Toxicidad del Fipronil. Revisión sistemática de la literatura

Introducción: El Fipronil es un pesticida de amplio espectro que pertenece a la familia de los fenilpirazoles. Posee efectos gabaérgicos y glutamatérgicos. Se ha aplicado de manera extensiva, principalmente en cultivos de chontaduro Bactris gasipaes, como control al picudo Rhynchophorus palmarum. Ob...

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Fecha de publicación:: 2025

Institución:: Universidad de Caldas

Repositorio:: Repositorio Institucional U. Caldas

Idioma:: spa

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network_acronym_str	REPOUCALDA
network_name_str	Repositorio Institucional U. Caldas
repository_id_str
dc.title.none.fl_str_mv	Toxicidad del Fipronil. Revisión sistemática de la literatura Fipronil toxicity. Systematic review of literature
title	Toxicidad del Fipronil. Revisión sistemática de la literatura
spellingShingle	Toxicidad del Fipronil. Revisión sistemática de la literatura Fipronil neonicotinoides agricultura pesticidas/toxicidad chontaduro pesticidas/análisis Fipronil neonicotinoids agriculture pesticides/toxicity peach palm pesticides/analysis
title_short	Toxicidad del Fipronil. Revisión sistemática de la literatura
title_full	Toxicidad del Fipronil. Revisión sistemática de la literatura
title_fullStr	Toxicidad del Fipronil. Revisión sistemática de la literatura
title_full_unstemmed	Toxicidad del Fipronil. Revisión sistemática de la literatura
title_sort	Toxicidad del Fipronil. Revisión sistemática de la literatura
dc.subject.none.fl_str_mv	Fipronil neonicotinoides agricultura pesticidas/toxicidad chontaduro pesticidas/análisis Fipronil neonicotinoids agriculture pesticides/toxicity peach palm pesticides/analysis
topic	Fipronil neonicotinoides agricultura pesticidas/toxicidad chontaduro pesticidas/análisis Fipronil neonicotinoids agriculture pesticides/toxicity peach palm pesticides/analysis
description	Introducción: El Fipronil es un pesticida de amplio espectro que pertenece a la familia de los fenilpirazoles. Posee efectos gabaérgicos y glutamatérgicos. Se ha aplicado de manera extensiva, principalmente en cultivos de chontaduro Bactris gasipaes, como control al picudo Rhynchophorus palmarum. Objetivo: La presente revisión tiene como objetivo analizar la información bibliográfica centrada en las investigaciones realizadas acerca de la toxicidad del Fipronil, con especial énfasis en las herramientas de análisis toxicológico, los puntos finales y las rutas de toxicidad en humanos y animales. Materiales y métodos: La búsqueda de publicaciones con las palabras clave “Fipronil” y “toxicity”, se realizó en las bases de datos Thomson Reuters Web of Science (ISI Web of Knowledge) y Scopus en el periodo comprendido entre los años 1993 y 2022. Las 1492 referencias se descargaron para su análisis utilizando la teoría de grafos para determinar los artículos y autores relevantes, las palabras clave, la evolución de la temática y las distintas relaciones entre ellos. Se realizó, utilizando un script de RStudio desarrollado en el Core of science. Resultados y discusión: Esta revisión permitió identificar tendencias en investigación acerca de los efectos toxicológicos relacionados con la exposición a Fipronil en la reducción de los niveles hormonales asociados al desarrollo sexual, alteraciones en el sistema nervioso, malformaciones congénitas y alteraciones al del comportamiento, combinando estudios patológicos con aproximaciones metabolómicas, las metodologías analíticas para la identificación y propuestas de desarrollo de metodologías in silico para el análisis toxicológico.
publishDate	2025
dc.date.none.fl_str_mv	2025-02-05T00:00:00Z 2025-10-08T21:17:14Z 2025-02-05T00:00:00Z 2025-10-08T21:17:14Z 2025-02-05
dc.type.none.fl_str_mv	Artículo de revista http://purl.org/coar/resource_type/c_6501 http://purl.org/coar/resource_type/c_2df8fbb1 Text info:eu-repo/semantics/article Journal article http://purl.org/redcol/resource_type/ART info:eu-repo/semantics/publishedVersion http://purl.org/coar/version/c_970fb48d4fbd8a85
status_str	publishedVersion
dc.identifier.none.fl_str_mv	1657-9550 https://repositorio.ucaldas.edu.co/handle/ucaldas/23818 10.17151/biosa.2020.19.1.3 2462-960X https://doi.org/10.17151/biosa.2020.19.1.3
