Study on the interaction between diet, quercetin and intestinal microbiota

135 páginas

Autores:

Tipo de recurso:

Fecha de publicación:: 2020

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

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spelling	Study on the interaction between diet, quercetin and intestinal microbiotaFlavonoidesMetabolitos microbianosMicrobioma gastrointestinalMembranas plasmáticas135 páginasFlavonoids are secondary metabolites of plants which have anti-cancer, anti-inflammatory, and antioxidant properties. However, the intestinal microbiota can change the bioactivity and bioavailability of these compounds, which may trigger different levels of response to a treatment. In order to expand our understanding of the capacity of the gut microbiota to modify these therapeutic compounds, we explored the microbial degradation of quercetin, one the most abundant flavonoids in the human diet. First, we revealed that a non-quercetin degrader (Bacteroides thetaiotaomicron) can provide, via crossfeeding, substrates to a quercetin-degrader (Eubacterium ramulus) for the cometabolization of the flavonoid. Second, through a metataxonomic analysis of fecal communities exposed to the flavonoid, we detected two variants related to the quercetin degrader, Flavonifractor plautii, that presented a negative correlation in their relative abundances upon incubation with quercetin. Lastly, a bioinformatic analysis of the genome of the closest relatives of these variantsshowed that they are discordant for the catabolism of an important substrate in the gastrointestinal tract, ethanolamine, which it is formed from bacterial and intestinal cell membranes and is abundant even in the absence of dietary compounds due to the constant washing away of these cells in the intestinal mucus. Overall, these observations indicate that flavonoid-degrading bacteria can be differentially affected by dietary and host¿s substrates and interactions with different microbial species. Thus, the community structure and metabolic capacity of each individual¿s gut microbiota may impact the health-related effects of these compounds.Universidad de La SabanaRey, FedericoAcosta González, Luis AlejandroRodríguez Castano, Gina Paola del Carmen5/14/2020 11:405/14/2020 11:402020-03-13Tesis/Trabajo de grado – Doctoradoinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfapplication/pdfhttps://hdl.handle.net/10818/41023276807TE10643Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaengAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2oai:intellectum.unisabana.edu.co:10818/410232025-09-05T16:33:56Z
dc.title.none.fl_str_mv	Study on the interaction between diet, quercetin and intestinal microbiota
title	Study on the interaction between diet, quercetin and intestinal microbiota
spellingShingle	Study on the interaction between diet, quercetin and intestinal microbiota Flavonoides Metabolitos microbianos Microbioma gastrointestinal Membranas plasmáticas
title_short	Study on the interaction between diet, quercetin and intestinal microbiota
title_full	Study on the interaction between diet, quercetin and intestinal microbiota
title_fullStr	Study on the interaction between diet, quercetin and intestinal microbiota
title_full_unstemmed	Study on the interaction between diet, quercetin and intestinal microbiota
title_sort	Study on the interaction between diet, quercetin and intestinal microbiota
dc.contributor.none.fl_str_mv	Rey, Federico Acosta González, Luis Alejandro
dc.subject.none.fl_str_mv	Flavonoides Metabolitos microbianos Microbioma gastrointestinal Membranas plasmáticas
topic	Flavonoides Metabolitos microbianos Microbioma gastrointestinal Membranas plasmáticas
description	135 páginas
publishDate	2020
dc.date.none.fl_str_mv	2020-03-13 5/14/2020 11:40 5/14/2020 11:40
dc.type.none.fl_str_mv	Tesis/Trabajo de grado – Doctorado info:eu-repo/semantics/acceptedVersion http://purl.org/coar/resource_type/c_db06 info:eu-repo/semantics/doctoralThesis
status_str	acceptedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10818/41023 276807 TE10643
url	https://hdl.handle.net/10818/41023
identifier_str_mv	276807 TE10643
dc.language.none.fl_str_mv	eng
language	eng
dc.rights.none.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	Universidad de La Sabana
publisher.none.fl_str_mv	Universidad de La Sabana
dc.source.none.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Study on the interaction between diet, quercetin and intestinal microbiota

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