Estudio del papel de la Laminina Beta 1 en células endoteliales de la barrera hematoencefálica (hCMEC/D3) bajo condiciones inflamatorias
The blood-brain barrier is crucial for protecting the central nervous system, and its dysfunction is associated with various neurological diseases. The present study investigates the role of laminin beta 1 in blood-brain barrier integrity and its influence on cell viability using a model of human mi...
- Autores:
-
González Bonilla, Emily Vanessa
Losada Barragán, Mónica
Vargas Sánchez, Karina
- Tipo de recurso:
- Tesis
- Fecha de publicación:
- 2024
- Institución:
- Universidad Antonio Nariño
- Repositorio:
- Repositorio UAN
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.uan.edu.co:123456789/12193
- Acceso en línea:
- https://repositorio.uan.edu.co/handle/123456789/12193
- Palabra clave:
- Barrera hematoencefálica
Uniones estrechas
Matriz extracelular
Inflamación
Laminina
blood-brain barrier
tight junctions
extracellular matrix
inflammation
laminin
- Rights
- restrictedAccess
- License
- http://purl.org/coar/access_right/c_16ec
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Estudio del papel de la Laminina Beta 1 en células endoteliales de la barrera hematoencefálica (hCMEC/D3) bajo condiciones inflamatorias |
| title |
Estudio del papel de la Laminina Beta 1 en células endoteliales de la barrera hematoencefálica (hCMEC/D3) bajo condiciones inflamatorias |
| spellingShingle |
Estudio del papel de la Laminina Beta 1 en células endoteliales de la barrera hematoencefálica (hCMEC/D3) bajo condiciones inflamatorias Barrera hematoencefálica Uniones estrechas Matriz extracelular Inflamación Laminina blood-brain barrier tight junctions extracellular matrix inflammation laminin |
| title_short |
Estudio del papel de la Laminina Beta 1 en células endoteliales de la barrera hematoencefálica (hCMEC/D3) bajo condiciones inflamatorias |
| title_full |
Estudio del papel de la Laminina Beta 1 en células endoteliales de la barrera hematoencefálica (hCMEC/D3) bajo condiciones inflamatorias |
| title_fullStr |
Estudio del papel de la Laminina Beta 1 en células endoteliales de la barrera hematoencefálica (hCMEC/D3) bajo condiciones inflamatorias |
| title_full_unstemmed |
Estudio del papel de la Laminina Beta 1 en células endoteliales de la barrera hematoencefálica (hCMEC/D3) bajo condiciones inflamatorias |
| title_sort |
Estudio del papel de la Laminina Beta 1 en células endoteliales de la barrera hematoencefálica (hCMEC/D3) bajo condiciones inflamatorias |
| dc.creator.fl_str_mv |
González Bonilla, Emily Vanessa Losada Barragán, Mónica Vargas Sánchez, Karina |
| dc.contributor.advisor.none.fl_str_mv |
Losada Barragán , Mónica Vargas Sánchez , Karina |
| dc.contributor.author.none.fl_str_mv |
González Bonilla, Emily Vanessa Losada Barragán, Mónica Vargas Sánchez, Karina |
| dc.subject.none.fl_str_mv |
Barrera hematoencefálica Uniones estrechas Matriz extracelular Inflamación Laminina |
| topic |
Barrera hematoencefálica Uniones estrechas Matriz extracelular Inflamación Laminina blood-brain barrier tight junctions extracellular matrix inflammation laminin |
| dc.subject.keyword.none.fl_str_mv |
blood-brain barrier tight junctions extracellular matrix inflammation laminin |
| description |
The blood-brain barrier is crucial for protecting the central nervous system, and its dysfunction is associated with various neurological diseases. The present study investigates the role of laminin beta 1 in blood-brain barrier integrity and its influence on cell viability using a model of human microvascular endothelial cells exposed to interleukin 1 beta-induced inflammation. |
| publishDate |
2024 |
| dc.date.created.none.fl_str_mv |
2024-11-30 |
| dc.date.accessioned.none.fl_str_mv |
2025-02-04T19:38:15Z |
| dc.date.available.none.fl_str_mv |
2025-02-04T19:38:15Z |
| dc.date.issued.none.fl_str_mv |
2025-02-03 |
| dc.type.none.fl_str_mv |
Tesis/Trabajo de grado - Monografía - Pregrado |
| dc.type.document.none.fl_str_mv |
Estudio descriptivo |
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info:eu-repo/semantics/draft |
