Cardiopatías congénitas y su relación con los trastornos del neurodesarrollo en población infantil: revisión sistemática de literatura /
Este artículo presenta resultados de una revisión sistemática orientada a indagar la relación entre la presencia de cardiopatías congénitas y los trastornos del neurodesarrollo en la población infantil. La unidad muestral estuvo compuesta por 36 investigaciones, identificadas en las bases de datos P...
- Autores:
-
Klimenko, Olena
Orozco-Santander, María José
Forero-Meza, María Francisca
Hernández Flórez, Nubia Esther
Lhoeste Charris, Alvaro Enrique
González Martelo, Victoria Eugenia
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2022
- Institución:
- Corporación Universitaria del Caribe - CECAR
- Repositorio:
- Repositorio Digital CECAR
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.cecar.edu.co:cecar/10916
- Acceso en línea:
- https://repositorio.cecar.edu.co/handle/cecar/10916
- Palabra clave:
- Cardiopatías congénitas
Neurodesarrollo
Neurodesenvolvimento
Deterioro cognitivo
- Rights
- openAccess
- License
- Derechos Reservados - Corporación Universitaria del Caribe CECAR
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Cardiopatías congénitas y su relación con los trastornos del neurodesarrollo en población infantil: revisión sistemática de literatura / |
| title |
Cardiopatías congénitas y su relación con los trastornos del neurodesarrollo en población infantil: revisión sistemática de literatura / |
| spellingShingle |
Cardiopatías congénitas y su relación con los trastornos del neurodesarrollo en población infantil: revisión sistemática de literatura / Cardiopatías congénitas Neurodesarrollo Neurodesenvolvimento Deterioro cognitivo |
| title_short |
Cardiopatías congénitas y su relación con los trastornos del neurodesarrollo en población infantil: revisión sistemática de literatura / |
| title_full |
Cardiopatías congénitas y su relación con los trastornos del neurodesarrollo en población infantil: revisión sistemática de literatura / |
| title_fullStr |
Cardiopatías congénitas y su relación con los trastornos del neurodesarrollo en población infantil: revisión sistemática de literatura / |
| title_full_unstemmed |
Cardiopatías congénitas y su relación con los trastornos del neurodesarrollo en población infantil: revisión sistemática de literatura / |
| title_sort |
Cardiopatías congénitas y su relación con los trastornos del neurodesarrollo en población infantil: revisión sistemática de literatura / |
| dc.creator.fl_str_mv |
Klimenko, Olena Orozco-Santander, María José Forero-Meza, María Francisca Hernández Flórez, Nubia Esther Lhoeste Charris, Alvaro Enrique González Martelo, Victoria Eugenia |
| dc.contributor.author.none.fl_str_mv |
Klimenko, Olena Orozco-Santander, María José Forero-Meza, María Francisca Hernández Flórez, Nubia Esther Lhoeste Charris, Alvaro Enrique González Martelo, Victoria Eugenia |
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Corporación Universitaria del Caribe - CECAR |
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Dimensiones Humanas (DH) |
| dc.subject.proposal.spa.fl_str_mv |
Cardiopatías congénitas Neurodesarrollo Neurodesenvolvimento Deterioro cognitivo |
| topic |
Cardiopatías congénitas Neurodesarrollo Neurodesenvolvimento Deterioro cognitivo |
| description |
