Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosano

30 Páginas.

Autores:: Andrade Becerra, Laura Patricia

Tipo de recurso:: Trabajo de grado de pregrado

Fecha de publicación:: 2016

Institución:: Universidad de la Sabana

Repositorio:: Repositorio Universidad de la Sabana

Idioma:: spa

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repository_id_str
dc.title.es_CO.fl_str_mv	Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosano
title	Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosano
spellingShingle	Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosano Ingeniería química Fusión nuclear Compatibilidad -- Pruebas
title_short	Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosano
title_full	Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosano
title_fullStr	Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosano
title_full_unstemmed	Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosano
title_sort	Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosano
dc.creator.fl_str_mv	Andrade Becerra, Laura Patricia
dc.contributor.advisor.none.fl_str_mv	Valero Valdivieso, Manuel Fernando
dc.contributor.author.none.fl_str_mv	Andrade Becerra, Laura Patricia
dc.subject.none.fl_str_mv	Ingeniería química Fusión nuclear Compatibilidad -- Pruebas
topic	Ingeniería química Fusión nuclear Compatibilidad -- Pruebas
description	30 Páginas.
publishDate	2016
dc.date.created.none.fl_str_mv	2016
dc.date.accessioned.none.fl_str_mv	2017-03-03T19:29:18Z
dc.date.available.none.fl_str_mv	2017-03-03T19:29:18Z
dc.date.issued.none.fl_str_mv	2017-03-03
dc.type.es_CO.fl_str_mv	Tesis/Trabajo de grado - Pregrado
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dc.type.content.es_CO.fl_str_mv	Texto
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dc.identifier.citation.none.fl_str_mv	Adamczak, M. I., Hagesaether, E., Smistad, G., & Hiorth, M. (2016). An in vitro study of mucoadhesion and biocompatibility of polymer coated liposomes on HT29-MTX mucus-producing cells. International Journal of Pharmaceutics, 498(1¿2), 225¿33. https://doi.org/10.1016/j.ijpharm.2015.12.030 Aranaz, I., Mengibar, M., Harris, R., Panos, I., Miralles, B., Acosta, N., ¿ Heras, A. (2009). Functional Characterization of Chitin and Chitosan. Current Chemical Biology, 3(2), 203¿230. https://doi.org/10.2174/187231309788166415 Arévalo, S., & Ramirez, C. (2015). Síntesis, Caracterización y Degradabilidad in vitro de Polímeros Obtenidos de Aceite de Higuerilla y Quitosano. Bakhshi, H., Yeganeh, H., Mehdipour-Ataei, S., Shokrgozar, M. A., Yari, A., & Saeedi-Eslami, S. N. (2013). Synthesis and characterization of antibacterial polyurethane coatings from quaternary ammonium salts functionalized soybean oil based polyols. Materials Science and Engineering: C, 33(1), 153¿164. https://doi.org/10.1016/j.msec.2012.08.023 Bakhshi, H., Yeganeh, H., Yari, A., & Nezhad, S. K. (2014). Castor oil-based polyurethane coatings containing benzyl triethanol ammonium chloride: synthesis, characterization, and biological properties. Journal of Materials Science, 49(15), 5365¿5377. https://doi.org/10.1007/s10853-014- 8244-x Berridge, M. V, Herst, P. M., & Tan, A. S. (2005). Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnology Annual Review, 11, 127¿52. https://doi.org/10.1016/S1387-2656(05)11004-7 Berridge, M. V, & Tan, A. S. (1993). Characterization of the Cellular Reduction of 3.pdf. Archives of Biochemestry and Biophisics, 474¿482. Retrieved from http://www.sciencedirect.com.ezproxy.unisabana.edu.co/science/article/pii/S0003986183713111 Brown, R. P., & Fustinoni, S. (2015). Chapter 5 ¿ Toxicity of Metals Released from Implanted Medical Devices. In Handbook on the Toxicology of Metals (pp. 113¿122). https://doi.org/10.1016/B978-0- 444-59453-2.00005-6 Caon, T., Zanetti-Ramos, B. G., Lemos-Senna, E., Cloutet, E., Cramail, H., Borsali, R., ¿ Simões, C. M. O. (2010). Evaluation of DNA damage and cytotoxicity of polyurethane-based nano- and microparticles as promising biomaterials for drug delivery systems. Journal of Nanoparticle Research, 12(5), 1655¿1665. https://doi.org/10.1007/s11051-009-9828-2 Castañeda Ramírez, C., De la Fuente Salcido, N. M., Pacheco Cano, R. D., Ortiz-Rodriguez, T., & Barbosa Corona, J. E. (2011). Potencial de los quito-oligosacáridos generados de quitina y quitosana. Acta Universitaria, 21(3), 14¿23. Castro, C. (2006). Pruebas de tamizaje para determinar efectos citotóxicos en extractos, fracciones o sustancias, utilizando la prueba MTT. Universidad San Martín. Retrieved from http://old.iupac.org/publications/cd/medicinal_chemistry/Practica-IV-2.pdf Chapdelaine, J. M. (n.d.). MTT reduction -a tetrazolium-based colorimetric assay for cell survival and proliferation. Chen, Y., Tang¿, H., Liu¿, Y., & Tan, H. (2016). Preparation and study on the volume phase transition properties of novel carboxymethyl chitosan grafted polyampholyte superabsorbent polymers. Journal of the Taiwan Institute of Chemical Engineers, 59, 569¿577. https://doi.org/10.1016/j.jtice.2015.09.011 Chen, Y., Zhou, Y., Yang, S., Li, J. J., Li, X., Ma, Y., ¿ Yu, B. (2016). Novel bone substitute composed of chitosan and strontium-doped ¿-calcium sulfate hemihydrate: Fabrication, characterisation and evaluation of biocompatibility. Materials Science and Engineering: C, 66, 84¿91. https://doi.org/10.1016/j.msec.2016.04.070 Chien, R.-C., Yen, M.-T., & Mau, J.-L. (2015). Antimicrobial and antitumor activities of chitosan from shiitake stipes, compared to commercial chitosan from crab shells. Carbohydrate Polymers, 138, 259¿264. https://doi.org/10.1016/j.carbpol.2015.11.061 Crichton, M. L., Chen, X., Huang, H., & Kendall, M. A. F. (2013). Elastic modulus and viscoelastic properties of full thickness skin characterised at micro scales. Biomaterials, 34(8), 2087¿2097. https://doi.org/10.1016/j.biomaterials.2012.11.035 Croisier, F., & Jérôme, C. (2013). Chitosan-based biomaterials for tissue engineering. European Polymer Journal, 49(4), 780¿792. https://doi.org/10.1016/j.eurpolymj.2012.12.009 De Souza, J. F., Maia, K. N., De Oliveira Patrício, P. S., Fernandes-Cunha, G. M., Da Silva, M. G., De Matos Jensen, C. E., & Da Silva, G. R. (2016). Ocular inserts based on chitosan and brimonidine tartrate: Development, characterization and biocompatibility. Journal of Drug Delivery Science and Technology, 32, 21¿30. https://doi.org/10.1016/j.jddst.2016.01.008 Deng, M., Zhou, J., Chen, G., Burkley, D., Xu, Y., Jamiolkowski, D., & Barbolt, T. (2005). Effect of load and temperature on in vitro degradation of poly(glycolide-co-L-lactide) multifilament braids. Biomaterials, 26, 4327¿4336. https://doi.org/10.1016/j.biomaterials.2004.09.067 Dragostin, O. M., Samal, S. K., Dash, M., Lupascu, F., Pânzariu, A., Tuchilus, C., ¿ Profire, L. (2016). New antimicrobial chitosan derivatives for wound dressing applications. Carbohydrate Polymers, 141, 28¿40. https://doi.org/10.1016/j.carbpol.2015.12.078 Dutta, S., Karak, N., Saikia, J. P., & Konwar, B. K. (2009). Biocompatible epoxy modified bio-based polyurethane nanocomposites: Mechanical