Genes, the serotonergic system and suicidal behavior

The study of suicidal behavior has gained relevance given that recently about 50% of the population between 14 and 19 years old exhibit suicidal ideation and, in the population in general, there has been a rise of up to 150% in suicidal behavior. The outcomes of these studies of genetic epidemiology...

Full description

Autores:
Tovilla-Zarate, Carlos Alfonso
Gómez Mendoza, Alma Delia
Tipo de recurso:
Article of journal
Fecha de publicación:
2012
Institución:
Universidad de San Buenaventura
Repositorio:
Repositorio USB
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.usb.edu.co:10819/25653
Acceso en línea:
https://hdl.handle.net/10819/25653
https://doi.org/10.21500/20112084.751
Palabra clave:
Suicide
serotonin
genetics
polymorphism
association studies
Rights
openAccess
License
International Journal of Psychological Research - 2012
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spelling Tovilla-Zarate, Carlos AlfonsoGómez Mendoza, Alma Delia2012-06-30T00:00:00Z2025-07-31T16:11:01Z2012-06-30T00:00:00Z2025-07-31T16:11:01Z2012-06-30The study of suicidal behavior has gained relevance given that recently about 50% of the population between 14 and 19 years old exhibit suicidal ideation and, in the population in general, there has been a rise of up to 150% in suicidal behavior. The outcomes of these studies of genetic epidemiology show that several genes may be associated with suicidal behavior. In particular, one of the hypotheses propounds that genes of proteins that participate in the serotonergic pathway could be responsible for the development of this behavior. There is neurochemical evidence showing alterations at different levels along this pathway. In this work, a review is made of several of the genes participating in the serotonergic pathway and their possible participation in suicidal behavior.application/pdf10.21500/20112084.7512011-79222011-2084https://hdl.handle.net/10819/25653https://doi.org/10.21500/20112084.751engUniversidad San Buenaventura - USB (Colombia)https://revistas.usb.edu.co/index.php/IJPR/article/download/751/550581525International Journal of Psychological ResearchAnguelova, M., Benkelfat, C., & Turecki, G. (2003). A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Molecular Psychiatry, 8(7), 646-653. Arango, V., Underwood, M. D., Gubbi, A. V., & Mann, J. J. (1995). Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Research, 688(1-2), 121-133. Asberg, M., Traskman, L., & Thoren, P. (1976). 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Archives of General Psychiatry, 33(10), 1193-1197. Baldessarini, R. J. & Hennen, J. (2004). Genetics of suicide: an overview. Harvard of Review Psychiatry, 12(1), 1-13. Beck, A. T., Weissman, A., Lester, D., & Trexler, L. (1976). Classification of suicidal behaviors. II. Dimensions of suicidal intent. Archives of General Psychiatry, 33(7), 835-837. Bellivier, F., Chaste, P., & Malafosse, A. (2004). Association between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysis. American Journal of Medical Genetics. Part B Neuropsychiatric Genetics, 124B(1), 87-91.International Journal of Psychological Research - 2012info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2https://creativecommons.org/licenses/by-nc-sa/4.0/https://revistas.usb.edu.co/index.php/IJPR/article/view/751Suicideserotoningeneticspolymorphismassociation studiesGenes, the serotonergic system and suicidal behaviorGenes, the serotonergic system and suicidal behaviorArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Textinfo:eu-repo/semantics/articleJournal articleinfo:eu-repo/semantics/publishedVersionPublicationOREORE.xmltext/xml2540https://bibliotecadigital.usb.edu.co/bitstreams/b70c6e4d-ad75-4e1c-b0fd-cb7ec8c44197/downloada06c8224b082cfe2614858ba64185b6cMD5110819/25653oai:bibliotecadigital.usb.edu.co:10819/256532025-07-31 11:11:01.681https://creativecommons.org/licenses/by-nc-sa/4.0/https://bibliotecadigital.usb.edu.coRepositorio Institucional Universidad de San Buenaventura Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv Genes, the serotonergic system and suicidal behavior
dc.title.translated.spa.fl_str_mv Genes, the serotonergic system and suicidal behavior
title Genes, the serotonergic system and suicidal behavior
spellingShingle Genes, the serotonergic system and suicidal behavior
Suicide
serotonin
genetics
polymorphism
association studies
title_short Genes, the serotonergic system and suicidal behavior
title_full Genes, the serotonergic system and suicidal behavior
title_fullStr Genes, the serotonergic system and suicidal behavior
title_full_unstemmed Genes, the serotonergic system and suicidal behavior
title_sort Genes, the serotonergic system and suicidal behavior
dc.creator.fl_str_mv Tovilla-Zarate, Carlos Alfonso
Gómez Mendoza, Alma Delia
dc.contributor.author.eng.fl_str_mv Tovilla-Zarate, Carlos Alfonso
Gómez Mendoza, Alma Delia
dc.subject.eng.fl_str_mv Suicide
serotonin
genetics
polymorphism
association studies
topic Suicide
serotonin
genetics
polymorphism
association studies
description The study of suicidal behavior has gained relevance given that recently about 50% of the population between 14 and 19 years old exhibit suicidal ideation and, in the population in general, there has been a rise of up to 150% in suicidal behavior. The outcomes of these studies of genetic epidemiology show that several genes may be associated with suicidal behavior. In particular, one of the hypotheses propounds that genes of proteins that participate in the serotonergic pathway could be responsible for the development of this behavior. There is neurochemical evidence showing alterations at different levels along this pathway. In this work, a review is made of several of the genes participating in the serotonergic pathway and their possible participation in suicidal behavior.
publishDate 2012
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2025-07-31T16:11:01Z
dc.date.available.none.fl_str_mv 2012-06-30T00:00:00Z
2025-07-31T16:11:01Z
dc.date.issued.none.fl_str_mv 2012-06-30
dc.type.spa.fl_str_mv Artículo de revista
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dc.identifier.issn.none.fl_str_mv 2011-2084
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https://doi.org/10.21500/20112084.751
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language eng
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dc.relation.citationendpage.none.fl_str_mv 58
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dc.relation.citationstartpage.none.fl_str_mv 52
dc.relation.citationvolume.eng.fl_str_mv 5
dc.relation.ispartofjournal.eng.fl_str_mv International Journal of Psychological Research
dc.relation.references.eng.fl_str_mv Anguelova, M., Benkelfat, C., & Turecki, G. (2003). A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Molecular Psychiatry, 8(7), 646-653. Arango, V., Underwood, M. D., Gubbi, A. V., & Mann, J. J. (1995). Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Research, 688(1-2), 121-133. Asberg, M., Traskman, L., & Thoren, P. (1976). 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Archives of General Psychiatry, 33(10), 1193-1197. Baldessarini, R. J. & Hennen, J. (2004). Genetics of suicide: an overview. Harvard of Review Psychiatry, 12(1), 1-13. Beck, A. T., Weissman, A., Lester, D., & Trexler, L. (1976). Classification of suicidal behaviors. II. Dimensions of suicidal intent. Archives of General Psychiatry, 33(7), 835-837. Bellivier, F., Chaste, P., & Malafosse, A. (2004). Association between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysis. American Journal of Medical Genetics. Part B Neuropsychiatric Genetics, 124B(1), 87-91.
dc.rights.eng.fl_str_mv International Journal of Psychological Research - 2012
dc.rights.accessrights.eng.fl_str_mv info:eu-repo/semantics/openAccess
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institution Universidad de San Buenaventura
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