Factores de virulencia de Candida spp y mecanismos moleculares de resistencia a los azoles expresados por Candida tropicalis
Introducción: Debido al panorama epidemiológico de la candidiasis producida por Candida tropicalis y la marcada resistencia generada hacia los azoles, se hace necesario profundizar en el conocimiento de la virulencia y mecanismos de resistencia a fármacos. Objetivo: Sintetizar los factores de virule...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2025
- Institución:
- Universidad de Caldas
- Repositorio:
- Repositorio Institucional U. Caldas
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.ucaldas.edu.co:ucaldas/23823
- Acceso en línea:
- https://repositorio.ucaldas.edu.co/handle/ucaldas/23823
https://doi.org/10.17151/biosa.2020.19.2.1
- Palabra clave:
- Candida tropicalis
Factores de virulencia
Resistencia a medicamentos
Azoles
Antifúngicos
Candida tropicalis
Virulence Factors
Drug Resistance
Azoles
Antifungals
- Rights
- openAccess
- License
- Biosalud - 2025
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Repositorio Institucional U. Caldas |
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| dc.title.none.fl_str_mv |
Factores de virulencia de Candida spp y mecanismos moleculares de resistencia a los azoles expresados por Candida tropicalis Virulence factors of Candida spp and molecular mechanisms of resistance to azoles expressed by Candida tropicalis |
| title |
Factores de virulencia de Candida spp y mecanismos moleculares de resistencia a los azoles expresados por Candida tropicalis |
| spellingShingle |
Factores de virulencia de Candida spp y mecanismos moleculares de resistencia a los azoles expresados por Candida tropicalis Candida tropicalis Factores de virulencia Resistencia a medicamentos Azoles Antifúngicos Candida tropicalis Virulence Factors Drug Resistance Azoles Antifungals |
| title_short |
Factores de virulencia de Candida spp y mecanismos moleculares de resistencia a los azoles expresados por Candida tropicalis |
| title_full |
Factores de virulencia de Candida spp y mecanismos moleculares de resistencia a los azoles expresados por Candida tropicalis |
| title_fullStr |
Factores de virulencia de Candida spp y mecanismos moleculares de resistencia a los azoles expresados por Candida tropicalis |
| title_full_unstemmed |
Factores de virulencia de Candida spp y mecanismos moleculares de resistencia a los azoles expresados por Candida tropicalis |
| title_sort |
Factores de virulencia de Candida spp y mecanismos moleculares de resistencia a los azoles expresados por Candida tropicalis |
| dc.subject.none.fl_str_mv |
Candida tropicalis Factores de virulencia Resistencia a medicamentos Azoles Antifúngicos Candida tropicalis Virulence Factors Drug Resistance Azoles Antifungals |
| topic |
Candida tropicalis Factores de virulencia Resistencia a medicamentos Azoles Antifúngicos Candida tropicalis Virulence Factors Drug Resistance Azoles Antifungals |
| description |
Introducción: Debido al panorama epidemiológico de la candidiasis producida por Candida tropicalis y la marcada resistencia generada hacia los azoles, se hace necesario profundizar en el conocimiento de la virulencia y mecanismos de resistencia a fármacos. Objetivo: Sintetizar los factores de virulencia de Candida spp. y los mecanismos moleculares de resistencia a azoles expresados por Candida tropicalis. Materiales y métodos: Se realizó una búsqueda bibliográfica en la base de datos Pubmed y los manuscritos fueron seleccionados según los criterios de análisis crítico propuestos por el instrumento PRISMA. La pregunta orientadora de la búsqueda fue: ¿Cuáles son los factores de virulencia de Candida spp y los mecanismos de resistencia a los azoles expresados por la especie C.tropicalis? y los resultados se organizaron en dos categorías: Factores de virulencia de Candida spp y mecanismos moleculares de resistencia a azoles. Resultados: Los factores de virulencia de Candida spp. están representados por la producción de toxinas y enzimas, la formación de biopelículas, la modificación del medio ambiente, la filamentación y el crecimiento hifal; por otro lado, los mecanismos de resistencia a los azoles expresados por C.tropicalis están determinados principalmente por la sobreexpresión de los genes ERG11 y MDR1 y por mutaciones en el gen ERG11. Conclusiones: Los factores de virulencia son similares entre las distintas especies de Candida y los mecanismos moleculares de resistencia a los azoles expresados por C. tropicalis se traducen fundamentalmente en una menor afinidad por la diana farmacológica y una menor concentración intracelular del fármaco. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025-10-06T00:00:00Z 2025-10-08T21:17:16Z 2025-10-06T00:00:00Z 2025-10-08T21:17:16Z 2025-10-06 |
