Efecto del extracto de Passiflora ligularis Juss 1805 (Malpighiales: Passifloraceae) como agente reductor de marcadores de inflamación crónica

Objetivo: El objetivo del presente estudio fue determinar el efecto de la suplementación con extracto de Passiflora ligularis (granadilla), sobre algunos marcadores de inflamación crónica de bajo grado asociados al sobrepeso en un modelo de ratones albinos alimentados con dieta alta en grasa. Materi...

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Tipo de recurso:
Fecha de publicación:
2022
Institución:
Universidad de Caldas
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Repositorio Institucional U. Caldas
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spa
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oai:repositorio.ucaldas.edu.co:ucaldas/23449
Acceso en línea:
https://repositorio.ucaldas.edu.co/handle/ucaldas/23449
https://doi.org/10.17151/bccm.2022.26.2.3
Palabra clave:
Síndrome metabólico
obesidad
granadilla
inflamación
Metabolic syndrome
obesity
granadilla
inflammation
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openAccess
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https://creativecommons.org/licenses/by-nc-sa/4.0/
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oai_identifier_str oai:repositorio.ucaldas.edu.co:ucaldas/23449
network_acronym_str REPOUCALDA
network_name_str Repositorio Institucional U. Caldas
repository_id_str
dc.title.none.fl_str_mv Efecto del extracto de Passiflora ligularis Juss 1805 (Malpighiales: Passifloraceae) como agente reductor de marcadores de inflamación crónica
Effect of the extract of Passiflora ligularis Juss 1805 (Malpighiales: Passifloraceae) as a reducing agent of chronic inflammation markers
title Efecto del extracto de Passiflora ligularis Juss 1805 (Malpighiales: Passifloraceae) como agente reductor de marcadores de inflamación crónica
spellingShingle Efecto del extracto de Passiflora ligularis Juss 1805 (Malpighiales: Passifloraceae) como agente reductor de marcadores de inflamación crónica
Síndrome metabólico
obesidad
granadilla
inflamación
Metabolic syndrome
obesity
granadilla
inflammation
title_short Efecto del extracto de Passiflora ligularis Juss 1805 (Malpighiales: Passifloraceae) como agente reductor de marcadores de inflamación crónica
title_full Efecto del extracto de Passiflora ligularis Juss 1805 (Malpighiales: Passifloraceae) como agente reductor de marcadores de inflamación crónica
title_fullStr Efecto del extracto de Passiflora ligularis Juss 1805 (Malpighiales: Passifloraceae) como agente reductor de marcadores de inflamación crónica
title_full_unstemmed Efecto del extracto de Passiflora ligularis Juss 1805 (Malpighiales: Passifloraceae) como agente reductor de marcadores de inflamación crónica
title_sort Efecto del extracto de Passiflora ligularis Juss 1805 (Malpighiales: Passifloraceae) como agente reductor de marcadores de inflamación crónica
dc.subject.none.fl_str_mv Síndrome metabólico
obesidad
granadilla
inflamación
Metabolic syndrome
obesity
granadilla
inflammation
topic Síndrome metabólico
obesidad
granadilla
inflamación
Metabolic syndrome
obesity
granadilla
inflammation
description Objetivo: El objetivo del presente estudio fue determinar el efecto de la suplementación con extracto de Passiflora ligularis (granadilla), sobre algunos marcadores de inflamación crónica de bajo grado asociados al sobrepeso en un modelo de ratones albinos alimentados con dieta alta en grasa. Materiales y métodos: Se utilizaron 36 ratones albinos, distribuidos en un diseño irrestrictamente al azar, en 3 tratamientos y 12 repeticiones. Los tratamientos representaron un grupo con dieta control, un segundo tratamiento con dieta alta en grasa y un grupo que recibió alimento alto en grasa y suplementación con 3g/L de extracto de Passiflora ligularis en el agua de bebida. Pasados 49 días, se evaluaron las variables consumo de alimento, consumo de agua y ganancia de peso, además se evaluaron las concentraciones séricas de los marcadores de inflamación IL-6 y TNF-α. Resultados: La suplementación con extracto de Passiflora ligularis redujo (p < 0,05) la ganancia de peso de los ratones, en comparación con los animales que recibieron la dieta alta en grasa sin suplementación, los niveles séricos de TNF- α en los ratones suplementados no presentaron diferencias con ninguno de los dos grupos control, mientras que las cantidades de IL-6 no fueron afectados por los tratamientos. Conclusión: La concentración de 3g/L en el agua de bebida el extracto de Passiflora ligularis disminuyó la ganancia de peso producida por el aumento de la grasa en la dieta, y redujo la medición del marcador de inflamación sérico TNF-α, indicando un efecto benéfico sobre el riesgo asociado a la inflamación crónica de bajo grado.
