Emotions, anxiety, depression and the immune system: an integrative view of psychoneuroimmunology from a meta-analytic review of the narrative /

The study focused on conducting a meta-analytic review of three variables psychoneuroimmunology, emotions, and the immune system, intending to find a relationship between them. The methodology was the PRISMA statement with inclusion criteria: production of the last five years, full text, exclusion c...

Full description

Autores:
Hernández-Flórez, Jorge
Ortiz-González, Andrea Liliana
Lhoeste-Charris, Álvaro
Klimenko, Olena
Moncada-Navas, Francia
Hernández-Flórez, Nubia
Tipo de recurso:
Article of investigation
Fecha de publicación:
2023
Institución:
Corporación Universitaria del Caribe - CECAR
Repositorio:
Repositorio Digital CECAR
Idioma:
eng
OAI Identifier:
oai:repositorio.cecar.edu.co:cecar/10772
Acceso en línea:
https://repositorio.cecar.edu.co/handle/cecar/10772
Palabra clave:
Anxiety
Depression
Emotions
Immune system
Psychoneuroimmunology
Rights
openAccess
License
Derechos Reservados - Corporación Universitaria del Caribe CECAR
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oai_identifier_str oai:repositorio.cecar.edu.co:cecar/10772
network_acronym_str RepoCECAR2
network_name_str Repositorio Digital CECAR
repository_id_str
dc.title.eng.fl_str_mv Emotions, anxiety, depression and the immune system: an integrative view of psychoneuroimmunology from a meta-analytic review of the narrative /
title Emotions, anxiety, depression and the immune system: an integrative view of psychoneuroimmunology from a meta-analytic review of the narrative /
spellingShingle Emotions, anxiety, depression and the immune system: an integrative view of psychoneuroimmunology from a meta-analytic review of the narrative /
Anxiety
Depression
Emotions
Immune system
Psychoneuroimmunology
title_short Emotions, anxiety, depression and the immune system: an integrative view of psychoneuroimmunology from a meta-analytic review of the narrative /
title_full Emotions, anxiety, depression and the immune system: an integrative view of psychoneuroimmunology from a meta-analytic review of the narrative /
title_fullStr Emotions, anxiety, depression and the immune system: an integrative view of psychoneuroimmunology from a meta-analytic review of the narrative /
title_full_unstemmed Emotions, anxiety, depression and the immune system: an integrative view of psychoneuroimmunology from a meta-analytic review of the narrative /
title_sort Emotions, anxiety, depression and the immune system: an integrative view of psychoneuroimmunology from a meta-analytic review of the narrative /
dc.creator.fl_str_mv Hernández-Flórez, Jorge
Ortiz-González, Andrea Liliana
Lhoeste-Charris, Álvaro
Klimenko, Olena
Moncada-Navas, Francia
Hernández-Flórez, Nubia
dc.contributor.author.none.fl_str_mv Hernández-Flórez, Jorge
Ortiz-González, Andrea Liliana
Lhoeste-Charris, Álvaro
Klimenko, Olena
Moncada-Navas, Francia
Hernández-Flórez, Nubia
dc.contributor.corporatename.none.fl_str_mv Corporación Universitaria del Caribe - CECAR
dc.contributor.researchgroup.none.fl_str_mv Dimensiones Humanas (DH)
dc.subject.proposal.eng.fl_str_mv Anxiety
Depression
Emotions
Immune system
Psychoneuroimmunology
topic Anxiety
Depression
Emotions
Immune system
Psychoneuroimmunology
description The study focused on conducting a meta-analytic review of three variables psychoneuroimmunology, emotions, and the immune system, intending to find a relationship between them. The methodology was the PRISMA statement with inclusion criteria: production of the last five years, full text, exclusion criteria: book chapters, reviews, editorials, letters to the editorials, as well as systematic and meta-analytic reviews; a formula was created from the variables with Boolean operators (AND, OR, NOT) in databases: Web of Science, PubMed and Elsevier. The first sweep denotes (n=2237) articles and after the application of the screening, the final sample was (n=26). Among the findings is the emergence of three categories of analysis using a word map: cognitive abilities, mental fatigue, and stressors. In conclusion, psychoneuroimmunology is a science that articulates mental processes and the functioning of the nervous, immune, and endocrine systems that affect the individual in such a way that the psychological aspects linked to emotional management and control can present better management and intervention in mental illnesses.
