Early clinical, radiographic and ultrasonographic evaluation of induced osteoarthritis in rabbits treated with autologous platelet concentrate

The objective of this study was to evaluate, the early effect of the autologous platelet concentrates (APC) on induced osteoarthritis (OA) in the stifle joint through clinical, radiographic and ultrasonographic exams. Fourteen adult males of the New Zealand breed rabbits, with an average body mass o...

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Fecha de publicación:
2018
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Universidad de Caldas
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Repositorio Institucional U. Caldas
Idioma:
eng
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oai:repositorio.ucaldas.edu.co:ucaldas/25446
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https://repositorio.ucaldas.edu.co/handle/ucaldas/25446
https://doi.org/10.17151/vetzo.2018.12.1.4
Palabra clave:
degenerative joint process
diagnostic imaging
regenerative therapy
platelet rich plasma
processo articular degenerativo
diagnóstico por imagem
terapia regenerativa
plasma rico em plaquetas
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Revista Veterinaria y Zootecnia (On Line) - 2018
id REPOUCALDA_b1d954005408be9edb8632028282a0ed
oai_identifier_str oai:repositorio.ucaldas.edu.co:ucaldas/25446
network_acronym_str REPOUCALDA
network_name_str Repositorio Institucional U. Caldas
repository_id_str
dc.title.none.fl_str_mv Early clinical, radiographic and ultrasonographic evaluation of induced osteoarthritis in rabbits treated with autologous platelet concentrate
Avaliação clínica, radiográfica e ultrassonográfica precoce da osteoartrose induzida em coelhos e tratados com concentrado autólogo de plaquetas
title Early clinical, radiographic and ultrasonographic evaluation of induced osteoarthritis in rabbits treated with autologous platelet concentrate
spellingShingle Early clinical, radiographic and ultrasonographic evaluation of induced osteoarthritis in rabbits treated with autologous platelet concentrate
degenerative joint process
diagnostic imaging
regenerative therapy
platelet rich plasma
processo articular degenerativo
diagnóstico por imagem
terapia regenerativa
plasma rico em plaquetas
title_short Early clinical, radiographic and ultrasonographic evaluation of induced osteoarthritis in rabbits treated with autologous platelet concentrate
title_full Early clinical, radiographic and ultrasonographic evaluation of induced osteoarthritis in rabbits treated with autologous platelet concentrate
title_fullStr Early clinical, radiographic and ultrasonographic evaluation of induced osteoarthritis in rabbits treated with autologous platelet concentrate
title_full_unstemmed Early clinical, radiographic and ultrasonographic evaluation of induced osteoarthritis in rabbits treated with autologous platelet concentrate
title_sort Early clinical, radiographic and ultrasonographic evaluation of induced osteoarthritis in rabbits treated with autologous platelet concentrate
dc.subject.none.fl_str_mv degenerative joint process
diagnostic imaging
regenerative therapy
platelet rich plasma
processo articular degenerativo
diagnóstico por imagem
terapia regenerativa
plasma rico em plaquetas
topic degenerative joint process
diagnostic imaging
regenerative therapy
platelet rich plasma
processo articular degenerativo
diagnóstico por imagem
terapia regenerativa
plasma rico em plaquetas
description The objective of this study was to evaluate, the early effect of the autologous platelet concentrates (APC) on induced osteoarthritis (OA) in the stifle joint through clinical, radiographic and ultrasonographic exams. Fourteen adult males of the New Zealand breed rabbits, with an average body mass of 3.0 kg were used to induce OA in the right hind limb (RHL). Rabbits were randomly divided into two groups, control group and APC group. Animals in the control group received 0.5 ml intra-articular Ringer Lactate solution. Immediately after the repair of the cranial cruciate ligament, the APC group received 0.5 ml APC intra-articular injections whose mean