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http://purl.org/coar/resource_type/c_46ec |
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http://purl.org/redcol/resource_type/PIC |
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https://repositorio.uan.edu.co/handle/123456789/12193 |
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https://repositorio.uan.edu.co/handle/123456789/12193 |
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spa |
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spa |
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info:eu-repo/semantics/restrictedAccess |
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pdf |
| dc.publisher.none.fl_str_mv |
Universidad Antonio Nariño |
| dc.publisher.program.none.fl_str_mv |
Bioquímica |
| dc.publisher.faculty.none.fl_str_mv |
Facultad de Ciencias |
| dc.publisher.campus.none.fl_str_mv |
Bogotá - Circunvalar |
| publisher.none.fl_str_mv |
Universidad Antonio Nariño |
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instname:Universidad Antonio Nariño |
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Universidad Antonio Nariño |
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Abbott, N.J., Patabendige, A. A.K., Dolman, D. E.M., Yusof, S. R., & Begley, D. J. (2010, January). Structure and function of the blood–brain barrier. Neurobiology of Disease, 37(1), 13-25. https://doi.org/10.1016/j.nbd.2009.07.030 Adelman, K., Kennedy, M. A., Nechaev, S., Gilchrist, D. A., Muse, G. W., Chinenov, Y., & Rogatsky, I. (2009). Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.0910177106 Alahmari, A. (2021). Blood-Brain Barrier Overview: Structural and Functional Correlation. Neural Plasticity. https://doi.org/10.1155/2021/6564585 Baeten, K. M., & Akassoglou, K. (2011). Extracellular Matrix and Matrix Receptors in Blood-Brain Barrier Formation and Stroke. Developmental Neurobiology. https://doi.org/10.1002/dneu.20954 Berselli, A., Alberini, G., Benfenati, F., & Maragliano, L. (2022). Computational Assessment of Different Structural Models for Claudin-5 Complexes in Blood-Brain Barrier Tight Junctions. ACS Chemical Neuroscience. https://doi.org/10.1021/acschemneuro.2c00139 Bhat, A. A., Haris, M., Macha, M. A., & Dhawan, P. (Eds.). (2023). Tight Junctions in Inflammation and Cancer. Springer Nature Singapore. https://doi.org/10.1007/978-981-99-2415-8_6 Chean Lim, W., Olding, M., Healy, E., & Millar, T. M. (2018). Human Endothelial Cells Modulate CD4+ T Cell Populations and Enhance Regulatory T Cell Suppressive Capacity. Frontiers in immunology, 23(9). https://doi.org/10.3389/fimmu.2018.00565 Chen, L., Deng, H., Cui, H., Fang, J., Zuo, Z., Deng, J., Li, Y., Wang, X., & Zhao, L. (2017). Inflammatory responses and inflammation-associated diseases in organs. Oncotarget, 9(6), 7204–7218. https://doi.org/10.18632/oncotarget.23208 Chen, T., Dai, Y., Hu, C., Lin, Z., Wang, S., Yang, J., Zeng, L., Li, S., & Li, W. (2024). Cellular and molecular mechanisms of the blood–brain barrier dysfunction in neurodegenerative diseases. Fluids Barriers CNS. https://doi.org/10.1186/s12987-024-00557-1 Dahm, T., Rudolph, H., Schwerk, C., Schroten, H., & Tenenbaum, T. (2016). Neuroinvasion and Inflammation in Viral Central Nervous System Infections. Mediators of Inflammation. https://doi.org/10.1155/2016/8562805 |
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Losada Barragán , MónicaVargas Sánchez , KarinaGonzález Bonilla, Emily VanessaLosada Barragán, MónicaVargas Sánchez, Karina2025-02-04T19:38:15Z2025-02-04T19:38:15Z2024-11-302025-02-03https://repositorio.uan.edu.co/handle/123456789/12193The blood-brain barrier is crucial for protecting the central nervous system, and its dysfunction is associated with various neurological diseases. The present study investigates the role of laminin beta 1 in blood-brain barrier integrity and its influence on cell viability using a model of human microvascular endothelial cells exposed to interleukin 1 beta-induced inflammation.La barrera hematoencefálica es crucial para proteger el sistema nervioso central, y su disfunción