Microbiological, inmunological and biochemical features of mechanical ventilation-associated neumonia (MICROVAP) development
This study focuses on the complex relationship between positive pressure mechanical ventilation, the pulmonary microbiome, cytokine dynamics, and metabolomic profiles in patients with ventilator-associated pneumonia (VAP). Our research emphasizes how alterations in microbial dynamics are associated...
- Autores:
-
Bustos Moya, Ingrid Gisell
Reyes Velasco, Luis Felipe
- Tipo de recurso:
- Doctoral thesis
- Fecha de publicación:
- 2024
- Institución:
- Universidad de la Sabana
- Repositorio:
- Repositorio Universidad de la Sabana
- Idioma:
- eng
- OAI Identifier:
- oai:intellectum.unisabana.edu.co:10818/63003
- Acceso en línea:
- https://hdl.handle.net/10818/63003
- Palabra clave:
- Microbioma pulmonar
Enfermedades respiratorias virales -- Estudios clínicos
COVID-19
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Microbiological, inmunological and biochemical features of mechanical ventilation-associated neumonia (MICROVAP) development |
| title |
Microbiological, inmunological and biochemical features of mechanical ventilation-associated neumonia (MICROVAP) development |
| spellingShingle |
Microbiological, inmunological and biochemical features of mechanical ventilation-associated neumonia (MICROVAP) development Microbioma pulmonar Enfermedades respiratorias virales -- Estudios clínicos COVID-19 |
| title_short |
Microbiological, inmunological and biochemical features of mechanical ventilation-associated neumonia (MICROVAP) development |
| title_full |
Microbiological, inmunological and biochemical features of mechanical ventilation-associated neumonia (MICROVAP) development |
| title_fullStr |
Microbiological, inmunological and biochemical features of mechanical ventilation-associated neumonia (MICROVAP) development |
| title_full_unstemmed |
Microbiological, inmunological and biochemical features of mechanical ventilation-associated neumonia (MICROVAP) development |
| title_sort |
Microbiological, inmunological and biochemical features of mechanical ventilation-associated neumonia (MICROVAP) development |
| dc.creator.fl_str_mv |
Bustos Moya, Ingrid Gisell Reyes Velasco, Luis Felipe |
| dc.contributor.author.none.fl_str_mv |
Bustos Moya, Ingrid Gisell Reyes Velasco, Luis Felipe |
| dc.subject.other.none.fl_str_mv |
Microbioma pulmonar Enfermedades respiratorias virales -- Estudios clínicos COVID-19 |
| topic |
Microbioma pulmonar Enfermedades respiratorias virales -- Estudios clínicos COVID-19 |
| description |
This study focuses on the complex relationship between positive pressure mechanical ventilation, the pulmonary microbiome, cytokine dynamics, and metabolomic profiles in patients with ventilator-associated pneumonia (VAP). Our research emphasizes how alterations in microbial dynamics are associated with the onset of VAP, underscoring the pivotal role of microbiomes in maintaining respiratory health, particularly in the context of viral respiratory diseases such as COVID-19. We observed significant variations in microbial abundances, which have implications for the development and progression of VAP. Furthermore, our analysis of cytokine dynamics revealed a distinctive immunological modulation in VAP patients, characterized by an enhanced response of neutralizing antibodies coupled with reduced levels of proinflammatory cytokines. |
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2024 |
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2024-11-28T14:38:54Z |
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2024-11-28T14:38:54Z |
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2024-10-23 |
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Tesis/Trabajo de grado - Doctorado |
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https://hdl.handle.net/10818/63003 |
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https://hdl.handle.net/10818/63003 |
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eng |
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eng |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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154 páginas |
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Universidad de La Sabana |
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Doctorado en Biociencias |
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Facultad de Ingeniería |
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Universidad de la Sabana |
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Bustos Moya, Ingrid GisellReyes Velasco, Luis Felipevirtual::274-12024-11-28T14:38:54Z2024-11-28T14:38:54Z2024-10-23https://hdl.handle.net/10818/63003This study focuses on the complex relationship between positive pressure mechanical ventilation, the pulmonary microbiome, cytokine dynamics, and metabolomic profiles in patients with ventilator-associated pneumonia (VAP). Our research emphasizes how alterations in microbial dynamics are associated with the onset of VAP, underscoring the pivotal role of microbiomes in maintaining respiratory health, particularly in the context of viral respiratory diseases such as COVID-19. We observed significant variations in microbial abundances, which have implications for the development and progression of VAP. Furthermore, our analysis of cytokine dynamics revealed a distinctive immunological modulation in VAP patients, characterized by an enhanced response of neutralizing antibodies coupled with reduced levels of proinflammatory cytokines.El presente estudio se enfoca en la compleja relación entre la ventilación mecánica con presión positiva, el