publishDate 2023
dc.date.issued.none.fl_str_mv 2023
dc.date.accessioned.none.fl_str_mv 2025-08-28T00:41:01Z
dc.type.none.fl_str_mv Artículo de revista
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dc.type.content.none.fl_str_mv Text
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dc.identifier.eissn.none.fl_str_mv 0367-4762
url https://repositorio.cecar.edu.co/handle/cecar/10772
identifier_str_mv 0367-4762
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.citationendpage.none.fl_str_mv 463
dc.relation.citationissue.none.fl_str_mv 3
dc.relation.citationstartpage.none.fl_str_mv 444
dc.relation.citationvolume.none.fl_str_mv Volumen 131
dc.relation.ispartofjournal.none.fl_str_mv Gaceta Médica de Caracas
dc.relation.references.none.fl_str_mv Peña-Vargas C, Armaiz-Peña G. Behavioral sciences A Biopsychosocial Approach to Grief, Depression, and the Role of Emotional Regulation. Behav Sci (Basel). 2021;11(8):110.
Kiecolt-Glaser JK, McGuire L, Robles TF, Glaser R. Emotions, morbidity, and mortality: New perspectives from psychoneuroimmunology. Ann Rev Psychol. 2002;53:83-107.
Zachariae R. Psychoneuroimmunology : A bio-psycho-social approach to health and disease. Scand J Psychol. 2009;50(6):645–51.
Lugović-Mihić L, Mihatović D, Šitum M. Psychoneuroimmunology and skin diseases. Rad Hrvat Akad Znan i Umjet Med Znan. 2019;537(46- 47):25-36.
Kautz MM. Applications of psychoneuroimmunology models of toxic stress in prevention and intervention efforts across early development. Brain, Behav Immun Heal. 2021;16:100322.
D’Acquisto F. Affective immunology: Where emotions and the immune response converge. Dialogues Clin Neurosci. 2017;19(1):9-19.
Jaremka LM, Lindgren ME, Kiecolt-Glaser JK. Synergistic relationships among stress, depression, and troubled relationships: insights from psychoneuroimmunology. Depress Anxiety. 2013;30(4):288-296.
Littrell JL. The Importance of Psychoneuroimmunology for Social Workers. Fam Soc. 2019;100(1):17-33.
Shields GS, Spahr CM, Slavich GM. Psychosocial Interventions and Immune System Function: A Systematic Review and Meta-analysis of Randomized Clinical Trials. JAMA Psychiatry. 2020;77(10):1031- 1043.
Murray DR, Prokosch ML, Airington Z. PsychoBehavioroimmunology: Connecting the behavioral immune system to its physiological foundations. Front Psychol. 2019;10:1-7.
Ulloa A, Sánchez R. Metaconocimientos de los estados emocionales de estudiantes de educación superior Meta-knowledge of the emotional states of higher education students. Cienc Lat Rev Científica Multidiscip. 2022;7:445-459.
Hernández-Flórez N, Moncada-Navas F, Lhoeste- Charris A, Klimenko O, Ortíz-González A. Habilidades de pensamiento crítico creativo e inteligencia emocional en estudiantes universitarios: Una revisión bibliométrica desde la literatura. Cienc Lat Rev Científica Multidiscip. 2022;6:2029-2054.
Molina J. Psiconeuroinmunología: una propuesta no inmune a la critica. Cent Centroaméricano José Simeón. 2020;1(1):15-18.
Hernández-Flórez N, Leal-Leal GA, Mogollón-Canal OM, Moreno-Salgado A, Rodríguez-Rivera D, Vergel- Rodríguez C, et al. Variables de personalidad y estilos de vida saludable en estudiantes universitarios de la Corporación Universitaria Minuto de Dios en el centro regional Cúcuta. Inf Psicológicos. 2020;20(2):83-94
Pérez L, Moré C, González Y, Alemán A. Psychoneuroendocrinoimmunology: Claim for a comprehensive vision in medical studies. Edumecentro. 2019;11(3):254-261
Jara C, Acuña L, Gengler J. Estrés e Inmunidad. Medwave. 2001;1(11):171-174.