identifier_str_mv	1657-9550 10.17151/biosa.2020.19.1.3 2462-960X
url	https://repositorio.ucaldas.edu.co/handle/ucaldas/23818 https://doi.org/10.17151/biosa.2020.19.1.3
dc.language.none.fl_str_mv	spa
language	spa
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spelling	Toxicidad del Fipronil. Revisión sistemática de la literaturaFipronil toxicity. Systematic review of literatureFipronilneonicotinoidesagriculturapesticidas/toxicidadchontaduropesticidas/análisisFipronilneonicotinoidsagriculturepesticides/toxicitypeach palmpesticides/analysisIntroducción: El Fipronil es un pesticida de amplio espectro que pertenece a la familia de los fenilpirazoles. Posee efectos gabaérgicos y glutamatérgicos. Se ha aplicado de manera extensiva, principalmente en cultivos de chontaduro Bactris gasipaes, como control al picudo Rhynchophorus palmarum. Objetivo: La presente revisión tiene como objetivo analizar la información bibliográfica centrada en las investigaciones realizadas acerca de la toxicidad del Fipronil, con especial énfasis en las herramientas de análisis toxicológico, los puntos finales y las rutas de toxicidad en humanos y animales. Materiales y métodos: La búsqueda de publicaciones con las palabras clave “Fipronil” y “toxicity”, se realizó en las bases de datos Thomson Reuters Web of Science (ISI Web of Knowledge) y Scopus en el periodo comprendido entre los años 1993 y 2022. Las 1492 referencias se descargaron para su análisis utilizando la teoría de grafos para determinar los artículos y autores relevantes, las palabras clave, la evolución de la temática y las distintas relaciones entre ellos. Se realizó, utilizando un script de RStudio desarrollado en el Core of science. Resultados y discusión: Esta revisión permitió identificar tendencias en investigación acerca de los efectos toxicológicos relacionados con la exposición a Fipronil en la reducción de los niveles hormonales asociados al desarrollo sexual, alteraciones en el sistema nervioso, malformaciones congénitas y alteraciones al del comportamiento, combinando estudios patológicos con aproximaciones metabolómicas, las metodologías analíticas para la identificación y propuestas de desarrollo de metodologías in silico para el análisis toxicológico.Introduction: Fipronil is a broad-spectrum pesticide belonging to the phenyl pyrazole family. It has GABAergic and glutaminergic effects and has been extensively applied mainly on peach palm Bactris gasipaes crops, as a control of the Rhynchophorus palmarum weevil. Objective: The present review aims to conduct a literature review focused on published papers regarding the toxicity of fipronil, with special emphasis on toxicological analysis tools, endpoints, adverse outcome pathways, and mechanisms of toxicity in humans and animals. Materials and methods: The search for publications with the keywords “fipronil” and “toxicity” was carried out in the Thomson Reuters Web of Science (ISI Web of Knowledge) and Scopus databases between 1993 and 2022. The 1492 references were downloaded for analysis using graph theory to determine among others the relevant articles, authors, keywords, the evolution of the topics, and the different relationships between them, using an R studio script developed by the core of science. Results and discussion: This review identified trends in research on toxicological effects associated with fipronil exposure, in the reduction of hormone levels associated with sexual development, alterations in the nervous system, teratogenesis and behavioral alterations, combining pathological studies with metabolomic approaches, analytical methodologies for identification and proposals for the development of in silico methodologies for toxicological analysis.Universidad de Caldas2025-02-05T00:00:00Z2025-10-08T21:17:14Z2025-02-05T00:00:00Z2025-10-08T21:17:14Z2025-02-05Artículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articleJournal articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85application/pdf1657-9550https://repositorio.ucaldas.edu.co/handle/ucaldas/2381810.17151/biosa.2020.19.1.32462-960Xhttps://doi.org/10.17151/biosa.2020.19.1.3https://revistasojs.ucaldas.edu.co/index.php/biosalud/article/view/9857spa8715019BiosaludAcero, C. y Machuca, D. 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