Efectos fisiológicos favorables de un protocolo de hidroterapia de colón (PHTC) en mujeres adultas jóvenes con sobrepeso

Ilustraciones, fotos

Autores:

Tipo de recurso:

Fecha de publicación:: 2023

Institución:: Universidad de Caldas

Repositorio:: Repositorio Institucional U. Caldas

Idioma:: eng
spa

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network_acronym_str	REPOUCALDA
network_name_str	Repositorio Institucional U. Caldas
repository_id_str
dc.title.none.fl_str_mv	Efectos fisiológicos favorables de un protocolo de hidroterapia de colón (PHTC) en mujeres adultas jóvenes con sobrepeso
title	Efectos fisiológicos favorables de un protocolo de hidroterapia de colón (PHTC) en mujeres adultas jóvenes con sobrepeso
spellingShingle	Efectos fisiológicos favorables de un protocolo de hidroterapia de colón (PHTC) en mujeres adultas jóvenes con sobrepeso Microbiota intestinal Sobrepeso Hidroterapia de colon Dislipidemia Metainflamación Ciencias médicas
title_short	Efectos fisiológicos favorables de un protocolo de hidroterapia de colón (PHTC) en mujeres adultas jóvenes con sobrepeso
title_full	Efectos fisiológicos favorables de un protocolo de hidroterapia de colón (PHTC) en mujeres adultas jóvenes con sobrepeso
title_fullStr	Efectos fisiológicos favorables de un protocolo de hidroterapia de colón (PHTC) en mujeres adultas jóvenes con sobrepeso
title_full_unstemmed	Efectos fisiológicos favorables de un protocolo de hidroterapia de colón (PHTC) en mujeres adultas jóvenes con sobrepeso
title_sort	Efectos fisiológicos favorables de un protocolo de hidroterapia de colón (PHTC) en mujeres adultas jóvenes con sobrepeso
dc.contributor.none.fl_str_mv	Gómez Buitrago, Paola Andrea Carlos Augusto González Correa Bioimpedancia eléctrica (Categoría A)
dc.subject.none.fl_str_mv	Microbiota intestinal Sobrepeso Hidroterapia de colon Dislipidemia Metainflamación Ciencias médicas
topic	Microbiota intestinal Sobrepeso Hidroterapia de colon Dislipidemia Metainflamación Ciencias médicas
description	Ilustraciones, fotos
publishDate	2023
dc.date.none.fl_str_mv	2023-06-28T14:37:53Z 2023-06-28T14:37:53Z 2023-06-28
dc.type.none.fl_str_mv	Datos - colección de datos Trabajo de grado - Doctorado http://purl.org/coar/resource_type/c_db06 Text info:eu-repo/semantics/doctoralThesis https://purl.org/redcol/resource_type/TD
dc.type.coarversion.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.identifier.none.fl_str_mv	https://repositorio.ucaldas.edu.co/handle/ucaldas/19514 Universidad de Caldas Repositorio Institucional Universidad de Caldas https://repositorio.ucaldas.edu.co/
url	https://repositorio.ucaldas.edu.co/handle/ucaldas/19514 https://repositorio.ucaldas.edu.co/
identifier_str_mv	Universidad de Caldas Repositorio Institucional Universidad de Caldas
dc.language.none.fl_str_mv	eng spa
language	eng spa
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International Journal of Environmental Research and Public Health, 19(19), Article 19. https://doi.org/10.3390/ijerph191912009 Xu, P., Hong, F., Wang, J., Cong, Y., Dai, S., Wang, S., Wang, J., Jin, X., Wang, F., Liu, J., & Zhai, Y. (2017). Microbiome Remodeling via the Montmorillonite AdsorptionExcretion Axis Prevents Obesity-related Metabolic Disorders. EBioMedicine, 16, 251–261. https://doi.org/10.1016/j.ebiom.2017.01.019 Yong, E. (2008). Human gut bacteria linked to obesity. https://www.nationalgeographic.com/science/article/human-gut-bacteria-linked-toobesity Yoo, E.-G. (2016). Waist-to-height ratio as a screening tool for obesity and cardiometabolic risk. Korean Journal of Pediatrics, 59(11), 425–431. https://doi.org/10.3345/kjp.2016.59.11.425 Yue, B., Yu, Z.-L., Lv, C., Geng, X.-L., Wang, Z.-T., & Dou, W. (2020). Regulation of the intestinal microbiota: An emerging therapeutic strategy for inflammatory bowel disease. World Journal of Gastroenterology, 26(30), 4378–4393. https://doi.org/10.3748/wjg.v26.i30.4378 Zhang, W., Zou, G., Li, B., Du, X., Sun, Z., Sun, Y., & Jiang, X. (2020). Fecal Microbiota Transplantation (FMT) Alleviates Experimental Colitis in Mice by Gut Microbiota Regulation. Journal of Microbiology and Biotechnology, 30(8), 1132–1141. https://doi.org/10.4014/jmb.2002.02044 Zhou, Y., Xu, H., Huang, H., Li, Y., Chen, H., He, J., Du, Y., Chen, Y., Zhou, Y., & Nie, Y. (2019). Are There Potential Applications of Fecal Microbiota Transplantation beyond Intestinal Disorders? BioMed Research International, 2019, 3469754. https://doi.org/10.1155/2019/3469754
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dc.publisher.none.fl_str_mv	Facultad de Ciencias para la Salud Manizales Doctorado en Ciencias Biomédicas