concentration of platelets was1.8 times the basal levels. Intra-articular injections were applied immediately after joint stabilization. Rabbits treated with APC showed significantly better clinical scores (p<0.05) when compared with rabbits in the control group in relation to pain sensitivity, joint effusion presence and limb support 15 days after APC application (M3). The range of limb motion showed statistically significant difference (p<0.05) in flexion and extension of RHL in M3 in both groups. The radiographic and ultrassonographic images showed the presence of degenerative joint process in both groups without statistical difference between them. From the results it can be concluded that APC has a beneficial clinical effect in joints affected by OA, favoring the use of the limb and controlling pain sensitivity, and that radiography and ultrasonography images are successful tools in the evaluation of the progression of OA.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01T00:00:00Z
2018-01-01T00:00:00Z
2018-01-01
2025-10-08T21:57:22Z
2025-10-08T21:57:22Z
dc.type.none.fl_str_mv Artículo de revista
http://purl.org/coar/resource_type/c_6501
http://purl.org/coar/resource_type/c_2df8fbb1
Text
info:eu-repo/semantics/article
Journal article
http://purl.org/redcol/resource_type/ART
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/version/c_970fb48d4fbd8a85
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.ucaldas.edu.co/handle/ucaldas/25446
10.17151/vetzo.2018.12.1.4
2011-5415
https://doi.org/10.17151/vetzo.2018.12.1.4
url https://repositorio.ucaldas.edu.co/handle/ucaldas/25446
https://doi.org/10.17151/vetzo.2018.12.1.4
identifier_str_mv 10.17151/vetzo.2018.12.1.4
2011-5415
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 61
1
35
12
Revista Veterinaria y Zootecnia (On Line)
 Ayral, X. et al. Synovitis: A potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis. Results of a 1 year longitudinal arthroscopic study in 422 patients. Osteoarthr Cartilage, v. 13, p. 361-367, 2005.
 Baines, S. Histopathological changes in synovial membrane in cranial cruciate ligament rupture. In: BSAVA Congress, n. 1, 1994, Birmingham.
 Beckwee, D. et al. Osteoarthritis of the knee: Why does exercise work? A qualitative study of the literature. Ageing Res Rev, v. 12, n. 1, p. 226-236, 2013.
 Bolon, B. et al. Interleukin-1beta and tumor necrosis factor alpha produce distinct, time-dependent patterns of acute arthritis in the rat knee. Vet Pathol, v. 41, n. 3, p. 235- 243, 2004.
 Brandt, K.D. Pain, synovitis, and articular cartilage changes in osteoarthritis. Semin Arthritis Rheum, v. 18, n. 4, supl. 2, p. 77-80, 1989.
 Carter, S.D.; BARNES, A.; GILMORE, W.H. Canine rheumatoid arthritis and inflammatory cytokines. Vet Immunol Immunopathol, v. 69, p. 201-214, 1999.
 Clark, T.P. The clinical pharmacology of ciclooxigenase-2-selective and dual inhibitors. VetClin North Am Small Anim Pract, v. 36, n. 5, p. 1061-1085, 2006.
 de Bruin, T. et al. Interleukin-8 mRNA expression in synovial fluid of canine stifle joints with osteoarthritis. Vet Immunol and Immunopathol, v. 108, n. 3-4, p. 387-397, 2005.
 Doom, M. et al. Immunopathological mechanisms in dogs with rupture of the cranial cruciate ligament. Vet Immunol Immunopathol, v. 125, n. 1-2, p. 143-161, 2008.
 Flynn, K.A.; Whitcomb, M.B. Equine meniscal injuries: A retrospective study of 14 horses. Proc Am Assoc Equine Pract, v. 48, p. 249-254, 2002.
 Franklin, S.P.; Park, R.D.; Egger, E.L. Metacarpophalangeal and metatarsophalangealosteoarthritis in 49 dogs. J Am Anim Hosp Assoc, v. 45, n. 3, p. 112-117, 2009.
 Froum, S.J. et al. Effect of platelet-rich plasma on bone growth and osseointegration in human maxillary sinus grafts: Three bilateral case reports. Int J Periodontics Restorative Dent, v. 22, n. 1, p. 45-54, 2002.
 Gale, N.W.; Yancopoulos, G.D. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes Dev, v. 13, n. 9, p. 1055-1066, 1999.
 Gao, J.; Symons, A.L.; Bartold, M.P. Expression of transforming growth factor β receptors types II and III within various cells in the rat periodontium. J Periodont Res, v. 34, n. 2, p. 113-122, 1999.