está relacionada con diversas enfermedades neurológicas. El presente estudio investiga el papel de la laminina beta 1 en la integridad de la barrera hematoencefálica y su influencia en la viabilidad celular, utilizando un modelo de células endoteliales microvasculares humanas expuestas a inflamación inducida por interleucina 1 beta.finalBioquímico(a)PregradoPresencialInvestigaciónpdfUniversidad Antonio NariñoBioquímicaFacultad de CienciasBogotá - Circunvalarinstname:Universidad Antonio NariñoAbbott, N.J., Patabendige, A. A.K., Dolman, D. E.M., Yusof, S. R., & Begley, D. J. (2010, January). Structure and function of the blood–brain barrier. Neurobiology of Disease, 37(1), 13-25. https://doi.org/10.1016/j.nbd.2009.07.030Adelman, K., Kennedy, M. A., Nechaev, S., Gilchrist, D. A., Muse, G. W., Chinenov, Y., & Rogatsky, I. (2009). Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.0910177106Alahmari, A. (2021). Blood-Brain Barrier Overview: Structural and Functional Correlation. Neural Plasticity. https://doi.org/10.1155/2021/6564585Baeten, K. M., & Akassoglou, K. (2011). Extracellular Matrix and Matrix Receptors in Blood-Brain Barrier Formation and Stroke. Developmental Neurobiology. https://doi.org/10.1002/dneu.20954Berselli, A., Alberini, G., Benfenati, F., & Maragliano, L. (2022). Computational Assessment of Different Structural Models for Claudin-5 Complexes in Blood-Brain Barrier Tight Junctions. ACS Chemical Neuroscience. https://doi.org/10.1021/acschemneuro.2c00139Bhat, A. A., Haris, M., Macha, M. A., & Dhawan, P. (Eds.). (2023). Tight Junctions in Inflammation and Cancer. Springer Nature Singapore. https://doi.org/10.1007/978-981-99-2415-8_6Chean Lim, W., Olding, M., Healy, E., & Millar, T. M. (2018). Human Endothelial Cells Modulate CD4+ T Cell Populations and Enhance Regulatory T Cell Suppressive Capacity. Frontiers in immunology, 23(9). https://doi.org/10.3389/fimmu.2018.00565Chen, L., Deng, H., Cui, H., Fang, J., Zuo, Z., Deng, J., Li, Y., Wang, X., & Zhao, L. (2017). Inflammatory responses and inflammation-associated diseases in organs. Oncotarget, 9(6), 7204–7218. https://doi.org/10.18632/oncotarget.23208Chen, T., Dai, Y., Hu, C., Lin, Z., Wang, S., Yang, J., Zeng, L., Li, S., & Li, W. (2024). Cellular and molecular mechanisms of the blood–brain barrier dysfunction in neurodegenerative diseases. Fluids Barriers CNS. https://doi.org/10.1186/s12987-024-00557-1Dahm, T., Rudolph, H., Schwerk, C., Schroten, H., & Tenenbaum, T. (2016). Neuroinvasion and Inflammation in Viral Central Nervous System Infections. Mediators of Inflammation. https://doi.org/10.1155/2016/8562805Barrera hematoencefálicaUniones estrechasMatriz extracelularInflamaciónLamininablood-brain barriertight junctionsextracellular matrixinflammationlamininEstudio del papel de la Laminina Beta 1 en células endoteliales de la barrera hematoencefálica (hCMEC/D3) bajo condiciones inflamatoriasTesis/Trabajo de grado - Monografía - PregradoEstudio descriptivoinfo:eu-repo/semantics/drafthttp://purl.org/coar/resource_type/c_46echttp://purl.org/redcol/resource_type/PIChttp://purl.org/coar/version/c_b1a7d7d4d402bcceEspecializadainfo:eu-repo/semantics/restrictedAccesshttp://purl.org/coar/access_right/c_16ecspaORIGINAL2024_EmilyVanessaGonzálezBonilla2024_EmilyVanessaGonzálezBonillaTrabajo de gradoapplication/pdf5677276https://repositorio.uan.edu.co/bitstreams/51d6b566-8a27-4517-a695-dd2e8e31b1d0/download085f3fec6958821b4ca617ddef02af12MD512024_EmilyVanessaGonzálezBonilla_Acta.pdf2024_EmilyVanessaGonzálezBonilla_Acta.pdfActaapplication/pdf832744https://repositorio.uan.edu.co/bitstreams/8449581e-3be1-4714-b84d-779ad03c8a5c/download59136affb68a09508d20432b72d8cae9MD522024_EmilyVanessaGonzálezBonilla_Autorización2024_EmilyVanessaGonzálezBonilla_AutorizaciónAutorizaciónapplication/pdf9164993https://repositorio.uan.edu.co/bitstreams/de4779b7-8712-4273-aeaf-34e1e4f93f24/download9fe7cda65684e3ea25cae9b1113bcb59MD53123456789/12193oai:repositorio.uan.edu.co:123456789/121932025-02-04 19:38:17.057restrictedhttps://repositorio.uan.edu.coRepositorio Institucional UANalertas.repositorio@uan.edu.co |