publisher.none.fl_str_mv	Facultad de Ciencias para la Salud Manizales Doctorado en Ciencias Biomédicas
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spelling	Efectos fisiológicos favorables de un protocolo de hidroterapia de colón (PHTC) en mujeres adultas jóvenes con sobrepesoMicrobiota intestinalSobrepesoHidroterapia de colonDislipidemiaMetainflamaciónCiencias médicasIlustraciones, fotosspa:Introducción: en lo que ha corrido del presente siglo, la ciencia ha demostrado una asociación clara entre la composición de la microbiota intestinal y diversos tipos de enfermedades crónicas no transmisibles, de manera especial con la hiperadiposidad corporal (sobrepeso y obesidad). La hiperadiposidad abdominal es considerada el factor principal alrededor del cual gravita el síndrome metabólico (aumento de la presión arterial, niveles altos de glucosa en sangre y niveles anormales de colesterol o triglicéridos), con su consecuente riesgo elevado de enfermedad cardiovascular. La Organización Mundial de la Salud ha propuesto un esquema general de manejo del sobrepeso y la obesidad basado en tres componentes fundamentales: a) ajuste de la dieta, b) incremento del ejercicio físico y c) intervenciones de tipo cognitivo conductual. Sin embargo, lo que se ha logrado evidenciar, es que los tratamientos de adelgazamiento se han mostrado, en alto grado, ineficaces en el mediano y largo plazo. Actualmente, se considera que el colon es clave para el bienestar, la salud y la enfermedad, y la modulación de la microbiota intestinal se está convirtiendo en un objetivo terapéutico para algunas afecciones médicas. Las intervenciones para esta modulación van desde las tradicionales basadas en dieta y ejercicio, hasta los trasplantes fecales intestinales, pasando por el consumo de pro- pre y simbióticos. El objetivo principal del presente estudio consistió en medir los efectos de un tratamiento de hidroterapia del colon, considerado como una alternativa de modulación de la microbiota intestinal humana, sobre una serie de variables fisiológicas físicas, químicas y biológicas asociadas al sobrepeso/obesidad. Métodología: se propuso un protocolo de limpieza de colon de 6 días para modular la composición de la microbiota intestinal y obtener mejoras visibles en un conjunto seleccionado de 22 variables fisiológicas asociadas al sobrepeso y la obesidad: 11 físicas, 9 químicas y 2 biológicas (razón Firmicutes/Bacteroidota , RF/B, y la prevalencia de Akkermansia sp). Todas las participantes, luego de leer la hoja de información del proyecto y firmar el consentimiento informado, fueron examinadas en tres tiempos distintos (T1, T2, T3 y T4). Se utilizó una prueba t de Student para comparar las medias de cada variable entre ambos grupos en T1, T2 T3 y T4, mientras que se aplicó un ANOVA de medidas repetidas para los puntos temporales para la comparación de las medias de cada variable en cada grupo en los tres momentos diferentes. La variable de respuesta fue cada una de las variables fisiológicas medidas (peso, % de PMGC, etc.). Cuando el ANOVA mostró diferencias, se utilizó la prueba de Bonferroni para determinar dónde estaban esas diferencias. En ambos casos, los valores p < 0,05 se consideran estadísticamente significativos. La correlación entre las medias de cada una de las variables fisiológicas físicas y químicas estudiadas con las medias del biomarcador biológico RF /B se realizó con la prueba de correlación de rangos de Spearman. Resultados: aquí, mostramos que los cambios favorables en todas las variables seleccionadas están presentes en el grupo experimental inmediatamente después del tratamiento y un mes después, sin más intervención, y que los cambios observados en las variables físicas y químicas están altamente correlacionados con los cambios en la RF/B. Hubo correlaciones estadísticamente significativas entre la mayoría de las variables fisiológicas físicas y químicas con la RF/B, excepto para tres de ellas: FCR, PAD, PAS. Las tres variables que muestran una correlación negativa son aquellas cuyo incremento puede considerarse beneficioso: FAMM, PWMSA y HDL. Discusión: el sobrepeso o la obesidad, al igual que la mayoría de las enfermedades crónicas no transmisibles (ECNTs), se asocian a hábitos de vida poco saludables, que producen alteraciones en el equilibrio del MBIH (disbiosis). Dado que los hábitos de vida son modificables, las ECNTs se consideran prevenibles. La modulación de la microbiota al inicio de una intervención de adelgazamiento para restablecer ese equilibrio (eubiosis) podría resultar muy útil como coadyuvante de los cambios en la dieta y la actividad física y mejorar su eficacia. Los resultados preliminares aportados por este trabajo de investigación