 Gardner, D.L. Problems and paradigms in joint pathology. J Anat, v. 184, Pt. 3, 1994.
 Gnudi, G.; Bertoni, G. Echografic examination of the stifle joint affected by cranial cruciate ligament rupture in the dog. Vet Radiol Ultrasound, v. 42, n. 3, p. 266-270, 2001.
 Guermazi, A. et al. Osteoarthritis: A review of strengths and weaknesses of different imaging options. Rheum Dis Clin N Am, v. 39, n. 3, p. 567-591, 2013.
 Guilak, F. et al. Mechanical and biochemical changes in the superficial zone of articular cartilage in canine experimental osteoarthritis. J Orthop Res, v. 12, n. 4, p. 474-484, 1994.
 Heldin, C.H.; Westermark, B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev, v. 79, n. 4, p. 1283-1316, 1999.
 Henrotin, Y. et al. Usefulness of specific OA biomarkers, Coll2-1 and Coll2-1NO2, in the anterior cruciate ligament OA canine model.Osteoarthritis Cartilage, v. 20, n. 7, p. 787-790, 2012.
 Huang, T.F. et al. Isolation and characterization of mesenchymal stromal cells from human anterior cruciate ligament. Cytotherapy, v. 10, n. 8, p. 806-814, 2008.
 Iacopetti, I. et al. Application of Platelet-Rich Gel to Enhance Wound Healing in the Horse: A Case Report. J Equine Vet Sci, v. 32, n. 3, p. 123-128, 2012.
 Innes, J.F. et al. Long-term outcome of surgery for dogs with cranial cruciate ligament deficiency. Vet Rec, v. 147, n. 12, p. 325-328, 2000.
 Innes, J.F.; Costello, M.; Barr, M.J. Radiographic progression of osteoarthritis of the canine stifle joint: A prospective study. Vet Rad Ultrasound, v. 45, n. 2, p. 143-148, 2004.
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 Johnston, S. Osteoarthritis. Vet Clin N Am: Small Anim Pract, v. 27, n. 4, 1997.
 Konttinen, Y.T. et al. Osteoarthritis as an autoinflammatory disease caused by chondrocyte-mediated inflammatory responses. Arthritis Rheum, v. 64, n. 3, p. 613- 616, 2012.
 Lavigne, P. et al. Subchondral and trabecular bone metabolism regulation in canine experimental knee osteoarthritis. OsteoArthritis Cartilage, v. 13, n. 4, p. 310-317, 2005.
 Louboutin, H. et al. Osteoarthritis in patients with anterior cruciate ligament rupture: A review of risk factors. Knee, v. 16, n. 4, p. 239-244, 2009.
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Núm. 1 , Año 2018 : Enero - Junio
https://revistasojs.ucaldas.edu.co/index.php/vetzootec/article/download/3346/3106
dc.rights.none.fl_str_mv Revista Veterinaria y Zootecnia (On Line) - 2018
https://creativecommons.org/licenses/by-nc-sa/4.0/
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rights_invalid_str_mv Revista Veterinaria y Zootecnia (On Line) - 2018
https://creativecommons.org/licenses/by-nc-sa/4.0/
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dc.publisher.none.fl_str_mv Universidad de Caldas
publisher.none.fl_str_mv Universidad de Caldas
dc.source.none.fl_str_mv https://revistasojs.ucaldas.edu.co/index.php/vetzootec/article/view/3346
institution Universidad de Caldas
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spelling Early clinical, radiographic and ultrasonographic evaluation of induced osteoarthritis in rabbits treated with autologous platelet concentrateAvaliação clínica, radiográfica e ultrassonográfica precoce da osteoartrose induzida em coelhos e tratados com concentrado autólogo de plaquetasdegenerative joint processdiagnostic imagingregenerative therapyplatelet rich plasmaprocesso articular degenerativodiagnóstico por imagemterapia regenerativaplasma rico em plaquetasThe objective of this study was to evaluate, the early effect of the autologous platelet concentrates (APC) on induced osteoarthritis (OA) in the stifle joint through clinical, radiographic and ultrasonographic exams. Fourteen adult males of the New Zealand breed rabbits, with an average body mass of 3.0 kg were used to induce OA in the right hind limb (RHL). Rabbits were randomly divided