Este artículo presenta resultados de una revisión sistemática orientada a indagar la relación entre la presencia de cardiopatías congénitas y los trastornos del neurodesarrollo en la población infantil. La unidad muestral estuvo compuesta por 36 investigaciones, identificadas en las bases de datos PubMed, Science Direct, Web of Science y Refseek, en la ventana de observación de los últimos cinco años (2019 - 2022), de publicaciones en español, inglés y portugués. El procesamiento de los datos es realizado mediante metodología PRISMA. Los resultados indican que las alteraciones del desarrollo neurológico están relacionadas con fenómenos biológicos, como anomalías de tipo genético (malformaciones), las dificultades cardíacas, el déficit de oxigenación en el cerebro en la gestación por detenciones en el aspecto cardiopulmonar, afectando las capacidades de aprendizaje y un desenvolvimiento óptimo familiar y social a lo largo de la vida. Se requiere un seguimiento y atención personalizada en cada caso particular, combinanado los tratamientos médicos con atención psicosocial y estrategias educativas adecuadas para minimizar las consecuencia adversas de las afecciones cardíacas. |
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2022 |
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2022 |
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2025-09-09T20:23:13Z |
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Artículo de revista |
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Volumen 130 |
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Gaceta Médica de Caracas |
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Leon RL, Mir IN, Herrera CL, Sharma K, Spong CY, Twickler DM, et al. Neuroplacentology in congenital heart disease: Placental connections to neurodevelopmental outcomes. Pediatr Res. 2022;91(4):787-794. Ehrler M, Latal B, Polentarutti S, von Rhein M, Held L, Wehrle FM. Pitfalls of using IQ short forms in neurodevelopmental disorders: A study in patients with congenital heart disease. Pediatr Res. 2020;87(5):917-923. Sadhwani A, Wypij D, Rofeberg V, Gholipour A, Mittleman M, Rohde J, et al. Fetal Brain Volume Predicts Neurodevelopment in Congenital Heart Disease. Circulation. 2022;145(15):1108-1119. Mendoza-Sánchez V, Hernández-Negrete LE, Cazarez-Ortiz M, González E, Guido-Campuzano MA. Neurodesarrollo en niños con cardiopatía congénita a los 30 meses de edad. Rev Mex Pediat. 2019;86(4):143-146. Mendoza-Carretero M, Ares-Segura S, Sáenz-Rico B. Dificultades en el neurodesarrollo con repercusión en el ámbito educativo en menores con cardiopatías congénitas: revisión sistemática. Rev Esp Discapac. 2019;7(2):43-53. Meuwly E, Feldmann M, Knirsch W, von Rhein M, Payette K, Dave H, et al. Postoperative brain volumes are associated with one-year neurodevelopmental outcome in children with severe congenital heart disease. Sci Rep. 2019;9(1):1-11. White B, Rogers L, Kirschen M. Recent advances in our understanding of neurodevelopmental outcomes in congenital heart disease. HHS Public Access. 2019;176(1):139-148. Valentín-Rodríguez A. Cardiopatías congénitas en edad pediátrica, aspectos clínicos y epidemiológicos. Rev Medica Electron. 2018;40(4):1083-1099. Page M, McKenzie J, Bossuyt P, Boutron I. Declaración PRISMA 2020: una guía actualizada para la publicación de revisiones sistemáticas. Rev Esp Cardiol. 2022;75(2):192. Hutton B, Catalá-lópez F, Moher D. La extensión de la declaración PRISMA para revisiones sistemáticas que incorporan metaanálisis en red: PRISMA-NMA. Med Clin (Barc). 2016;(xx):10-14. Bravo-Toledo R. La declaración PRISMA 2020: una guía actualizada para la publicación de revisiones sistemáticas. PLoS Med. 2021:1-15. Barrios-Serna K, Orozco-Núñez D, Pérez-Navas E, Conde-Cardona G. Nuevas recomendaciones de la versión PRISMA 2020 para revisiones sistemáticas y metaanálisis. Acta Neurol Colomb. 