property, cytotoxicity and biodegradation. Bioresource Technology, 100(24), 6391¿6397. https://doi.org/10.1016/j.biortech.2009.06.029 ESCOBAR M, L., RIVERA, A., & ARISTIZÁBAL G, F. A. (2010). ESTUDIO COMPARATIVO DE LOS MÉTODOS DE RESAZURINA Y MTT EN ESTUDIOS DE CITOTOXICIDAD EN LÍNEAS CELULARES TUMORALES HUMANAS. Vitae, 17(1), 67¿74. Ghorbanian, L., Emadi, R., Razavi, S. M., Shin, H., & Teimouri, A. (2013). Fabrication and characterization of novel diopside/silk fibroin nanocomposite scaffolds for potential application in maxillofacial bone regeneration. International Journal of Biological Macromolecules, 58, 275¿80. https://doi.org/10.1016/j.ijbiomac.2013.04.004 Gómez, A. A. (n.d.). El fibroblasto: su origen, estructura, funciones y heterogeneidad dentro del periodonto Fibroblast: its origin, structure, functions and heterogeneity within the periodontium. Habiba, U., Islam, M. S., Siddique, T. A., Afifi, A. M., & Ang, B. C. (2016). Adsorption and photocatalytic degradation of anionic dyes on Chitosan/PVA/Na¿Titanate/TiO2 composites synthesized by solution casting method. Carbohydrate Polymers, 149, 317¿331. https://doi.org/10.1016/j.carbpol.2016.04.127 He, J., He, F.-L., Li, D.-W., Liu, Y.-L., & Yin, D.-C. (2016). A novel porous Fe/Fe-W alloy scaffold with a double-layer structured skeleton: Preparation, in vitro degradability and biocompatibility. Colloids and Surfaces. B, Biointerfaces, 142, 325¿33. https://doi.org/10.1016/j.colsurfb.2016.03.002 ISO, 10993-5 DIN EN. (n.d.). Biological evaluation of medical devices ¿ Part 5: Tests for in vitro cytotoxicity. Retrieved April 28, 2016, from https://www.iso.org/obp/ui/#iso:std:iso:10993:-5:ed- 3:v1:en Janik, H., & Marzec, M. (2015). A review: Fabrication of porous polyurethane scaffolds. Materials Science and Engineering: C, 48, 586¿591. https://doi.org/10.1016/j.msec.2014.12.037 Kwan, S., & Mari¿, M. (2016). Thermoresponsive polymers with tunable cloud point temperatures grafted from chitosan via nitroxide mediated polymerization. Polymer, 86, 69¿82. https://doi.org/10.1016/j.polymer.2016.01.039 La Rosa, A. D. (2016). 4 ¿ Life cycle assessment of biopolymers. In Biopolymers and Biotech Admixtures for Eco-Efficient Construction Materials (pp. 57¿78). https://doi.org/10.1016/B978-0- 08-100214-8.00004-X López-Saucedo, F., Alvarez-Lorenzo, C., Concheiro, A., & Bucio, E. (2016). Radiation-grafting of vinyl monomers separately onto polypropylene monofilament sutures. https://doi.org/10.1016/j.radphyschem.2016.11.006 Macocinschi, D., Filip, D., Vlad, S., Butnaru, M., & Knieling, L. (2013). Evaluation of polyurethane based on cellulose derivative-ketoprofen biosystem for implant biomedical devices. International Journal of Biological Macromolecules, 52, 32¿7. https://doi.org/10.1016/j.ijbiomac.2012.09.026
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/10818/29878
dc.identifier.local.none.fl_str_mv	263585 TE08924
identifier_str_mv	Adamczak, M. I., Hagesaether, E., Smistad, G., & Hiorth, M. (2016). An in vitro study of mucoadhesion and biocompatibility of polymer coated liposomes on HT29-MTX mucus-producing cells. International Journal of Pharmaceutics, 498(1¿2), 225¿33. https://doi.org/10.1016/j.ijpharm.2015.12.030 Aranaz, I., Mengibar, M., Harris, R., Panos, I., Miralles, B., Acosta, N., ¿ Heras, A. (2009). Functional Characterization of Chitin and Chitosan. Current Chemical Biology, 3(2), 203¿230. https://doi.org/10.2174/187231309788166415 Arévalo, S., & Ramirez, C. (2015). Síntesis, Caracterización y Degradabilidad in vitro de Polímeros