Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings
páginas
- Autores:
-
Guerrero, Juan I.
Barragán, Luis A.
Martínez, Juan D.
Montoya, Juan P.
Peña, Alejandra
Sobrino, Fidel E.
Tovar Spinoza, Zulma
Ghotme Ghotme, Kemel Ahmed
- Tipo de recurso:
- Fecha de publicación:
- 2020
- Institución:
- Universidad de la Sabana
- Repositorio:
- Repositorio Universidad de la Sabana
- Idioma:
- eng
- OAI Identifier:
- oai:intellectum.unisabana.edu.co:10818/44055
- Acceso en línea:
- http://hdl.handle.net/10818/44055
- Palabra clave:
- Central and peripheral nervous system
SARS-CoV-2
COVID-19
Pathophysiology
Clinical manifestations
Neuropathology
Neuroimaging
Electrophysiology
Cerebrospinal fluid findings
- Rights
- License
- Attribution-NonCommercial-NoDerivatives 4.0 International
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| dc.title.es_CO.fl_str_mv |
Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings |
| title |
Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings |
| spellingShingle |
Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings Central and peripheral nervous system SARS-CoV-2 COVID-19 Pathophysiology Clinical manifestations Neuropathology Neuroimaging Electrophysiology Cerebrospinal fluid findings |
| title_short |
Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings |
| title_full |
Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings |
| title_fullStr |
Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings |
| title_full_unstemmed |
Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings |
| title_sort |
Central and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings |
| dc.creator.fl_str_mv |
Guerrero, Juan I. Barragán, Luis A. Martínez, Juan D. Montoya, Juan P. Peña, Alejandra Sobrino, Fidel E. Tovar Spinoza, Zulma Ghotme Ghotme, Kemel Ahmed |
| dc.contributor.author.none.fl_str_mv |
Guerrero, Juan I. Barragán, Luis A. Martínez, Juan D. Montoya, Juan P. Peña, Alejandra Sobrino, Fidel E. Tovar Spinoza, Zulma Ghotme Ghotme, Kemel Ahmed |
| dc.subject.es_CO.fl_str_mv |
Central and peripheral nervous system SARS-CoV-2 COVID-19 Pathophysiology Clinical manifestations Neuropathology Neuroimaging Electrophysiology Cerebrospinal fluid findings |
| topic |
Central and peripheral nervous system SARS-CoV-2 COVID-19 Pathophysiology Clinical manifestations Neuropathology Neuroimaging Electrophysiology Cerebrospinal fluid findings |
| description |
páginas |
| publishDate |
2020 |
| dc.date.accessioned.none.fl_str_mv |
11/10/2020 18:38 |
| dc.date.available.none.fl_str_mv |
2020-11-10T23:38:57Z |
| dc.date.issued.none.fl_str_mv |
2020-07-24 |
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article |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_6501 |
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publishedVersion |
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http://hdl.handle.net/10818/44055 |
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http://hdl.handle.net/10818/44055 |
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eng |
| language |
eng |
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Attribution-NonCommercial-NoDerivatives 4.0 International |
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http://purl.org/coar/access_right/c_abf2 |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2 |
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application/pdf |
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Universidad de La Sabana Intellectum Repositorio Universidad de La Sabana |
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Universidad de la Sabana |