publishDate 2022
dc.date.none.fl_str_mv 2022-07-01T00:00:00Z
2022-07-01T00:00:00Z
2022-07-01
2025-10-08T21:06:17Z
2025-10-08T21:06:17Z
dc.type.none.fl_str_mv Artículo de revista
http://purl.org/coar/resource_type/c_6501
Text
info:eu-repo/semantics/article
Journal article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
status_str publishedVersion
dc.identifier.none.fl_str_mv 0123-3068
https://repositorio.ucaldas.edu.co/handle/ucaldas/23449
10.17151/bccm.2022.26.2.3
2462-8190
https://doi.org/10.17151/bccm.2022.26.2.3
identifier_str_mv 0123-3068
10.17151/bccm.2022.26.2.3
2462-8190
url https://repositorio.ucaldas.edu.co/handle/ucaldas/23449
https://doi.org/10.17151/bccm.2022.26.2.3
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv 64
2
53
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Boletín Científico Centro de Museos Museo de Historia Natural
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Núm. 2 , Año 2022 : Julio - Diciembre
https://revistasojs.ucaldas.edu.co/index.php/boletincientifico/article/download/7516/6589
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spelling Efecto del extracto de Passiflora ligularis Juss 1805 (Malpighiales: Passifloraceae) como agente reductor de marcadores de inflamación crónicaEffect of the extract of Passiflora ligularis Juss 1805 (Malpighiales: Passifloraceae) as a reducing agent of chronic inflammation markersSíndrome metabólicoobesidadgranadillainflamaciónMetabolic syndromeobesitygranadillainflammationObjetivo: El objetivo del presente estudio fue determinar el efecto de la suplementación con extracto de Passiflora ligularis (granadilla), sobre algunos marcadores de inflamación crónica de bajo grado asociados al sobrepeso en un modelo de ratones albinos alimentados con dieta alta en grasa. Materiales y métodos: Se utilizaron 36 ratones albinos, distribuidos en un diseño irrestrictamente al azar, en 3 tratamientos y 12 repeticiones. Los tratamientos representaron un grupo con dieta control, un segundo tratamiento con dieta alta en grasa y un grupo que recibió alimento alto en grasa y suplementación con 3g/L de extracto de Passiflora ligularis en el agua de bebida. Pasados 49 días, se evaluaron las variables consumo de alimento, consumo de agua y ganancia de peso, además se evaluaron las concentraciones séricas de los marcadores de inflamación IL-6 y TNF-α. Resultados: La suplementación con extracto de Passiflora ligularis redujo (p < 0,05) la ganancia de peso de los ratones, en comparación con los animales que recibieron la dieta alta en grasa sin suplementación, los niveles séricos de TNF- α en los ratones suplementados no presentaron diferencias con ninguno de los dos grupos control, mientras que las cantidades de IL-6 no fueron afectados por los tratamientos. Conclusión: La concentración de 3g/L en el agua de bebida el extracto de Passiflora ligularis disminuyó la ganancia de peso producida por el aumento de la grasa en la dieta, y redujo la medición del marcador de inflamación sérico TNF-α, indicando un efecto benéfico sobre el riesgo asociado a la inflamación crónica de bajo grado.Objective: The objective of this study was to determine the effect of the supplementation with Passiflora ligularis (granadilla) extract on some low-grade chronic inflammation markers associated with overweight in a model of albino mice fed a high-fat diet. Materials and methods: thirty-six albino mice were used, distributed in an unrestrictedly random design in 3 treatments and 12 repetitions. The treatments represented a group with a control diet, a secondtreatment with a high-fat diet, and a group that received high-fat food and supplementation with 3g/L of Passiflora ligularis extract in the drinking water. After 49 days, the