Obtenidos de Aceite de Higuerilla y Quitosano. Bakhshi, H., Yeganeh, H., Mehdipour-Ataei, S., Shokrgozar, M. A., Yari, A., & Saeedi-Eslami, S. N. (2013). Synthesis and characterization of antibacterial polyurethane coatings from quaternary ammonium salts functionalized soybean oil based polyols. Materials Science and Engineering: C, 33(1), 153¿164. https://doi.org/10.1016/j.msec.2012.08.023 Bakhshi, H., Yeganeh, H., Yari, A., & Nezhad, S. K. (2014). Castor oil-based polyurethane coatings containing benzyl triethanol ammonium chloride: synthesis, characterization, and biological properties. Journal of Materials Science, 49(15), 5365¿5377. https://doi.org/10.1007/s10853-014- 8244-x Berridge, M. V, Herst, P. M., & Tan, A. S. (2005). Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnology Annual Review, 11, 127¿52. https://doi.org/10.1016/S1387-2656(05)11004-7 Berridge, M. V, & Tan, A. S. (1993). Characterization of the Cellular Reduction of 3.pdf. Archives of Biochemestry and Biophisics, 474¿482. Retrieved from http://www.sciencedirect.com.ezproxy.unisabana.edu.co/science/article/pii/S0003986183713111 Brown, R. P., & Fustinoni, S. (2015). Chapter 5 ¿ Toxicity of Metals Released from Implanted Medical Devices. In Handbook on the Toxicology of Metals (pp. 113¿122). https://doi.org/10.1016/B978-0- 444-59453-2.00005-6 Caon, T., Zanetti-Ramos, B. G., Lemos-Senna, E., Cloutet, E., Cramail, H., Borsali, R., ¿ Simões, C. M. O. (2010). Evaluation of DNA damage and cytotoxicity of polyurethane-based nano- and microparticles as promising biomaterials for drug delivery systems. Journal of Nanoparticle Research, 12(5), 1655¿1665. https://doi.org/10.1007/s11051-009-9828-2 Castañeda Ramírez, C., De la Fuente Salcido, N. M., Pacheco Cano, R. D., Ortiz-Rodriguez, T., & Barbosa Corona, J. E. (2011). Potencial de los quito-oligosacáridos generados de quitina y quitosana. Acta Universitaria, 21(3), 14¿23. Castro, C. (2006). Pruebas de tamizaje para determinar efectos citotóxicos en extractos, fracciones o sustancias, utilizando la prueba MTT. Universidad San Martín. Retrieved from http://old.iupac.org/publications/cd/medicinal_chemistry/Practica-IV-2.pdf Chapdelaine, J. M. (n.d.). MTT reduction -a tetrazolium-based colorimetric assay for cell survival and proliferation. Chen, Y., Tang¿, H., Liu¿, Y., & Tan, H. (2016). Preparation and study on the volume phase transition properties of novel carboxymethyl chitosan grafted polyampholyte superabsorbent polymers. Journal of the Taiwan Institute of Chemical Engineers, 59, 569¿577. https://doi.org/10.1016/j.jtice.2015.09.011 Chen, Y., Zhou, Y., Yang, S., Li, J. J., Li, X., Ma, Y., ¿ Yu, B. (2016). Novel bone substitute composed of chitosan and strontium-doped ¿-calcium sulfate hemihydrate: Fabrication, characterisation and evaluation of biocompatibility. Materials Science and Engineering: C, 66, 84¿91. https://doi.org/10.1016/j.msec.2016.04.070 Chien, R.-C., Yen, M.-T., & Mau, J.-L. (2015). Antimicrobial and antitumor activities of chitosan from shiitake stipes, compared to commercial chitosan from crab shells. Carbohydrate Polymers, 138, 259¿264. https://doi.org/10.1016/j.carbpol.2015.11.061 Crichton, M. L., Chen, X., Huang, H., & Kendall, M. A. F. (2013). Elastic modulus and viscoelastic properties of full thickness skin characterised at micro scales. Biomaterials, 34(8), 2087¿2097. https://doi.org/10.1016/j.biomaterials.2012.11.035 Croisier, F., & Jérôme, C. (2013). Chitosan-based biomaterials for tissue engineering. European Polymer Journal, 49(4), 