Bioprospección en actinobacterias cultivables de las riberas del río Arauca (Colombia)
Esta investigación tiene su enfoque principal en las actinobacterias extraídas a partir de sedimentos de las riberas del río Arauca en Colombia, como microorganismos productores de compuestos potencialmente bioactivos. Para el tratamiento de los sedimentos y asilamiento de actinobacterias, fueron ut...
- Autores:
-
Arango Rosero, Carolina
- Tipo de recurso:
- Doctoral thesis
- Fecha de publicación:
- 2024
- Institución:
- Universidad de la Sabana
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- Repositorio Universidad de la Sabana
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- spa
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- Acceso en línea:
- https://hdl.handle.net/10818/62987
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- Actinobacterias
Sedimento
Pretratamientos físico-químicos
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Bioprospección en actinobacterias cultivables de las riberas del río Arauca (Colombia) |
| title |
Bioprospección en actinobacterias cultivables de las riberas del río Arauca (Colombia) |
| spellingShingle |
Bioprospección en actinobacterias cultivables de las riberas del río Arauca (Colombia) Actinobacterias Sedimento Pretratamientos físico-químicos |
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Bioprospección en actinobacterias cultivables de las riberas del río Arauca (Colombia) |
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Bioprospección en actinobacterias cultivables de las riberas del río Arauca (Colombia) |
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Bioprospección en actinobacterias cultivables de las riberas del río Arauca (Colombia) |
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Bioprospección en actinobacterias cultivables de las riberas del río Arauca (Colombia) |
| title_sort |
Bioprospección en actinobacterias cultivables de las riberas del río Arauca (Colombia) |
| dc.creator.fl_str_mv |
Arango Rosero, Carolina |
| dc.contributor.advisor.none.fl_str_mv |
Díaz Barrera, Luis Eduardo Acosta González, Alejandro |
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Arango Rosero, Carolina |
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Actinobacterias Sedimento Pretratamientos físico-químicos |
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Actinobacterias Sedimento Pretratamientos físico-químicos |
| description |
Esta investigación tiene su enfoque principal en las actinobacterias extraídas a partir de sedimentos de las riberas del río Arauca en Colombia, como microorganismos productores de compuestos potencialmente bioactivos. Para el tratamiento de los sedimentos y asilamiento de actinobacterias, fueron utilizados cinco pretratamientos físico-químicos (Carbonato de Calcio-C, Fenol-F, Térmico-T, Microondas-M, Sonicación-U) y dos clases de medio de cultivo selectivos (agar de Ácido Húmico y agar-avena ISP3). Un total de 790 aislados de actinobacterias fueron obtenidos. Todos los aislados fueron incluidos en la colección biológica de microorganismos de la Universidad de La Sabana (ActinosUsab). A partir de esta colección biológica se realizó una estrategia de dereplicación biológica por embudo, mediante ensayos antimicrobianos por confrontación directa. La totalidad de aislados de actinobacterias fueron llevados a ensayos de confrontacion directa frente a 4 bacterias patógenas: Klebsiella pneumoniae, Staphylococcus aureus-MRSA, Enterococcus faecium-VRE y Bacillus subtilis. Los asilados con actividad antibacterial positiva fueron luego llevados a ensayos de confrontación directa frente a 3 aislados clínicos de hongos dermatofitos: Cladosporium cladosporioides, Cladosporium cladosporioides y Epicoccum nigrum. . |
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2024-11-28T14:38:47Z |
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2024-10-24 |
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Tesis/Trabajo de grado - Doctorado |
