Scoping review on population pharmacokinetics of vancomy- 2 cin in hospitalized adults

14 páginas

Autores:

Tipo de recurso:

Fecha de publicación:: 2022

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: eng

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spelling	Scoping review on population pharmacokinetics of vancomy- 2 cin in hospitalized adultsHospitalizadosFarmacocinéticaMedicamentos -- Efectos fisiológicos14 páginasVancomycin is an effective first-line therapy in MRSA infection, however, achieving an 13 appropriate serum concentration is challenging. Population pharmacokinetics can offer assistance 14 to the clinician in the selection of better regimen dosing and improve effectiveness and safety out- 15 comes. This scoping review aims to outline the evidence in population pharmacokinetic models in 16 non-critical adults hospitalized from 1980 to 2021 and describe the principal software and covaria- 17 bles used in this. A total of 209 papers were fully screened. Finally, we included 17 articles con- 18 ducted in different locations around the world. This review identified 13 retrospective articles and 19 4 prospective, 5 describing the use in a general population with gram-positive bacterial infection, 20 11 evaluated special populations (older, obese, and cancer patients), and 1 mixed population. The 21 main parameters in the models were renal clearance and volume of distribution. The principal co- 22 variables that affected the models were creatinine clearance and weight. All studies use internal 23 validation methods, and three of them used an external validation group. This scoping review high- 24 lights the principal information of different population pharmacokinetic models and the heteroge- 25 neity in the parameters and methods of evaluation. These methods can be used to guide the dosing 26 regimen in different subpopulations. However, it is imperative to define the best fit in every popu- 27 lation and conduct an experiment due to the high variability in the present studies.Universidad de La SabanaBustos Cruz, Rosa HelenaVivas Suarez, Juan DavidNivia Fonseca, Diego ArmandoBriceño, WilsonParra, DanielJaimes, Diego2022-08-29T16:14:51Z2022-08-29T16:14:51Z2022-04-28Tesis/Trabajo de grado - Especializaciónhttp://purl.org/coar/resource_type/c_7a1fTextoinfo:eu-repo/semantics/otherhttp://purl.org/redcol/resource_type/COtherinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/10818/51536286896TE11832Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaengAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2oai:intellectum.unisabana.edu.co:10818/515362025-12-11T18:44:13Z
dc.title.none.fl_str_mv	Scoping review on population pharmacokinetics of vancomy- 2 cin in hospitalized adults
title	Scoping review on population pharmacokinetics of vancomy- 2 cin in hospitalized adults
spellingShingle	Scoping review on population pharmacokinetics of vancomy- 2 cin in hospitalized adults Hospitalizados Farmacocinética Medicamentos -- Efectos fisiológicos
title_short	Scoping review on population pharmacokinetics of vancomy- 2 cin in hospitalized adults
title_full	Scoping review on population pharmacokinetics of vancomy- 2 cin in hospitalized adults
title_fullStr	Scoping review on population pharmacokinetics of vancomy- 2 cin in hospitalized adults
title_full_unstemmed	Scoping review on population pharmacokinetics of vancomy- 2 cin in hospitalized adults
title_sort	Scoping review on population pharmacokinetics of vancomy- 2 cin in hospitalized adults
dc.contributor.none.fl_str_mv	Bustos Cruz, Rosa Helena
dc.subject.none.fl_str_mv	Hospitalizados Farmacocinética Medicamentos -- Efectos fisiológicos
topic	Hospitalizados Farmacocinética Medicamentos -- Efectos fisiológicos
description	14 páginas
publishDate	2022
dc.date.none.fl_str_mv	2022-08-29T16:14:51Z 2022-08-29T16:14:51Z 2022-04-28
dc.type.none.fl_str_mv	Tesis/Trabajo de grado - Especialización http://purl.org/coar/resource_type/c_7a1f Texto info:eu-repo/semantics/other http://purl.org/redcol/resource_type/COther info:eu-repo/semantics/acceptedVersion
status_str	acceptedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10818/51536 286896 TE11832
url	https://hdl.handle.net/10818/51536
identifier_str_mv	286896 TE11832
dc.language.none.fl_str_mv	eng
language	eng
dc.rights.none.fl_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv	Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	Universidad de La Sabana
publisher.none.fl_str_mv	Universidad de La Sabana
dc.source.none.fl_str_mv	Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana
institution	Universidad de la Sabana
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Scoping review on population pharmacokinetics of vancomy- 2 cin in hospitalized adults

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