Sánchez-Serrano S, Pedraza-Navarro I, Donoso- González M. How to conduct a systematic review under PRISMA protocol? Uses and fundamental strategies for its application in the educational field through a practical case study. Bordon Rev Pedagog. 2022;74(3):51-66.
Hutton B, Catalá-lópez F, Moher D. La extensión de la declaración PRISMA para revisiones sistemáticas que incorporan metaanálisis en red: PRISMA-NMA. Med Clin (Barc). 2016;(xx):10-14.
Page M, McKenzie J, Bossuyt P. Declaración PRISMA 2020: Una guía actualizada para la publicación de las revisiones sistemáticas. Rev Esp Cardiol. 2021;74(9):790-799.
Barrios-Serna K, Orozco-Núñez D, Pérez-Navas E, Conde-Cardona G. Nuevas recomendaciones de la versión PRISMA 2020 para revisiones sistemáticas y metaanálisis. Acta Neurol Colomb. 2021;37(2):105- 106.
Benavidez V, Flores R. La importancia de las emociones para la neurodidáctica The importance of emotions for the neurodidactics Introducción Los resultados de las investigaciones actuales en el campo de las Neurociencias. Wimblu Rev Estud Psicol. 2019;14(1):25-53.
Bueno D. La neurociencia como fundamento de la educación emocional Neuroscience as a Basis of Emotional Education Introducción. Rev Int Educ Emoc. 2021;1:47-61.
Bitzer-Quintero OK, Ortiz GG, Jaramillo-Bueno S, Ramos-González EJ, Márquez-Rosales MG, Delgado-Lara DLC, et al. Psycho-Neuro-Endocrine- Immunology: A Role for Melatonin in This New Paradigm. Molecules. 2022;27(15):4888.
Vernaza-Pinz P, Posadas-P L. Dolor y emoción, una reflexión para el profesional en ciencias de la salud. Duazary. 2019;16(1):145-155.
Soria V, Uribe J, Salvat-Pujol N, Palao D. Psiconeuroinmunología de los trastornos mentales. Rev Psiquiatr y Salud Ment. 2017;11:115-124.
Moscoso MS. Chronic stress and the Mindfulness- Based Cognitive Therapy: A new dimension in psychoneuroimmunology. Pers Rev la Fac Psicol. 2010;(13):11-29.
Álvaro T, Traver F. Una visión psiconeuroinmuno-lógica de la fibromialgia. Rev Psicopatol Psicol Clín 2010;15(3):149-163.
Linares V, Rivero R, Piqueras A, García L, Armando L. Psiconeuroinmunología: conexiones entre sistema nervioso y sistema inmune. Suma Psicológica. 2008;15(15):115-142.
Andrea D, Actis M, Dra P, Outomuro D. Medicine and stress: Historical background and scientific evidence. Gac Méd Caracas. 2018;119(3):183-187.
Solano R, Velásquez V. Efecto inmunomodulador del estrés psicológico. Bárbula. 2012;16(1):51-57.
Kuthati Y, Davuluri VNG, Yang CP, Chang HC, Chang CP, Wong CS. Melatonin MT2 receptor agonist IIK-7 produces antinociception by modulation of ROS and suppression of spinal microglial activation in neuropathic pain rats. J Pain Res. 2019;12:2473- 2485.
Molina T. Psiconeuroinmunoendocrinología, emociones y enfermedad. MedULA, Rev Fac Med Univ Los Andes. 2009;18:155-163.
Sánchez-Teruel D, Robles-Bello M. Psiconeuro-inmunología: hacia la transdisciplinariedad en la salud. Educ Médica. 2018;19:171-178.
Alessi MG, Bennett JM. Mental health is the health of the whole body: How psychoneuroimmunology & health psychology can inform & improve treatment. J Eval Clin Pract. 2020;26(5):1539-1547.
Slavich GM. Psychoneuroimmunology of Stress and Mental Health. The Oxford Handbook of Stress and Mental Health. 2020:518-546.
