Lee, A. H., Davidson, T. B., Wang, A. C., Ellingson, B. M., Rytlewski, J. A., Sanders, C. M., Kawaguchi, E. S., Du, L., Li, G., Yong, W. H., Gaffey, S. C., Cohen, A. L., Mellinghoff, I. K., Lee, E. Q., Reardon, D. A., … Prins, R. M. (2019). Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma. Nature Medicine, 25(3), 477–486. https://doi.org/10.1038/s41591-018-0337-7Codrici, E., Popescu, I. D., Tanase, C., & Enciu, A. M. (2022). Friends with Benefits: Chemokines, Glioblastoma-Associated Microglia/Macrophages and Tumor Microenvironment. In International Journal of Molecular Sciences (Vol. 23, Issue 5). MDPI. https://doi.org/10.3390/ijms23052509De Leo, A., Ugolini, A., & Veglia, F. (2021). Myeloid cells in glioblastoma microenvironment. In Cells (Vol. 10, Issue 1, pp. 1–20). MDPI. https://doi.org/10.3390/cells10010018Dinarello, C. A. (2011). Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood, 117(14), 3720–3732. https://doi.org/10.1182/blood-2010-07-273417Microglia,GlioblastomaAngiogenesisEvasión ImmuneMicroglia,GlioblastomaAngiogenesisImmune EvasionRol de la Microglía en el desarrollo del GlioblastomaTesis/Trabajo de grado - Monografía - PregradoEstudio descriptivoVersión original del autor, Borrador, Manuscritohttp://purl.org/redcol/resource_type/PIChttp://purl.org/coar/version/c_b1a7d7d4d402bcceEspecializadaAcceso cerradohttp://purl.org/coar/access_right/c_16ecspaORIGINAL2024_GabrielNicolasGomezRivas_Acta2024_GabrielNicolasGomezRivas_ActaActaapplication/pdf1612092https://repositorio.uan.edu.co/bitstreams/a95b6b42-377e-4db2-b59c-1d0bcbd4d32f/downloade4104ec90831ea1b43fe792fc1aa4638MD512024_GabrielNicolasGomezRivas_Autorización2024_GabrielNicolasGomezRivas_AutorizaciónAutorizaciónapplication/pdf2353869https://repositorio.uan.edu.co/bitstreams/f95aaba8-8398-4ac8-ba94-e1f5db49b614/download3de2a8cd8034b5d9cfe8ae4283e46befMD522024_GabrielNicolasGomezRivas2024_GabrielNicolasGomezRivasTrabajo de gradoapplication/pdf757989https://repositorio.uan.edu.co/bitstreams/c2f96d61-e272-4f60-8643-c9e864472a79/download3804aba668bb217d1731ce3e660d9004MD53123456789/11843oai:repositorio.uan.edu.co:123456789/118432024-11-23 16:34:50.852restrictedhttps://repositorio.uan.edu.coRepositorio Institucional UANalertas.repositorio@uan.edu.co

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