2021;37(2):105-106. Marino BS, Lipkin PH, Newburger JW, Peacock G, Gerdes M, Gaynor JW, et al. Neurodevelopmental outcomes in children with congenital heart disease: Evaluation and management a scientific statement from the American heart association. Circulation. 2012;126(9):1143-1172. Tan A, Semmel E, Rodrigues N, Bishop M, Ilardi D. Adaptive Functioning in Adolescents with Congenital Heart Disease Referred for Neurodevelopmental Follow-Up. Pediatr Neuropsychol. 2022:68-78. Eagleson KJ, Gilmore L, Auld B, Hirst A, Johnson S, Stocker C, et al. Neurodevelopmental and health-related quality-of-life outcomes in adolescence after surgery for congenital heart disease in infancy. Dev Med Child Neurol. 2019:1-7. Startin CM, D’Souza H, Ball G, Hamburg S, Hithersay R, Hughes KMO, et al. Health comorbidities and cognitive abilities across the lifespan in down syndrome. J Neurodev Disord. 2020;12(1):1-13. Strzelczyk A, Schubert-Bast S. Psychobehavioural and Cognitive Adverse Events of Anti-Seizure Medications for the Treatment of Developmental and Epileptic Encephalopathies [Internet]. CNS Drugs. Springer International Publishing; 2022;36:1079-1111. Available from: https://doi.org/10.1007/s40263-022-00955-9 Feldmann M, Hagmann C, de Vries L, Disselhoff V, Pushparajah K, Logeswaran T, et al. Neuromonitoring, neuroimaging, and neurodevelopmental follow-up practices in neonatal congenital heart disease: a European survey. Pediatr Res. 2022:1-8. Ilardi D, Sanz JH, Cassidy AR, Sananes R, Rollins CK, Ullman Shade C, et al. Neurodevelopmental evaluation for school-age children with congenital heart disease: Recommendations from the cardiac neurodevelopmental outcome collaborative. Cardiol Young. 2020;30(11):1623-1636. Robinson J, Uzun O, Loh NR, Harris IR, Woolley TE, Harwood AJ, et al. The association of neurodevelopmental abnormalities, congenital heart and renal defects in a tuberous sclerosis complex patient cohort. BMC Med. 2022;20(1):1-19. Simons J, Sood ED, Derby CD, Pizarro C. Predictive value of near-infrared spectroscopy on neurodevelopmental outcome after surgery for congenital heart disease in infancy. J Thorac Cardiovasc Surg. 2012;143(1):118-125. Sood E, Jacobs JP, Marino BS. The Cardiac Neurodevelopmental Outcome Collaborative: A new community improving outcomes for individuals with congenital heart disease. Cardiol Young. 2020;30(11):1595-1596. Naef N, Schlosser L, Brugger P, Greutmann M, Oxenius A, Wehrle F, et al. Brain volumes in adults with congenital heart disease correlate with executive function abilities. Brain Imaging Behav. 2021;15(5):2308-2316. Peyvandi S, Chau V, Guo T, Xu D, Glass HC, Synnes A, et al. Neonatal Brain Injury and Timing of Neurodevelopmental Assessment in Patients With Congenital Heart Disease. J Am Coll Cardiol. 2018;71(18):1986-1996. Song KJ, Kim MG, Ko EJ. Neurodevelopmental Outcomes after Congenital Heart Disease Surgery in Infancy: A 2-Year Serial Follow-Up. Children. 2021;8:9-11. Barkhuizen M, Abella R, Vles JSH, Zimmermann LJI, Gazzolo D, Gavilanes AWD. Antenatal and Perioperative Mechanisms of Global Neurological Injury in Congenital Heart Disease. Pediatr Cardiol. 2021;42(1):1-18. Li P, Chen W, Li M, Zhao Z, Feng Z, Gao H, et al. Copy number variant analysis for syndromic congenital heart disease in the Chinese population. Hum Genomics. 2022;16:1-22. Santoro JD, Partridge R, Tanna R, Pagarkar D, Khoshnood M, Rehmani M, et al. Evidence of neuroinflammation and immunotherapy responsiveness in individuals with down syndrome regression disorder. J Neurodev Disord. 2022;14(1):1-14. Gładysz D, Krzywdzińska A, Hozyasz KK. Immune Abnormalities in Autism Spectrum Disorder—Could They Hold Promise for Causative Treatment? Mol Neurobiol. 