Moraes LJ, Miranda MB, Loures LF, Mainieri AG, Mármora CHC. A systematic review of psychoneuroimmunology-based interventions. Psychol Heal Med. 2018;23(6):635-652.
Cohen S, Herbert TB. Health Psychology: Psychological Factors and Physical Disease from the Perspective of Human Psychoneuroimmunology. Ann Rev Psychol. 1996;47:113-142.
Ehrlich KB. Attachment and psychoneuroimmunology. Curr Opin Psychol. 2019;25:96-100.
Carrico AW, Cherenack EM, Rubin LH, McIntosh R, Ghanooni D, Chavez J V, et al. Through the Looking- Glass: Psychoneuroimmunology and the Microbiome- Gut-Brain Axis in the Modern Antiretroviral Therapy Era. Psychosom Med. 2022;84(8):984-994
Zachariae R. Psychoneuroimmunology: A bio-psycho-social approach to health and disease. Scand J Psychol. 2009;50(6):645-651.
Sturmberg JP. Health and Disease Are Dynamic Complex-Adaptive States Implications for Practice and Research. Front Psychiatry. 2021;12.
González-Díaz SN, Arias-Cruz A, Elizondo- Villarreal B, Monge-Ortega OP. Psychoneuro-immunoendocrinology: Clinical implications. World Allergy Organ J. 2017;10(1):19.
Chen MA, Leroy AS, Majd M, Chen JY, Brown RL, Christian LM, et al. Immune and Epigenetic Pathways Linking Childhood Adversity and Health Across the Lifespan. Front Psychol. 2021;12:788351.
Benros ME, Waltoft BL, Nordentoft M, Ostergaard SD, Eaton WW, Krogh J, et al. Autoimmune Diseases and Severe Infections as Risk Factors for Mood Disorders A Nationwide Study. JAMA Psychiatry. 2013;70(8):812-820.
Kelley KW, Peng Y, Liu Q, Chang H, Spencer SJ, Hutchinson MR, et al. Psychoneuroimmunology goes East: Development of the PNIRS China affiliate and its expansion into PNIRS Asia-Pacific. Brain Behav Immunity. 2020;88:75-187.
Seiler A, von Känel R, Slavich GM. The Psychobiology of Bereavement and Health: A Conceptual Review From the Perspective of Social Signal Transduction Theory of Depression. Front Psychiatry. 2020;11:565239.
Shields GS, Kuchenbecker SY, Pressman SD, Sumida KD, Slavich GM. Better cognitive control of emotional information is associated with reduced pro-inflammatory cytokine reactivity to emotional stress. Stress. 2016;19(1):63-68.
Capuron L, Castanon N. Role of Inflammation in the Development of Neuropsychiatric Symptom Domains: Evidence and Mechanisms. Brain Imaging Behav Neurosci. 2012;289-320.
Chen Y, Baram TZ. Toward understanding how early-life stress reprograms cognitive and emotional brain networks. Neuropsychopharmacology. 2016;41(1):197-206.
Schulz KH, Gold S. Psychische belastung, immunfunktionen und krankheitsentwicklungen. Die psychoneuroimmunologische perspektive. Bundesgesundheitsblatt - Gesundheitsforsch - Gesundheitsschutz. 2006;49(8):759-772.