variables food consumption, water consumption, and weight gain were evaluated, in addition to the serum concentration of the inflammation markers IL-6 and TNF-α. Results: Supplementation with Passiflora ligularis extract reduced (p <0.05) the weight gain of mice compared to animals that received the high-fat diet without supplementation. Serum levels of TNF-α on supplemented mice did not show differences with neither of both control groups while the amounts of IL-6 were not affected by the treatments. Conclusion: The concentration of 3g/L in the drinking water of the of Passiflora ligularis extract decreased the weight gain produced by the increase fat in diet and reduced the measurement of the serum inflammation marker TNF-α indicating a beneficial effect on the risk associated with chronic low-grade inflammation.Boletín Científico2022-07-01T00:00:00Z2025-10-08T21:06:17Z2022-07-01T00:00:00Z2025-10-08T21:06:17Z2022-07-01Artículo de revistahttp://purl.org/coar/resource_type/c_6501Textinfo:eu-repo/semantics/articleJournal articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1application/pdf0123-3068https://repositorio.ucaldas.edu.co/handle/ucaldas/2344910.17151/bccm.2022.26.2.32462-8190https://doi.org/10.17151/bccm.2022.26.2.3https://revistasojs.ucaldas.edu.co/index.php/boletincientifico/article/view/7516spa6425326Boletín Científico Centro de Museos Museo de Historia NaturalBak. M. J., Truong, V. L., Kang, H. S. & Jun, M. (2013). Jeong WS. Anti-inflammatory effect of procyanidins from wild grape (Vitis amurensis) seeds in LPS-induced RAW 264.7 cells. Oxidative Medicine and Cellular Longevity. https://doi.org/10.1155/2013/409321Cao, Y. J., Zhang, Y. M., Qi, J. P., Liu, R., Zhang, H. & He, L. C. (2015). Ferulic acid inhibits H2O2-induced oxidative stress and inflammation in rat vascular smooth muscle cells via inhibition of the NADPH oxidase and NF-κB pathway. International immunopharmacology, 28(2): 1018-1025. https://doi.org/10.1016/j.intimp.2015.07.037Carmona-Hernández, J. C., Ángel-Isaza, J., González-Correa, C. H. & Narváez-Solarte, W. (2017). Anti-inflammatory effects of flavonoids evaluated in murine models: a descriptive review. Animal Science Papers & Reports, 35(4).Carmona-Hernández, J. C., Taborda-Ocampo, G., Valdez, J. C., Bolling, B. W. & González-Correa, C. H. (2019). polyphenol extracts from three colombian passifloras (passion fruits) prevent inflammation-induced barrier dysfunction of caco-2 cells. Molecules, 24(24). https://doi.org/10.3390/molecules24244614Chaparro, D. C., Maldonado, M. E., Franco, M. C. & Urango, L. A. (2015). Nutritional and antioxidant characteristics of banana passion fruit (Passiflora mollisima Bailey). Biotecnología en el Sector Agropecuario y Agroindustrial, 13(1): 120-128. https://doi.org/10.17533/udea.penh.v16n2a07Chen, N., Bezzina, R., Hinch, E., Lewandowski, P. A., Cameron-Smith, D., Mathai, M. L. & Weisinger, R. S. (2009). Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet. Nutrition Research, 29(11): 784-793. https://doi.org/10.1016/j.nutres.2009.10.003DANE. (2016). Encuesta Nacional Agropecuaria ENA. Boletín Técnico. Comunicación informativa.De Melo, T. S., Lima, P. R., Carvalho, K. M. 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Food Chemistry, 109(4): 691-702. https://doi.org/10.1016/j.foodchem.2008.02.039Núm. 2 , Año 2022 : Julio - Diciembrehttps://revistasojs.ucaldas.edu.co/index.php/boletincientifico/article/download/7516/6589https://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Carmona Hernández, Juan C.Ángel Isaza, JaimeRestrepo López, Juan P.Narváez Solarte, WilliamGonzález Correa, Clara H.oai:repositorio.ucaldas.edu.co:ucaldas/234492025-10-08T21:06:18Z

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