2018;55(8):6387-6435. Nhu N, Ram K, Hodge F, Macey P. Cerebral autoregulation in neonates with and without congenital heart disease. Am Assoc Crit Nurses. 2018;27(5):410-416. Spillmann R, Polentarutti S, Ehrler M, Kretschmar O, Wehrle FM, Latal B. Congenital heart disease in school-aged children: Cognition, education, and participation in leisure activities. Pediatr Res. 2021. Katheria AC, Stout J, Morales AL, Poeltler D, Rich WD, Steen J, et al. Association between early cerebral oxygenation and neurodevelopmental impairment or death in premature infants. J Perinatol. 2021;41(4):743-748. Nadine K, Heye KN, Rousson V, Knirsch W, Rn IB, Liamlahi R, et al. Growth and Intellectual Abilities of Six-Year-Old Children with Congenital Heart Disease. Growth and intellectual abilities at six years in congenital heart disease. Author affiliations: Child. Development Center, University Children´s Hospital, Zurich. J Pediatr. 2019;204:24-30. Parekh SA, Cox SM, Barkovich AJ, Chau V, Steurer MA, Xu D, et al. The Effect of Size and Asymmetry at Birth on Brain Injury and Neurodevelopmental Outcomes in Congenital Heart Disease. Pediatr Cardiol. 2022;43(4):868-877. Ji W, Ferdman D, Copel J, Scheinost D, Shabanova V, Brueckner M, et al. De novo damaging variants associated with congenital heart diseases contribute to the connectome. Sci Rep. 2020;10(1):1-11. Cainelli E, Bisiacchi PS, Cogo P, Padalino M, Simonato M, Vergine M, et al. Detecting neurodevelopmental trajectories in congenital heart diseases with a machine-learning approach. Sci Rep. 2021;11(1):1-11. Loblein HJ, Vukmirovich PW, Donofrio MT, Sanz JH. Prevalence of neurodevelopmental disorders in a clinically referred sample of children with CHD. Cardiol Young. 2022:1-8. Ware J, Butcher JL, Latal B, Sadhwani A, Rollins CK, Brosig Soto CL, et al. Neurodevelopmental evaluation strategies for children with congenital heart disease aged birth through 5 years: Recommendations from the cardiac neurodevelopmental outcome collaborative. Cardiol Young. 2020;30(11):1609-1622. Lengyel A, Pinti É, Pikó H, Kristóf Á, Abonyi T, Némethi Z, et al. Clinical evaluation of rare copy number variations identified by chromosomal microarray in a Hungarian neurodevelopmental disorder patient cohort. Mol Cytogenet. 2022;15:1-13. Bonthrone AF, Dimitrova R, Chew A, Kelly CJ, Cordero-Grande L, Carney O, et al. Individualized brain development and cognitive outcome in infants with congenital heart disease. Brain Commun. 2021;3(2):1-14. Roberts SD, Kazazian V, Ford MK, Marini D, Miller SP, Chau V, et al. The association between parent stress, coping and mental health, and neurodevelopmental outcomes of infants with congenital heart disease. Clin Neuropsychol. 2021;35(5):948-972. Sommariva G, Zilli T, Crescentini C, Marini A, Pilotto C, Venchiarutti M, et al. Toward a characterization of language development in children with congenital heart disease: A pilot study. Child Neuropsychol. 2020;26(1):1-14. Jakab A, Meuwly E, Feldmann M, von Rhein M, Kottke R, O’Gorman Tuura R, et al. Left temporal plane growth predicts language development in newborns with congenital heart disease. Brain. 2019;142(5):1270-1281. Fontes K, Courtin F, Rohlicek CV, Saint-Martin C, Gilbert G, Easson K, et al. Characterizing the Subcortical Structures in Youth with Congenital Heart Disease. Am J Neuroradiol. 2020;41(8):1503-1508. Fourdain S, St-Denis A, Harvey J, Birca A, Carmant L, Gallagher A, et al. Language development in children with congenital heart disease aged 12–24 months. Eur J Paediatr Neurol. 2019;23(3):491-499. Claessens NHP, Khalili N, Isgum I, Ter Heide H, Steenhuis TJ, Turk E, et al. Brain and CSF volumes in fetuses and neonates with antenatal diagnosis of critical congenital heart disease: A longitudinal MRI study. Am J Neuroradiol. 