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spelling Hernández-Flórez, JorgeOrtiz-González, Andrea LilianaLhoeste-Charris, ÁlvaroKlimenko, OlenaMoncada-Navas, FranciaHernández-Flórez, NubiaCorporación Universitaria del Caribe - CECARDimensiones Humanas (DH)2025-08-28T00:41:01Z2023https://repositorio.cecar.edu.co/handle/cecar/107720367-4762The study focused on conducting a meta-analytic review of three variables psychoneuroimmunology, emotions, and the immune system, intending to find a relationship between them. The methodology was the PRISMA statement with inclusion criteria: production of the last five years, full text, exclusion criteria: book chapters, reviews, editorials, letters to the editorials, as well as systematic and meta-analytic reviews; a formula was created from the variables with Boolean operators (AND, OR, NOT) in databases: Web of Science, PubMed and Elsevier. The first sweep denotes (n=2237) articles and after the application of the screening, the final sample was (n=26). Among the findings is the emergence of three categories of analysis using a word map: cognitive abilities, mental fatigue, and stressors. In conclusion, psychoneuroimmunology is a science that articulates mental processes and the functioning of the nervous, immune, and endocrine systems that affect the individual in such a way that the psychological aspects linked to emotional management and control can present better management and intervention in mental illnesses.El estudio se centró en la realización de una revisión meta-analítica de tres variables psiconeuroinmuno-logía, emociones, y el sistema inmunológico, con la intención de encontrar una relación entre ellos. La metodología fue la declaración PRISMA con criterios de inclusión: producción investigative de los últimos cinco años con texto completo; y criterios de exclusión: capítulos de libros, reseñas, editoriales, cartas a los editoriales, así como revisiones sistemáticas y meta-revisiones analíticas; se creó una fórmula a partir de las variables con operadores booleanos (AND, OR, NOT) en bases de datos: Web of Science, PubMed y Elsevier. El primer barrido arrojo (n=2237) artículos y después de la aplicación del cribado, la muestra final fue (n=26). Entre los hallazgos se encuentra la aparición de tres categorías de análisis utilizando un mapa de palabras: capacidades cognitivas, fatiga mental y factores estresantes. En conclusión, la psiconeuroinmunología es una ciencia que articula los procesos mentales y el funcionamiento de los sistemas inmunológicos y endocrinos son afectados por los aspectos psicológicos relacionados con el manejo y control emocional, siendo necesario un mejor manejo e intervención de estos en las enfermedades mentales.Deporte, actividad física y salud.Desarrollo cognitivo, salud mental y neuropsicología.Gestión ciudadana y del estado en el desarrollo organizacional, social y comunitario.Vulnerabilidad social y grupos poblacionales.21 páginasapplication/pdfengDerechos Reservados - Corporación Universitaria del Caribe CECARhttps://creativecommons.org/licenses/by-nc/4.0/Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2https://doi.org/10.47307/GMC.2023.131.s3.20Emotions, anxiety, depression and the immune system: an integrative view of psychoneuroimmunology from a meta-analytic review of the narrative /Artículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/resource_type/c_18wsTextinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/IFIinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Colombia4633444Volumen 131Gaceta Médica de CaracasPeña-Vargas C, Armaiz-Peña G. Behavioral sciences A Biopsychosocial Approach to Grief, Depression, and the Role of Emotional Regulation. Behav Sci (Basel). 2021;11(8):110.Kiecolt-Glaser JK, McGuire L, Robles TF, Glaser R. Emotions, morbidity, and mortality: New perspectives from psychoneuroimmunology. Ann Rev Psychol. 2002;53:83-107.Zachariae R. Psychoneuroimmunology : A bio-psycho-social approach to health and disease. Scand J Psychol. 