Variantes genéticas y metabolismo de los opiáceos, los opioides y la cocaína

Resumen: Algunas variantes en los genes que codifican proteínas involucradas en el metabolismo o biotransformación de drogas de abuso, pueden afectar la vulnerabilidad a desarrollar una adicción; y otras variantes relacionadas con el metabolismo de los opiáceos y la cocaína, han sido identificadas y...

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Fecha de publicación:: 2005

Institución:: Universidad de Caldas

Repositorio:: Repositorio Institucional U. Caldas

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dc.title.none.fl_str_mv	Variantes genéticas y metabolismo de los opiáceos, los opioides y la cocaína Variantes genéticas y metabolismo de los opiáceos, los opioides y la cocaína
title	Variantes genéticas y metabolismo de los opiáceos, los opioides y la cocaína
spellingShingle	Variantes genéticas y metabolismo de los opiáceos, los opioides y la cocaína metabolismo opiáceos opioides cocaína Metabolism opiate opioides cocaine
title_short	Variantes genéticas y metabolismo de los opiáceos, los opioides y la cocaína
title_full	Variantes genéticas y metabolismo de los opiáceos, los opioides y la cocaína
title_fullStr	Variantes genéticas y metabolismo de los opiáceos, los opioides y la cocaína
title_full_unstemmed	Variantes genéticas y metabolismo de los opiáceos, los opioides y la cocaína
title_sort	Variantes genéticas y metabolismo de los opiáceos, los opioides y la cocaína
dc.subject.none.fl_str_mv	metabolismo opiáceos opioides cocaína Metabolism opiate opioides cocaine
topic	metabolismo opiáceos opioides cocaína Metabolism opiate opioides cocaine
description	Resumen: Algunas variantes en los genes que codifican proteínas involucradas en el metabolismo o biotransformación de drogas de abuso, pueden afectar la vulnerabilidad a desarrollar una adicción; y otras variantes relacionadas con el metabolismo de los opiáceos y la cocaína, han sido identificadas y pueden estar asociadas con la vulnerabilidad a desarrollar o afectar el tratamiento de las enfermedades adictivas. Esta revisión está enfocada sobre los opiáceos, los opioides y la cocaína, mencionando algunas variantes genéticas que pueden alterar su metabolismo.
publishDate	2005
dc.date.none.fl_str_mv	2005-01-01 2006-01-01T00:00:00Z 2006-01-01T00:00:00Z 2025-10-08T21:49:29Z 2025-10-08T21:49:29Z
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dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_2df8fbb1
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dc.identifier.none.fl_str_mv	0122-8455 https://repositorio.ucaldas.edu.co/handle/ucaldas/25085 2590-7840 https://revistasojs.ucaldas.edu.co/index.php/culturaydroga/article/view/5983
identifier_str_mv	0122-8455 2590-7840
url	https://repositorio.ucaldas.edu.co/handle/ucaldas/25085 https://revistasojs.ucaldas.edu.co/index.php/culturaydroga/article/view/5983
dc.language.none.fl_str_mv	spa
language	spa
dc.relation.none.fl_str_mv	54 13 39 11 Cultura y Droga Arnsten A.F. (2000a). Through the looking glass: differential noradrenergic modulation of prefrontal cortical function. Neural Plast 7: 133-146. _________. (2000b). Stress impairs prefrontal cortical function in rats and monkeys: role of dopamine D1 and norepinephrine-1 receptor mechanisms. Prog Brain Res 126: 183-192. Azaryan AV, Coughlin LJ. Buzas B, Clock BJ. and Cox BM (1996) Effect of chronic cocaine treatment on- and-opioid receptor mRNA levels in dopaminergically innervated brain regions. J Neurochem 66: 443-448. Bart G. Borg L. Schluger J.H. Green M. Ho A. and Kreek M.J. (2003). Suppressed