son muy alentadores y merecen un futuro estudio clínico más amplio para obtener un sólido apoyo estadístico a esta propuesta. Recomendaciones: a partir de los resultados obtenidos en el presente estudio, se sugiere: a) realizar nuevos estudios con un número mayor de participantes; b) incluir un programa de actividad física complementario al Protocolo de Hidroterapia de Colon; c) explorar a mayor profundidad los cambios producidos en la composición de la microbiota intestinal; d) considerar otros grupos de posibles participantes del estudio.eng:Introduction: in the course of the present century, science has demonstrated a clear association between the composition of the intestinal microbiota and various types of chronic non-communicable diseases, especially with body hyperadiposity (overweight and obesity). Abdominal hyperadiposity is considered the main factor around which the metabolic syndrome (increased blood pressure, high blood sugar levels and abnormal cholesterol or triglyceride levels) gravitates, with its consequent elevated risk of cardiovascular disease. The World Health Organization has proposed a general management scheme for overweight and obesity based on three fundamental components: a) dietary adjustment, b) increased physical exercise and c) cognitive-behavioral interventions. However, what has become evident is that weight loss treatments have been shown, to a high degree, to be ineffective in the medium and long term. The colon is now considered key to wellness, health and disease, and modulation of the gut microbiota is becoming a therapeutic target for some medical conditions. Interventions for this modulation range from traditional ones based basically on diet and exercise, to intestinal fecal transplants (microbiota/microbiome), to the consumption of pro- pre and symbiotics. The main objective of the present study consisted in measuring the effects of a colon hydrotherapy treatment on some physiological variables (physical, chemical and biological) associated whith being overweight or obese, as a possible alternative for human intestinal microbiota modulation. Methodology: a 6-day colon cleansing protocol was proposed to modulate the intestinal microbiota and obtain visible improvements in a selected set of 22 physiological variables associated with overweight and obesity: 11 physical, 9 chemical and 2 biological (Firmicutes/Bacteroidetes , ratio, and the prevalence of Akkermansia sp). All participants, after reading the project information sheet and signing the informed consent, were examined at three different times (T1, T2, T3 and T4). A Student's t-test was used to compare the means of each variable between both groups at T1, T2, T3 and T4, while a repeated measures ANOVA for time points was applied for the comparison of the means of each variable in each group at the three different times. The response variable was each of the physiological variables measured (weight, % PBFM, etc.). When the ANOVA showed differences, the Bonferroni test was used to determine where those differences were. In both cases, p-values < 0.05 are considered statistically significant. The correlation between the means of each of the physical and chemical physiological variables studied with the means of the biological biomarker F/BR was performed with Spearman's rank correlation test. Results: here, we show that favorable changes in all selected variables are present in the experimental group immediately after treatment and one month later, without further intervention, and that the observed changes in the physical and chemical variables are highly correlated with changes in F/BR. There were statistically significant correlations between most of the physical and chemical physiological variables with RF/B, except for three of them: RCR, DBP, SBP. The three variables showing a negative correlation are those whose increase can be considered beneficial: MHGS, MWSRT and HDL. Discussion: overweight or obesity, like most chronic noncommunicable diseases (NCDs), are associated with unhealthy lifestyle habits, which produce epigenetic changes and alterations in the balance of the IM (dysbiosis). Since lifestyle habits are modifiable, NCDs are considered preventable. Modulation of the microbiota at the beginning of a weight loss intervention to restore this balance (eubiosis) could be very useful as an adjuvant to changes in diet and physical activity and improve their efficacy. The preliminary results provided by this research work are very encouraging and deserve a future larger clinical study to obtain a solid statistical support for this proposal. Recommendations: based on the results obtained in the