Influencia de Hormonas Reguladoras del Apetito en Trastornos Alimentarios: Leptina y Grelina como Protagonistas: una revisión narrativa.

Esta revisión narrativa tuvo como objetivo examinar y analizar el juego de las hormonas reguladoras del apetito y la saciedad, grelina y leptina, dentro de diferentes trastornos de la conducta alimentaria, entre ellos la anorexia nerviosa y el trastorno por atracón. Mediante el análisis de estudios...

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Autores:
Bernal Arias, María Fernanda
Tipo de recurso:
Fecha de publicación:
2025
Institución:
Universidad Libre
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RIU - Repositorio Institucional UniLibre
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OAI Identifier:
oai:repository.unilibre.edu.co:10901/31519
Acceso en línea:
https://hdl.handle.net/10901/31519
Palabra clave:
Leptina
grelina
trastornos de la conducta alimentaria
anorexia nerviosa
trastorno por atracón
regulación del apetito
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openAccess
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http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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network_acronym_str RULIBRE2
network_name_str RIU - Repositorio Institucional UniLibre
repository_id_str
dc.title.spa.fl_str_mv Influencia de Hormonas Reguladoras del Apetito en Trastornos Alimentarios: Leptina y Grelina como Protagonistas: una revisión narrativa.
dc.title.alternative.spa.fl_str_mv Influence of Appetite-Regulating Hormones in Eating Disorders: Leptin and Ghrelin as Protagonists: A Narrative Review.
title Influencia de Hormonas Reguladoras del Apetito en Trastornos Alimentarios: Leptina y Grelina como Protagonistas: una revisión narrativa.
spellingShingle Influencia de Hormonas Reguladoras del Apetito en Trastornos Alimentarios: Leptina y Grelina como Protagonistas: una revisión narrativa.
Leptina
grelina
trastornos de la conducta alimentaria
anorexia nerviosa
trastorno por atracón
regulación del apetito
title_short Influencia de Hormonas Reguladoras del Apetito en Trastornos Alimentarios: Leptina y Grelina como Protagonistas: una revisión narrativa.
title_full Influencia de Hormonas Reguladoras del Apetito en Trastornos Alimentarios: Leptina y Grelina como Protagonistas: una revisión narrativa.
title_fullStr Influencia de Hormonas Reguladoras del Apetito en Trastornos Alimentarios: Leptina y Grelina como Protagonistas: una revisión narrativa.
title_full_unstemmed Influencia de Hormonas Reguladoras del Apetito en Trastornos Alimentarios: Leptina y Grelina como Protagonistas: una revisión narrativa.
title_sort Influencia de Hormonas Reguladoras del Apetito en Trastornos Alimentarios: Leptina y Grelina como Protagonistas: una revisión narrativa.
dc.creator.fl_str_mv Bernal Arias, María Fernanda
dc.contributor.advisor.none.fl_str_mv Campos Ceballos, Frank stiven
dc.contributor.author.none.fl_str_mv Bernal Arias, María Fernanda
dc.subject.spa.fl_str_mv Leptina
grelina
trastornos de la conducta alimentaria
anorexia nerviosa
trastorno por atracón
regulación del apetito
topic Leptina
grelina
trastornos de la conducta alimentaria
anorexia nerviosa
trastorno por atracón
regulación del apetito
description Esta revisión narrativa tuvo como objetivo examinar y analizar el juego de las hormonas reguladoras del apetito y la saciedad, grelina y leptina, dentro de diferentes trastornos de la conducta alimentaria, entre ellos la anorexia nerviosa y el trastorno por atracón. Mediante el análisis de estudios clínicos, se pudo evidenciar que estas hormonas muestran alteraciones significativas en los trastornos alimentarios, las cuales parecen estar relacionados con el estado nutricional y la conducta alimentaria. Se evidenciaron niveles disminuidos de leptina en el trastorno de anorexia nerviosa y niveles elevados en el trastorno por atracón. Por el contrario, la grelina mostró un comportamiento elevado en la anorexia nerviosa y disminuido en el trastorno por atracón. De igual forma ,se identificaron posibles influencias epigenéticas y neurobiológicas que podrían tener implicación en la disfunción de las señales del hambre y la saciedad. Estos resultados destacan la importancia de proponer un enfoque más integral ,donde se incluya el análisis hormonal en el tratamiento nutricional de los trastornos de la conducta alimentaria.