780¿792. https://doi.org/10.1016/j.eurpolymj.2012.12.009 De Souza, J. F., Maia, K. N., De Oliveira Patrício, P. S., Fernandes-Cunha, G. M., Da Silva, M. G., De Matos Jensen, C. E., & Da Silva, G. R. (2016). Ocular inserts based on chitosan and brimonidine tartrate: Development, characterization and biocompatibility. Journal of Drug Delivery Science and Technology, 32, 21¿30. https://doi.org/10.1016/j.jddst.2016.01.008 Deng, M., Zhou, J., Chen, G., Burkley, D., Xu, Y., Jamiolkowski, D., & Barbolt, T. (2005). Effect of load and temperature on in vitro degradation of poly(glycolide-co-L-lactide) multifilament braids. Biomaterials, 26, 4327¿4336. https://doi.org/10.1016/j.biomaterials.2004.09.067 Dragostin, O. M., Samal, S. K., Dash, M., Lupascu, F., Pânzariu, A., Tuchilus, C., ¿ Profire, L. (2016). New antimicrobial chitosan derivatives for wound dressing applications. Carbohydrate Polymers, 141, 28¿40. https://doi.org/10.1016/j.carbpol.2015.12.078 Dutta, S., Karak, N., Saikia, J. P., & Konwar, B. K. (2009). Biocompatible epoxy modified bio-based polyurethane nanocomposites: Mechanical property, cytotoxicity and biodegradation. Bioresource Technology, 100(24), 6391¿6397. https://doi.org/10.1016/j.biortech.2009.06.029 ESCOBAR M, L., RIVERA, A., & ARISTIZÁBAL G, F. A. (2010). ESTUDIO COMPARATIVO DE LOS MÉTODOS DE RESAZURINA Y MTT EN ESTUDIOS DE CITOTOXICIDAD EN LÍNEAS CELULARES TUMORALES HUMANAS. Vitae, 17(1), 67¿74. Ghorbanian, L., Emadi, R., Razavi, S. M., Shin, H., & Teimouri, A. (2013). Fabrication and characterization of novel diopside/silk fibroin nanocomposite scaffolds for potential application in maxillofacial bone regeneration. International Journal of Biological Macromolecules, 58, 275¿80. https://doi.org/10.1016/j.ijbiomac.2013.04.004 Gómez, A. A. (n.d.). El fibroblasto: su origen, estructura, funciones y heterogeneidad dentro del periodonto Fibroblast: its origin, structure, functions and heterogeneity within the periodontium. Habiba, U., Islam, M. S., Siddique, T. A., Afifi, A. M., & Ang, B. C. (2016). Adsorption and photocatalytic degradation of anionic dyes on Chitosan/PVA/Na¿Titanate/TiO2 composites synthesized by solution casting method. Carbohydrate Polymers, 149, 317¿331. https://doi.org/10.1016/j.carbpol.2016.04.127 He, J., He, F.-L., Li, D.-W., Liu, Y.-L., & Yin, D.-C. (2016). A novel porous Fe/Fe-W alloy scaffold with a double-layer structured skeleton: Preparation, in vitro degradability and biocompatibility. Colloids and Surfaces. B, Biointerfaces, 142, 325¿33. https://doi.org/10.1016/j.colsurfb.2016.03.002 ISO, 10993-5 DIN EN. (n.d.). Biological evaluation of medical devices ¿ Part 5: Tests for in vitro cytotoxicity. Retrieved April 28, 2016, from https://www.iso.org/obp/ui/#iso:std:iso:10993:-5:ed- 3:v1:en Janik, H., & Marzec, M. (2015). A review: Fabrication of porous polyurethane scaffolds. Materials Science and Engineering: C, 48, 586¿591. https://doi.org/10.1016/j.msec.2014.12.037 Kwan, S., & Mari¿, M. (2016). Thermoresponsive polymers with tunable cloud point temperatures grafted from chitosan via nitroxide mediated polymerization. Polymer, 86, 69¿82. https://doi.org/10.1016/j.polymer.2016.01.039 La Rosa, A. D. (2016). 4 ¿ Life cycle assessment of biopolymers. In Biopolymers and Biotech Admixtures for Eco-Efficient Construction Materials (pp. 57¿78). https://doi.org/10.1016/B978-0- 08-100214-8.00004-X López-Saucedo, F., Alvarez-Lorenzo, C., Concheiro, A., & Bucio, E. (2016). Radiation-grafting of vinyl monomers separately onto polypropylene monofilament sutures. https://doi.org/10.1016/j.radphyschem.2016.11.006 Macocinschi, D., Filip, D., Vlad, S., Butnaru, M., & Knieling, L. (2013). Evaluation of polyurethane based on cellulose derivative-ketoprofen biosystem for implant biomedical devices. International Journal of Biological Macromolecules, 52, 32¿7. https://doi.org/10.1016/j.ijbiomac.2012.09.026 263585 TE08924