2019;40(5):885-891. Liamlahi R, Latal B. Neurodevelopmental outcome of children with congenital heart disease. Handbook of Clinical Neurology. Elsevier B.V.; 2019:162:329-345. Claessens NHP, Algra SO, Ouwehand TL, Jansen NJG, Schappin R, Haas F, et al. Perioperative neonatal brain injury is associated with worse school-age neurodevelopment in children with critical congenital heart disease. Dev Med Child Neurol. 2018;60(10):1052-1058. Wotherspoon JM, Eagleson KJ, Gilmore L, Auld B, Hirst A, Johnson S, et al. Neurodevelopmental and health-related quality-of-life outcomes in adolescence after surgery for congenital heart disease in infancy. Dev Med Child Neurol. 2020;62(2):214-220. Calderon J, Bellinger DC, Hartigan C, Lord A, Stopp C, Wypij D, et al. Improving neurodevelopmental outcomes in children with congenital heart disease: Protocol for a randomised controlled trial of working memory training. BMJ Open. 2019;9(2):1-10. Seed M, Miller SP. A Life-Course Approach to the Neurodevelopmental Trajectory of Congenital Heart Disease. Circulation. 2021;143(9):892-894. Cassidy AR, Butler SC, Briend J, Calderon J, Casey F, Crosby LE, et al. Neurodevelopmental and psychosocial interventions for individuals with CHD: A research agenda and recommendations from the Cardiac Neurodevelopmental Outcome Collaborative. Cardiol Young. 2021;31(6):888-899. Smith R, Nel H, Marais C, Kraaij R, Le Roux H, Scholtz E, et al. Neurodevelopmental evaluation and referral practices in children with congenital heart disease in central South Africa. SA Hear. 2019;16(4):12-14. Giorgione V, Parazzini F, Fesslova V, Cipriani S, Candiani M, Inversetti A, et al. Congenital heart defects in IVF/ICSI pregnancy: Systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2018;51(1):33-42. Gonzalez VJ, Kimbro RT, Cutitta KE, Shabosky JC, Bilal MF, Penny DJ, et al. Mental health disorders in children with congenital heart disease. Pediatrics. 2021;147(2). Russell MW, Chung WK, Kaltman JR, Miller TA. Advances in the understanding of the genetic determinants of congenital heart disease and their impact on clinical outcomes. J Am Heart Assoc. 2018;7(6):1-15. Saliba A, Figueiredo ACV, Baroneza JE, Afiune JY, Pic-Taylor A, Oliveira SF de, et al. Genetic and genomics in congenital heart disease: a clinical review. J Pediatr (Rio J). 2020;96(3):279-288. Rodrigues Moraes B, Bassi D, Magalhães dos Santos PH, Santos-de-Araújo AD, Vanin Alves de Souza Matias PH, Do Nascimento Calles AC. Desenvolvimento neuropsicomotor de crianças com cardiopatias congênitas. Rev Pesqui em Fisioter. 2019;9(3):316-320. Freire RMA de C, Tressoldi K de P, Frizzo RJ, Mori J de SM, Rafael DI, Pinto JM, et al. Possíveis fatores de risco para o desenvolvimento em crianças com cardiopatia congênita. Res Soc Dev. 2021;10(11):e83101119138. De Assis NRG, Roberti BN, Carvalho L de S, Mendes LPB, Dias LGF, Marques L, et al. Cardiopatias congênitas e sua associação com o uso de antidepressivos na gestação: uma revisão sistemática. Rev Eletrônica Acervo Saúde. 2020;12(10):e4715. Montis S, Sirigu D, Marini A, Lai A, Setti P, Camboni M, et al. L’ipnosi nell’ecocardiografia transesofagea. L’esperienza di un Centro di Cardiologia Pediatrica e delle Cardiopatie Congenite. G Ital Cardiol. 2019;20(11):651-657. Almeida C, Duarte Y, Braz B, Conceição L, Moura G. Tipologia da cardiopatia congênita em bebês. Rev Lib Accesum. 2019;4(1):1-14. Rodrigues PF, Cristhine A, Araujo G, Pereira AC, Larissa B, Viana A, et al. Cardiopatias na gestação: aspectos clínicos. Heart diseases in pregnancy: Clinical aspects. Cardiopatías en el embarazo: aspectos clínicos. Rev Eletrônica Acervo Saúde. 2020;12(11):1-8. Zanini M. Treatment Evolution and the Impact of Pre-Surgical Predictors on Outcomes of Patients with Congenital Heart Disease. Arq Bras Cardiol. 2022;118(2):420-421. |