into two groups, control group and APC group. Animals in the control group received 0.5 ml intra-articular Ringer Lactate solution. Immediately after the repair of the cranial cruciate ligament, the APC group received 0.5 ml APC intra-articular injections whose mean concentration of platelets was1.8 times the basal levels. Intra-articular injections were applied immediately after joint stabilization. Rabbits treated with APC showed significantly better clinical scores (p<0.05) when compared with rabbits in the control group in relation to pain sensitivity, joint effusion presence and limb support 15 days after APC application (M3). The range of limb motion showed statistically significant difference (p<0.05) in flexion and extension of RHL in M3 in both groups. The radiographic and ultrassonographic images showed the presence of degenerative joint process in both groups without statistical difference between them. From the results it can be concluded that APC has a beneficial clinical effect in joints affected by OA, favoring the use of the limb and controlling pain sensitivity, and that radiography and ultrasonography images are successful tools in the evaluation of the progression of OA.O objetivo desta pesquisa foi avaliar, por meio de exames clínicos, radiográficos e ultrassonográficos o efeito do concentrado autólogo de plaquetas (CAP) na osteoartrose (OA) induzida na articulação fêmoro-tíbio-patelar (FTP). Foram empregados 14 coelhos machos, adultos, com massa corporal média de 3,0 kg, da raça Nova Zelândia nos quais foi induzida a OA no membro posterior direito (MPD). Os coelhos foram divididos aleatoriamente em dois grupos constituindo o grupo controle e o grupo CAP. Os animais do grupo controle receberam 0,5 ml de Ringer Lactato intra-articular. O grupo CAP recebeu imediatamente após a reparação do ligamento cruzado cranial 0,5 ml de CAP intra-articular, cuja concentração média de plaquetas foi de 1,8 vezes os níveis basais. Estas injeções foram realizadas imediatamente após a estabilização articular. Os coelhos tratados com CAP apresentaram scores clínicos significativamente melhores (p<0,05) quando comparados com os coelhos do grupo controle em relação à sensibilidade dolorosa, presença de efusão articular e apoio do membro 15 dias após a aplicação do CAP (M3). A amplitude de movimento articular mostrou diferença estatisticamente significativa (p<0,05) na flexão e extensão do MPD no M3 em ambos os grupos. As imagens radiográficas e ultrassonográficas mostraram presença de processo articular degenerativo em ambos os grupos sem diferença estatística entre eles. Dos resultados pode-se concluir que o CAP tem efeito clínico benéfico em articulações acometidas pela OA, favorecendo o uso do membro e controlando a sensibilidade dolorosa, e que a radiografia e a ultrassonografia são ferramentas úteis na avaliação da progressão da OA.Universidad de Caldas2018-01-01T00:00:00Z2025-10-08T21:57:22Z2018-01-01T00:00:00Z2025-10-08T21:57:22Z2018-01-01Artículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articleJournal articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85application/pdfhttps://repositorio.ucaldas.edu.co/handle/ucaldas/2544610.17151/vetzo.2018.12.1.42011-5415https://doi.org/10.17151/vetzo.2018.12.1.4https://revistasojs.ucaldas.edu.co/index.php/vetzootec/article/view/3346eng6113512Revista Veterinaria y Zootecnia (On Line) Ayral, X. et al. Synovitis: A potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis. Results of a 1 year longitudinal arthroscopic study in 422 patients. Osteoarthr Cartilage, v. 13, p. 361-367, 2005. Baines, S. Histopathological changes in synovial membrane in cranial cruciate ligament rupture. In: BSAVA Congress, n. 1, 1994, Birmingham. Beckwee, D. et al. Osteoarthritis of the knee: Why does exercise work? A qualitative study of the literature. Ageing Res