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spelling	Valero Valdivieso, Manuel FernandoAndrade Becerra, Laura PatriciaIngeniero Químico2017-03-03T19:29:18Z2017-03-03T19:29:18Z20162017-03-03Adamczak, M. I., Hagesaether, E., Smistad, G., & Hiorth, M. (2016). An in vitro study of mucoadhesion and biocompatibility of polymer coated liposomes on HT29-MTX mucus-producing cells. International Journal of Pharmaceutics, 498(1¿2), 225¿33. https://doi.org/10.1016/j.ijpharm.2015.12.030Aranaz, I., Mengibar, M., Harris, R., Panos, I., Miralles, B., Acosta, N., ¿ Heras, A. (2009). Functional Characterization of Chitin and Chitosan. Current Chemical Biology, 3(2), 203¿230. https://doi.org/10.2174/187231309788166415Arévalo, S., & Ramirez, C. (2015). Síntesis, Caracterización y Degradabilidad in vitro de Polímeros Obtenidos de Aceite de Higuerilla y Quitosano.Bakhshi, H., Yeganeh, H., Mehdipour-Ataei, S., Shokrgozar, M. A., Yari, A., & Saeedi-Eslami, S. N. (2013). Synthesis and characterization of antibacterial polyurethane coatings from quaternary ammonium salts functionalized soybean oil based polyols. Materials Science and Engineering: C, 33(1), 153¿164. https://doi.org/10.1016/j.msec.2012.08.023Bakhshi, H., Yeganeh, H., Yari, A., & Nezhad, S. K. (2014). Castor oil-based polyurethane coatings containing benzyl triethanol ammonium chloride: synthesis, characterization, and biological properties. Journal of Materials Science, 49(15), 5365¿5377. https://doi.org/10.1007/s10853-014- 8244-xBerridge, M. V, Herst, P. M., & Tan, A. S. (2005). Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnology Annual Review, 11, 127¿52. https://doi.org/10.1016/S1387-2656(05)11004-7Berridge, M. V, & Tan, A. S. (1993). Characterization of the Cellular Reduction of 3.pdf. Archives of Biochemestry and Biophisics, 474¿482. 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Pruebas de tamizaje para determinar efectos citotóxicos en extractos, fracciones o sustancias, utilizando la prueba MTT. Universidad San Martín. Retrieved from http://old.iupac.org/publications/cd/medicinal_chemistry/Practica-IV-2.pdfChapdelaine, J. M. (n.d.). MTT reduction -a tetrazolium-based colorimetric assay for cell survival and proliferation.Chen, Y., Tang¿, H., Liu¿, Y., & Tan, H. (2016). Preparation and study on the volume phase transition properties of novel carboxymethyl chitosan grafted polyampholyte superabsorbent polymers. Journal of the Taiwan Institute of Chemical Engineers, 59, 569¿577. https://doi.org/10.1016/j.jtice.2015.09.011Chen, Y., Zhou, Y., Yang, S., Li, J. J., Li, X., Ma, Y., ¿ Yu, B. (2016). Novel bone substitute composed of chitosan and strontium-doped ¿-calcium sulfate hemihydrate: Fabrication, characterisation and evaluation of biocompatibility. 