microbioma pulmonar, la dinámica de citoquinas y los perfiles metabolómicos en pacientes con neumonía asociada a ventilación (VAP). Nuestra investigación destaca cómo las alteraciones en la dinámica microbiana están asociadas con el inicio de VAP, subrayando el papel crucial de los microbiomas en el mantenimiento de la salud respiratoria, especialmente en el contexto de enfermedades respiratorias virales como COVID-19. Observamos variaciones significativas en las abundancias microbianas, lo que tiene implicaciones en el desarrollo y progresión de VAP. Además, el análisis de la dinámica de citoquinas reveló una modulación inmunológica distintiva en pacientes con VAP, caracterizada por una respuesta aumentada de anticuerpos neutralizantes junto con niveles reducidos de citoquinas proinflamatorias.Doctor en BiocienciasDoctorado154 páginasapplication/pdfengUniversidad de La SabanaDoctorado en BiocienciasFacultad de IngenieríaAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Microbioma pulmonarEnfermedades respiratorias virales -- Estudios clínicosCOVID-19Microbiological, inmunological and biochemical features of mechanical ventilation-associated neumonia (MICROVAP) developmentTesis/Trabajo de grado - Doctoradohttp://purl.org/coar/resource_type/c_db06http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/doctoralThesishttp://purl.org/redcol/resource_type/TDLira-Lucio JA, Falfán-Valencia R, Ramírez-Venegas A, Buendía-Roldán I, RojasSerrano J, Mejía M, Pérez-Rubio G. Lung Microbiome Participation in Local Immune Response Regulation in Respiratory Diseases. Microorganisms. 2020;8(7). Moffatt MF, Cookson WO. The lung microbiome in health and disease. Clin Med (Lond). 2017;17(6):525-9. Unger SA, Bogaert D. The respiratory microbiome and respiratory infections. J Infect. 2017;74 Suppl 1:S84-S8. Invernizzi R, Lloyd CM, Molyneaux PL. Respiratory microbiome and epithelial interactions shape immunity in the lungs. Immunology. 2020;160(2):171-82. Yang D, Xing Y, Song X, Qian Y. The impact of lung microbiota dysbiosis on inflammation. Immunology. 2020;159(2):156-66. Yagi K, Huffnagle GB, Lukacs NW, Asai N. The Lung Microbiome during Health and Disease. Int J Mol Sci. 2021;22(19). Wang J, Li F, Tian Z. Role of microbiota on lung homeostasis and diseases. Sci China Life Sci. 2017;60(12):1407-15. Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007;44 Suppl 2(Suppl 2):S27-72. Jain S, Self WH, Wunderink RG, Fakhran S, Balk R, Bramley AM, et al. Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults. N Engl J Med. 2015;373(5):415-27. Torres A, Cilloniz C, Niederman MS, Menendez R, Chalmers JD, Wunderink RG, van der Poll T. Pneumonia. Nat Rev Dis Primers. 2021;7(1):25. Torres A, Niederman MS, Chastre J, Ewig S, Fernandez-Vandellos P, Hanberger H, et al. 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Changes in upper airways microbiota in ventilator-associated pneumonia. Intensive Care Med Exp. 2023;11(1):17. Otsuji K, Fukuda K, Ogawa M, Fujino Y, Kamochi M, Saito M. Dynamics of microbiota during mechanical ventilation in aspiration pneumonia. BMC Pulm Med. 2019;19(1):260. Cheema HA, Shahid A, Ayyan M, Mustafa B, Zahid A, Fatima M, et al. Probiotics for the Prevention of Ventilator-Associated Pneumonia: An Updated Systematic Review and Meta-Analysis of Randomised Controlled Trials. Nutrients. 2022;14(8). Huang YJ. The respiratory microbiome and innate immunity in asthma. Curr Opin Pulm Med. 2015;21(1):27-32. Boyton RJ, Reynolds CJ, Quigley KJ, Altmann DM. Immune mechanisms and the impact of the disrupted lung microbiome in chronic bacterial lung infection and bronchiectasis. Clin Exp Immunol. 2013;171(2):117-23. Dickson RP, Erb-Downward JR, Huffnagle GB. The role of the bacterial microbiome in lung disease. Expert Rev Respir Med. 2013;7(3):245-57. Lambring CB, Siraj S, Patel K, Sankpal UT, Mathew S, Basha R. Impact of the Microbiome on the Immune System. Crit Rev Immunol. 2019;39(5):313-28. Larsen JM, Steen-Jensen DB, Laursen JM, Sondergaard JN, Musavian HS, Butt TM, Brix S. Divergent pro-inflammatory profile of human dendritic cells in response to commensal and pathogenic bacteria associated with the airway microbiota. PLoS One. 2012;7(2):e31976. Siebert JC, Gorg C, Palmer B, Lozupone C. Visualizing microbiome-immune system interplay. Immunotherapy. 2019;11(2):63-7. Neish AS. Mucosal immunity and the microbiome. Ann Am Thorac Soc. 2014;11 Suppl 1(Suppl 1):S28-32. Clarke TB. Early innate immunity to bacterial infection in the lung is regulated systemically by the commensal microbiota via nod-like receptor ligands. Infect Immun. 2014;82(11):4596-606. Gasaly N, de Vos P, Hermoso MA. Impact of Bacterial Metabolites on Gut Barrier Function and Host Immunity: A Focus on Bacterial Metabolism and Its Relevance for Intestinal Inflammation. Front Immunol. 2021;12:658354. Lopez LR, Ahn JH, Alves T, Arthur JC. Microenvironmental Factors that Shape Bacterial Metabolites in Inflammatory Bowel Disease. Front Cell Infect Microbiol. 2022;12:934619. O'Dwyer DN, Dickson RP, Moore BB. The Lung Microbiome, Immunity, and the Pathogenesis of Chronic Lung Disease. J Immunol. 2016;196(12):4839-47. Wang Z, Jenabian MA, Alexandrova Y, Pagliuzza A, Olivenstein R, Samarani S, et al. Interplay between the Lung Microbiome, Pulmonary Immunity and Viral Reservoirs in People Living with HIV under Antiretroviral Therapy. Viruses. 2022;14(11). Dickson RP, Erb-Downward JR, Prescott HC, Martinez FJ, Curtis JL, Lama VN, Huffnagle GB. Intraalveolar Catecholamines and the Human Lung Microbiome. Am J Respir Crit Care Med. 2015;192(2):257-9. Caverly LJ, Huang YJ, Sze MA. 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