publishDate 2025
dc.date.accessioned.none.fl_str_mv 2025-07-17T14:28:15Z
dc.date.available.none.fl_str_mv 2025-07-17T14:28:15Z
dc.date.created.none.fl_str_mv 2025-06-10
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.local.spa.fl_str_mv Tesis de Pregrado
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/bachelorThesis
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10901/31519
url https://hdl.handle.net/10901/31519
dc.relation.references.spa.fl_str_mv 1. Scaglioni S, De Cosmi V, Ciappolino V, Brambilla P, Agostoni C. Factors Influencing Children's Eating Behaviours. Nutrients. 2018;10(6):706. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024598/ 2. Inoue S, Nakao H, Fujikawa T, Denda K, Nakahara T. The Role of Ghrelin in Anorexia Nervosa. Curr Protein Pept Sci. 2018;19(7):758-764. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073411/ 3. Seidel M, Markmann Jensen S, Healy D, Dureja A, Watson HJ, Holst B, et al. A Systematic Review and Meta-Analysis Finds Increased Blood Levels of All Forms of Ghrelin in Both Restricting and Binge-Eating/Purging Subtypes of Anorexia Nervosa. Nutrients. 2021;13(2):709. Disponible en: https://www.mdpi.com/2072-6643/13/2/709 4. Blume M, Friedrichs S, Gronwald B, et al. Leptin, but not ghrelin, is associated with food addiction scores in a young female population. Front Psychiatry. 2023;14:1200021. Disponible en: https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1200021/full 5. World Healt
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3. Seidel M, Markmann Jensen S, Healy D, Dureja A, Watson HJ, Holst B, et al. A Systematic Review and Meta-Analysis Finds Increased Blood Levels of All Forms of Ghrelin in Both Restricting and Binge-Eating/Purging Subtypes of Anorexia Nervosa.
4. Blume M, Friedrichs S, Gronwald B, et al. Leptin, but not ghrelin, is associated with food addiction scores in a young female population. Front Psychiatry. 2023;14:1200021. Disponible en: https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1200021/full
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13. Misra M, Klibanski A. Endocrine consequences of anorexia nervosa. Lancet Diabetes Endocrinol. 2014;2(7):581-592. Disponible en: https://pubmed.ncbi.nlm.nih.gov/24731664/
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15. Miller KK, Grinspoon SK, Ciampa J, Hier J, Herzog D, Klibanski A. Leptin levels in acute and recovered eating disorders: A BMI-adjusted meta-analysis. J Clin Endocrinol Metab. 2020;105(4):e1613-e1623. Disponible en: https://pubmed.ncbi.nlm.nih.gov/39643920/
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17. Friedman J. Leptin and the endocrine control of energy balance. Nat Metab. 2019;1(8):754-764. Disponible en: https://www.nature.com/articles/s42255-019-0095-yNature
18. Batury VL, van Elburg AA, Kas MJ, Henneman P. DNA methylation of ghrelin and leptin receptors in underweight and weight-recovered females with anorexia nervosa. J Psychiatr Res. 2020;130:283-290. Disponible en:
19. Hübel C, Gaspar HA, Coleman JRI, Hanscombe KB, Purves K, Prokopenko I, et al. Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent. Nat Commun. 2019;10(1):5765. Disponible en: https://www.nature.com/articles/s41467-019-13544-0Home Page+1Repositorio Digital de Carolina+1
20. Monteleone P, Di Lieto A, Tortorella A, Longobardi N, Maj M. Circulating levels of leptin and soluble leptin receptor across the eating disorder spectrum. J Psychiatr Res. 2002;36(5):391–7. doi:10.1016/S0022-3956(02)00019-3.
21. Westwater ML, Mancini F, Shapleske J, Serfontein J, Ernst M, Ziauddeen H, et al. Dissociable hormonal profiles for psychopathology and stress in anorexia and bulimia nervosa. Psychol Med. 2021;51(16):2814–24. doi:10.1017/S0033291720001440.
22. Kim YR, Lauze MS, Slattery M, Perlis RH, Holsen LM, Breithaupt L, et al. Association between ghrelin and body weight trajectory in individuals with anorexia nervosa. JAMA Netw Open. 2023;6(3):e234625. doi:10.1001/jamanetworkopen.2023.4625.
23. García-González CL, Romero-Velarde E, Gurrola-Díaz CM, Sánchez-Muñoz MP, Soto-Luna GIC. Perfil metabólico, concentración de grelina y obestatina en niños y adolescentes con obesidad. Rev Med Inst Mex Seguro Soc. 2022;60(3):268–74. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC10399755/pdf/04435117-60-3-268.pdf.
24. Urbanovych A, Laniush F. The role of appetite-controlling hormones in the development of eating disorders in diabetic 2 patients. Curr Issues Pharm Med Sci. 2022;35(2):86–8. doi:10.2478/cipms-2022-0016.
25. Kaye WH, Wierenga CE, Bischoff-Grethe A, Berner LA, Ely AV, Bailer UF, et al. Neural insensitivity to the effects of hunger in women remitted from anorexia nervosa. Am J Psychiatry. 2020;177(7):601–10. doi:10.1176/appi.ajp.2019.19030261.