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International Journal of Biological Macromolecules, 52, 32¿7. https://doi.org/10.1016/j.ijbiomac.2012.09.026https://hdl.handle.net/10818/29878263585TE0892430 Páginas.En el presente trabajo se evaluaron materiales poliméricos a partir del aceite de higuerilla, por medio de transesterificación se obtuvieron tres variaciones de polioles (183, 196 y 236 mg KOH/g). Los cuales reaccionaron con diisocianato de isoforona para conformar una matriz de poliuretano, adicionalmente se incorporó quitosano en diferentes concentraciones (0, 2.5, 5 y 7.5 %p/p) con el fin de mejorar la viabilidad celular del polímero. El objetivo del estudio se centró en determinar el efecto de la adición de quitosano a la matriz de poliuretano sobre la viabilidad celular y así establecer si la mezcla tiene potencial para ser usada en aplicaciones biomédicas. Se evaluó la viabilidad celular in vitro de los polímeros y de sus extractos por medio del ensayo MTT sobre fibroblastos embrionarios de ratón L-929 (ATCC® CCL-1). Adicionalmente, se estudió una degradación acelerada de éstos en buffer fosfato a una temperatura de 105ºC por 72 horas. Se encontró que el incremento en la funcionalidad del poliol favorece la viabilidad celular y la adición de quitosano no afecta la proliferación celular. Además, se evidenció la resistencia a la degradación con valores menores a 1%. Con base en los resultados obtenidos, se concluyó que los polímeros pueden tener un alto potencial en aplicaciones biomédicas.spaUniversidad de La SabanaIngeniería QuímicaFacultad de IngenieríaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_16ecUniversidad de la SabanaIntellectum Repositorio Universidad de la SabanaIngeniería químicaFusión nuclearCompatibilidad -- PruebasEvaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosanoTesis/Trabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/version/c_970fb48d4fbd8a85Textoinfo:eu-repo/semantics/bachelorThesishttp://purl.org/redcol/resource_type/TPPublicationTEXTLaura Patricia Andrade Becerra (Tesis).pdf.txtLaura Patricia Andrade Becerra (Tesis).pdf.txtExtracted Texttext/plain69516https://intellectum.unisabana.edu.co/bitstreams/7bdf9f62-bfb5-52b7-e053-7e0910accd73/downloadebda430cf762386895475dd21c9cd4f7MD55falseORIGINALLaura Patricia Andrade Becerra (Tesis).pdfLaura Patricia Andrade Becerra (Tesis).pdfVer documento en PDFapplication/pdf1514194https://intellectum.unisabana.edu.co/bitstreams/7bdf9f62-bf97-52b7-e053-7e0910accd73/download60ba5d0377154d6359ac292316498b38MD51trueCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81223https://intellectum.unisabana.edu.co/bitstreams/7bdf9f62-bf98-52b7-e053-7e0910accd73/download7c9ab7f006165862d8ce9ac5eac01552MD52falseAdministratorREADAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-8498https://intellectum.unisabana.edu.co/bitstreams/7bdf9f62-bf99-52b7-e053-7e0910accd73/downloadf52a2cfd4df262e08e9b300d62c85cabMD53falseAdministratorREADAnonymousREADLaura Patricia Andrade Becerra (Carta).pdfLaura Patricia Andrade Becerra (Carta).pdfapplication/pdf80720https://intellectum.unisabana.edu.co/bitstreams/7bdf9f62-bf9a-52b7-e053-7e0910accd73/download79084fc9cc2e96d8b46713e1c4a3a20bMD54falseTHUMBNAILLaura Patricia Andrade Becerra (Tesis).pdf.jpgLaura Patricia Andrade Becerra (Tesis).pdf.jpgGenerated Thumbnailimage/jpeg6676https://intellectum.unisabana.edu.co/bitstreams/f21fab88-0888-416e-9379-101f16987aa3/download19449173bf799b184a4cfb7775d5b7dcMD56false10818/29878oai:intellectum.unisabana.edu.co:10818/298782025-12-15 12:49:14.105http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internationalrestrictedhttps://intellectum.unisabana.edu.coIntellectum Repositorio Universidad de La Sabanacontactointellectum@unisabana.edu.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

Evaluación de la citotoxicidad de poliuretanos a partir de aceite de higuerilla y quitosano

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