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Díaz Barrera, Luis EduardoAcosta González, AlejandroArango Rosero, Carolina2024-11-28T14:38:47Z2024-11-28T14:38:47Z2024-10-24https://hdl.handle.net/10818/62987Esta investigación tiene su enfoque principal en las actinobacterias extraídas a partir de sedimentos de las riberas del río Arauca en Colombia, como microorganismos productores de compuestos potencialmente bioactivos. Para el tratamiento de los sedimentos y asilamiento de actinobacterias, fueron utilizados cinco pretratamientos físico-químicos (Carbonato de Calcio-C, Fenol-F, Térmico-T, Microondas-M, Sonicación-U) y dos clases de medio de cultivo selectivos (agar de Ácido Húmico y agar-avena ISP3). Un total de 790 aislados de actinobacterias fueron obtenidos. Todos los aislados fueron incluidos en la colección biológica de microorganismos de la Universidad de La Sabana (ActinosUsab). A partir de esta colección biológica se realizó una estrategia de dereplicación biológica por embudo, mediante ensayos antimicrobianos por confrontación directa. La totalidad de aislados de actinobacterias fueron llevados a ensayos de confrontacion directa frente a 4 bacterias patógenas: Klebsiella pneumoniae, Staphylococcus aureus-MRSA, Enterococcus faecium-VRE y Bacillus subtilis. Los asilados con actividad antibacterial positiva fueron luego llevados a ensayos de confrontación directa frente a 3 aislados clínicos de hongos dermatofitos: Cladosporium cladosporioides, Cladosporium cladosporioides y Epicoccum nigrum. .Doctor en BiocienciasDoctorado156 páginasapplication/pdfspaUniversidad de La SabanaDoctorado en BiocienciasFacultad de IngenieríaAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2ActinobacteriasSedimentoPretratamientos físico-químicosBioprospección en actinobacterias cultivables de las riberas del río Arauca (Colombia)Tesis/Trabajo de grado - Doctoradohttp://purl.org/coar/resource_type/c_db06http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/doctoralThesishttp://purl.org/redcol/resource_type/TDAnandan, R., Dharumadurai, D., & Manogaran, G. P. (2016). An Introduction to Actinobacteria. En: Dhanasekaran, D. & Jiang, Y. (Eds.), Actinobacteria - Basics and Biotechnological Applications. Intech Ed. Capítulo 1. Arifuzzaman, M., Khatun, M. R., & Rahman, H. (2010). Isolation and screening of actinomycetes from Sundarbans soil for antibacterial activity. Afr. J. Biotechnol., 9: 4615-4619. Atta, H. M., Dabour, M., & Desoukey, S. G. (2009). Sparsomycin Antibiotic Production by Streptomyces sp. AZ-NIOFD1: Taxonomy, Fermentation, Purification and Biological Activities. American-Eurasian J. Agric. & Environ. Sci., 5 (3): 368-377. Baltz, R. H. (2006). Marcel Faber Roundtable: Is our antibiotic pipeline unproductive because of starvation, constipation or lack of inspiration? J Ind Microbiol Biotechnol, 33: 507–513. Baltz, R. H. (2007). Antimicrobials from Actinomycetes: Back to the Future. Microbe, Volume 2, Number 3. Barka, E. A. et al. (2016). Taxonomy, Physiology, and Natural Products of Actinobacteria. Microbiol Mol Biol Rev., 80: 1-43. Bentley, S. D. et al. (2002). 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Bredholt, H., Fjærvik, E., Johnsen, G., & Zotchev, S. B. (2008). Actinomycetes from Sediments in the Trondheim Fjord, Norway: Diversity and Biological Activity. Mar. Drugs, 6(1), 12–24. Bull, A. T. (2011). Actinobacteria of the Extremobiosphere. En: Horikoshi, K. et al. (Eds.), Extremophiles Handbook. Springer, págs. 1203-1240. Cannell, R. J. P. (1999). Natural Products Isolation. Humana Press Ed. New Jersey. Cardona, G., Peña, C., & Ruiz, M. (2009). Comunidades de hongos actinobacterias en tres tipos de vegetación de la Amazonía colombiana: abundancia, morfotipos y el gen 16s ADNr. Rev Biol Trop., 57(4): 1119-1139. Carrano, L., & Marinelli, F. (2015). The relevance of chemical dereplication in microbial natural product screening. Journal of Applied Bioanalysis, págs. 55-67. Casino, P., Rubio, V., & Marina, A. (2010). The mechanism of signal transduction by two-component systems. Current Opinion in Structural Biology, 20: 763–771. Chaudhary, H. S. et al. (2013). 