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Klimenko, OlenaOrozco-Santander, María JoséForero-Meza, María FranciscaHernández Flórez, Nubia Esthervirtual::343-1Lhoeste Charris, Alvaro Enriquevirtual::344-1González Martelo, Victoria Eugeniavirtual::345-1Corporación Universitaria del Caribe - CECARDimensiones Humanas (DH)2025-09-09T20:23:13Z2022https://repositorio.cecar.edu.co/handle/cecar/109160367-4762Este artículo presenta resultados de una revisión sistemática orientada a indagar la relación entre la presencia de cardiopatías congénitas y los trastornos del neurodesarrollo en la población infantil. La unidad muestral estuvo compuesta por 36 investigaciones, identificadas en las bases de datos PubMed, Science Direct, Web of Science y Refseek, en la ventana de observación de los últimos cinco años (2019 - 2022), de publicaciones en español, inglés y portugués. El procesamiento de los datos es realizado mediante metodología PRISMA. Los resultados indican que las alteraciones del desarrollo neurológico están relacionadas con fenómenos biológicos, como anomalías de tipo genético (malformaciones), las dificultades cardíacas, el déficit de oxigenación en el cerebro en la gestación por detenciones en el aspecto cardiopulmonar, afectando las capacidades de aprendizaje y un desenvolvimiento óptimo familiar y social a lo largo de la vida. Se requiere un seguimiento y atención personalizada en cada caso particular, combinanado los tratamientos médicos con atención psicosocial y estrategias educativas adecuadas para minimizar las consecuencia adversas de las afecciones cardíacas.Deporte, actividad física y salud.Desarrollo cognitivo, salud mental y neuropsicología.Gestión ciudadana y del estado en el desarrollo organizacional, social y comunitario.Vulnerabilidad social y grupos poblacionales.14 páginasapplication/pdfspaDerechos Reservados - Corporación Universitaria del Caribe CECARhttps://creativecommons.org/licenses/by-nc/4.0/Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2https://doi.org/10.47307/GMC.2022.130.4.14Cardiopatías congénitas y su relación con los trastornos del neurodesarrollo en población infantil: revisión sistemática de literatura /Artículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/resource_type/c_18wsTextinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/IFIinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Colombia8044791Volumen 130Gaceta Médica de CaracasLeon RL, Mir IN, Herrera CL, Sharma K, Spong CY, Twickler DM, et al. 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Arq Bras Cardiol. 2022;118(2):420-421.Cardiopatías congénitasNeurodesarrolloNeurodesenvolvimentoDeterioro cognitivoPublication988f13a9-f5a4-4b37-b6d7-4dbaf24b4ca3virtual::343-165eea4d1-da8d-45dc-812b-9c6ffc231715virtual::344-139b3ce40-ecd7-4061-9336-1e04e40f4b14virtual::345-1988f13a9-f5a4-4b37-b6d7-4dbaf24b4ca3virtual::343-165eea4d1-da8d-45dc-812b-9c6ffc231715virtual::344-139b3ce40-ecd7-4061-9336-1e04e40f4b14virtual::345-1ORIGINALCardiopatias_congenitas_y_su_relacion_con_los_tras.pdfCardiopatias_congenitas_y_su_relacion_con_los_tras.pdfapplication/pdf814308https://repositorio.cecar.edu.co/bitstreams/101eda93-7f0a-453f-8b97-2683c85a8ac8/downloadc109656d5eb9af3f2669b6f0d7674ec0MD51trueAnonymousREADLICENSElicense.txtlicense.txttext/plain; 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