Rev, v. 12, n. 1, p. 226-236, 2013. Bolon, B. et al. Interleukin-1beta and tumor necrosis factor alpha produce distinct, time-dependent patterns of acute arthritis in the rat knee. Vet Pathol, v. 41, n. 3, p. 235- 243, 2004. Brandt, K.D. Pain, synovitis, and articular cartilage changes in osteoarthritis. Semin Arthritis Rheum, v. 18, n. 4, supl. 2, p. 77-80, 1989. Carter, S.D.; BARNES, A.; GILMORE, W.H. Canine rheumatoid arthritis and inflammatory cytokines. Vet Immunol Immunopathol, v. 69, p. 201-214, 1999. Clark, T.P. The clinical pharmacology of ciclooxigenase-2-selective and dual inhibitors. VetClin North Am Small Anim Pract, v. 36, n. 5, p. 1061-1085, 2006. de Bruin, T. et al. Interleukin-8 mRNA expression in synovial fluid of canine stifle joints with osteoarthritis. Vet Immunol and Immunopathol, v. 108, n. 3-4, p. 387-397, 2005. Doom, M. et al. Immunopathological mechanisms in dogs with rupture of the cranial cruciate ligament. Vet Immunol Immunopathol, v. 125, n. 1-2, p. 143-161, 2008. Flynn, K.A.; Whitcomb, M.B. Equine meniscal injuries: A retrospective study of 14 horses. Proc Am Assoc Equine Pract, v. 48, p. 249-254, 2002. Franklin, S.P.; Park, R.D.; Egger, E.L. Metacarpophalangeal and metatarsophalangealosteoarthritis in 49 dogs. J Am Anim Hosp Assoc, v. 45, n. 3, p. 112-117, 2009. Froum, S.J. et al. Effect of platelet-rich plasma on bone growth and osseointegration in human maxillary sinus grafts: Three bilateral case reports. Int J Periodontics Restorative Dent, v. 22, n. 1, p. 45-54, 2002. Gale, N.W.; Yancopoulos, G.D. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes Dev, v. 13, n. 9, p. 1055-1066, 1999. Gao, J.; Symons, A.L.; Bartold, M.P. Expression of transforming growth factor β receptors types II and III within various cells in the rat periodontium. J Periodont Res, v. 34, n. 2, p. 113-122, 1999. Gardner, D.L. Problems and paradigms in joint pathology. J Anat, v. 184, Pt. 3, 1994. Gnudi, G.; Bertoni, G. Echografic examination of the stifle joint affected by cranial cruciate ligament rupture in the dog. Vet Radiol Ultrasound, v. 42, n. 3, p. 266-270, 2001. Guermazi, A. et al. Osteoarthritis: A review of strengths and weaknesses of different imaging options. 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Vet Rec, v. 147, n. 12, p. 325-328, 2000. Innes, J.F.; Costello, M.; Barr, M.J. Radiographic progression of osteoarthritis of the canine stifle joint: A prospective study. Vet Rad Ultrasound, v. 45, n. 2, p. 143-148, 2004. Johnson, J.M.; Johnson, A.L. Cranial cruciate ligament rupture: Pathogenesis, diagnosis and postoperative rehabilitation. Vet Clin N Am: Small Anim Pract, v. 23, n. 4, p. 717-733, 1993. Johnston, S. Osteoarthritis. Vet Clin N Am: Small Anim Pract, v. 27, n. 4, 1997. Konttinen, Y.T. et al. Osteoarthritis as an autoinflammatory disease caused by chondrocyte-mediated inflammatory responses. Arthritis Rheum, v. 64, n. 3, p. 613- 616, 2012. Lavigne, P. et al. Subchondral and trabecular bone metabolism regulation in canine experimental knee osteoarthritis. OsteoArthritis Cartilage, v. 13, n. 4, p. 310-317, 2005. Louboutin, H. et al. Osteoarthritis in patients with anterior cruciate ligament rupture: A review of risk factors. 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Osteoarthritis Cartilage, v. 21, n. 1, p. 1627- 1637, 2013.Núm. 1 , Año 2018 : Enero - Juniohttps://revistasojs.ucaldas.edu.co/index.php/vetzootec/article/download/3346/3106Revista Veterinaria y Zootecnia (On Line) - 2018https://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Osorio-Carmona, EstebanCastro-Varón, Jessica AlejandraSánchez-Árcila, Diego FelipeSacchetto-Tôrres, Renato CesarCarvalhoNepomuceno, AneliseCarvalho-de Souza, Juliade Faria-Rezende, Cleuza Mariaoai:repositorio.ucaldas.edu.co:ucaldas/254462025-10-08T21:57:23Z

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