prolactin response to dynorphin A (1-13) in methadone maintained versus control subjects. J Pharmacol Exp Ther 306: 581-587. Becker A. Grecksch G. Brodemann R. Kraus J. Peters B. Schroeder H. Thiemann W. Loh H.H. and Ho¨llt V. (2000). Morphine self-administration in-opioid receptordeficient mice. Naunyn-Schmiedeberg’s Arch Pharmacol 361: 584-589. Becker A. Grecksch G. Kraus J. Loh H.H. Schroeder H. and Ho¨llt V. (2002). Rewarding effects of ethanol and cocaine in mu opioid receptor-deficient mice. Naunyn- Schmiedeberg’s Arch Pharmacol 365: 296-302. Berrettini W.H. Ferraro T.N. Alexander R.C. Buchberg A.M. and Vogel W.H. (1994). Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains. Nat Genet 7: 54-58. Bohn L.M. Xu F. Gainetdinov R.R. and Caron M.G. (2000). Potentiated opioid analgesia in norepinephrine transporter knock-out mice. J Neurosci 20: 9040-9045. Bond C. LaForge K.S. Tian M. Melia D. Zhang S. Borg L. Gong J. Schluger J. Strong J.A. Leal S.M. et al. (1998). Single nucleotide polymorphism in the human mu opioid receptor gene alters-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci USA 95: 9608-9613. Bowen D.V. Smit A.L.C. and Kreek M.J. (1978).F ecal excretion of methadone and its metabolites in man: application of GC-MS. in Advances in Mass Spectrometry (Daly NR ed.) pp. 1634-1639, Heyden and SonS. PhiladelphiA. PA. Brzezinski M.R. Abraham T.L. Stone C.L. Dean R.A. and Bosron W.F. (1994). Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine. Biochem Pharmacol 48: 1747-1755. Carroll K.M. Fenton L.R. Ball S.A. Nich C. Frankforter T.L. Shi J. and Rounsaville B.J (2004). Efficacy of disulfiram and cognitive behavior therapy in cocaine-dependent outpatients. Arch Gen Psychiatry 61: 264-272. Carroll K.M. Ziedonis D. O’Malley S.S. McCance-Katz E. Gordon L.T. and Rounsaville B.J. (1993). Pharmacological interventions for abusers of alcohol and cocaine: a pilot study of disulfiram versus naltrexone. Am J Addict 2: 77-79. Chen A.C.H. LaForge K.S. Ho A. McHugh P.F. Bell K. Schluger R.P. Leal S.M. and Kreek M.J. (2002). A potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse. Am J Med Genet 114: 429-435. Comings D.E. Blake H. Dietz G. Gade-Andavolu R. Legro R.S. Saucier G. Johnson P. Verde R. and MacMurray J.P. (1999). The proenkephalin gene (PENK) and opioid dependence. Neuroreport 10: 1133-1135. Crowley J.J. Oslin D.W. Patkar A.A. Gottheil E. DeMaria P.A.Jr. O’Brien C.P. Berrettini W.H. and Grice D.E. (2003). A genetic association study of the mu opioid receptor and severe opioid dependence. Psychiatr Genet 13: 169-173. Dai D. Tang J. Rose R. Hodgson E. Bienstock R.J. Mohrenweiser H.W. and Goldstein J.A. (2001). Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos. J Pharmacol Exp Ther 299: 825-831. Dean R.A. Christian C.D. Sample R.H. and Bosron W.F. (1991). Human liver cocaine esterases: ethanol-mediated formation of ethylcocaine. FASEB J 5: 2735-2739. Dole V.P., Nyswander M.E. and Kreek M.J. (1966). Narcotic blockade. Arch Intern Med 118: 304-309. Duguay Y., Skorpen F. and Guillemette C. (2004).Anovel functional polymorphism in the uridine diphosphate-glucuronsyltransferase 2B7 promoter with significant impact on promoter activity. Clin Pharmacol Ther 75: 223-233. Eap C.B., Broly F., Mino A., Ha¨mmig R., De´glon J.J. Uehlinger C., Meili D., Chevalley AF., Bertschy G., Zullino D., et al. (2001). Cytochrome P450 2D6 genotype and methadone steady-state concentrations. J Clin Psychopharmacol 21: 229-234. Eiselt R., Domanski T.L., Zibat A., Mueller R., Presecan-Siedel E., Hustert E., Zanger U.M., Brockmoller J., Klenk H.P., Meyer