| dc.type.none.fl_str_mv |
Artículo de revista http://purl.org/coar/resource_type/c_6501 http://purl.org/coar/resource_type/c_2df8fbb1 Text info:eu-repo/semantics/article Journal article http://purl.org/redcol/resource_type/ART info:eu-repo/semantics/publishedVersion http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| status_str |
publishedVersion |
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1657-9550 https://repositorio.ucaldas.edu.co/handle/ucaldas/23823 10.17151/biosa.2020.19.2.1 2462-960X https://doi.org/10.17151/biosa.2020.19.2.1 |
| identifier_str_mv |
1657-9550 10.17151/biosa.2020.19.2.1 2462-960X |
| url |
https://repositorio.ucaldas.edu.co/handle/ucaldas/23823 https://doi.org/10.17151/biosa.2020.19.2.1 |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
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Azole Antifungal Resistance in Candida albicans and Emerging Non-albicans Candida Species. Front Microbiol. 2017;7:2173. https://doi.org/10.3389/fmicb.2016.02173 Flowers SA, Colón B, Whaley SG, Schuler MA, Rogers PD. Contribution of Clinically Derived Mutations in ERG11 to Azole Resistance in Candida albicans. Antimicrob Agents Chemother. 2015;59(1):450-60. https://doi.org/10.1128/AAC.03470-14 López-Ávila K, Dzul-Rosado KR, Lugo-Caballero C, Arias-León JJ, Zavala-Castro JE. Mecanismos de resistencia antifúngica de los azoles en Candida albicans. Una revisión. Rev Bioméd. Doi:83. Bloise E, Ortiga-Carvalho TM, Reis FM, Lye SJ, Gibb W, Matthews SG. ATP-binding cassette transporters in reproduction: a new frontier. Hum Reprod Update. abril de 2016;22(2):164-81.https://doi.org/10.1093/humupd/dmv049 Morales-Pérez M, García-Milian AJ, Morales-Pérez M, García-Milian AJ. Papel de la superfamilia ABC en la resistencia farmacológica. Horiz Sanit. 2017;16(2):93-101. https://doi.org/10.19136/hs.v16i2.1469 Fuentes M, Hermosilla G, Alburquenque C, Falconer MA, Amaro J, Tapia C. [Characterization of azole resistance mechanisms in Chilean clinical isolates of Candida albicans]. Rev Chil Infectologia Organo of Soc Chil Infectologia. octubre de 2014;31(5):511-7. https://doi.org/10.4067/s0716-10182014000500001 Pristov KE, Ghannoum MA. Resistance of Candida to azoles and echinocandins worldwide. Clin Microbiol Infect. 2019;25(7):792-8. https://doi.org/10.1016/j.cmi.2019.03.028 Sasani E, Yadegari MH, Khodavaisy S, Rezaie S, Salehi M, Getso MI. Virulence Factors and Azole-Resistant Mechanism of Candida Tropicalis Isolated from Candidemia. Mycopathologia.2021;186(6):847-56. https://doi.org/10.1007/s11046-021-00580-y Jiang C, Dong D, Yu B, Cai G, Wang X, Ji Y, et al. Mechanisms of azole resistance in 52 clinical isolates of Candida tropicalis in China. 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J Fungi Basel Switz. 2022;8(9):896. https://doi.org/10.3390/jof8090896 Benedetti VP, Savi DC, Aluizio R, Adamoski D, Kava V, Galli-Terasawa LV, et al. ERG11 gene polymorphisms and susceptibility to fluconazole in Candida isolates from diabetic and kidney transplant patients. Rev Soc Bras Med Trop. 2019;52:e20180473. https://doi.org/10.1590/0037-8682-0473-2018 Arastehfar A, Hilmioğlu-Polat S, Daneshnia F, Hafez A, Salehi M, Polat F, et al. Recent Increase in the Prevalence of Fluconazole-Non-susceptible Candida tropicalis Blood Isolates in Turkey: Clinical Implication of Azole-Non-susceptible and Fluconazole Tolerant Phenotypes and Genotyping. Front Microbiol. 2020;11:587278. https://doi.org/10.3389/fmicb.2020.587278 Teo JQM, Lee SJY, Tan AL, Lim RSM, Cai Y, Lim TP, et al. Molecular mechanisms of azole resistance in Candida bloodstream isolates. BMC Infect Dis. 2019;19(1):63. https://doi.org/10.1186/s12879-019-3672-5 Eddouzi J, Parker JE, Vale-Silva LA, Coste A, Ischer F, Kelly S, et al. Molecular mechanisms of drug resistance in clinical Candida species isolated from Tunisian hospitals. Antimicrob Agents Chemother.2013;57(7):3182-93. https://doi.org/10.1128/AAC.00555-13 Astvad KMT, Sanglard D, Delarze E, Hare RK, Arendrup MC. Implications of the EUCAST Trailing Phenomenon in Candida tropicalis for the In Vivo Susceptibility in Invertebrate and Murine Models. Antimicrob Agents Chemother. 2018;62(12):e01624-18. https://doi.org/10.1128/aac.01624-18 Khalifa HO, Watanabe A, Kamei K. Azole and echinocandin resistance mechanisms and genotyping of Candida tropicalis in Japan: cross-boundary dissemination and animal–human transmission of C. tropicalis infection. Clin Microbiol Infect. 2022;28(2):302.e5-302.e8. https://doi.org/10.1016/j. cmi.2021.10.004 Jiang C, Ni Q, Dong D, Zhang L, Li Z, Tian Y, et al. The Role of UPC2 Gene in Azole-Resistant Candida tropicalis. Mycopathologia. 2016;181(11-12):833-8. https://doi.org/10.1007/s11046-016-0050-3 You L, Qian W, Yang Q, Mao L, Zhu L, Huang X, et al. ERG11 Gene Mutations and MDR1 Upregulation Confer Pan-Azole Resistance in Candida tropicalis Causing Disseminated Candidiasis in an Acute Lymphoblastic Leukemia Patient on Posaconazole Prophylaxis. Antimicrob Agents Chemother.2017;61(7):e02496-16. https://doi.org/10.1128/AAC.02496-16 Núm. 2 , Año 2020 : Julio - Diciembre https://revistasojs.ucaldas.edu.co/index.php/biosalud/article/download/10985/8009 |