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Guerrero, Juan I.Barragán, Luis A.Martínez, Juan D.Montoya, Juan P.Peña, AlejandraSobrino, Fidel E.Tovar Spinoza, ZulmaGhotme Ghotme, Kemel Ahmed11/10/2020 18:382020-11-10T23:38:57Z2020-07-24http://hdl.handle.net/10818/44055páginasBackground: SARS-CoV-2 can affect the human brain and other neurological structures. An increasing number of publications report neurological manifestations in patients with COVID-19. However, no studies have comprehensively reviewed the clinical and paraclinical characteristics of the central and peripheral nervous system's involvement in these patients. This study aimed to describe the features of the central and peripheral nervous system involvement by COVID-19 in terms of pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings. Methods: We conducted a comprehensive systematic review of all the original studies reporting patients with neurological involvement by COVID-19, from December 2019 to June 2020, without language restriction. We excluded studies with animal subjects, studies not related to the nervous system, and opinion articles. Data analysis combined descriptive measures, frequency measures, central tendency measures, and dispersion measures for all studies reporting neurological conditions and abnormal ancillary tests in patients with confirmed COVID-19. Results: A total of 143 observational and descriptive studies reported central and peripheral nervous system involvement by COVID-19 in 10723 patients. Fifty-one studies described pathophysiologic mechanisms of neurological involvement by COVID-19, 119 focused on clinical manifestations, 4 described neuropathology findings, 62 described neuroimaging findings, 28 electrophysiology findings, and 60 studies reported cerebrospinal fluid results. The reviewed studies reflect a significant prevalence of the nervous system's involvement in patients with COVID-19, ranging from 22.5% to 36.4% among different studies, without mortality rates explicitly associated with neurological involvement by SARS-COV-2. We thoroughly describe the clinical and paraclinical characteristics of neurological involvement in these patients. Conclusions: Our evidence synthesis led to a categorical analysis of the central and peripheral involvement by COVID-19 and provided a comprehensive explanation of the reported pathophysiological mechanisms by which SARS-CoV-2 infection may cause neurological impairment. International collaborative efforts and exhaustive neurological registries will enhance the translational knowledge of COVID-19's CNS and PNS involvement and generate strategies for therapeutic decision-making.application/pdfengAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Universidad de La SabanaIntellectum Repositorio Universidad de La SabanaCentral and peripheral nervous systemSARS-CoV-2COVID-19PathophysiologyClinical manifestationsNeuropathologyNeuroimagingElectrophysiologyCerebrospinal fluid findingsCentral and peripheral nervous system involvement by COVID-19: A systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findingsarticlepublishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501PublicationORIGINALARTICLES INCLUDED IN NEUROCOVID SYSTEMATIC REVIEW.pdfARTICLES INCLUDED IN NEUROCOVID SYSTEMATIC REVIEW.pdfVer Articles included in NEUROCOVID systematic reviewapplication/pdf322879https://dspace-unisabana.metabuscador.org/bitstreams/3afb2e72-e65e-4c06-8bbc-37bd03efff21/download8d540bea4bc8b399440892b6cc58910aMD54trueAnonymousREADTEXTARTICLES INCLUDED IN NEUROCOVID SYSTEMATIC REVIEW.pdf.txtARTICLES INCLUDED IN NEUROCOVID SYSTEMATIC REVIEW.pdf.txtExtracted texttext/plain23343https://dspace-unisabana.metabuscador.org/bitstreams/1a045bd7-f679-4656-bb7e-ed56f0186f5a/downloadb029dd7b02ab22001b80db99d737457aMD55falseAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://dspace-unisabana.metabuscador.org/bitstreams/e89d942a-0f3e-4f01-b96c-391370cf6011/downloadf52a2cfd4df262e08e9b300d62c85cabMD53falseAnonymousREADCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://dspace-unisabana.metabuscador.org/bitstreams/ae20cf9c-3240-4b8b-b535-b498eb98cdc0/download4460e5956bc1d1639be9ae6146a50347MD52falseAnonymousREADTHUMBNAILARTICLES INCLUDED IN NEUROCOVID SYSTEMATIC REVIEW.pdf.jpgARTICLES INCLUDED IN NEUROCOVID SYSTEMATIC REVIEW.pdf.jpgGenerated Thumbnailimage/jpeg9474https://dspace-unisabana.metabuscador.org/bitstreams/43b8417d-6ec0-4dda-9a2b-555906b813f5/download72142a089c8eb4b1a4376de374b39a3cMD56falseAnonymousREAD10818/44055oai:dspace-unisabana.metabuscador.org:10818/440552025-08-08 11:01:36.754http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internationalopen.accesshttps://dspace-unisabana.metabuscador.orgIntellectum Repositorio Universidad de La Sabanacontactointellectum@unisabana.edu.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 |