2009;50(6):645–51.Lugović-Mihić L, Mihatović D, Šitum M. Psychoneuroimmunology and skin diseases. Rad Hrvat Akad Znan i Umjet Med Znan. 2019;537(46- 47):25-36.Kautz MM. Applications of psychoneuroimmunology models of toxic stress in prevention and intervention efforts across early development. Brain, Behav Immun Heal. 2021;16:100322.D’Acquisto F. Affective immunology: Where emotions and the immune response converge. Dialogues Clin Neurosci. 2017;19(1):9-19.Jaremka LM, Lindgren ME, Kiecolt-Glaser JK. Synergistic relationships among stress, depression, and troubled relationships: insights from psychoneuroimmunology. Depress Anxiety. 2013;30(4):288-296.Littrell JL. The Importance of Psychoneuroimmunology for Social Workers. Fam Soc. 2019;100(1):17-33.Shields GS, Spahr CM, Slavich GM. Psychosocial Interventions and Immune System Function: A Systematic Review and Meta-analysis of Randomized Clinical Trials. JAMA Psychiatry. 2020;77(10):1031- 1043.Murray DR, Prokosch ML, Airington Z. PsychoBehavioroimmunology: Connecting the behavioral immune system to its physiological foundations. Front Psychol. 2019;10:1-7.Ulloa A, Sánchez R. Metaconocimientos de los estados emocionales de estudiantes de educación superior Meta-knowledge of the emotional states of higher education students. Cienc Lat Rev Científica Multidiscip. 2022;7:445-459.Hernández-Flórez N, Moncada-Navas F, Lhoeste- Charris A, Klimenko O, Ortíz-González A. Habilidades de pensamiento crítico creativo e inteligencia emocional en estudiantes universitarios: Una revisión bibliométrica desde la literatura. Cienc Lat Rev Científica Multidiscip. 2022;6:2029-2054.Molina J. Psiconeuroinmunología: una propuesta no inmune a la critica. Cent Centroaméricano José Simeón. 2020;1(1):15-18.Hernández-Flórez N, Leal-Leal GA, Mogollón-Canal OM, Moreno-Salgado A, Rodríguez-Rivera D, Vergel- Rodríguez C, et al. Variables de personalidad y estilos de vida saludable en estudiantes universitarios de la Corporación Universitaria Minuto de Dios en el centro regional Cúcuta. Inf Psicológicos. 2020;20(2):83-94Pérez L, Moré C, González Y, Alemán A. Psychoneuroendocrinoimmunology: Claim for a comprehensive vision in medical studies. Edumecentro. 2019;11(3):254-261Jara C, Acuña L, Gengler J. Estrés e Inmunidad. Medwave. 2001;1(11):171-174.Sánchez-Serrano S, Pedraza-Navarro I, Donoso- González M. How to conduct a systematic review under PRISMA protocol? Uses and fundamental strategies for its application in the educational field through a practical case study. Bordon Rev Pedagog. 2022;74(3):51-66.Hutton B, Catalá-lópez F, Moher D. La extensión de la declaración PRISMA para revisiones sistemáticas que incorporan metaanálisis en red: PRISMA-NMA. Med Clin (Barc). 2016;(xx):10-14.Page M, McKenzie J, Bossuyt P. Declaración PRISMA 2020: Una guía actualizada para la publicación de las revisiones sistemáticas. Rev Esp Cardiol. 2021;74(9):790-799.Barrios-Serna K, Orozco-Núñez D, Pérez-Navas E, Conde-Cardona G. Nuevas recomendaciones de la versión PRISMA 2020 para revisiones sistemáticas y metaanálisis. Acta Neurol Colomb. 2021;37(2):105- 106.Benavidez V, Flores R. La importancia de las emociones para la neurodidáctica The importance of emotions for the neurodidactics Introducción Los resultados de las investigaciones actuales en el campo de las Neurociencias. Wimblu Rev Estud Psicol. 2019;14(1):25-53.Bueno D. La neurociencia como fundamento de la educación emocional Neuroscience as a Basis of Emotional Education Introducción. Rev Int Educ Emoc. 2021;1:47-61.Bitzer-Quintero OK, Ortiz GG, Jaramillo-Bueno S, Ramos-González EJ, Márquez-Rosales MG, Delgado-Lara DLC, et al. Psycho-Neuro-Endocrine- Immunology: A Role for Melatonin in This New Paradigm. Molecules. 2022;27(15):4888.Vernaza-Pinz P, Posadas-P L. Dolor y emoción, una reflexión para el profesional en ciencias de la salud. Duazary. 2019;16(1):145-155.Soria V, Uribe J, Salvat-Pujol N, Palao D. Psiconeuroinmunología de los trastornos mentales. Rev Psiquiatr y Salud Ment. 2017;11:115-124.Moscoso MS. Chronic stress and the Mindfulness- Based Cognitive Therapy: A new dimension in psychoneuroimmunology. Pers Rev la Fac Psicol. 