present study, it is suggested: a) to carry out new studies with a larger number of participants; b) to include a physical activity program complementary to the Colon Hydrotherapy Protocol; c) to explore in greater depth the changes produced in the composition of the intestinal microbiota; d) to consider other groups of possible study participants.Resumen / Abstract / Agradecimientos / Tabla de contenido / Lista de figuras / Lista de tablas / Lista de abreviaturas y símbolos / Lista de anexos / 1. INTRODUCCIÓN / 1.1. Antecedentes locales / 1.2. Bacterias y microbiota intestinal humana (MBIH) / 1.3. MBIH e hiperadiposidad corporal (sobrepeso/obesidad) / 1.4. Modulación de la microbiota intestinal y sobrepeso/obesidad / 1.4.1. Dieta / 1.4.2. Bióticos / 1.4.3. Trasplante de microbiota/microbioma (materia fecal) (TMF) / 1.4.4. Cirugía bariátrica / 1.4.5. Enemas y limpieza intestinal o del colon / 1.5. Breves consideraciones sobre algunos componentes del PHTC / 1.5.1. Cáscara de psyllium / 1.5.2. Montmorillonita / 1.5.3. Vinagre de cidra de manzana / 1.5.4. Miel de abejas / 1.5.5. Yogurt / 1.5.6. Dieta hipocalórica / 1.6. Consideraciones sobre las variables físicas seleccionadas para el estudio / 1.6.1. Variables físicas / 1.6.2. Variables químicas / 1.6.3. Variables biológicas / 2. HIPÓTESIS DE TRABAJO Y OBJETIVOS / 2.1. Hipótesis de trabajo / 2.2. Objetivos / 2.2.1. Objetivo general / 2.2.2. Objetivos específicos / 14 3. METODOLOGÍA / 3.1. Sujetos / 3.1.1. Participantes en el estudio / 3.1.2. Criterios de inclusión para las participantes con sobrepeso / 3.1.3. Criterios de exclusión para las participantes con sobrepeso / 3.1.4. Aprobación por parte de un Comité de Bioética / 3.1.5. Selección e inclusión de voluntarias / 3.2. Establecimiento de grupos y comparaciones a mostrar / 3.3. Línea de tiempo / 3.3.1. Flujo del estudio / 3.4. Variables / 3.5. Protocolo experimental / 3.6. Tipo de estudio / 3.7. Análisis estadístico / 3.8. Logro de los objetivos específicos / 3.8.1. Objetivo 1: comparación de las medias pre- versus las medias posttratamiento del GS, así como de ambas versus las medias del GD en T1. / 3.8.2. Objetivo 2: comportamiento de las variables asociadas a metainflamación durante la duración del estudio / 3.8.3. Objetivo 3: comportamiento de las variables físicas y químicas durante el estudio / 8 4. RESULTADOS / 4.1. Objetivo 1: comparación de las medias pre- versus las medias post-tratamiento del GS, así como de ambas versus las medias del GD en T1 / 4.2. Objetivo 2: comportamiento de las variables asociadas a metainflamación durante la duración del estudio / 4.3. Objetivo 3: comportamiento de las variables físicas y químicas durante el estudio / 4 5. DISCUSIÓN / 5.1. Objetivo 1: medias del GD y medias post- versus medias pre-tratamiento de los subgrupos SGC y SGE / 5.2. Objetivo 2: variables asociadas a metainflamación / 5.3. Objetivo 3: comportamiento de variables físicas y químicas durante el estudio / 6. CONCLUSIONES Y RECOMENDACIONES / Financiación / Reconocimientos / 7. REFERENCIASDoctoradoFinanciación: Este proyecto fue parcialmente financiado por el Ministerio de Ciencia, Tecnología e Innovación (MinCiencias) de la República de Colombia-Sur América, por medio de una beca para formación doctoral asignada a la estudiante en la convocatoria 785 de 2017.Reconocimientos: La realizacion de este proyecto fue posible gracias al aporyo de los laboratorios de Microbiología de la Universidad de Caldas, así como el de Biología Molecuar la Corpogen (Bogotá-Colombia), gracias a su apoyo en la fase experimental del mismo. También me gustaría agradecer a la nutricionista y compañera de doctorado de nuestro programa, Diana-María Trejos-Gallego, por su análisis del plan de alimentación del protocolo propuestoDoctor(a) en Ciencias BiomédicasFacultad de Ciencias para la SaludManizalesDoctorado en Ciencias BiomédicasGómez Buitrago, Paola AndreaCarlos Augusto González CorreaBioimpedancia eléctrica (Categoría A)Tapasco Tapasco, Luz Oleyda2023-06-28T14:37:53Z2023-06-28T14:37:53Z2023-06-28Datos - colección de datosTrabajo de grado - Doctoradohttp://purl.org/coar/resource_type/c_db06Textinfo:eu-repo/semantics/doctoralThesishttps://purl.org/redcol/resource_type/TDhttp://purl.org/coar/version/c_970fb48d4fbd8a85application/pdfapplication/pdfapplication/pdfapplication/pdfhttps://repositorio.ucaldas.edu.co/handle/ucaldas/19514Universidad de CaldasRepositorio Institucional Universidad de Caldashttps://repositorio.ucaldas.edu.co/engspaAbenavoli, L., Scarpellini, E., Colica, C., Boccuto, L., Salehi, B., Sharifi-Rad, J., Aiello, V., Romano, B., De Lorenzo, A., Izzo, A. 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