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(Eds.), Antibiotic Resistance: Implications for Global Health and Novel Intervention Strategies: Workshop Summary. National Academies Press. Apéndice A – A11. Li, Y. V., Terekhova, L. P., & Gapochka, M. G. (2002). Isolation of actinomycetes from soil using extremely high frequency radiation. Microbiology, Vol. 71, No. 1, págs. 105–108. Madden, A., Grassetti, A., Soriano, J. A. N., & Starks, P. T. (2013). Actinomycetes with Antimicrobial Activity Isolated from Paper Wasp (Hymenoptera: Vespidae: Polistinae) Nests. Environmental Entomology, Volume 42, Issue 4, págs. 703–710. Manivasagan, P., Venkatesan, J., Sivakumar, K., & Kim, S. K. (2014). Pharmaceutically active secondary metabolites of marine actinobacteria. Microbiol Res; 169, 262–278. Mendes, M. V. et al. (2007). The two-component phoR-phoP system of Streptomyces natalensis: Inactivation or deletion of phoP reduces the negative phosphate regulation of pimaricin biosynthesis. Metab Eng, 9: 217-227. Mishra, T., Kushwah, P., Dholiya, K., & Kothari, V. (2013). Effect of Low Power Microwave Radiation on Microorganisms and other Life Forms. Advances in Microwave and Wireless Technologies, 4-11. Mohammadipanah, F., & Dehhaghi, M. (2017). Classification and Taxonomy of Actinobacteria. En: Wink, J., Mohammadipanah, F., & Hamedi, J. (Eds.), Biology and Biotechnology of Actinobacteria. Springer Ed. Switzerland. Capítulo 4. Mullowney, M. W. et al. (2015). Diaza-anthracene Antibiotics from a Freshwater-Derived Actinomycete with Selective Antibacterial Activity toward Mycobacterium tuberculosis. ACS Infect Dis; 4: 168–174. Nakaew, N., Pathom-aree, W., & Lumyong, S. (2009). Generic Diversity of Rare Actinomycetes from Thai Cave Soils and Their Possible Use as New Bioactive Compounds. Actinomycetologica, 23: 21–26. Natsume, M., Yasui, K., & Marumo, S. (1989). Calcium ion regulates aerial micellium formation in actinomycetes. The Journal of Antibiotics, Vol. XLII, No. 3. Naveena, B., Sakthiselvan, P., Elaiyaraju, P., & Partha, N. (2012). Ultrasound induced production of thrombinase by marine actinomycetes: Kinetic and optimization studies. Biochemical Engineering Journal, 61, 34–42. Ningthoujam, D. S., Sanasam, S., & Nimaichan, S. (2011). Studies on Bioactive Actinomycetes in a Niche Biotope, Nambul River in Manipur, India. J Microbial Biochem Technol, S6: 1-6. Ningthoujam, D. S., Sanasam, S., & Nimaichan, S. (2009). Screening of Actinomycete Isolates from Niche Habitats in Manipur for Antibiotic Activity. Am J Biochem Biotechnol; 5: 221-225. Niyomvong, N., Pathom-aree, W., Thamchaipenet, A., & Duangmal, K. (2012). Actinomycetes from Tropical Limestone Caves. Chiang Mai J. Sci., 39(3): 373-388. ODDR-Observatorio de Procesos de Desarme, Desmovilización y Reintegración. (2013). Caracterización Región de La Orinoquía. Universidad Nacional de Colombia. Sede Bogotá. Osbourn, A. (2010). Secondary metabolic gene clusters: evolutionary toolkits for chemical innovation. Trends in Genetics, 26, 449–457. Otero, V. (2011). Aislamiento, Selección e Identificación de Actinobacterias, Bacterias Fotosintéticas No Sulfurosas y Bacterias Ácido Lácticas con Potencial Biofertilizante, a Partir de Suelos Asociados al Cultivo de Plátano en la Costa Atlántica Colombiana. Tesis de Maestría. Universidad Nacional de Colombia. Otoguro, M., Hayakawa, M., Yamazaki, T., & Iimura, Y. (2001). An integrated method for the enrichment and selective isolation of Actinokineospora spp. in soil and plant litter. Journal of Applied Microbiology, 91, 118-130. Pastrana-Camacho, N. et al. (2016). Bioprospecting for culturable Actinobacteria with antimicrobial properties isolated from Rivers from the Colombian Orinoquia. Trop J Pharm Res; 15: 1259-1265. Poulsen, M., Oh, D. C., Clardy, J., & Currie, C. R. (2011). 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