Effect of histone demethylation on differentiation of pancreatic beta cells derived from induced pluripotent cells
Diabetes mellitus is one of the most frequent causes of mortality in the world, and its close etiological relationship with obesity makes the increase in prevalence continuously higher, especially in developing countries. Diabetes mellitus consists of two main clinical pictures: type 1 diabetes mell...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2025
- Institución:
- Universidad de la Sabana
- Repositorio:
- Repositorio Universidad de la Sabana
- Idioma:
- eng
- OAI Identifier:
- oai:intellectum.unisabana.edu.co:10818/67059
- Acceso en línea:
- https://hdl.handle.net/10818/67059
- Palabra clave:
- Diabetes mellitus
Obesidad
Mortalidad
Prevalencia
Enfermedades crónicas no transmisibles
- Rights
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Effect of histone demethylation on differentiation of pancreatic beta cells derived from induced pluripotent cellsDiabetes mellitusObesidadMortalidadPrevalenciaEnfermedades crónicas no transmisiblesDiabetes mellitus is one of the most frequent causes of mortality in the world, and its close etiological relationship with obesity makes the increase in prevalence continuously higher, especially in developing countries. Diabetes mellitus consists of two main clinical pictures: type 1 diabetes mellitus, characterized by the destruction of insulin-producing cells due to an autoimmune attack, and type 2 diabetes mellitus, in which the deterioration of insulin-producing pancreatic beta cells is partial, and insulin activity is impaired by resistance to its action in the tissues. Multiple therapeutic plans exist for chronic diabetes therapy, including subcutaneous insulin administration. However, the presence of cardiovascular complications means that the life expectancy and quality of life of diabetics are significantly impaired. La diabetes mellitus es una de las causas más frecuentes de mortalidad en el mundo y su estrecha relación etiológica con la obesidad, hace que el aumento en la prevalencia sea continuamente mayor, especialmente en los países en vías de desarrollo. La diabetes mellitus está constituida por dos principales cuadros clínicos: la diabetes mellitus tipo 1 caracterizada por una destrucción completa de las células productoras de insulina debido a un ataque autoinmune y la diabetes mellitus tipo 2, en la que el deterioro de las células beta pancreáticas productoras de insulina es parcial y la actividad de la insulina está deteriorada por resistencia a su acción en los tejidos. Múltiples planes terapéuticos existen para la terapia crónica de la diabetes, dentro de los que se incluye la administración subcutánea de insulina. Sin embargo, la presencia de complicaciones cardiovasculares hace que la expectativa y la calidad de vida de los diabéticos este muy deteriorada. Doctor en BiocienciasDoctoradoUniversidad de La SabanaDoctorado en BiocienciasFacultad de IngenieríaLizcano Losada, FernandoArroyave Rovida, Felipe Esteban2025-10-02T22:07:17Z2025-05-05Tesis/Trabajo de grado – Doctoradohttp://purl.org/coar/resource_type/c_db06http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersion125 páginasapplication/pdfapplication/pdfapplication/pdfhttps://hdl.handle.net/10818/67059engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_16ecoai:intellectum.unisabana.edu.co:10818/670592025-11-12T09:00:34Z |
| dc.title.none.fl_str_mv |
Effect of histone demethylation on differentiation of pancreatic beta cells derived from induced pluripotent cells |
| title |
Effect of histone demethylation on differentiation of pancreatic beta cells derived from induced pluripotent cells |
| spellingShingle |
Effect of histone demethylation on differentiation of pancreatic beta cells derived from induced pluripotent cells Diabetes mellitus Obesidad Mortalidad Prevalencia Enfermedades crónicas no transmisibles |
| title_short |
Effect of histone demethylation on differentiation of pancreatic beta cells derived from induced pluripotent cells |
| title_full |
Effect of histone demethylation on differentiation of pancreatic beta cells derived from induced pluripotent cells |
| title_fullStr |
Effect of histone demethylation on differentiation of pancreatic beta cells derived from induced pluripotent cells |
| title_full_unstemmed |
Effect of histone demethylation on differentiation of pancreatic beta cells derived from induced pluripotent cells |
| title_sort |
Effect of histone demethylation on differentiation of pancreatic beta cells derived from induced pluripotent cells |
| dc.contributor.none.fl_str_mv |
Lizcano Losada, Fernando |
| dc.subject.none.fl_str_mv |
Diabetes mellitus Obesidad Mortalidad Prevalencia Enfermedades crónicas no transmisibles |
| topic |
Diabetes mellitus Obesidad Mortalidad Prevalencia Enfermedades crónicas no transmisibles |
| description |
Diabetes mellitus is one of the most frequent causes of mortality in the world, and its close etiological relationship with obesity makes the increase in prevalence continuously higher, especially in developing countries. Diabetes mellitus consists of two main clinical pictures: type 1 diabetes mellitus, characterized by the destruction of insulin-producing cells due to an autoimmune attack, and type 2 diabetes mellitus, in which the deterioration of insulin-producing pancreatic beta cells is partial, and insulin activity is impaired by resistance to its action in the tissues. Multiple therapeutic plans exist for chronic diabetes therapy, including subcutaneous insulin administration. However, the presence of cardiovascular complications means that the life expectancy and quality of life of diabetics are significantly impaired. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025-10-02T22:07:17Z 2025-05-05 |
| dc.type.none.fl_str_mv |
Tesis/Trabajo de grado – Doctorado http://purl.org/coar/resource_type/c_db06 http://purl.org/coar/version/c_970fb48d4fbd8a85 info:eu-repo/semantics/doctoralThesis info:eu-repo/semantics/publishedVersion |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10818/67059 |
| url |
https://hdl.handle.net/10818/67059 |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.rights.none.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_16ec |
| rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_16ec |
| dc.format.none.fl_str_mv |
125 páginas application/pdf application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Universidad de La Sabana Doctorado en Biociencias Facultad de Ingeniería |
| publisher.none.fl_str_mv |
Universidad de La Sabana Doctorado en Biociencias Facultad de Ingeniería |
| institution |
Universidad de la Sabana |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1850008186014138368 |