26. Stengel A, Tache Y. Ghrelin – a pleiotropic hormone secreted from endocrine x/a-like cells of the stomach. Front Neurosci. 2012;6:24. Disponible en: https://www.frontiersin.org/articles/10.3389/fnins.2012.00024/full
27. Misra M, Miller KK, Kuo K, Griffin K, Stewart V, Hunter E, et al. Secretory dynamics of ghrelin in adolescent girls with anorexia nervosa and healthy adolescents. Am J Physiol Endocrinol Metab. 2005;289(2):E347–56. Disponible en: https://doi.org/10.1152/ajpendo.00074.2005
28. Seidel M, Jensen SM, Healy D, Dureja A, Watson HJ, Holst B, et al. A systematic review and meta-analysis finds increased blood levels of all forms of ghrelin in both restricting and binge-eating/purging subtypes of anorexia nervosa. Nutrients. 2021;13(2):709. Disponible en: https://www.mdpi.com/2072-6643/13/2/709
29. Harrold JA, Dovey TM, Blundell JE, Halford JC. CNS regulation of appetite. Neuropharmacology. 2012;63(1):3–17. Disponible en: https://doi.org/10.1016/j.neuropharm.2012.01.013
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44. Holtkamp K, Herpertz-Dahlmann B, Mika C, Heer M, Heussen N, Fichter M, et al. High physical activity and low leptin levels co-occur in patients with anorexia nervosa. J Clin Endocrinol Metab. 2003;88(11):5169–74.
45. Verhagen LAW, Luijendijk HJ, Adan RAH. Leptin and Physical Activity in Adult Patients with Anorexia Nervosa: Failure to Demonstrate a Simple Linear Association. Nutrients. 2017;9(11):1210. doi: 10.3390/nu9111210.
46. Gómez-Peresmitré G, Acosta-Ramírez N, Platas-Acevedo RS. Trastornos de la conducta alimentaria en estudiantes universitarios: un problema latente. Av Enferm [Internet]. 2017 [citado 2025 Abr 6];35(1):53-62. Disponible en: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-52562017000100005
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spelling Campos Ceballos, Frank stivenBernal Arias, María FernandaPereira2025-07-17T14:28:15Z2025-07-17T14:28:15Z2025-06-10https://hdl.handle.net/10901/31519Esta revisión narrativa tuvo como objetivo examinar y analizar el juego de las hormonas reguladoras del apetito y la saciedad, grelina y leptina, dentro de diferentes trastornos de la conducta alimentaria, entre ellos la anorexia nerviosa y el trastorno por atracón. Mediante el análisis de estudios clínicos, se pudo evidenciar que estas hormonas muestran alteraciones significativas en los trastornos alimentarios, las cuales parecen estar relacionados con el estado nutricional y la conducta alimentaria. Se evidenciaron niveles disminuidos de leptina en el trastorno de anorexia nerviosa y niveles elevados en el trastorno por atracón. Por el contrario, la grelina mostró un comportamiento elevado en la anorexia nerviosa y disminuido en el trastorno por atracón. De igual forma ,se identificaron posibles influencias epigenéticas y neurobiológicas que podrían tener implicación en la disfunción de las señales del hambre y la saciedad. Estos resultados destacan la importancia de proponer un enfoque más integral ,donde se incluya el análisis hormonal en el tratamiento nutricional de los trastornos de la conducta alimentaria.Universidad Libre Seccional Pereira -- Facultad de Ciencias de la Salud, Exactas y Naturales -- Nutrición y DietéticaThis narrative review aimed to examine and analyze the role of appetite- and satiety-regulating hormones, ghrelin and leptin, in various eating disorders, including anorexia nervosa and binge eating disorder. Through the analysis of clinical studies, it was shown that these hormones show significant alterations in eating disorders, which appear to be related to nutritional status and eating behavior. Decreased leptin levels were observed in anorexia nervosa and elevated levels in binge eating disorder. In contrast, ghrelin was elevated in anorexia nervosa and decreased in binge eating disorder. Similarly, potential epigenetic and neurobiological influences that could be implicated in the dysfunction of hunger and satiety signals were identified. These results highlight the importance of proposing a more comprehensive approach, including hormonal analysis in the nutritional treatment of eating disorders.PDFhttp://creativecommons.org/licenses/by-nc-nd/2.5/co/Atribución-NoComercial-SinDerivadas 2.5 Colombiainfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Leptinagrelinatrastornos de la conducta alimentariaanorexia nerviosatrastorno por atracónregulación del apetitoInfluencia de Hormonas Reguladoras del Apetito en Trastornos Alimentarios: Leptina y Grelina como Protagonistas: una revisión narrativa.Influence of Appetite-Regulating Hormones in Eating Disorders: Leptin and Ghrelin as Protagonists: A Narrative Review.Tesis de Pregradoinfo:eu-repo/semantics/bachelorThesishttp://purl.org/coar/resource_type/c_7a1f1. Scaglioni S, De Cosmi V, Ciappolino V, Brambilla P, Agostoni C. Factors Influencing Children's Eating Behaviours. Nutrients. 2018;10(6):706. 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