Animal toxins, pharmacological opportunities against brain ischemia?

Cerebrovascular diseases (CVD) comprise a group of disorders of the cerebral vasculature that decrease blood flow in the brain with temporary or permanent, generalized or focal involvement, with no apparent cause other than vascular origin. This review addresses a type of cerebrovascular accident -...

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Tipo de recurso:: Article of journal

Fecha de publicación:: 2022

Institución:: Universidad Antonio Nariño

Repositorio:: Repositorio UAN

Idioma:: spa

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spelling	2022-10-132024-10-10T02:55:14Z2024-10-10T02:55:14Zhttps://revistas.uan.edu.co/index.php/saywa/article/view/1000https://repositorio.uan.edu.co/handle/123456789/11130Cerebrovascular diseases (CVD) comprise a group of disorders of the cerebral vasculature that decrease blood flow in the brain with temporary or permanent, generalized or focal involvement, with no apparent cause other than vascular origin. This review addresses a type of cerebrovascular accident - ischemic (CVA) - which is defined as the death of an area of brain tissue as a consequence of an insufficient supply of blood and oxygen to the brain due to a blocked artery. Stroke is one of the main causes of death from chronic diseases around the world, and the second cause of death in Colombia (1). The objective is to present how peptide toxins of arachnid origin, specifically from the Phoneutria boliviensis species, could represent an alternative treatment thanks to their interesting potential in pharmacological development, since it is known that animal toxins act on specific receptors in the nervous system (SN).Las enfermedades cerebrovasculares (ECV) comprenden un conjunto de trastornos de la vasculatura cerebral que disminuyen el flujo sanguíneo en el cerebro con afectación transitoria o permanente, generalizada o focal, sin que exista otra causa aparente que el origen vascular. Esta revisión aborda un tipo de accidente cerebrovascular, -(ACV) isquémico- que se define como la muerte de una zona de tejido cerebral como consecuencia de un suministro insuficiente de sangre y oxígeno al cerebro debido a la obstrucción de una arteria. Siendo el ACV una de las principales causas de muerte por enfermedades crónicas alrededor del mundo, y la segunda causa de muerte en Colombia (1). El objetivo es presentar cómo unas toxinas peptídicas de origen arácnido, puntualmente de la especie Phoneutria boliviensis, podrían representar un tratamiento alternativo gracias a su interesante potencial en el desarrollo farmacológico, puesto que las toxinas animales actúan sobre receptores específicos en el sistema nervioso.application/pdfspaUNIVERSIDAD ANTONIO NARIÑOhttps://revistas.uan.edu.co/index.php/saywa/article/view/1000/1113Derechos de autor 2021 Yair Santiago Bermúdez Urrego, Edwin Alfredo ReyesGuzmán, María Elisa Forero Vivashttps://creativecommons.org/licenses/by-nc-sa/4.0http://purl.org/coar/access_right/c_abf2REVISTA SAYWA; Vol. 3 Núm. 4 (2021); 33-402744-85762711-1571IsquemiaReceptor NMDAToxinasCitotoxicidadTratamientoExcitotoxicidadGlutamatoFarmacológicoAnimal toxins, pharmacological opportunities against brain ischemia?Toxinas animales ¿oportunidades farmacológicas frente a la isquemia cerebral?info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionDivulgación científicahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Bermúdez Urrego, Yair SantiagoReyesGuzmán, Edwin AlfredoForero Vivas, María Elisa123456789/11130oai:repositorio.uan.edu.co:123456789/111302024-10-14 03:47:59.926metadata.onlyhttps://repositorio.uan.edu.coRepositorio Institucional UANalertas.repositorio@uan.edu.co
dc.title.en-US.fl_str_mv	Animal toxins, pharmacological opportunities against brain ischemia?
dc.title.es-ES.fl_str_mv	Toxinas animales ¿oportunidades farmacológicas frente a la isquemia cerebral?
title	Animal toxins, pharmacological opportunities against brain ischemia?
spellingShingle	Animal toxins, pharmacological opportunities against brain ischemia? Isquemia Receptor NMDA Toxinas Citotoxicidad Tratamiento Excitotoxicidad Glutamato Farmacológico
title_short	Animal toxins, pharmacological opportunities against brain ischemia?
title_full	Animal toxins, pharmacological opportunities against brain ischemia?
title_fullStr	Animal toxins, pharmacological opportunities against brain ischemia?
title_full_unstemmed	Animal toxins, pharmacological opportunities against brain ischemia?
title_sort	Animal toxins, pharmacological opportunities against brain ischemia?
dc.subject.es-ES.fl_str_mv	Isquemia Receptor NMDA Toxinas Citotoxicidad Tratamiento Excitotoxicidad Glutamato Farmacológico
topic	Isquemia Receptor NMDA Toxinas Citotoxicidad Tratamiento Excitotoxicidad Glutamato Farmacológico
description	Cerebrovascular diseases (CVD) comprise a group of disorders of the cerebral vasculature that decrease blood flow in the brain with temporary or permanent, generalized or focal involvement, with no apparent cause other than vascular origin. This review addresses a type of cerebrovascular accident - ischemic (CVA) - which is defined as the death of an area of brain tissue as a consequence of an insufficient supply of blood and oxygen to the brain due to a blocked artery. Stroke is one of the main causes of death from chronic diseases around the world, and the second cause of death in Colombia (1). The objective is to present how peptide toxins of arachnid origin, specifically from the Phoneutria boliviensis species, could represent an alternative treatment thanks to their interesting potential in pharmacological development, since it is known that animal toxins act on specific receptors in the nervous system (SN).
publishDate	2022
dc.date.accessioned.none.fl_str_mv	2024-10-10T02:55:14Z
dc.date.available.none.fl_str_mv	2024-10-10T02:55:14Z
dc.date.none.fl_str_mv	2022-10-13
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
dc.type.es-ES.fl_str_mv	Divulgación científica
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.spa.fl_str_mv	http://purl.org/coar/resource_type/c_6501
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status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://revistas.uan.edu.co/index.php/saywa/article/view/1000
dc.identifier.uri.none.fl_str_mv	https://repositorio.uan.edu.co/handle/123456789/11130
url	https://revistas.uan.edu.co/index.php/saywa/article/view/1000 https://repositorio.uan.edu.co/handle/123456789/11130
dc.language.none.fl_str_mv	spa
language	spa
dc.relation.none.fl_str_mv	https://revistas.uan.edu.co/index.php/saywa/article/view/1000/1113
dc.rights.es-ES.fl_str_mv	https://creativecommons.org/licenses/by-nc-sa/4.0
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rights_invalid_str_mv	https://creativecommons.org/licenses/by-nc-sa/4.0 http://purl.org/coar/access_right/c_abf2
dc.format.none.fl_str_mv	application/pdf
dc.publisher.es-ES.fl_str_mv	UNIVERSIDAD ANTONIO NARIÑO
dc.source.es-ES.fl_str_mv	REVISTA SAYWA; Vol. 3 Núm. 4 (2021); 33-40
dc.source.none.fl_str_mv	2744-8576 2711-1571
institution	Universidad Antonio Nariño
repository.name.fl_str_mv	Repositorio Institucional UAN
repository.mail.fl_str_mv	alertas.repositorio@uan.edu.co
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Animal toxins, pharmacological opportunities against brain ischemia?

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