2010;(13):11-29.Álvaro T, Traver F. Una visión psiconeuroinmuno-lógica de la fibromialgia. Rev Psicopatol Psicol Clín 2010;15(3):149-163.Linares V, Rivero R, Piqueras A, García L, Armando L. Psiconeuroinmunología: conexiones entre sistema nervioso y sistema inmune. Suma Psicológica. 2008;15(15):115-142.Andrea D, Actis M, Dra P, Outomuro D. Medicine and stress: Historical background and scientific evidence. Gac Méd Caracas. 2018;119(3):183-187.Solano R, Velásquez V. Efecto inmunomodulador del estrés psicológico. Bárbula. 2012;16(1):51-57.Kuthati Y, Davuluri VNG, Yang CP, Chang HC, Chang CP, Wong CS. Melatonin MT2 receptor agonist IIK-7 produces antinociception by modulation of ROS and suppression of spinal microglial activation in neuropathic pain rats. J Pain Res. 2019;12:2473- 2485.Molina T. Psiconeuroinmunoendocrinología, emociones y enfermedad. MedULA, Rev Fac Med Univ Los Andes. 2009;18:155-163.Sánchez-Teruel D, Robles-Bello M. Psiconeuro-inmunología: hacia la transdisciplinariedad en la salud. Educ Médica. 2018;19:171-178.Alessi MG, Bennett JM. Mental health is the health of the whole body: How psychoneuroimmunology & health psychology can inform & improve treatment. J Eval Clin Pract. 2020;26(5):1539-1547.Slavich GM. Psychoneuroimmunology of Stress and Mental Health. The Oxford Handbook of Stress and Mental Health. 2020:518-546.Moraes LJ, Miranda MB, Loures LF, Mainieri AG, Mármora CHC. A systematic review of psychoneuroimmunology-based interventions. Psychol Heal Med. 2018;23(6):635-652.Cohen S, Herbert TB. Health Psychology: Psychological Factors and Physical Disease from the Perspective of Human Psychoneuroimmunology. Ann Rev Psychol. 1996;47:113-142.Ehrlich KB. Attachment and psychoneuroimmunology. Curr Opin Psychol. 2019;25:96-100.Carrico AW, Cherenack EM, Rubin LH, McIntosh R, Ghanooni D, Chavez J V, et al. Through the Looking- Glass: Psychoneuroimmunology and the Microbiome- Gut-Brain Axis in the Modern Antiretroviral Therapy Era. Psychosom Med. 2022;84(8):984-994Zachariae R. Psychoneuroimmunology: A bio-psycho-social approach to health and disease. Scand J Psychol. 2009;50(6):645-651.Sturmberg JP. Health and Disease Are Dynamic Complex-Adaptive States Implications for Practice and Research. Front Psychiatry. 2021;12.González-Díaz SN, Arias-Cruz A, Elizondo- Villarreal B, Monge-Ortega OP. Psychoneuro-immunoendocrinology: Clinical implications. World Allergy Organ J. 2017;10(1):19.Chen MA, Leroy AS, Majd M, Chen JY, Brown RL, Christian LM, et al. Immune and Epigenetic Pathways Linking Childhood Adversity and Health Across the Lifespan. Front Psychol. 2021;12:788351.Benros ME, Waltoft BL, Nordentoft M, Ostergaard SD, Eaton WW, Krogh J, et al. Autoimmune Diseases and Severe Infections as Risk Factors for Mood Disorders A Nationwide Study. JAMA Psychiatry. 2013;70(8):812-820.Kelley KW, Peng Y, Liu Q, Chang H, Spencer SJ, Hutchinson MR, et al. Psychoneuroimmunology goes East: Development of the PNIRS China affiliate and its expansion into PNIRS Asia-Pacific. Brain Behav Immunity. 2020;88:75-187.Seiler A, von Känel R, Slavich GM. The Psychobiology of Bereavement and Health: A Conceptual Review From the Perspective of Social Signal Transduction Theory of Depression. Front Psychiatry. 2020;11:565239.Shields GS, Kuchenbecker SY, Pressman SD, Sumida KD, Slavich GM. Better cognitive control of emotional information is associated with reduced pro-inflammatory cytokine reactivity to emotional stress. Stress. 2016;19(1):63-68.Capuron L, Castanon N. Role of Inflammation in the Development of Neuropsychiatric Symptom Domains: Evidence and Mechanisms. Brain Imaging Behav Neurosci. 2012;289-320.Chen Y, Baram TZ. Toward understanding how early-life stress reprograms cognitive and emotional brain networks. Neuropsychopharmacology. 2016;41(1):197-206.Schulz KH, Gold S. Psychische belastung, immunfunktionen und krankheitsentwicklungen. Die psychoneuroimmunologische perspektive. 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