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Universidad de Caldas |
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Factores de virulencia de Candida spp y mecanismos moleculares de resistencia a los azoles expresados por Candida tropicalisVirulence factors of Candida spp and molecular mechanisms of resistance to azoles expressed by Candida tropicalisCandida tropicalisFactores de virulenciaResistencia a medicamentosAzolesAntifúngicosCandida tropicalisVirulence FactorsDrug ResistanceAzolesAntifungalsIntroducción: Debido al panorama epidemiológico de la candidiasis producida por Candida tropicalis y la marcada resistencia generada hacia los azoles, se hace necesario profundizar en el conocimiento de la virulencia y mecanismos de resistencia a fármacos. Objetivo: Sintetizar los factores de virulencia de Candida spp. y los mecanismos moleculares de resistencia a azoles expresados por Candida tropicalis. Materiales y métodos: Se realizó una búsqueda bibliográfica en la base de datos Pubmed y los manuscritos fueron seleccionados según los criterios de análisis crítico propuestos por el instrumento PRISMA. La pregunta orientadora de la búsqueda fue: ¿Cuáles son los factores de virulencia de Candida spp y los mecanismos de resistencia a los azoles expresados por la especie C.tropicalis? y los resultados se organizaron en dos categorías: Factores de virulencia de Candida spp y mecanismos moleculares de resistencia a azoles. Resultados: Los factores de virulencia de Candida spp. están representados por la producción de toxinas y enzimas, la formación de biopelículas, la modificación del medio ambiente, la filamentación y el crecimiento hifal; por otro lado, los mecanismos de resistencia a los azoles expresados por C.tropicalis están determinados principalmente por la sobreexpresión de los genes ERG11 y MDR1 y por mutaciones en el gen ERG11. Conclusiones: Los factores de virulencia son similares entre las distintas especies de Candida y los mecanismos moleculares de resistencia a los azoles expresados por C. tropicalis se traducen fundamentalmente en una menor afinidad por la diana farmacológica y una menor concentración intracelular del fármaco.Introduction: Due to the epidemiological panorama of candidiasis caused by Candida tropicalis and the marked resistance generated towards azoles, it is necessary to deepen the knowledge of virulence and drug resistance mechanisms. Objective: To synthesize the virulence factors of Candida spp. and the molecular mechanisms of azole resistance expressed by Candida tropicalis. Materials and methods: The bibliographical search were conducted in the PubMed database and manuscripts were selected according to the critical analysis criteria proposed by the PRISMA instrument. The guiding question for the search was: What are the virulence factors of Candida spp, and the azole resistance mechanisms expressed by the species C. tropicalis? The results were organized into two categories: Virulence factors of Candida spp and molecular mechanisms of resistance to azoles. Results: The virulence factors of Candida spp. are represented by toxin and enzyme production, biofilm formation, environmental modification, filamentation, and hyphal growth. The mechanisms of resistance to azoles expressed by C. tropicalis are mainly determined by overexpression of the ERG11 and MDR1 genes and by mutations in the ERG11 gene. Conclusion: Virulence factors are similar among Candida species and the molecular mechanisms of resistance to azoles expressed by C. tropicalis fundamentally result in decreased affinity for the pharmacological target and lower intracellular concentration of the drug.Universidad de Caldas2025-10-06T00:00:00Z2025-10-08T21:17:16Z2025-10-06T00:00:00Z2025-10-08T21:17:16Z2025-10-06Artículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articleJournal articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85application/pdf1657-9550https://repositorio.ucaldas.edu.co/handle/ucaldas/2382310.17151/biosa.2020.19.2.12462-960Xhttps://doi.org/10.17151/biosa.2020.19.2.1https://revistasojs.ucaldas.edu.co/index.php/biosalud/article/view/10985eng252719BiosaludArendrup MC. Candida and Candidaemia. Susceptibility and epidemiology. 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