U.A., et al. (2001). Identification and functional characterization of eight CYP3A4 protein variants. Pharmacogenetics 11: 447-458. Fernandes L.C., Kilicarlsan T., Kaplan H.L., Tyndale R.F., Sellers E.M. and Romach M.K., (2002). Treatment of codeine dependence with inhibitors of cytochrome P450 2D6. J Clin Psychopharmacol 22: 326-329. Holthe M., Klepstad P., Idle J.R., Kaasa S., Krokan H.E. and Skorpen F. (2003). Sequence variations in the UDP-glucuronsyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients. Pharmacogenomics J 3: 17-26. Holthe M., Klepstad P., Zahlsen K., Borchgrevink P.C., Hagen L., Dale O., Kaasa S., Krokan H.E. and Skorpen F. (2002). Morphine glucuronide- to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy. Eur J Clin Pharmacol 58: 353-356. Howard L.A., Sellers E.M. and Tyndale R.F. (2002). The role of pharmacogeneticallyvariable cytochrome P450 enzymes in drug abuse and dependence. 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dc.publisher.none.fl_str_mv	Universidad de Caldas
publisher.none.fl_str_mv	Universidad de Caldas
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spelling	Variantes genéticas y metabolismo de los opiáceos, los opioides y la cocaínaVariantes genéticas y metabolismo de los opiáceos, los opioides y la cocaínametabolismoopiáceosopioidescocaínaMetabolismopiateopioidescocaineResumen: Algunas variantes en los genes que codifican proteínas involucradas en el metabolismo o biotransformación de drogas de abuso, pueden afectar la vulnerabilidad a desarrollar una adicción; y otras variantes relacionadas con el metabolismo de los opiáceos y la cocaína, han sido identificadas y pueden estar asociadas con la vulnerabilidad a desarrollar o afectar el tratamiento de las enfermedades adictivas. Esta revisión está enfocada sobre los opiáceos, los opioides y la cocaína, mencionando algunas variantes genéticas que pueden alterar su metabolismo.Abstract: biotransformation of abusive drugs may affect the vulnerability of developing an addiction. Other variants related to the metabolism of opiates and cocaine have been identified and may be associated with the vulnerability of developing or affecting the treatment of addictive diseases. This revision is focussed on opiates, opioids and cocaine mentioning some genetic variants that can alter their metabolism.Universidad de Caldas2006-01-01T00:00:00Z2025-10-08T21:49:29Z2006-01-01T00:00:00Z2025-10-08T21:49:29Z2005-01-01Artículo de revistahttp://purl.org/coar/resource_type/c_6501Textinfo:eu-repo/semantics/articleJournal articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1application/pdf0122-8455https://repositorio.ucaldas.edu.co/handle/ucaldas/250852590-7840https://revistasojs.ucaldas.edu.co/index.php/culturaydroga/article/view/5983https://revistasojs.ucaldas.edu.co/index.php/culturaydroga/article/view/5983spa54133911Cultura y DrogaArnsten A.F. (2000a). Through the looking glass: differential noradrenergic modulation of prefrontal cortical function. Neural Plast 7: 133-146._________. (2000b). Stress impairs prefrontal cortical function in rats and monkeys: role of dopamine D1 and norepinephrine-1 receptor mechanisms. Prog Brain Res 126: 183-192.Azaryan AV, Coughlin LJ. Buzas B, Clock BJ. and Cox BM (1996) Effect of chronic cocaine treatment on- and-opioid receptor mRNA levels in dopaminergically innervated brain regions. J Neurochem 66: 443-448.Bart G. Borg L. Schluger J.H. Green M. Ho A. and Kreek M.J. (2003). Suppressed prolactin response to dynorphin A (1-13) in methadone maintained versus control subjects. J Pharmacol Exp Ther 306: 581-587.Becker A. Grecksch G. Brodemann R. Kraus J. Peters B. Schroeder H. Thiemann W. Loh H.H. and Ho¨llt V. (2000). Morphine self-administration in-opioid receptordeficient mice. Naunyn-Schmiedeberg’s Arch Pharmacol 361: 584-589.Becker A. Grecksch G. Kraus J. Loh H.H. Schroeder H. and Ho¨llt V. (2002). Rewarding effects of ethanol and cocaine in mu opioid receptor-deficient mice. Naunyn- Schmiedeberg’s Arch Pharmacol 365: 296-302.Berrettini W.H. Ferraro T.N. Alexander R.C. Buchberg A.M. and Vogel W.H. (1994). Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains. Nat Genet 7: 54-58.Bohn L.M. Xu F. Gainetdinov R.R. and Caron M.G. (2000). Potentiated opioid analgesia in norepinephrine transporter knock-out mice. J Neurosci 20: 9040-9045.Bond C. LaForge K.S. Tian M. Melia D. Zhang S. Borg L. Gong J. Schluger J. Strong J.A. Leal S.M. et al. (1998). Single nucleotide polymorphism in the human mu opioid receptor gene alters-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci USA 95: 9608-9613. Bowen D.V. Smit A.L.C. and Kreek M.J. (1978).F ecal excretion of methadone and its metabolites in man: application of GC-MS. in Advances in Mass Spectrometry (Daly NR ed.) pp. 1634-1639, Heyden and SonS. PhiladelphiA. PA.Brzezinski M.R. Abraham T.L. Stone C.L. Dean R.A. and Bosron W.F. (1994). Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine. Biochem Pharmacol 48: 1747-1755.Carroll K.M. Fenton L.R. Ball S.A. Nich C. Frankforter T.L. Shi J. and Rounsaville B.J (2004). Efficacy of disulfiram and cognitive behavior therapy in cocaine-dependent outpatients. Arch Gen Psychiatry 61: 264-272.Carroll K.M. Ziedonis D. O’Malley S.S. McCance-Katz E. Gordon L.T. and Rounsaville B.J. (1993). Pharmacological interventions for abusers of alcohol and cocaine: a pilot study of disulfiram versus naltrexone. Am J Addict 2: 77-79.Chen A.C.H. LaForge K.S. Ho A. McHugh P.F. Bell K. Schluger R.P. Leal S.M. and Kreek M.J. (2002). A potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse. Am J Med Genet 114: 429-435.Comings D.E. Blake H. Dietz G. Gade-Andavolu R. Legro R.S. Saucier G. Johnson P. Verde R. and MacMurray J.P. (1999). The proenkephalin gene (PENK) and opioid dependence. Neuroreport 10: 1133-1135.Crowley J.J. Oslin D.W. Patkar A.A. Gottheil E. DeMaria P.A.Jr. O’Brien C.P. Berrettini W.H. and Grice D.E. (2003). A genetic association study of the mu opioid receptor and severe opioid dependence. Psychiatr Genet 13: 169-173. Dai D. Tang J. Rose R. Hodgson E. Bienstock R.J. Mohrenweiser H.W. and Goldstein J.A. (2001). Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos. J Pharmacol Exp Ther 299: 825-831.Dean R.A. Christian C.D. Sample R.H. and Bosron W.F. (1991). Human liver cocaine esterases: ethanol-mediated formation of ethylcocaine. FASEB J 5: 2735-2739.Dole V.P., Nyswander M.E. and Kreek M.J. (1966). Narcotic blockade. Arch Intern Med 118: 304-309.Duguay Y., Skorpen F. and Guillemette C. (2004).Anovel functional polymorphism in the uridine diphosphate-glucuronsyltransferase 2B7 promoter with significant impact on promoter activity. Clin Pharmacol Ther 75: 223-233.Eap C.B., Broly F., Mino A., Ha¨mmig R., De´glon J.J. Uehlinger C., Meili D., Chevalley AF., Bertschy G., Zullino D., et al. (2001). Cytochrome P450 2D6 genotype and methadone steady-state concentrations. J Clin Psychopharmacol 21: 229-234.Eiselt R., Domanski T.L., Zibat A., Mueller R., Presecan-Siedel E., Hustert E., Zanger U.M., Brockmoller J., Klenk H.P., Meyer U.A., et al. (2001). Identification and functional characterization of eight CYP3A4 protein variants. 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